List of works - Alessandra Tolomelli

A Microwave-Enhanced, Lewis Acid-Catalyzed Synthesis of 1,3-Dioxolanes and Oxazolines from Epoxides

A Nonclassical Stereoselective Semi-Synthesis of Drospirenone via Cross-Metathesis Reaction

A Stereoselective Synthesis of (2R,3S)-N-Benzoylphenylisoserine Methyl Ester

A convenient synthesis of functionalized isoxazolines and related 5-hydroxyisoxazolidine-4-carboxylates

A novel family of minimal PMRI cyclic peptides as versatile scaffolds for generating new molecular topology

scientific article

A simple route towards peptide analogues containing substituted (S)- or (R)-tryptophans

A straightforward route to enantiopure 2-substituted-3,4-dehydro-β-proline via ring closing metathesis

scientific article

A translation of the twelve principles of green chemistry to guide the development of cross-coupling reactions

scientific article published in 2022

An Investigation of the Reactivity of MCPBA and α-Bromoalkenes under Traditional or Microwave-Assisted Conditions: Selective Formation of Epoxides or Allylic Bromides

An improved microwave assisted protocol for Yonemitsu-type trimolecular condensation

Antiangiogenic effect of dual/selective alpha(5)beta(1)/alpha(v)beta(3) integrin antagonists designed on partially modified retro-inverso cyclotetrapeptide mimetics

scientific article

Antinociception by a peripherally administered novel endomorphin-1 analogue containing beta-proline

scientific article

Application of Af4-Multidetection to Liraglutide in Its Formulation: Preserving and Representing Native Aggregation

scientific article published in 2022

Asymmetric 1,4 addition of Grignard reagents to chiral α,β-unsaturated esters in the presence of Lewis acids

article

Asymmetric Synthesis of Three- and Four-Membered Ring Heterocycles

Asymmetric synthesis of 5-isopropyl-oxazoline-4-imide as syn-hydroxyleucine precursor

Asymmetric synthesis of syn hydroxyphenylalanine via aziridine ring expansion to an oxazoline

Can Integrin Agonists Have Cards to Play against Cancer? A Literature Survey of Small Molecules Integrin Activators

scientific article published on 5 July 2017

Conformational analysis and mu-opioid receptor affinity of short peptides, endomorphin models in a low polarity solvent

scientific article

Conjugate addition of hydroxylamino derivatives to alkylidene malonates in the presence of chiral Lewis acids

article

Controlled Solid Phase Peptide Bond Formation Using N-Carboxyanhydrides and PEG Resins in Water

Convenient Synthesis of the Antibiotic Linezolid via an Oxazolidine-2,4-dione Intermediate Derived from the Chiral Building Block Isoserine

Cyclopeptide analogs for generating new molecular and 3D diversity

scientific article

Cyclotetrapeptide Mimics Based on a 13-Membered, Partially Modified Retro-Inverso Structure

article published in 2008

Dehydro-β-amino Acid Containing Peptides as Promising Sequences for Drug Development

article

Dehydro-β-proline Containing α4β1 Integrin Antagonists: Stereochemical Recognition in Ligand-Receptor Interplay.

scientific article published on 5 May 2015

Development of isoxazoline-containing peptidomimetics as dual αvβ3 and α5β1 integrin ligands

scientific article published on 26 September 2011

Enantioselective synthesis of aziridine 2,2-dicarboxylates. Part I: Copper(II)-bisoxazoline complex-catalysed Michael reaction on alkylidene malonates

Enantioselective synthesis of aziridine 2,2-dicarboxylates. Part II: Determination of the absolute configuration

Enzymatic Resolution of α-Alkyl β-Amino Acids Using Immobilized Penicillin G Acylase

Enzymatic resolution of ethyl 3-hydroxy-2(1′substituted-methylidene)-butyrate by Pseudomonas cepacia lipase catalyzed acetylation

Expedient synthesis of pseudo-Pro-containing peptides: towards constrained peptidomimetics and foldamers

article by Rossella De Marco et al published 21 March 2012 in Organic and Biomolecular Chemistry

