List of works - Derren J Heyes

A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites

scientific article published on 24 July 2019

Advantages of brain penetrating inhibitors of kynurenine-3-monooxygenase for treatment of neurodegenerative diseases

scientific article published on 01 December 2020

Carbon monoxide poisoning is prevented by the energy costs of conformational changes in gas-binding haemproteins

scientific article

Catalytic mechanism of cofactor-free dioxygenases and how they circumvent spin-forbidden oxygenation of their substrates.

scientific article published on 4 June 2015

Comprehensive analysis of the green-to-blue photoconversion of full-length Cyanobacteriochrome Tlr0924

scientific article

Conformational changes in an ultrafast light-driven enzyme determine catalytic activity

scientific article

Conformational changes in the catalytic cycle of protochlorophyllide oxidoreductase: what lessons can be learnt from dihydrofolate reductase?

scientific article published on April 2009

Conformational events during ternary enzyme-substrate complex formation are rate limiting in the catalytic cycle of the light-driven enzyme protochlorophyllide oxidoreductase.

scientific article

Cross-Species Analysis of Protein Dynamics Associated with Hydride and Proton Transfer in the Catalytic Cycle of the Light-Driven Enzyme Protochlorophyllide Oxidoreductase.

scientific article published on 25 January 2016

Cryogenic and laser photoexcitation studies identify multiple roles for active site residues in the light-driven enzyme protochlorophyllide oxidoreductase

scientific article

Demonstration of proton-coupled electron transfer in the copper-containing nitrite reductases

scientific article published on 7 July 2009

Direct Evidence of an Excited-State Triplet Species upon Photoactivation of the Chlorophyll Precursor Protochlorophyllide.

scientific article published on 28 February 2017

Does the pressure dependence of kinetic isotope effects report usefully on dynamics in enzyme H-transfer reactions?

scientific article

Energy landscapes and catalysis in nitric-oxide synthase

scientific article published on 7 March 2014

Engineering proximal vs. distal heme-NO coordination via dinitrosyl dynamics: implications for NO sensor design.

scientific article

Enzymatic Carboxylation of 2-Furoic Acid Yields 2,5-Furandicarboxylic Acid (FDCA)

scientific article published on 15 February 2019

Enzyme activation and catalysis: characterisation of the vibrational modes of substrate and product in protochlorophyllide oxidoreductase

scientific article published on 22 November 2010

Enzymology below 200 K: the kinetics and thermodynamics of the photochemistry catalyzed by protochlorophyllide oxidoreductase

scientific article

Excited state dynamics and catalytic mechanism of the light-driven enzyme protochlorophyllide oxidoreductase

scientific article published on 14 March 2012

Excited-State Properties of Protochlorophyllide Analogues and Implications for Light-Driven Synthesis of Chlorophyll.

scientific article

Excited-state charge separation in the photochemical mechanism of the light-driven enzyme protochlorophyllide oxidoreductase

scientific article published on 8 December 2014

Gating mechanisms for biological electron transfer: integrating structure with biophysics reveals the nature of redox control in cytochrome P450 reductase and copper-dependent nitrite reductase.

scientific article published on 14 July 2011

Human cryptochrome-1 confers light independent biological activity in transgenic Drosophila correlated with flavin radical stability.

scientific article

Identification and characterization of the product release steps within the catalytic cycle of protochlorophyllide oxidoreductase

scientific article published in June 2004

Internal electron transfer in multi-site redox enzymes is accessed by laser excitation of thiouredopyrene-3,6,8-trisulfonate (TUPS).

scientific article

Isolation and characterisation of 13 pterosins and pterosides from bracken (Pteridium aquilinum (L.) Kuhn) rhizome

scientific article

Kinetic and spectroscopic probes of motions and catalysis in the cytochrome P450 reductase family of enzymes

scientific article published on 09 January 2012

Kinetic characterisation of Erv1, a key component for protein import and folding in yeast mitochondria

scientific article published on 16 October 2019

Kinetic characterisation of the light-driven protochlorophyllide oxidoreductase (POR) from Thermosynechococcus elongatus

scientific article published on 9 September 2005

Laser excitation studies of the product release steps in the catalytic cycle of the light-driven enzyme, protochlorophyllide oxidoreductase

scientific article

Laser photoexcitation of NAD(P)H induces reduction of P450 BM3 heme domain on the microsecond time scale

scientific article

Light-driven biocatalytic reduction of α,β-unsaturated compounds by ene reductases employing transition metal complexes as photosensitizers.

