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List of works by Ilya Frolov

A chikungunya fever vaccine utilizing an insect-specific virus platform

scientific article (publication date: 19 December 2016)

A chimeric Sindbis-based vaccine protects cynomolgus macaques against a lethal aerosol challenge of eastern equine encephalitis virus.

scientific article published on 16 January 2013

A new role for ns polyprotein cleavage in Sindbis virus replication

scientific article

Adaptation of Venezuelan equine encephalitis virus lacking 51-nt conserved sequence element to replication in mammalian and mosquito cells

scientific article published on 12 February 2007

Alpha-beta T cells provide protection against lethal encephalitis in the murine model of VEEV infection

scientific article

Alphavirus-based expression vectors: strategies and applications

scientific article published on October 1996

Analysis of Venezuelan equine encephalitis virus capsid protein function in the inhibition of cellular transcription

scientific article

Analysis of the 3' cis-acting elements of rubella virus by using replicons expressing a puromycin resistance gene

scientific article published on March 2004

Both RIG-I and MDA5 detect alphavirus replication in concentration-dependent mode

scientific article published on 6 November 2015

Changes of the secondary structure of the 5' end of the Sindbis virus genome inhibit virus growth in mosquito cells and lead to accumulation of adaptive mutations

scientific article published on May 2004

Characterization of the RepliVax platform for replication-defective flavivirus vaccines

scientific article published on 26 May 2011

Chimeric Chikungunya viruses are nonpathogenic in highly sensitive mouse models but efficiently induce a protective immune response

scientific article

Chimeric Sindbis/eastern equine encephalitis vaccine candidates are highly attenuated and immunogenic in mice

scientific article

Chimeric alphavirus vaccine candidates for chikungunya

scientific article

Chimeric alphavirus vaccine candidates protect mice from intranasal challenge with western equine encephalitis virus

scientific article published on 27 May 2009

Cis-acting RNA elements at the 5' end of Sindbis virus genome RNA regulate minus- and plus-strand RNA synthesis

scientific article

Comparative analysis of the alphavirus-based vectors expressing Rift Valley fever virus glycoproteins

scientific article

Design of chimeric alphaviruses with a programmed, attenuated, cell type-restricted phenotype

scientific article

Development of Sindbis Viruses Encoding nsP2/GFP Chimeric Proteins and Their Application for Studying nsP2 Functioning

scientific article (publication date: May 2007)

Different types of nsP3-containing protein complexes in Sindbis virus-infected cells

scientific article

Dual mechanisms of pestiviral superinfection exclusion at entry and RNA replication

scientific article

Early events in alphavirus replication determine the outcome of infection

scientific article

Efficient Translation Initiation Is Required for Replication of Bovine Viral Diarrhea Virus Subgenomic Replicons

scientific article

Efficient, trans-complementing packaging systems for chimeric, pseudoinfectious dengue 2/yellow fever viruses

scientific article (publication date: 25 April 2010)

Enhancement of protein expression by alphavirus replicons by designing self-replicating subgenomic RNAs

scientific article

Evaluation of replicative capacity and genetic stability of West Nile virus replicons using highly efficient packaging cell lines

scientific article published on 2 May 2006

Formation of nsP3-Specific Protein Complexes during Sindbis Virus Replication

scientific article (publication date: April 2006)

Functional Sindbis virus replicative complexes are formed at the plasma membrane

scientific article published on 8 September 2010

Gene therapy for malignant glioma using Sindbis vectors expressing a fusogenic membrane glycoprotein

scientific article published on October 2004

Hypervariable Domain of Eastern Equine Encephalitis Virus nsP3 Redundantly Utilizes Multiple Cellular Proteins for Replication Complex Assembly

scientific article

Hypervariable Domain of nsP3 of Eastern Equine Encephalitis Virus is a Critical Determinant of Viral Virulence

scientific article published on 24 June 2020

Hypervariable domain of nonstructural protein nsP3 of Venezuelan equine encephalitis virus determines cell-specific mode of virus replication

scientific article published on May 2013

Hypervariable domains of nsP3 proteins of New World and Old World alphaviruses mediate formation of distinct, virus-specific protein complexes

scientific article published on 5 December 2012

IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon

scientific article published on 30 April 2015

IRES-dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells

scientific article

IRES-driven expression of the capsid protein of the Venezuelan equine encephalitis virus TC-83 vaccine strain increases its attenuation and safety

scientific article

Identification of Mutated Cyclization Sequences That Permit Efficient Replication of West Nile Virus Genomes: Use in Safer Propagation of a Novel Vaccine Candidate

scientific article

Infection of human dendritic cells by a sindbis virus replicon vector is determined by a single amino acid substitution in the E2 glycoprotein

scientific article

Infection, dissemination, and transmission of a West Nile virus green fluorescent protein infectious clone by Culex pipiens quinquefasciatus mosquitoes

scientific article

Inhibition of Transcription and Translation in Sindbis Virus-Infected Cells

scientific article (publication date: August 2005)

Interferon-stimulated poly(ADP-Ribose) polymerases are potent inhibitors of cellular translation and virus replication

scientific article published on 11 December 2013

Interplay of acute and persistent infections caused by Venezuelan equine encephalitis virus encoding mutated capsid protein.

