List of works - Giuseppe Danilo Norata

-374 T/A RAGE polymorphism is associated with chronic kidney disease progression in subjects affected by nephrocardiovascular disease.

scientific article

Anti-inflammatory and anti-atherogenic effects of cathechin, caffeic acid and trans-resveratrol in apolipoprotein E deficient mice

Antigen-Dependent and Antigen-Independent Pathways Modulate CD4 + CD28 null T-Cells During Atherosclerosis ⬇️

scientific article published on 01 July 2012

ApoE gene delivery inhibits severe hypercholesterolemia in newborn ApoE-KO mice

scientific article published on 23 July 2007

Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population

scientific article

Cardiometabolic and immune factors associated with increased common carotid artery intima-media thickness and cardiovascular disease in patients with systemic lupus erythematosus.

scientific article published on February 2014

Carotid intima-media thickness progression and risk of vascular events in people with diabetes: results from the PROG-IMT collaboration

scientific article

Circulating CD4+CD25hiCD127lo regulatory T-Cell levels do not reflect the extent or severity of carotid and coronary atherosclerosis.

scientific article published on 10 June 2010

Circulating soluble receptor for advanced glycation end products is inversely associated with body mass index and waist/hip ratio in the general population

scientific article published on 2 July 2008

Class II phosphoinositide 3-kinases contribute to endothelial cells morphogenesis

scientific article

Correction: Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration

scientific article published in PLoS ONE

Deficiency of the Long Pentraxin PTX3 Promotes Vascular Inflammation and Atherosclerosis

Dihydrotestosterone decreases tumor necrosis factor-alpha and lipopolysaccharide-induced inflammatory response in human endothelial cells.

scientific article published on 29 November 2005

Disease trends over time and CD4+CCR5+ T-cells expansion predict carotid atherosclerosis development in patients with systemic lupus erythematosus

scientific article published on 18 September 2017

Effect of Tie-2 conditional deletion of BDNF on atherosclerosis in the ApoE null mutant mouse.

scientific article published on 22 February 2012

Effect of the -420C/G variant of the resistin gene promoter on metabolic syndrome, obesity, myocardial infarction and kidney dysfunction.

scientific article published in July 2007

Effect of the Toll-like receptor 4 (TLR-4) variants on intima-media thickness and monocyte-derived macrophage response to LPS

scientific article published on 01 July 2005

Effect of treatment with pravastatin or ezetimibe on endothelial function in patients with moderate hypercholesterolemia

scientific article

Effects of PCSK9 variants on common carotid artery intima media thickness and relation to ApoE alleles.

scientific article published on 27 June 2009

Effects of fractalkine receptor variants on common carotid artery intima-media thickness

scientific article published on 04 May 2006

Emerging role of high density lipoproteins as a player in the immune system.

scientific article

European lipoprotein club: report of the 35th ELC annual conference (Tutzing, 10th-13th September 2012).

scientific article published on 5 December 2012

Fibronectin extra domain A stabilises atherosclerotic plaques in apolipoprotein E and in LDL-receptor-deficient mice.

scientific article

Fuel for thought: immunometabolism is a paradigm shift in understanding immunity in cardiovascular disease

scientific article published on 01 July 2019

Gene silencing approaches for the management of dyslipidaemia.

scientific article published on 26 February 2013

Genetically determined hypercholesterolaemia results into premature leucocyte telomere length shortening and reduced haematopoietic precursors

scientific article published in 2020

Genetically determined telomeres shortening is associated with carotid atherosclerosis progression and increased incidence of cardiovascular events

scientific article

HDL and adaptive immunity: A tale of lipid rafts ⬇️

scientific article published on August 23, 2012

HDL in Immune-Inflammatory Responses: Implications beyond Cardiovascular Diseases

scientific article published in 2021

HDL in infectious diseases and sepsis

scientific article

HDL in innate and adaptive immunity.

scientific article

HDL3 induces cyclooxygenase-2 expression and prostacyclin release in human endothelial cells via a p38 MAPK/CRE-dependent pathway: effects on COX-2/PGI-synthase coupling

scientific article published on 4 March 2004

HDL: to treat or not to treat?