Highly Regio- and Diastereoselective Palladium-Catalyzed Allylic Substitution. Synthesis of 3-(2-Aminobutylidene)- 4-arylazetidin-2-ones

Highly diastereoselective allylic azide formation and isomerization. Synthesis of 3(2'-amino)-beta-lactams

scientific article published in 2005

Highly regio- and stereoselective palladium-catalyzed allylic carbonate amination. A practical route to dehydro-β-amino esters

Highly stable atropisomers by electrophilic amination of a chiral γ-lactam within the synthesis of an elusive conformationally restricted analogue of α-methylhomoserine.

scientific article published on 24 September 2015

In-peptide synthesis of di-oxazolidinone and dehydroamino acid-oxazolidinone motifs as β-turn inducers

scientific article

Inhibition of cancer cell adhesion by heterochiral Pro-containing RGD mimetics

scientific article

Integrin Ligands with α/β-Hybrid Peptide Structure: Design, Bioactivity, and Conformational Aspects

scientific article

Integrin-mediated adhesive properties of neutrophils are reduced by hyperbaric oxygen therapy in patients with chronic non-healing wound

scientific article published on 18 August 2020

Investigation of the interaction between the atypical agonist c[YpwFG] and MOR.

scientific article

Lewis Acid Induced Highly Regioselective Synthesis of a New Class of Substituted Isoxazolidines

Lipase-mediated kinetic resolution of allylic(hydroxymethyl)methylenecyclopentane building blocks

Microwave-assisted ring expansion of N-acetyl 3′-unsubstituted aziridine in the presence of Lewis acids

Modulation of αvβ₃- and α₅β₁-integrin-mediated adhesion by dehydro-β-amino acids containing peptidomimetics.

scientific article published on 12 June 2013

Molecular docking of opiates and opioid peptides, a tool for the design of selective agonists and antagonists, and for the investigation of atypical ligand-receptor interactions.

scientific article published on January 2012

NMR investigations on boron complexes in the conjugate addition on alpha,beta-unsaturated imides.

scientific article

New isoxazolidinone and 3,4-dehydro-β-proline derivatives as antibacterial agents and MAO-inhibitors: A complex balance between two activities.

scientific article

Novel insights into the chemistry of an old medicine: A general degradative pathway for penicillins from a piperacillin/tazobactam stability study

scientific article published on 14 June 2019

One-Pot Two-Step Microwave-Assisted Synthesis of Alkylidene Acetoacetamido Esters, Useful Intermediates for β-Dehydropeptides

Opioid activity profiles of oversimplified peptides lacking in the protonable N-terminus

scientific article

Peptides and peptidomimetics in medicine, surgery and biotechnology

scientific article published on January 2006

Peripheral antinociceptive effects of the cyclic endomorphin-1 analog c[YpwFG] in a mouse visceral pain model

scientific article published on 14 August 2010

Practical synthesis of 3-bromo-5,6-dihydropyridin-2-ones via β,γ-unsaturated α-bromo-ketene/imine cycloaddition

Recent advances in the investigation of the bioactive conformation of peptides active at the micro-opioid receptor. conformational analysis of endomorphins

scientific article published on January 2004

Ring expansion of N-acyl aziridine-2-imides to oxazoline-4-imides, useful precursors of pure β-Hydroxy α-aminoacids

Spectroscopic fingerprints of DNA/RNA pyrimidine nucleobases in third-order nonlinear electronic spectra

Stability against enzymatic hydrolysis of endomorphin-1 analogues containing beta-proline

scientific article published in May 2003

Stable and Biocompatible Monodispersion of C60 in Water by Peptides

scientific article published on 24 January 2019

Synthesis and assay of retro-α4β1 integrin-targeting motifs.

scientific article published on 19 December 2013

Synthesis and biological evaluation of azido- and aziridino-hydroxyl-beta-lactams through stereo- and regioselective epoxide ring opening

