List of works - Dennis W. Wolan

A Commensal Dipeptidyl Aminopeptidase with Specificity for N-Terminal Glycine Degrades Human-Produced Antimicrobial Peptides in Vitro

scientific article published on 23 August 2018

A comprehensive and scalable database search system for metaproteomics

scientific article

A glycal-based photoaffinity probe that enriches sialic acid binding proteins

scientific article published on 01 August 2019

Acetone-Linked Peptides: A Convergent Approach for Peptide Macrocyclization and Labeling

scientific article published on 11 June 2015

An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen

scientific article published on 20 July 2020

Announcement of 2019 Keystone Symposia Conference: "Microbiome: Chemical Mechanisms and Biological Consequences"

scientific article published on 24 July 2018

Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic

scientific article published on 01 August 2020

ComPIL 2.0: An Updated Comprehensive Metaproteomics Database

scientific article published on 14 January 2019

Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates

scientific article

Data Streaming for Metabolomics: Accelerating Data Processing and Analysis from Days to Minutes.

scientific article

Discovery of a highly selective caspase-3 substrate for imaging live cells

scientific article published on 20 August 2014

Discovery of small-molecule enzyme activators by activity-based protein profiling

scientific article published on 08 June 2020

Domain swapping in inducible nitric-oxide synthase. Electron transfer occurs between flavin and heme groups located on adjacent subunits in the dimer.

scientific article published in July 1998

Expanding the use of spectral libraries in proteomics

Fibrils colocalize caspase-3 with procaspase-3 to foster maturation

scientific article

Genetic basis for the cooperative bioactivation of plant lignans by Eggerthella lenta and other human gut bacteria

scientific article published on 04 November 2019

Identification and Co-complex Structure of a New S. pyogenes SpeB Small Molecule Inhibitor

scientific article

Inducible nitric oxide synthase: role of the N-terminal beta-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction

scientific article published on November 1999

Integrative X-ray Structure and Molecular Modeling for the Rationalization of Procaspase-8 Inhibitor Potency and Selectivity

scientific article published on 23 January 2020

Lipoprotein Signal Peptidase Inhibitors with Antibiotic Properties Identified through Design of a Robust In Vitro HT Platform.

scientific article published on 10 January 2018

METLIN: A Technology Platform for Identifying Knowns and Unknowns.

scientific article published on 30 January 2018

Metaproteomics Analysis of SARS-CoV-2-Infected Patient Samples Reveals Presence of Potential Coinfecting Microorganisms

scientific article published on 04 January 2021

Metaproteomics of colonic microbiota unveils discrete protein functions among colitic mice and control groups

scientific article published on 10 January 2018

Molecules that modulate Apaf-1 activity

scientific article published on 22 January 2010

N-Terminomics/TAILS Profiling of Proteases and Their Substrates in Ulcerative Colitis

scientific article published on 21 August 2019

Nitrosopurines en route to potently cytotoxic asmarines

scientific article published on 7 January 2015

Probing substrate recognition of bacterial lipoprotein signal peptidase using FRET reporters

scientific article published on 27 June 2018

Proteome-wide covalent ligand discovery in native biological systems

scientific article

Quantitative Metaproteomics and Activity-Based Probe Enrichment Reveals Significant Alterations in Protein Expression from a Mouse Model of Inflammatory Bowel Disease

scientific article

Quantitative Metaproteomics and Activity-based Protein Profiling of Patient Fecal Microbiome Identifies Host and Microbial Serine-type Endopeptidase Activity Associated With Ulcerative Colitis

scientific article published on 13 January 2022

Selective and Rapid Cell-Permeable Inhibitor of Human Caspase-3

scientific article published on 01 August 2019

Selective detection and inhibition of active caspase-3 in cells with optimized peptides.

scientific article published on 19 August 2013

Selective detection of caspase-3 versus caspase-7 using activity-based probes with key unnatural amino acids

scientific article

Selective inhibition of initiator versus executioner caspases using small peptides containing unnatural amino acids

scientific article

Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation

scientific article

Small-molecule activators of a proenzyme

scientific article

Small-molecule procaspase activators identified using fluorescence polarization.

scientific article

Structural insights into the avian AICAR transformylase mechanism

scientific article

Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor

scientific article

Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site

scientific article

Structure-based optimization and synthesis of antiviral drug Arbidol analogues with significantly improved affinity to influenza hemagglutinin

scientific article published on 28 June 2017

SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase

scientific article published on 04 September 2019

Substrate Profiling and High Resolution Co-complex Crystal Structure of a Secreted C11 Protease Conserved across Commensal Bacteria.