scientific article

Light-induced structural changes in a full-length cyanobacterial phytochrome probed by time-resolved X-ray scattering

scientific article published on 03 January 2019

Mechanistic reappraisal of early stage photochemistry in the light-driven enzyme protochlorophyllide oxidoreductase

scientific article

Modulation of ligand-heme reactivity by binding pocket residues demonstrated in cytochrome c' over the femtosecond-second temporal range.

scientific article published on 11 October 2013

Molecular basis of halorespiration control by CprK, a CRP-FNR type transcriptional regulator

scientific article

Multiple active site residues are important for photochemical efficiency in the light-activated enzyme protochlorophyllide oxidoreductase (POR).

scientific article published on June 2016

Mutagenesis alters the catalytic mechanism of the light-driven enzyme protochlorophyllide oxidoreductase

scientific article

NADPH:protochlorophyllide oxidoreductase from Synechocystis: overexpression, purification and preliminary characterisation

scientific article published on 01 October 2000

Nuclear quantum tunneling in the light-activated enzyme protochlorophyllide oxidoreductase

scientific article published on 10 December 2008

One-electron oxidation and reduction of glycosaminoglycan chloramides: a kinetic study

scientific article

Origin of the Proton-transfer Step in the Cofactor-free (1H)-3-Hydroxy-4-oxoquinaldine 2,4-Dioxygenase: EFFECT OF THE BASICITY OF AN ACTIVE SITE HIS RESIDUE

scientific article

Photochemical Mechanism of an Atypical Algal Phytochrome.

scientific article published on 15 March 2018

Photochemical Spin Dynamics of the Vitamin B12 Derivative, Methylcobalamin

scientific article published on 23 May 2019

Preparation and photophysical properties of a caged kynurenine

scientific article published on 06 March 2012

Pressurized CO2 as a carboxylating agent for the biocatalytic ortho-carboxylation of resorcinol.

scientific article

Protochlorophyllide excited-state dynamics in organic solvents studied by time-resolved visible and mid-infrared spectroscopy

scientific article published in April 2010

Protochlorophyllide oxidoreductase: "dark" reactions of a light-driven enzyme

scientific article published in January 2003

Proton-coupled electron transfer in the catalytic cycle of Alcaligenes xylosoxidans copper-dependent nitrite reductase

scientific article

Rapid P450 heme iron reduction by laser photoexcitation of Mycobacterium tuberculosis CYP121 and CYP51B1. Analysis of CO complexation reactions and reversibility of the P450/P420 equilibrium.

scientific article

Reaction of superoxide radicals with glycosaminoglycan chloramides: a kinetic study.

scientific article

Redox characterisation of Erv1, a key component for protein import and folding in yeast mitochondria

scientific article published on 12 November 2019

Simultaneous measurements of solvent dynamics and functional kinetics in a light-activated enzyme.

scientific article published on March 2009

Solvent-slaved protein motions accompany proton but not hydride tunneling in light-activated protochlorophyllide oxidoreductase

scientific article published in January 2009

Solvent-slaved protein motions accompany proton coupled electron transfer reactions catalysed by copper nitrite reductase

scientific article published on 03 May 2019

Spectroscopic characterization of the first ultrafast catalytic intermediate in protochlorophyllide oxidoreductase

scientific article published on 28 November 2011

Stepwise Hydride Transfer in a Biological System: Insights into the Reaction Mechanism of the Light-Dependent Protochlorophyllide Oxidoreductase

scientific article

Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis

scientific article published on 23 October 2019

Structural basis of kynurenine 3-monooxygenase inhibition

scientific article

Structure-based Mechanism of CMP-2-keto-3-deoxymanno-octulonic Acid Synthetase: CONVERGENT EVOLUTION OF A SUGAR-ACTIVATING ENZYME WITH DNA/RNA POLYMERASES

scientific article

The first catalytic step of the light-driven enzyme protochlorophyllide oxidoreductase proceeds via a charge transfer complex

scientific article published on 25 July 2006

The photoinitiated reaction pathway of full-length cyanobacteriochrome Tlr0924 monitored over 12 orders of magnitude

scientific article

Ultrafast enzymatic reaction dynamics in protochlorophyllide oxidoreductase.

