List of works - Tanja Wenzler

3D QSAR on a library of heterocyclic diamidine derivatives with antiparasitic activity

scientific article published on 25 January 2006

A Trk/HKT-type K+ transporter from Trypanosoma brucei

scientific article

A new approach to chemotherapy: drug-induced differentiation kills African trypanosomes

scientific article published on 2 March 2016

A well-plate format isothermal multi-channel microcalorimeter for monitoring the activity of living cells and tissues

Anti-protozoal activity of aporphine and protoberberine alkaloids from Annickia kummeriae (Engl. & Diels) Setten & Maas (Annonaceae)

scientific article published on 27 February 2013

Antiparasitic agents: new drugs on the horizon

scientific article published on 29 May 2012

Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues

scientific article published on 9 November 2013

Antitrypanosomal activity of 1,2-dihydroquinolin-6-ols and their ester derivatives

scientific article published in February 2010

Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol

scientific article (publication date: 2013)

Azaterphenyl diamidines as antileishmanial agents

scientific article published on 30 October 2007

Beyond immune escape: a variant surface glycoprotein causes suramin resistance in Trypanosoma brucei.

scientific article published on 30 September 2017

Correction to Synthesis and Antiprotozoal Activity of Cationic 1,4-Diphenyl-1H-1,2,3-triazoles

scholarly article published in Journal of Medicinal Chemistry

Dicationic DNA-targeted antiprotozoal agents: naphthalene replacement of benzimidazole

scientific article published in 2006

Dicationic biphenyl benzimidazole derivatives as antiprotozoal agents

scientific article published in October 2004

Dicationic near-linear biphenyl benzimidazole derivatives as DNA-targeted antiprotozoal agents

scientific article published on 15 August 2005

Dicationic phenyl-2,2'-bichalcophenes and analogues as antiprotozoal agents

scientific article

Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes

scientific article published on 21 May 2007

Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis

scientific article published on 5 August 2008

Exploration of DAPI analogues: Synthesis, antitrypanosomal activity, DNA binding and fluorescence properties

scientific article published on 24 January 2017

Exploration of larger central ring linkers in furamidine analogues: synthesis and evaluation of their DNA binding, antiparasitic and fluorescence properties

scientific article

Flagellar cAMP signaling controls trypanosome progression through host tissues

scientific article published on 18 February 2019

In vitro and in vivo evaluation of 28DAP010, a novel diamidine for treatment of second-stage African sleeping sickness

scientific article

Indole and Benzimidazole Bichalcophenes: Synthesis, DNA Binding and Antiparasitic Activity

scientific article

Isothermal microcalorimetry - A quantitative method to monitor Trypanosoma congolense growth and growth inhibition by trypanocidal drugs in real time.

scientific article published on 16 March 2018

Isothermal microcalorimetry, a new tool to monitor drug action against Trypanosoma brucei and Plasmodium falciparum

scientific article

Molecular modeling study and synthesis of novel dicationic flexible triaryl guanidines and imidamides as antiprotozoal agents

scientific article

New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289

scientific article published on 20 July 2009

Novel dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents

scientific article

Novel linear triaryl guanidines, N-substituted guanidines and potential prodrugs as antiprotozoal agents.

scientific article published on 29 February 2008

Pharmacokinetic comparison to determine the mechanisms underlying the differential efficacies of cationic diamidines against first- and second-stage human African trypanosomiasis

scientific article

Pharmacokinetics, Trypanosoma brucei gambiense efficacy, and time of drug action of DB829, a preclinical candidate for treatment of second-stage human African trypanosomiasis

scientific article published on 19 August 2013

Pharmacophore model for pentamidine analogs active against Plasmodium falciparum

scientific article published on 18 September 2010

Structure-activity study of pentamidine analogues as antiprotozoal agents

scientific article published in April 2009

Substituted 2-phenylimidazopyridines: a new class of drug leads for human African trypanosomiasis

scientific article

Synthesis and Antiparasitic Evaluation of Bis-2,5-[4-guanidinophenyl]thiophenes

Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum

scientific article published on 7 August 2009

Synthesis and antiparasitic activity of new bis-arylimidamides: DB766 analogs modified in the terminal groups

scientific article

Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes

scientific article published on 22 November 2006

Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives

scientific article published on 25 June 2013

Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes.

scientific article published on 24 March 2009

Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles

scientific article published on 27 March 2010

Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles

scientific article

Synthesis and antiprotozoal activity of cationic 2-phenylbenzofurans

scientific article

Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues

scientific article published on 13 August 2013

Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives

scientific article published on 24 June 2013

Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines.

scientific article published on 18 October 2007

Synthesis and antiprotozoal activity of pyridyl analogues of pentamidine.

scientific article published in August 2009

Synthesis and antiprotozoal properties of pentamidine congeners bearing the benzofuran motif

scientific article published on September 2009

Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation

scientific article published in 2011

Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles

scientific article published on 18 April 2007

Synthesis and in vitro antiprotozoal activity of bisbenzofuran cations

scientific article published on 19 October 2007

Synthesis of novel amide and urea derivatives of thiazol-2-ethylamines and their activity against Trypanosoma brucei rhodesiense

scientific article

Synthesis, DNA Affinity, and Antiprotozoal Activity of Linear Dications: Terphenyl Diamidines and Analogues

scientific article published on 01 August 2006

Synthesis, DNA affinity, and antiprotozoal activity of fused ring dicationic compounds and their prodrugs.