Synthesis and biological evaluation of non-peptide alpha(v)beta(3)/alpha(5)beta(1) integrin dual antagonists containing 5,6-dihydropyridin-2-one scaffolds

scientific article

Synthesis and biological evaluation of unprecedented classes of spiro-beta-lactams and azido-beta-lactams as acyl-CoA:cholesterol acyltransferase inhibitors

scientific article published in 2007

Synthesis and evaluation of the affinity toward mu-opioid receptors of atypical, lipophilic ligands based on the sequence c[-Tyr-Pro-Trp-Phe-Gly-].

scientific article

Synthesis of Constrained Peptidomimetics Containing 2-Oxo-1,3-oxazolidine-4-carboxylic Acids

article by Luca Gentilucci et al published 13 July 2011 in European Journal of Organic Chemistry

Synthesis of Ethyl 5-Hydroxyisoxazolidine-4-carboxylates via Michael Addition/Intramolecular Hemiketalisation

article

Synthesis of Four-Membered Ring Spiro-β-lactams by Epoxide Ring-Opening

Synthesis of aziridine-2,2-dicarboxylates via 1,4-addition of N,O-(bistrimethylsilyl)hydroxylamine to alpha,beta-unsaturated malonates

scientific article published in December 2001

Synthesis of chiral non-racemic intermediates and Arg-Gly-Asp mimetics by CaLB-catalyzed resolution

Synthesis of dehydro-beta-amino esters via highly regioselective amination of allylic carbonates

scientific article published in 2008

Synthesis of enantiomerically pure syn and anti α-hydroxy β-amino acids through diastereoselective hydroxylation of perhydropyrimidin-4-ones

Synthesis of enantiomerically pure αvβ3 integrin ligands based on a 5,6-dihydropyridin-2-one scaffold

Synthesis of α/β dipeptides containing linear or cyclic α-dehydro-β-amino acids as scaffolds for bioactive compounds

scientific article published on 13 September 2019

Targeting integrins αvβ3 and α5β1 with new β-lactam derivatives

scientific article

The Cycloaddition Reaction Between α-Bromo Vinylketenes and Imines: A Combined Experimental and Theoretical Study

The inverse type II β-turn on D-Trp-Phe, a pharmacophoric motif for MOR agonists.

scientific article published on 30 June 2011

Topological exploration of cyclic endomorphin-1 analogues, structurally defined models for investigating the bioactive conformation of MOR agonists

article

Unusual amino acids: synthesis and introduction into naturally occurring peptides and biologically active analogues

scientific article

Zinc Metal-Promoted Nucleophilic Addition of Azetidin-2-ones to Aldehydes and Nitriles

article

List of works by Alessandra Tolomelli

A Microwave-Enhanced, Lewis Acid-Catalyzed Synthesis of 1,3-Dioxolanes and Oxazolines from Epoxides

A Nonclassical Stereoselective Semi-Synthesis of Drospirenone via Cross-Metathesis Reaction

A Stereoselective Synthesis of (2R,3S)-N-Benzoylphenylisoserine Methyl Ester

A convenient synthesis of functionalized isoxazolines and related 5-hydroxyisoxazolidine-4-carboxylates

A novel family of minimal PMRI cyclic peptides as versatile scaffolds for generating new molecular topology

A simple route towards peptide analogues containing substituted (S)- or (R)-tryptophans

A straightforward route to enantiopure 2-substituted-3,4-dehydro-β-proline via ring closing metathesis

A translation of the twelve principles of green chemistry to guide the development of cross-coupling reactions

An Investigation of the Reactivity of MCPBA and α-Bromoalkenes under Traditional or Microwave-Assisted Conditions: Selective Formation of Epoxides or Allylic Bromides

An improved microwave assisted protocol for Yonemitsu-type trimolecular condensation

Antiangiogenic effect of dual/selective alpha(5)beta(1)/alpha(v)beta(3) integrin antagonists designed on partially modified retro-inverso cyclotetrapeptide mimetics

Antinociception by a peripherally administered novel endomorphin-1 analogue containing beta-proline