scientific article published on 17 April 2017

Synthesis and Sulfur Electrophilicity of theNupharThiaspirane Pharmacophore

scientific article

Triflic Acid Treatment Enables LC-MS/MS Analysis of Insoluble Bacterial Biomass

scientific article published on 08 August 2018

Turning a protein kinase on or off from a single allosteric site via disulfide trapping

scientific article

Ultrahigh and High Resolution Structures and Mutational Analysis of Monomeric Streptococcus pyogenes SpeB Reveal a Functional Role for the Glycine-rich C-terminal Loop

scientific article

Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors

scientific article

X-ray Structures of Two Bacteroides thetaiotaomicron C11 Proteases in Complex with Peptide-Based Inhibitors

scientific article published on 14 March 2019

X-ray structure of an inactive zymogen clostripain-like protease from Parabacteroides distasonis

scientific article published on 28 February 2019

List of works by Dennis W. Wolan

A Commensal Dipeptidyl Aminopeptidase with Specificity for N-Terminal Glycine Degrades Human-Produced Antimicrobial Peptides in Vitro

A comprehensive and scalable database search system for metaproteomics

A glycal-based photoaffinity probe that enriches sialic acid binding proteins

Acetone-Linked Peptides: A Convergent Approach for Peptide Macrocyclization and Labeling

An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen

Announcement of 2019 Keystone Symposia Conference: "Microbiome: Chemical Mechanisms and Biological Consequences"

Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic

ComPIL 2.0: An Updated Comprehensive Metaproteomics Database

Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates

Data Streaming for Metabolomics: Accelerating Data Processing and Analysis from Days to Minutes.

Discovery of a highly selective caspase-3 substrate for imaging live cells

Discovery of small-molecule enzyme activators by activity-based protein profiling

Domain swapping in inducible nitric-oxide synthase. Electron transfer occurs between flavin and heme groups located on adjacent subunits in the dimer.

Expanding the use of spectral libraries in proteomics

Fibrils colocalize caspase-3 with procaspase-3 to foster maturation

Genetic basis for the cooperative bioactivation of plant lignans by Eggerthella lenta and other human gut bacteria

Identification and Co-complex Structure of a New S. pyogenes SpeB Small Molecule Inhibitor

Inducible nitric oxide synthase: role of the N-terminal beta-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction

Integrative X-ray Structure and Molecular Modeling for the Rationalization of Procaspase-8 Inhibitor Potency and Selectivity

Lipoprotein Signal Peptidase Inhibitors with Antibiotic Properties Identified through Design of a Robust In Vitro HT Platform.

METLIN: A Technology Platform for Identifying Knowns and Unknowns.

Metaproteomics Analysis of SARS-CoV-2-Infected Patient Samples Reveals Presence of Potential Coinfecting Microorganisms

Metaproteomics of colonic microbiota unveils discrete protein functions among colitic mice and control groups

Molecules that modulate Apaf-1 activity

N-Terminomics/TAILS Profiling of Proteases and Their Substrates in Ulcerative Colitis

Nitrosopurines en route to potently cytotoxic asmarines

Probing substrate recognition of bacterial lipoprotein signal peptidase using FRET reporters

Proteome-wide covalent ligand discovery in native biological systems

Quantitative Metaproteomics and Activity-Based Probe Enrichment Reveals Significant Alterations in Protein Expression from a Mouse Model of Inflammatory Bowel Disease

Quantitative Metaproteomics and Activity-based Protein Profiling of Patient Fecal Microbiome Identifies Host and Microbial Serine-type Endopeptidase Activity Associated With Ulcerative Colitis

Selective and Rapid Cell-Permeable Inhibitor of Human Caspase-3

Selective detection and inhibition of active caspase-3 in cells with optimized peptides.

Selective detection of caspase-3 versus caspase-7 using activity-based probes with key unnatural amino acids

Selective inhibition of initiator versus executioner caspases using small peptides containing unnatural amino acids

Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation

Small-molecule activators of a proenzyme

Small-molecule procaspase activators identified using fluorescence polarization.

Structural insights into the avian AICAR transformylase mechanism

Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor

Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site

Structure-based optimization and synthesis of antiviral drug Arbidol analogues with significantly improved affinity to influenza hemagglutinin

SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase

Substrate Profiling and High Resolution Co-complex Crystal Structure of a Secreted C11 Protease Conserved across Commensal Bacteria.

Synthesis and Sulfur Electrophilicity of theNupharThiaspirane Pharmacophore

Triflic Acid Treatment Enables LC-MS/MS Analysis of Insoluble Bacterial Biomass

Turning a protein kinase on or off from a single allosteric site via disulfide trapping

Ultrahigh and High Resolution Structures and Mutational Analysis of Monomeric Streptococcus pyogenes SpeB Reveal a Functional Role for the Glycine-rich C-terminal Loop

Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors

X-ray Structures of Two Bacteroides thetaiotaomicron C11 Proteases in Complex with Peptide-Based Inhibitors

X-ray structure of an inactive zymogen clostripain-like protease from Parabacteroides distasonis