scientific article published on August 2014

HDLs, immunity, and atherosclerosis.

scientific article published on October 2011

High density lipoprotein cholesterol levels are an independent predictor of the progression of chronic kidney disease

scientific article published on 11 May 2013

High density lipoproteins and atherosclerosis: emerging aspects.

scientific article published on December 2012

High-density lipoprotein subfraction 3 decreases ADAMTS-1 expression induced by lipopolysaccharide and tumor necrosis factor-alpha in human endothelial cells

scientific article published in January 2004

High-density lipoprotein subfractions--what the clinicians need to know

scientific article

High-density lipoproteins induce transforming growth factor-beta2 expression in endothelial cells.

scientific article published on 23 May 2005

Homozygous familial hypobetalipoproteinemia: two novel mutations in the splicing sites of apolipoprotein B gene and review of the literature

scientific article

Hormonal control of trained immunity: aldosterone at the crossroad between activation of innate immunity and cardiovascular diseases

scientific article published on 01 February 2020

IDOL N342S Variant, Atherosclerosis Progression and Cardiovascular Disorders in the Italian General Population

scientific article published on 30 April 2015

Identification of seven loci affecting mean telomere length and their association with disease

scientific article published on April 2013

Immunometabolic function of cholesterol in cardiovascular disease and beyond

scientific article published on 01 July 2019

Impact of systemic inflammation and autoimmune diseases on apoA-I and HDL plasma levels and functions

scientific article

Increased atherosclerosis and vascular inflammation in APP transgenic mice with apolipoprotein E deficiency.

scientific article published on 10 November 2009

Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project

scientific article published on May 2010

Inflammatory markers and extent and progression of early atherosclerosis: Meta-analysis of individual-participant-data from 20 prospective studies of the PROG-IMT collaboration

scientific article

LOX-1 Inhibition in ApoE KO Mice Using a Schizophyllan-based Antisense Oligonucleotide Therapy

scientific article published on 4 December 2012

LOX-1, OxLDL, and atherosclerosis

scientific article published on 10 July 2013

Lack of ApoA-I in ApoEKO Mice Causes Skin Xanthomas, Worsening of Inflammation, and Increased Coronary Atherosclerosis in the Absence of Hyperlipidemia

scientific article published in 2022

Leonurine: a new comer in the natural compounds affecting atherosclerosis

scientific article published on 07 March 2012

Leptin:adiponectin ratio is an independent predictor of intima media thickness of the common carotid artery

scientific article published on 06 September 2007

Lipid lowering activity of drugs affecting cholesterol absorption.

scientific article published on February 2004

Long pentraxin 3, a key component of innate immunity, is modulated by high-density lipoproteins in endothelial cells

scientific article published on 24 January 2008

Long pentraxin 3/tumor necrosis factor-stimulated gene-6 interaction: a biological rheostat for fibroblast growth factor 2-mediated angiogenesis

scientific journal article

Long pentraxin 3: experimental and clinical relevance in cardiovascular diseases

scientific article published on 7 April 2013

Loss of voltage-gated hydrogen channel 1 expression reveals heterogeneous metabolic adaptation to intracellular acidification by T cells

scientific article published in 2022

Mannose Receptor Deficiency Impacts Bone Marrow and Circulating Immune Cells during High Fat Diet Induced Obesity

scientific article published in 2022

Markers of inflammation associated with plaque progression and instability in patients with carotid atherosclerosis

scientific article published on 16 April 2015

MiR-143/145 deficiency attenuates the progression of atherosclerosis in Ldlr-/-mice.

scientific article published on 10 July 2014

MicroRNAs and lipoproteins: A connection beyond atherosclerosis? ⬇️

scientific article published on November 24, 2012

Modified HDL: biological and physiopathological consequences.

scientific article published on 23 June 2006

Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation

scientific article published in Nature Communications

New therapeutic principles for Familial Hypercholesterolemia

scientific article published on 20 May 2014

New therapeutic principles in dyslipidaemia: focus on LDL and Lp(a) lowering drugs ⬇️

scientific article published on March 18, 2013

Normative values for carotid intima media thickness and its progression: Are they transferrable outside of their cohort of origin?