Application of Af4-Multidetection to Liraglutide in Its Formulation: Preserving and Representing Native Aggregation

Asymmetric 1,4 addition of Grignard reagents to chiral α,β-unsaturated esters in the presence of Lewis acids

Asymmetric Synthesis of Three- and Four-Membered Ring Heterocycles

Asymmetric synthesis of 5-isopropyl-oxazoline-4-imide as syn-hydroxyleucine precursor

Asymmetric synthesis of syn hydroxyphenylalanine via aziridine ring expansion to an oxazoline

Can Integrin Agonists Have Cards to Play against Cancer? A Literature Survey of Small Molecules Integrin Activators

Conformational analysis and mu-opioid receptor affinity of short peptides, endomorphin models in a low polarity solvent

Conjugate addition of hydroxylamino derivatives to alkylidene malonates in the presence of chiral Lewis acids

Controlled Solid Phase Peptide Bond Formation Using N-Carboxyanhydrides and PEG Resins in Water

Convenient Synthesis of the Antibiotic Linezolid via an Oxazolidine-2,4-dione Intermediate Derived from the Chiral Building Block Isoserine

Cyclopeptide analogs for generating new molecular and 3D diversity

Cyclotetrapeptide Mimics Based on a 13-Membered, Partially Modified Retro-Inverso Structure

Dehydro-β-amino Acid Containing Peptides as Promising Sequences for Drug Development

Dehydro-β-proline Containing α4β1 Integrin Antagonists: Stereochemical Recognition in Ligand-Receptor Interplay.

Development of isoxazoline-containing peptidomimetics as dual αvβ3 and α5β1 integrin ligands

Enantioselective synthesis of aziridine 2,2-dicarboxylates. Part I: Copper(II)-bisoxazoline complex-catalysed Michael reaction on alkylidene malonates

Enantioselective synthesis of aziridine 2,2-dicarboxylates. Part II: Determination of the absolute configuration

Enzymatic Resolution of α-Alkyl β-Amino Acids Using Immobilized Penicillin G Acylase

Enzymatic resolution of ethyl 3-hydroxy-2(1′substituted-methylidene)-butyrate by Pseudomonas cepacia lipase catalyzed acetylation

Expedient synthesis of pseudo-Pro-containing peptides: towards constrained peptidomimetics and foldamers

Highly Regio- and Diastereoselective Palladium-Catalyzed Allylic Substitution. Synthesis of 3-(2-Aminobutylidene)- 4-arylazetidin-2-ones

Highly diastereoselective allylic azide formation and isomerization. Synthesis of 3(2'-amino)-beta-lactams

Highly regio- and stereoselective palladium-catalyzed allylic carbonate amination. A practical route to dehydro-β-amino esters

Highly stable atropisomers by electrophilic amination of a chiral γ-lactam within the synthesis of an elusive conformationally restricted analogue of α-methylhomoserine.

In-peptide synthesis of di-oxazolidinone and dehydroamino acid-oxazolidinone motifs as β-turn inducers

Inhibition of cancer cell adhesion by heterochiral Pro-containing RGD mimetics

Integrin Ligands with α/β-Hybrid Peptide Structure: Design, Bioactivity, and Conformational Aspects

Integrin-mediated adhesive properties of neutrophils are reduced by hyperbaric oxygen therapy in patients with chronic non-healing wound

Investigation of the interaction between the atypical agonist c[YpwFG] and MOR.

Lewis Acid Induced Highly Regioselective Synthesis of a New Class of Substituted Isoxazolidines

Lipase-mediated kinetic resolution of allylic(hydroxymethyl)methylenecyclopentane building blocks

Microwave-assisted ring expansion of N-acetyl 3′-unsubstituted aziridine in the presence of Lewis acids

Modulation of αvβ₃- and α₅β₁-integrin-mediated adhesion by dehydro-β-amino acids containing peptidomimetics.

Molecular docking of opiates and opioid peptides, a tool for the design of selective agonists and antagonists, and for the investigation of atypical ligand-receptor interactions.

