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List of works by Karl Broman

"Bias toward the null" means reduced power

scientific article published on October 2004

A Common Locus for Late-Onset Fuchs Corneal Dystrophy Maps to 18q21.2-q21.32

article

A Spontaneous Missense Mutation in Branched Chain Keto Acid Dehydrogenase Kinase in the Rat Affects Both the Central and Peripheral Nervous Systems

scientific article (publication date: 2016)

A comprehensive linkage map of the dog genome

scientific article

A genome screen of multiplex sibships with prostate cancer.

scientific article

A large-scale genome-lipid association map guides lipid identification

scientific article published on 21 September 2020

A major locus conferring susceptibility to infection by Streptococcus pneumoniae in mice.

scientific article

A model selection approach for the identification of quantitative trait loci in experimental crosses, allowing epistasis

scientific article

A modified vaccinia Ankara vaccine vector expressing a mosaic H5 hemagglutinin reduces viral shedding in rhesus macaques

scientific article

A new standard genetic map for the laboratory mouse

scientific article published on 17 June 2009

A novel locus on mouse chromosome 7 that influences survival after infection with tick-borne encephalitis virus.

scientific article published on 6 July 2018

A postgenomic method for predicting essential genes at subsaturation levels of mutagenesis: application to Mycobacterium tuberculosis

scientific article

A second-generation genetic linkage map of the domestic dog, Canis familiaris.

scientific article

A simple method for combining genetic mapping data from multiple crosses and experimental designs

scientific article

A simple regression-based method to map quantitative trait loci underlying function-valued phenotypes ⬇️

scientific article

Acute-phase CD8 T cell responses that select for escape variants are needed to control live attenuated simian immunodeficiency virus

scientific article published on 19 June 2013

An ADAMTSL2 founder mutation causes Musladin-Lueke Syndrome, a heritable disorder of beagle dogs, featuring stiff skin and joint contractures

scientific article

An SNP-Based Linkage Map for Zebrafish Reveals Sex Determination Loci

scientific article

An extension of the regression of offspring on mid-parent to test for association and estimate locus-specific heritability: the revised ROMP method

scientific article published on 27 November 2007

An imprinted locus epistatically influences Nstr1 and Nstr2 to control resistance to nerve sheath tumors in a neurofibromatosis type 1 mouse model

scientific article

An initial linkage map of the West Nile Virus vector Culex tarsalis.

scientific article published on 24 April 2009

Arlm1 is a male-specific modifier of astrocytoma resistance on mouse Chr 12.

scientific article published on 10 January 2012

BayesMendel: an R environment for Mendelian risk prediction

scientific article published on 17 September 2004

Binary trait mapping in experimental crosses with selective genotyping

scientific article

Breed distribution and history of canine mdr1-1Delta, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineage

scholarly article

Broad-scale recombination patterns underlying proper disjunction in humans

scientific article published on 18 September 2009

Characterization of human crossover interference.

scientific article

Characterization of killer immunoglobulin-like receptor genetics and comprehensive genotyping by pyrosequencing in rhesus macaques

scientific article

Cleaning Genotype Data from Diversity Outbred Mice

scientific article published on 07 May 2019

Cleaning genotype data from Diversity Outbred mice

Cleaning genotype data.

scientific article

Clinical and molecular characterization of the bladder exstrophy-epispadias complex: analysis of 232 families

scientific article published in December 2004

Comparing the degree of exothermic polymerization in commonly used acrylic and provisional composite resins for intraoral appliances

article

Comparison of human genetic and sequence-based physical maps

scientific article published in Nature

Comprehensive human genetic maps: individual and sex-specific variation in recombination

scientific article (publication date: September 1998)

Correlations between Synaptic Initiation and Meiotic Recombination: A Study of Humans and Mice

scientific article

Cortical, but not posterior subcapsular, cataract shows significant familial aggregation in an older population after adjustment for possible shared environmental factors

scientific article

Cross-reactive T cells are involved in rapid clearance of 2009 pandemic H1N1 influenza virus in nonhuman primates

scientific article

Crossover interference in the mouse.