scientific article

Ultrafast red light activation of Synechocystis phytochrome Cph1 triggers major structural change to form the Pfr signalling-competent state

scientific article

Unexpected Roles of a Tether Harboring a Tyrosine Gatekeeper Residue in Modular Nitrite Reductase Catalysis

scientific article published on 29 May 2019

List of works by Derren J Heyes

A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites

Advantages of brain penetrating inhibitors of kynurenine-3-monooxygenase for treatment of neurodegenerative diseases

Carbon monoxide poisoning is prevented by the energy costs of conformational changes in gas-binding haemproteins

Catalytic mechanism of cofactor-free dioxygenases and how they circumvent spin-forbidden oxygenation of their substrates.

Comprehensive analysis of the green-to-blue photoconversion of full-length Cyanobacteriochrome Tlr0924

Conformational changes in an ultrafast light-driven enzyme determine catalytic activity

Conformational changes in the catalytic cycle of protochlorophyllide oxidoreductase: what lessons can be learnt from dihydrofolate reductase?

Conformational events during ternary enzyme-substrate complex formation are rate limiting in the catalytic cycle of the light-driven enzyme protochlorophyllide oxidoreductase.

Cross-Species Analysis of Protein Dynamics Associated with Hydride and Proton Transfer in the Catalytic Cycle of the Light-Driven Enzyme Protochlorophyllide Oxidoreductase.

Cryogenic and laser photoexcitation studies identify multiple roles for active site residues in the light-driven enzyme protochlorophyllide oxidoreductase

Demonstration of proton-coupled electron transfer in the copper-containing nitrite reductases

Direct Evidence of an Excited-State Triplet Species upon Photoactivation of the Chlorophyll Precursor Protochlorophyllide.

Does the pressure dependence of kinetic isotope effects report usefully on dynamics in enzyme H-transfer reactions?

Energy landscapes and catalysis in nitric-oxide synthase

Engineering proximal vs. distal heme-NO coordination via dinitrosyl dynamics: implications for NO sensor design.

Enzymatic Carboxylation of 2-Furoic Acid Yields 2,5-Furandicarboxylic Acid (FDCA)

Enzyme activation and catalysis: characterisation of the vibrational modes of substrate and product in protochlorophyllide oxidoreductase

Enzymology below 200 K: the kinetics and thermodynamics of the photochemistry catalyzed by protochlorophyllide oxidoreductase

Excited state dynamics and catalytic mechanism of the light-driven enzyme protochlorophyllide oxidoreductase

Excited-State Properties of Protochlorophyllide Analogues and Implications for Light-Driven Synthesis of Chlorophyll.

Excited-state charge separation in the photochemical mechanism of the light-driven enzyme protochlorophyllide oxidoreductase

Gating mechanisms for biological electron transfer: integrating structure with biophysics reveals the nature of redox control in cytochrome P450 reductase and copper-dependent nitrite reductase.

Human cryptochrome-1 confers light independent biological activity in transgenic Drosophila correlated with flavin radical stability.

Identification and characterization of the product release steps within the catalytic cycle of protochlorophyllide oxidoreductase

Internal electron transfer in multi-site redox enzymes is accessed by laser excitation of thiouredopyrene-3,6,8-trisulfonate (TUPS).

Isolation and characterisation of 13 pterosins and pterosides from bracken (Pteridium aquilinum (L.) Kuhn) rhizome

Kinetic and spectroscopic probes of motions and catalysis in the cytochrome P450 reductase family of enzymes

Kinetic characterisation of Erv1, a key component for protein import and folding in yeast mitochondria

Kinetic characterisation of the light-driven protochlorophyllide oxidoreductase (POR) from Thermosynechococcus elongatus

Laser excitation studies of the product release steps in the catalytic cycle of the light-driven enzyme, protochlorophyllide oxidoreductase

Laser photoexcitation of NAD(P)H induces reduction of P450 BM3 heme domain on the microsecond time scale

Light-driven biocatalytic reduction of α,β-unsaturated compounds by ene reductases employing transition metal complexes as photosensitizers.