NMR investigations on boron complexes in the conjugate addition on alpha,beta-unsaturated imides.

New isoxazolidinone and 3,4-dehydro-β-proline derivatives as antibacterial agents and MAO-inhibitors: A complex balance between two activities.

Novel insights into the chemistry of an old medicine: A general degradative pathway for penicillins from a piperacillin/tazobactam stability study

One-Pot Two-Step Microwave-Assisted Synthesis of Alkylidene Acetoacetamido Esters, Useful Intermediates for β-Dehydropeptides

Opioid activity profiles of oversimplified peptides lacking in the protonable N-terminus

Peptides and peptidomimetics in medicine, surgery and biotechnology

Peripheral antinociceptive effects of the cyclic endomorphin-1 analog c[YpwFG] in a mouse visceral pain model

Practical synthesis of 3-bromo-5,6-dihydropyridin-2-ones via β,γ-unsaturated α-bromo-ketene/imine cycloaddition

Recent advances in the investigation of the bioactive conformation of peptides active at the micro-opioid receptor. conformational analysis of endomorphins

Ring expansion of N-acyl aziridine-2-imides to oxazoline-4-imides, useful precursors of pure β-Hydroxy α-aminoacids

Spectroscopic fingerprints of DNA/RNA pyrimidine nucleobases in third-order nonlinear electronic spectra

Stability against enzymatic hydrolysis of endomorphin-1 analogues containing beta-proline

Stable and Biocompatible Monodispersion of C60 in Water by Peptides

Synthesis and assay of retro-α4β1 integrin-targeting motifs.

Synthesis and biological evaluation of azido- and aziridino-hydroxyl-beta-lactams through stereo- and regioselective epoxide ring opening

Synthesis and biological evaluation of non-peptide alpha(v)beta(3)/alpha(5)beta(1) integrin dual antagonists containing 5,6-dihydropyridin-2-one scaffolds

Synthesis and biological evaluation of unprecedented classes of spiro-beta-lactams and azido-beta-lactams as acyl-CoA:cholesterol acyltransferase inhibitors

Synthesis and evaluation of the affinity toward mu-opioid receptors of atypical, lipophilic ligands based on the sequence c[-Tyr-Pro-Trp-Phe-Gly-].

Synthesis of Constrained Peptidomimetics Containing 2-Oxo-1,3-oxazolidine-4-carboxylic Acids

Synthesis of Ethyl 5-Hydroxyisoxazolidine-4-carboxylates via Michael Addition/Intramolecular Hemiketalisation

Synthesis of Four-Membered Ring Spiro-β-lactams by Epoxide Ring-Opening

Synthesis of aziridine-2,2-dicarboxylates via 1,4-addition of N,O-(bistrimethylsilyl)hydroxylamine to alpha,beta-unsaturated malonates

Synthesis of chiral non-racemic intermediates and Arg-Gly-Asp mimetics by CaLB-catalyzed resolution

Synthesis of dehydro-beta-amino esters via highly regioselective amination of allylic carbonates

Synthesis of enantiomerically pure syn and anti α-hydroxy β-amino acids through diastereoselective hydroxylation of perhydropyrimidin-4-ones

Synthesis of enantiomerically pure αvβ3 integrin ligands based on a 5,6-dihydropyridin-2-one scaffold

Synthesis of α/β dipeptides containing linear or cyclic α-dehydro-β-amino acids as scaffolds for bioactive compounds

Targeting integrins αvβ3 and α5β1 with new β-lactam derivatives

The Cycloaddition Reaction Between α-Bromo Vinylketenes and Imines: A Combined Experimental and Theoretical Study

The inverse type II β-turn on D-Trp-Phe, a pharmacophoric motif for MOR agonists.

Topological exploration of cyclic endomorphin-1 analogues, structurally defined models for investigating the bioactive conformation of MOR agonists

Unusual amino acids: synthesis and introduction into naturally occurring peptides and biologically active analogues

Zinc Metal-Promoted Nucleophilic Addition of Azetidin-2-ones to Aldehydes and Nitriles