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List of works by Hiten D. Madhani

A Non-Dicer RNase III and Four Other Novel Factors Required for RNAi-Mediated Transposon Suppression in the Human Pathogenic Yeast Cryptococcus neoformans

scientific article published on 09 July 2019

A comprehensive strategy enabling high-resolution functional analysis of the yeast genome.

scientific article

A conserved RING finger protein required for histone H2B monoubiquitination and cell size control.

scientific article

A conserved ncRNA-binding protein recruits silencing factors to heterochromatin through an RNAi-independent mechanism

scientific article published on September 2013

A link between virulence and homeostatic responses to hypoxia during infection by the human fungal pathogen Cryptococcus neoformans

scientific article

A major role for capsule-independent phagocytosis-inhibitory mechanisms in mammalian infection by Cryptococcus neoformans.

scientific article

A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans.

scientific article published on 21 June 2019

A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome

scientific article (publication date: 27 November 1992)

A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin

scientific article

Applying genetics and molecular biology to the study of the human pathogen Cryptococcus neoformans

scientific article published on March 2010

Approaching the functional annotation of fungal virulence factors using cross-species genetic interaction profiling.

scientific article

Can a Systems Perspective Help Us Appreciate the Biological Meaning of Small Effects? ⬇️

scientific article published on July 19, 2011

Chemical genomic profiling to identify intracellular targets of a multiplex kinase inhibitor.

scientific article

Chromodomain-mediated oligomerization of HP1 suggests a nucleosome-bridging mechanism for heterochromatin assembly.

scientific article published on January 2011

Contrasting host-pathogen interactions and genome evolution in two generalist and specialist microsporidian pathogens of mosquitoes

scientific article published on 13 May 2015

Control of MAPK signaling specificity by a conserved residue in the MEK-binding domain of the yeast scaffold protein Ste5.

scientific article published on 4 February 2006

Coordinate control of gene expression noise and interchromosomal interactions in a MAP kinase pathway

scientific article

Coordinate genomic association of transcription factors controlled by an imported quorum sensing peptide in Cryptococcus neoformans

scientific article published on 21 September 2020

Ctr2 links copper homeostasis to polysaccharide capsule formation and phagocytosis inhibition in the human fungal pathogen Cryptococcus neoformans

scientific article

Differential DNA repair in transcriptionally active and inactive proto-oncogenes: c-abl and c-mos

scientific article published on May 1986

Division of labor between the chromodomains of HP1 and Suv39 methylase enables coordination of heterochromatin spread.

scientific article published on July 2013

Ers1 links HP1 to RNAi ⬇️

scientific article published on June 25, 2012

Ers1, a rapidly diverging protein essential for RNA interference-dependent heterochromatic silencing in Schizosaccharomyces pombe

scientific article published on 25 July 2008

Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo

scientific article

Exploration of whole-genome responses of the human AIDS-associated yeast pathogen Cryptococcus neoformans var grubii: nitric oxide stress and body temperature.

scientific article

Functional analysis of protein kinase networks in living cells: beyond "knock-outs" and "knock-downs".

scientific article published on November 2006

Functional profiling of human fungal pathogen genomes.

scientific article

Genomewide screen for negative regulators of sirtuin activity in Saccharomyces cerevisiae reveals 40 loci and links to metabolism

scientific article published on 9 August 2008

Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin

scientific article published on 21 October 2005

Intracellular Action of a Secreted Peptide Required for Fungal Virulence

scientific article

Intrinsic Toxicity of Unchecked Heterochromatin Spread Is Suppressed by Redundant Chromatin Boundary Functions in Schizosacchromyces pombe

scientific article published on 8 May 2015

Multisite phosphorylation of the Saccharomyces cerevisiae filamentous growth regulator Tec1 is required for its recognition by the E3 ubiquitin ligase adaptor Cdc4 and its subsequent destruction in vivo

scientific article

Noncanoncial signal recognition particle RNAs in a major eukaryotic phylum revealed by purification of SRP from the human pathogen Cryptococcus neoformans

scientific article

Nonredundant requirement for multiple histone modifications for the early anaphase release of the mitotic exit regulator Cdc14 from nucleolar chromatin

scientific article

Optimizing TiO2-based phosphopeptide enrichment for automated multidimensional liquid chromatography coupled to tandem mass spectrometry.

scientific article published on 25 May 2007

Parallel beta-helix proteins required for accurate capsule polysaccharide synthesis and virulence in the yeast Cryptococcus neoformans.

scientific article published on 2 March 2007

Pheromone-dependent destruction of the Tec1 transcription factor is required for MAP kinase signaling specificity in yeast.

scientific article

Polymerase pausing induced by sequence-specific RNA-binding protein drives heterochromatin assembly.

scientific article published in July 2018

Principles of MAP kinase signaling specificity in Saccharomyces cerevisiae.

scientific article

Product binding enforces the genomic specificity of a yeast polycomb repressive complex

scientific article

Quantitative global studies reveal differential translational control by start codon context across the fungal kingdom

scientific article published on 01 March 2020

Quorum sensing in fungi: Q&A.

scientific article

Recognizing the enemy within: licensing RNA-guided genome defense.

scientific article

Selective kinase inhibition by exploiting differential pathway sensitivity

scientific article published on April 2006

Sensitive and Quantitative Three-Color Protein Imaging in Fission Yeast Using Spectrally Diverse, Recoded Fluorescent Proteins with Experimentally-Characterized In Vivo Maturation Kinetics.

scientific article

Shaping the landscape: mechanistic consequences of ubiquitin modification of chromatin.

scientific article

Signals for ribosomal frameshifting in the Rous sarcoma virus gag-pol region

scientific article

Site-specific acetylation mark on an essential chromatin-remodeling complex promotes resistance to replication stress

scientific article

Spt6 is required for heterochromatic silencing in the fission yeast Schizosaccharomyces pombe.

scientific article published on 15 August 2011

Stalled spliceosomes are a signal for RNAi-mediated genome defense.

scientific article published on 14 February 2013

The Cul4-Ddb1Cdt2 Ubiquitin Ligase Inhibits Invasion of a Boundary-Associated Antisilencing Factor into Heterochromatin ⬇️

scientific article published on January 7, 2011

The control of filamentous differentiation and virulence in fungi

scientific article

The frustrated gene: origins of eukaryotic gene expression

scientific article published on November 2013

The riddle of MAP kinase signaling specificity

scientific article published on 01 April 1998

Timing of transcriptional quiescence during gametogenesis is controlled by global histone H3K4 demethylation

scientific article

Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex

scientific article

snRNA catalysts in the spliceosome's ancient core

scientific article published on December 2013

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