List of works - Matthew E Gegg

A Drosophila Model of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by Rapamycin

scientific article

Ablation of the pro-inflammatory master regulator miR-155 does not mitigate neuroinflammation or neurodegeneration in a vertebrate model of Gaucher's disease

scientific article published on 11 April 2019

Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells

scientific article

Bioenergetic consequences of PINK1 mutations in Parkinson disease

scientific article

Co-culture of neurones with glutathione deficient astrocytes leads to increased neuronal susceptibility to nitric oxide and increased glutamate-cysteine ligase activity

scientific article

DJ-1 is a redox sensitive adapter protein for high molecular weight complexes involved in regulation of catecholamine homeostasis

scientific article published in October 2017

Determination of glutamate-cysteine ligase (gamma-glutamylcysteine synthetase) activity by high-performance liquid chromatography and electrochemical detection

scientific article published in May 2002

Differential effect of nitric oxide on glutathione metabolism and mitochondrial function in astrocytes and neurones: implications for neuroprotection/neurodegeneration?

scientific article

Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology.

scientific article published on 3 June 2009

Effects of ambroxol on the autophagy-lysosome pathway and mitochondria in primary cortical neurons.

scientific article

GBA mutation promotes early mitochondrial dysfunction in 3D neurosphere models

scientific article published on 21 November 2019

Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death

scientific article

Glucocerebrosidase activity, cathepsin D and monomeric α-synuclein interactions in a stem cell derived neuronal model of a PD associated GBA1 mutation

scientific article published on 18 October 2019

Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains

scientific article published on September 2012

Glucocerebrosidase in the pathogenesis and treatment of Parkinson disease

scientific article published on 14 February 2013

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

ICAM-1-mediated endothelial nitric oxide synthase activation via calcium and AMP-activated protein kinase is required for transendothelial lymphocyte migration

scientific article

Mitochondria and quality control defects in a mouse model of Gaucher disease--links to Parkinson's disease

scientific journal article

Mitochondrial Contribution to Parkinson's Disease Pathogenesis ⬇️

scientific article published on April 28, 2011

Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy

scientific article published on 28 October 2015

Mitochondrial dysfunction associated with glucocerebrosidase deficiency

scientific journal article

Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression

scientific journal article

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

scientific article

No evidence for substrate accumulation in Parkinson brains with GBA mutations

scientific article published on 11 June 2015

PINK1-parkin-dependent mitophagy involves ubiquitination of mitofusins 1 and 2: Implications for Parkinson disease pathogenesis ⬇️

scientific article published on February 1, 2011

Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models

scientific article published on 19 August 2016

Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cells

scientific article

The role of DJ-1 complexes and catecholamine metabolism: relevance for familial and idiopathic Parkinson's disease.

scientific article published in May 2018

The role of glucocerebrosidase in Parkinson disease pathogenesis

scientific article published on 31 January 2018

List of works by Matthew E Gegg

A Drosophila Model of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by Rapamycin

Ablation of the pro-inflammatory master regulator miR-155 does not mitigate neuroinflammation or neurodegeneration in a vertebrate model of Gaucher's disease

Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells

Bioenergetic consequences of PINK1 mutations in Parkinson disease

Co-culture of neurones with glutathione deficient astrocytes leads to increased neuronal susceptibility to nitric oxide and increased glutamate-cysteine ligase activity

DJ-1 is a redox sensitive adapter protein for high molecular weight complexes involved in regulation of catecholamine homeostasis

Determination of glutamate-cysteine ligase (gamma-glutamylcysteine synthetase) activity by high-performance liquid chromatography and electrochemical detection

Differential effect of nitric oxide on glutathione metabolism and mitochondrial function in astrocytes and neurones: implications for neuroprotection/neurodegeneration?

Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology.

Effects of ambroxol on the autophagy-lysosome pathway and mitochondria in primary cortical neurons.

GBA mutation promotes early mitochondrial dysfunction in 3D neurosphere models

Glucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death

Glucocerebrosidase activity, cathepsin D and monomeric α-synuclein interactions in a stem cell derived neuronal model of a PD associated GBA1 mutation

Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains

Glucocerebrosidase in the pathogenesis and treatment of Parkinson disease

Guidelines for the use and interpretation of assays for monitoring autophagy

ICAM-1-mediated endothelial nitric oxide synthase activation via calcium and AMP-activated protein kinase is required for transendothelial lymphocyte migration

Mitochondria and quality control defects in a mouse model of Gaucher disease--links to Parkinson's disease

Mitochondrial Contribution to Parkinson's Disease Pathogenesis ⬇️

Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy

Mitochondrial dysfunction associated with glucocerebrosidase deficiency

Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

No evidence for substrate accumulation in Parkinson brains with GBA mutations

PINK1-parkin-dependent mitophagy involves ubiquitination of mitofusins 1 and 2: Implications for Parkinson disease pathogenesis ⬇️

Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models

Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cells

The role of DJ-1 complexes and catecholamine metabolism: relevance for familial and idiopathic Parkinson's disease.

The role of glucocerebrosidase in Parkinson disease pathogenesis