scientific article published on 28 July 2010

Localization of four antigenic sites involved in Venezuelan equine encephalomyelitis virus protection

scientific article

Multiple Host Factors Interact with Hypervariable Domain of Chikungunya Virus nsP3 and Determine Viral Replication in Cell-Specific Mode

scientific article published on 31 July 2018

Mutations in Hypervariable Domain of Venezuelan Equine Encephalitis Virus nsP3 Protein Differentially Affect Viral Replication

scientific article published on 17 January 2020

Natural and Recombinant SARS-CoV-2 Isolates Rapidly Evolve <i>In Vitro</i> to Higher Infectivity through More Efficient Binding to Heparan Sulfate and Reduced S1/S2 Cleavage

scientific article published on 18 August 2021

New PARP gene with an anti-alphavirus function

scientific article published on 23 May 2012

New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes

scientific article

Noncytopathic Sindbis virus RNA vectors for heterologous gene expression

scientific article

Noncytopathic replication of Venezuelan equine encephalitis virus and eastern equine encephalitis virus replicons in Mammalian cells

scientific article

Novel chikungunya vaccine candidate with an IRES-based attenuation and host range alteration mechanism

scientific article

Novel insect-specific Eilat virus-based chimeric vaccine candidates provide durable, mono- and multi-valent, single dose protection against lethal alphavirus challenge.

scientific article published on 29 November 2017

Novel mutations in nsP2 abolish chikungunya virus-induced transcriptional shutoff and make virus less cytopathic without affecting its replication rates

scientific article published on 05 February 2019

Nucleotide sequence analysis of variola virus HindIII M, L, I genome fragments

scientific article published on January 1993

PKR-dependent and -independent mechanisms are involved in translational shutoff during Sindbis virus infection.

scientific article published on August 2004

Production and characterization of vaccines based on flaviviruses defective in replication

scientific article

Production of Pseudoinfectious Yellow Fever Virus with a Two-Component Genome

scientific article (publication date: November 2007)

Random insertion mutagenesis of sindbis virus nonstructural protein 2 and selection of variants incapable of downregulating cellular transcription

scientific article

Recombinant sindbis/Venezuelan equine encephalitis virus is highly attenuated and immunogenic

scientific article published on September 2003

Replication and clearance of Venezuelan equine encephalitis virus from the brains of animals vaccinated with chimeric SIN/VEE viruses

scientific article

Roles of nonstructural protein nsP2 and Alpha/Beta interferons in determining the outcome of Sindbis virus infection

scientific article

Selection of functional 5' cis-acting elements promoting efficient sindbis virus genome replication

scientific article published on January 2004

Sindbis Virus Infection Causes Cell Death by nsP2-Induced Transcriptional Shutoff or by nsP3-Dependent Translational Shutoff

scientific article published on 12 November 2018

Sindbis virus nonstructural protein nsP2 is cytotoxic and inhibits cellular transcription

scientific article published on June 2006

Sindbis virus with a tricomponent genome

scientific article

Stable alphavirus packaging cell lines for Sindbis virus and Semliki Forest virus-derived vectors

scientific article

Structural and Functional Characterization of Host FHL1 Protein Interaction with Hypervariable Domain of Chikungunya Virus nsP3 Protein

scientific article published on 14 October 2020

Structural and Nonstructural Protein Genome Regions of Eastern Equine Encephalitis Virus Are Determinants of Interferon Sensitivity and Murine Virulence

scientific article

Structural and functional elements of the promoter encoded by the 5' untranslated region of the Venezuelan equine encephalitis virus genome.

scientific article

The 5'UTR-specific mutation in VEEV TC-83 genome has a strong effect on RNA replication and subgenomic RNA synthesis, but not on translation of the encoded proteins

scientific article published on 17 March 2009

The Old World and New World alphaviruses use different virus-specific proteins for induction of transcriptional shutoff

scientific article published on 15 November 2006

The SD1 Subdomain of Venezuelan Equine Encephalitis Virus Capsid Protein Plays a Critical Role in Nucleocapsid and Particle Assembly

scientific article published on 9 December 2015

The amino-terminal domain of alphavirus capsid protein is dispensable for viral particle assembly but regulates RNA encapsidation through cooperative functions of its subdomains

scientific article published on 4 September 2013

The efficient packaging of Venezuelan equine encephalitis virus-specific RNAs into viral particles is determined by nsP1-3 synthesis

scientific article published on 18 October 2005

Third-generation flavivirus vaccines based on single-cycle, encapsidation-defective viruses

scientific article published on January 2008

Uncleaved NS2-3 is required for production of infectious bovine viral diarrhea virus

scientific article published on March 2004

Utilization of an Eilat Virus-Based Chimera for Serological Detection of Chikungunya Infection

scientific article

Venezuelan equine encephalitis virus capsid protein inhibits nuclear import in Mammalian but not in mosquito cells

scientific article published on 6 February 2008

Venezuelan equine encephalitis virus nsP2 protein regulates packaging of the viral genome into infectious virions

scientific article published on 30 January 2013

Venezuelan equine encephalitis virus variants lacking transcription inhibitory functions demonstrate highly attenuated phenotype

scientific article

β-D-N(4)-hydroxycytidine is a potent anti-alphavirus compound that induces high level of mutations in viral genome.

scientific article published on 22 November 2017

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