scientific article

Synthesis, DNA binding and antileishmanial activity of low molecular weight bis-arylimidamides

scientific article

Synthesis, DNA binding and antitrypanosomal activity of benzimidazole analogues of DAPI.

scientific article published on 3 November 2016

Synthesis, DNA binding, fluorescence measurements and antiparasitic activity of DAPI related diamidines

scientific article published on 11 December 2009

The Trypanocidal Effect of Novel Quinolines: In vitro And In vivo Studies

scientific article

List of works by Tanja Wenzler

3D QSAR on a library of heterocyclic diamidine derivatives with antiparasitic activity

A Trk/HKT-type K+ transporter from Trypanosoma brucei

A new approach to chemotherapy: drug-induced differentiation kills African trypanosomes

A well-plate format isothermal multi-channel microcalorimeter for monitoring the activity of living cells and tissues

Anti-protozoal activity of aporphine and protoberberine alkaloids from Annickia kummeriae (Engl. & Diels) Setten & Maas (Annonaceae)

Antiparasitic agents: new drugs on the horizon

Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues

Antitrypanosomal activity of 1,2-dihydroquinolin-6-ols and their ester derivatives

Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol

Azaterphenyl diamidines as antileishmanial agents

Beyond immune escape: a variant surface glycoprotein causes suramin resistance in Trypanosoma brucei.

Correction to Synthesis and Antiprotozoal Activity of Cationic 1,4-Diphenyl-1H-1,2,3-triazoles

Dicationic DNA-targeted antiprotozoal agents: naphthalene replacement of benzimidazole

Dicationic biphenyl benzimidazole derivatives as antiprotozoal agents

Dicationic near-linear biphenyl benzimidazole derivatives as DNA-targeted antiprotozoal agents

Dicationic phenyl-2,2'-bichalcophenes and analogues as antiprotozoal agents

Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes

Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis

Exploration of DAPI analogues: Synthesis, antitrypanosomal activity, DNA binding and fluorescence properties

Exploration of larger central ring linkers in furamidine analogues: synthesis and evaluation of their DNA binding, antiparasitic and fluorescence properties

Flagellar cAMP signaling controls trypanosome progression through host tissues

In vitro and in vivo evaluation of 28DAP010, a novel diamidine for treatment of second-stage African sleeping sickness

Indole and Benzimidazole Bichalcophenes: Synthesis, DNA Binding and Antiparasitic Activity

Isothermal microcalorimetry - A quantitative method to monitor Trypanosoma congolense growth and growth inhibition by trypanocidal drugs in real time.

Isothermal microcalorimetry, a new tool to monitor drug action against Trypanosoma brucei and Plasmodium falciparum

Molecular modeling study and synthesis of novel dicationic flexible triaryl guanidines and imidamides as antiprotozoal agents

New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289

Novel dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents

Novel linear triaryl guanidines, N-substituted guanidines and potential prodrugs as antiprotozoal agents.

Pharmacokinetic comparison to determine the mechanisms underlying the differential efficacies of cationic diamidines against first- and second-stage human African trypanosomiasis

Pharmacokinetics, Trypanosoma brucei gambiense efficacy, and time of drug action of DB829, a preclinical candidate for treatment of second-stage human African trypanosomiasis

Pharmacophore model for pentamidine analogs active against Plasmodium falciparum

Structure-activity study of pentamidine analogues as antiprotozoal agents

Substituted 2-phenylimidazopyridines: a new class of drug leads for human African trypanosomiasis

Synthesis and Antiparasitic Evaluation of Bis-2,5-[4-guanidinophenyl]thiophenes

Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum

Synthesis and antiparasitic activity of new bis-arylimidamides: DB766 analogs modified in the terminal groups

Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes

Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives

Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes.

Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles

Synthesis and antiprotozoal activity of cationic 1,4-diphenyl-1H-1,2,3-triazoles

Synthesis and antiprotozoal activity of cationic 2-phenylbenzofurans

Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues

Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives

Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines.

Synthesis and antiprotozoal activity of pyridyl analogues of pentamidine.

Synthesis and antiprotozoal properties of pentamidine congeners bearing the benzofuran motif

Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation

Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles

Synthesis and in vitro antiprotozoal activity of bisbenzofuran cations

Synthesis of novel amide and urea derivatives of thiazol-2-ethylamines and their activity against Trypanosoma brucei rhodesiense

Synthesis, DNA Affinity, and Antiprotozoal Activity of Linear Dications: Terphenyl Diamidines and Analogues

Synthesis, DNA affinity, and antiprotozoal activity of fused ring dicationic compounds and their prodrugs.

Synthesis, DNA binding and antileishmanial activity of low molecular weight bis-arylimidamides

Synthesis, DNA binding and antitrypanosomal activity of benzimidazole analogues of DAPI.

Synthesis, DNA binding, fluorescence measurements and antiparasitic activity of DAPI related diamidines

The Trypanocidal Effect of Novel Quinolines: In vitro And In vivo Studies