scientific article

Crossover interference underlies sex differences in recombination rates

scientific article published on 26 October 2007

Cytological studies of human meiosis: sex-specific differences in recombination originate at, or prior to, establishment of double-strand breaks

scientific article

Data Organization in Spreadsheets

Data organization in spreadsheets

Data organization in spreadsheets

Detecting single-nucleotide polymorphism by single-nucleotide polymorphism interactions in rheumatoid arthritis using a two-step approach with machine learning and a Bayesian threshold least absolute shrinkage and selection operator (LASSO) model

scientific article

Differential MHC class I expression in distinct leukocyte subsets

scientific article

Discrete gene loci regulate neurodegeneration, lymphocyte infiltration, and major histocompatibility complex class II expression in the CNS

article

Efficient imputation of missing markers in low-coverage genotyping-by-sequencing data from multiparental crosses.

scientific article

Endothelial dystrophy, iris hypoplasia, congenital cataract, and stromal thinning (edict) syndrome maps to chromosome 15q22.1–q25.3

scientific article published on 01 August 2002

Estimation of allele frequencies with data on sibships

scientific article

Estimation of antigen-responsive T cell frequencies in PBMC from human subjects

scientific article published in November 1996

Estimation of pairwise relationships in the presence of genotyping errors

scientific article published in November 1998

Ex vivo SIV-specific CD8 T cell responses in heterozygous animals are primarily directed against peptides presented by a single MHC haplotype

scientific article

Examining variation in recombination levels in the human female: a test of the production-line hypothesis

scientific article

Extralymphoid CD8+ T cells resident in tissue from simian immunodeficiency virus SIVmac239{Delta}nef-vaccinated macaques suppress SIVmac239 replication ex vivo

scientific article published on 20 January 2010

Extreme hyperopia is the result of null mutations in MFRP, which encodes a Frizzled-related protein

scientific article

FMR1 CGG expansions: prevalence and sex ratios

scientific article published on 05 June 2013

Fourteen Years of R/qtl: Just Barely Sustainable

scientific article

Gene loci associated with insulin secretion in islets from non-diabetic mice

scientific article published on 25 July 2019

GeneNetwork: framework for web-based genetics

article

Genetic Drivers of Pancreatic Islet Function

article

Genetic Fine-Mapping and Identification of Candidate Genes and Variants for Adiposity Traits in Outbred Rats.

scientific article published on 28 November 2017

Genetic analysis of complex traits in the emerging Collaborative Cross

scientific article

Genetic and physical mapping of the locus for autosomal dominant renal Fanconi syndrome, on chromosome 15q15.3.

scientific article

Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis

scholarly article

Genetic background modifies phenotypic severity and longevity in a mouse model of Niemann-Pick disease type C1

scientific article published on 29 January 2020

Genetic control of X chromosome inactivation in mice: definition of the Xce candidate interval

scientific article

Genetic determinants of gut microbiota composition and bile acid profiles in mice

scientific article published on 29 August 2019

Genetic dissection of a model complex trait using the Drosophila Synthetic Population Resource.

scientific article

Genetic resistance to diet-induced obesity in chromosome substitution strains of mice

scientific article published on 03 February 2010

Genetics of Rapid and Extreme Size Evolution in Island Mice

scientific article

Genetics of Skeletal Evolution in Unusually Large Mice from Gough Island

scientific article published on 30 September 2016

Genome Reshuffling for Advanced Intercross Permutation (GRAIP): simulation and permutation for advanced intercross population analysis

scientific article

Genome-wide linkage identifies novel modifier loci of aganglionosis in the Sox10Dom model of Hirschsprung disease

scientific journal article

Genome-wide variation in recombination in female meiosis: a risk factor for non-disjunction of chromosome 21

scientific article published on 01 March 2000

Genomewide scan for prostate cancer-aggressiveness loci.

scientific article

Genotype Probabilities at Intermediate Generations in the Construction of Recombinant Inbred Lines ⬇️

scientific article published on February 1, 2012

Genotypic analysis of HIV-1 drug resistance at the limit of detection: virus production without evolution in treated adults with undetectable HIV loads

scientific article

Genotyping for human whole-genome scans: past, present, and future

scientific article

Haplotype Probabilities in Advanced Intercross Populations ⬇️

scientific article published on February 1, 2012

Haplotype probabilities for multiple-strain recombinant inbred lines

scientific article published on 6 December 2006

High-resolution quantitative trait locus mapping reveals sign epistasis controlling ovariole number between two Drosophila species

scientific article

High-throughput computer vision introduces the time axis to a quantitative trait map of a plant growth response

scientific article

Identification and Correction of Sample Mix-Ups in Expression Genetic Data: A Case Study ⬇️

scientific article

Identification of Slco1a6 as a candidate gene that broadly affects gene expression in mouse pancreatic islets

article

Identification of X-linked quantitative trait loci affecting cold tolerance in Drosophila melanogaster and fine mapping by selective sweep analysis.