Light-induced structural changes in a full-length cyanobacterial phytochrome probed by time-resolved X-ray scattering

Mechanistic reappraisal of early stage photochemistry in the light-driven enzyme protochlorophyllide oxidoreductase

Modulation of ligand-heme reactivity by binding pocket residues demonstrated in cytochrome c' over the femtosecond-second temporal range.

Molecular basis of halorespiration control by CprK, a CRP-FNR type transcriptional regulator

Multiple active site residues are important for photochemical efficiency in the light-activated enzyme protochlorophyllide oxidoreductase (POR).

Mutagenesis alters the catalytic mechanism of the light-driven enzyme protochlorophyllide oxidoreductase

NADPH:protochlorophyllide oxidoreductase from Synechocystis: overexpression, purification and preliminary characterisation

Nuclear quantum tunneling in the light-activated enzyme protochlorophyllide oxidoreductase

One-electron oxidation and reduction of glycosaminoglycan chloramides: a kinetic study

Origin of the Proton-transfer Step in the Cofactor-free (1H)-3-Hydroxy-4-oxoquinaldine 2,4-Dioxygenase: EFFECT OF THE BASICITY OF AN ACTIVE SITE HIS RESIDUE

Photochemical Mechanism of an Atypical Algal Phytochrome.

Photochemical Spin Dynamics of the Vitamin B12 Derivative, Methylcobalamin

Preparation and photophysical properties of a caged kynurenine

Pressurized CO2 as a carboxylating agent for the biocatalytic ortho-carboxylation of resorcinol.

Protochlorophyllide excited-state dynamics in organic solvents studied by time-resolved visible and mid-infrared spectroscopy

Protochlorophyllide oxidoreductase: "dark" reactions of a light-driven enzyme

Proton-coupled electron transfer in the catalytic cycle of Alcaligenes xylosoxidans copper-dependent nitrite reductase

Rapid P450 heme iron reduction by laser photoexcitation of Mycobacterium tuberculosis CYP121 and CYP51B1. Analysis of CO complexation reactions and reversibility of the P450/P420 equilibrium.

Reaction of superoxide radicals with glycosaminoglycan chloramides: a kinetic study.

Redox characterisation of Erv1, a key component for protein import and folding in yeast mitochondria

Simultaneous measurements of solvent dynamics and functional kinetics in a light-activated enzyme.

Solvent-slaved protein motions accompany proton but not hydride tunneling in light-activated protochlorophyllide oxidoreductase

Solvent-slaved protein motions accompany proton coupled electron transfer reactions catalysed by copper nitrite reductase

Spectroscopic characterization of the first ultrafast catalytic intermediate in protochlorophyllide oxidoreductase

Stepwise Hydride Transfer in a Biological System: Insights into the Reaction Mechanism of the Light-Dependent Protochlorophyllide Oxidoreductase

Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis

Structural basis of kynurenine 3-monooxygenase inhibition

Structure-based Mechanism of CMP-2-keto-3-deoxymanno-octulonic Acid Synthetase: CONVERGENT EVOLUTION OF A SUGAR-ACTIVATING ENZYME WITH DNA/RNA POLYMERASES

The first catalytic step of the light-driven enzyme protochlorophyllide oxidoreductase proceeds via a charge transfer complex

The photoinitiated reaction pathway of full-length cyanobacteriochrome Tlr0924 monitored over 12 orders of magnitude

Ultrafast enzymatic reaction dynamics in protochlorophyllide oxidoreductase.

Ultrafast red light activation of Synechocystis phytochrome Cph1 triggers major structural change to form the Pfr signalling-competent state

Unexpected Roles of a Tether Harboring a Tyrosine Gatekeeper Residue in Modular Nitrite Reductase Catalysis