scientific article published on 24 December 2010

Identification of a novel polymorphism in X-linked sterol-4-alpha-carboxylate 3-dehydrogenase (Nsdhl) associated with reduced high-density lipoprotein cholesterol levels in I/LnJ mice

scientific article published on 03 October 2013

Identification of sample mix-ups and mixtures in microbiome data in Diversity Outbred mice

Identification of susceptibility loci for skin disease in a murine psoriasis model

scientific article published on 01 October 2006

Identification of the Bile Acid Transporter Slco1a6 as a Candidate Gene That Broadly Affects Gene Expression in Mouse Pancreatic Islets.

scientific article

Inheritance of a novel COL8A2 mutation defines a distinct early-onset subtype of fuchs corneal dystrophy

scientific article

Interactions in hypoxic and hypercapnic breathing are genetically linked to mouse chromosomes 1 and 5.

scientific article published on 20 February 2004

Linkage of late-onset Fuchs corneal dystrophy to a novel locus at 13pTel-13q12.13.

scientific article

Long homozygous chromosomal segments in reference families from the centre d'Etude du polymorphisme humain

scientific article

Loss of Imprinting of Insulin-Like Growth Factor-II (IGF2) Gene in Distinguishing Specific Biologic Subtypes of Wilms Tumor

scientific article published on 01 November 2001

Mapping Quantitative Trait Loci Underlying Function-Valued Traits Using Functional Principal Component Analysis and Multi-Trait Mapping

scientific article

Mapping expression in randomized rodent genomes

scientific article published on 01 March 2005

Mapping genetic determinants of host susceptibility to Pseudomonas aeruginosa lung infection in mice

scientific article

Mapping quantitative trait loci by an extension of the Haley-Knott regression method using estimating equations

scientific article

Mapping quantitative trait loci in the case of a spike in the phenotype distribution.

scientific article

Mapping quantitative trait loci onto a phylogenetic tree

scientific article

Mapping quantitative trait loci underlying function-valued traits using functional principal component analysis and multi-trait mapping

Meiotic recombination in human oocytes.

scientific article published on 18 September 2009

Method for constructing confidently ordered linkage maps

scientific article published in January 1999

Modified vaccinia virus Ankara encoding influenza virus hemagglutinin induces heterosubtypic immunity in macaques.

scientific article

Modifiers of von Willebrand factor identified by natural variation in inbred strains of mice

scientific article

Multigenic control of Listeria monocytogenes susceptibility in mice.

scientific article

Multiperson use of syringes among injection drug users in a needle exchange program: a gene-based molecular epidemiologic analysis

scientific article published on November 2006

Multiple loci contribute to genome-wide recombination levels in male mice

scientific article

Multiple polymorphic loci determine basal hepatic and splenic iron status in mice

scientific article

Novel autoantigens in autoimmune hypophysitis

scientific article published on 10 January 2008

Nuclear cataract shows significant familial aggregation in an older population after adjustment for possible shared environmental factors

scientific article

Olfactory receptor-gene clusters, genomic-inversion polymorphisms, and common chromosome rearrangements

scientific article

Particle Effects on Heart-Rate Regulation in Senescent Mice

article by Clarke G Tankersley et al published January 2004 in Inhalation Toxicology

Patterns of recombination activity on mouse chromosome 11 revealed by high resolution mapping

scientific article

Perturbation of nuclear architecture by long-distance chromosome interactions.

scientific article published in May 1996

Poor performance of bootstrap confidence intervals for the location of a quantitative trait locus

scientific article

Power and robustness of linkage tests for quantitative traits in general pedigrees

scientific article published in January 2005

Predisposition to efficient mammary tumor metastatic progression is linked to the breast cancer metastasis suppressor gene Brms1.

scientific article published in December 2001

QTLViewer: an interactive webtool for genetic analysis in the Collaborative Cross and Diversity Outbred mouse populations

scientific article published in 2022

Quantile-Based Permutation Thresholds for Quantitative Trait Loci Hotspots ⬇️

scientific article published on June 1, 2012

Quantitative lymphatic vessel trait analysis suggests Vcam1 as candidate modifier gene of inflammatory bowel disease.

scientific article

Quantitative trait linkage analysis by generalized estimating equations: unification of variance components and Haseman-Elston regression

scientific article published in May 2004

Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome.

scientific article published in December 2000

Quantitative trait loci x maternal cytoplasmic environment interaction for development rate in Oncorhynchus mykiss

scientific article published on 22 October 2006

Quantitative trait locus mapping identifies candidate alleles involved in adaptive introgression and range expansion in a wild sunflower.

scientific article published on 21 January 2015

Quantitative trait locus mapping methods for diversity outbred mice

scientific article

Quasi-linkage: a confounding factor in linkage analysis of complex diseases?

scientific article

R/qtl2: Software for Mapping Quantitative Trait Loci with High-Dimensional Data and Multiparent Populations

article

R/qtl2: software for mapping quantitative trait loci with high dimensional data and multi-parent populations

R/qtl: QTL mapping in experimental crosses

scientific article (publication date: May 2003)

R/qtl: high-throughput multiple QTL mapping

scientific article

R/qtlDesign: inbred line cross experimental design

scientific article published on February 2007

R/qtlcharts: interactive graphics for quantitative trait locus mapping

scientific article

R/qtlcharts: interactive graphics for quantitative trait locus mapping

Recombination rate variation in mice from an isolated island

scientific article published on 19 November 2016

Resistance to noise-induced hearing loss in 129S6 and MOLF mice: identification of independent, overlapping, and interacting chromosomal regions

scientific article

Review of statistical methods for QTL mapping in experimental crosses.

scientific article

SNP-specific array-based allele-specific expression analysis

scientific article

SNPs made routine

scientific article published on 01 November 2004

Scram1 is a modifier of spinal cord resistance for astrocytoma on mouse Chr 5.

scientific article published on 8 December 2011

Selective genotyping and phenotyping strategies in a complex trait context

scientific article published on 19 January 2009

Significance thresholds for quantitative trait locus mapping under selective genotyping

scientific article

Simulation-based P values: response to North et al.

scientific article published on February 2003

Spectrum of heart disease associated with murine and human GATA4 mutation

scientific journal article

Speeding up eQTL scans in the BXD population using GPUs

scientific article published on 16 August 2021

Systems genetics of susceptibility to obesity-induced diabetes in mice

scientific article published on 18 October 2011

Testing Pleiotropy vs. Separate QTL in Multiparental Populations

scientific article published on 09 July 2019

Testing pleiotropy vs. separate QTL in multiparental populations

The C. savignyi genetic map and its integration with the reference sequence facilitates insights into chordate genome evolution

scientific article

The Collaborative Cross, a community resource for the genetic analysis of complex traits

article

The Dissection of Expression Quantitative Trait Locus Hotspots.

scientific article published on 02 February 2016

The Lsktm1 locus modulates lung and skin tumorigenesis in the mouse

scientific article

The Transcription Factor Nfatc2 Regulates β-Cell Proliferation and Genes Associated with Type 2 Diabetes in Mouse and Human Islets

scientific article

The X chromosome in quantitative trait locus mapping

scientific article

The genomes of recombinant inbred lines

scientific article

The paternal-age effect in Apert syndrome is due, in part, to the increased frequency of mutations in sperm

scientific article

The recombinational anatomy of a mouse chromosome.

scientific article

Treatment of the X chromosome in mapping multiple quantitative trait loci

scientific article published in 2021

Tsc2, a positional candidate gene underlying a quantitative trait locus for hepatic steatosis

scientific article published on 23 May 2012

Two autoimmune diabetes loci influencing T cell apoptosis control susceptibility to experimental autoimmune myocarditis

scientific article published on 01 February 2005

Unknown biological mixtures evaluation using STR analytical quantification

scientific article published on February 2006

Variation in genome-wide levels of meiotic recombination is established at the onset of prophase in mammalian males

scientific article

Variation in genomic recombination rates among heterogeneous stock mice

scientific article published on 17 June 2009

betaA3/A1-crystallin in astroglial cells regulates retinal vascular remodeling during development

scientific journal article

xQTL workbench: a scalable web environment for multi-level QTL analysis

scientific article published on 3 February 2012

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