scientific article published on 8 January 2016

Novel biotinylated bile acid amphiphiles: micellar aggregates formation and interaction with hepatocytes.

scientific article published on 3 March 2011

Novel concepts in HDL pharmacology.

scientific article

Oxidised-HDL3 induces the expression of PAI-1 in human endothelial cells. Role of p38MAPK activation and mRNA stabilization

scholarly article by Giuseppe Danilo Norata et al published October 2004 in British Journal of Haematology

PCSK9 deficiency rewires heart metabolism and drives heart failure with preserved ejection fraction

scientific article published in 2021

PCSK9 inhibition for the treatment of hypercholesterolemia: promises and emerging challenges

scientific article

PCSK9 inhibition in statin-intolerant HeFH patients: What's new?

scientific article

PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling

scientific article published on 23 June 2015

Peak inflammation in atherosclerosis, primary biliary cirrhosis and autoimmune arthritis is counter-intuitively associated with regulatory T cell enrichment.

scientific article published on 26 February 2015

Pentraxin 3 (PTX3) plasma levels and carotid intima media thickness progression in the general population

scientific article published on 4 December 2013

Pentraxins and Atherosclerosis

Pharmacogenetics in cardiovascular disorders: an update on the principal drugs.

scientific article published on April 2013

Plasma adiponectin levels in chronic kidney disease patients: relation with molecular inflammatory profile and metabolic status

scientific article

Plasma resistin levels correlate with determinants of the metabolic syndrome

scientific article published in February 2007

Post-prandial endothelial dysfunction in hypertriglyceridemic subjects: Molecular mechanisms and gene expression studies

article

Postprandial lipemia as a cardiometabolic risk factor.

scientific article published on 02 May 2014

Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration

scientific article published on 12 April 2018

Prevalence of classical CD14++/CD16- but not of intermediate CD14++/CD16+ monocytes in hypoalphalipoproteinemia.

scientific article published on 23 April 2013

Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium

scientific article published on 16 October 2019

Proprotein Convertase Subtilisin-Kexin type-9 (PCSK9) and triglyceride-rich lipoprotein metabolism: Facts and gaps

scientific article published on 8 February 2018

Small dense LDL and VLDL predict common carotid artery IMT and elicit an inflammatory response in peripheral blood mononuclear and endothelial cells

scientific article published on 25 March 2009

Statins and periodontal inflammation: a pleiotropic effect of statins or a pleiotropic effect of LDL-cholesterol lowering?

scientific article published on 26 March 2014

Statins and skeletal muscles toxicity: from clinical trials to everyday practice

scientific article

Targeting PCSK9 for hypercholesterolemia

scientific article

Telomere shortening over 6 years is associated with increased subclinical carotid vascular damage and worse cardiovascular prognosis in the general population.

scientific article published on 19 July 2014

The CD1d-natural killer T cell axis in atherosclerosis.

scientific article published on 13 June 2013

The Cellular and Molecular Basis of Translational Immunometabolism.

scientific article published on September 2015

The Impact of Red Yeast Rice Extract Use on the Occurrence of Muscle Symptoms and Liver Dysfunction: An Update from the Adverse Event Reporting Systems and Available Meta-Analyses

scientific article published in 2024

The Missing Link Between High-Density Lipoprotein Cholesterol and Inflammatory Response in Cardiovascular Disease

scientific article published on 26 March 2014

The Role of Monocytes and Macrophages in Human Atherosclerosis, Plaque Neoangiogenesis, and Atherothrombosis

scientific article published on 04 April 2019

The androgen derivative 5alpha-androstane-3beta,17beta-diol inhibits tumor necrosis factor alpha and lipopolysaccharide induced inflammatory response in human endothelial cells and in mice aorta

scientific article published on 19 May 2010

The arachidonic acid metabolome serves as a conserved regulator of cholesterol metabolism

scientific article published on November 2014

The long pentraxin PTX3: a modulator of the immunoinflammatory response in atherosclerosis and cardiovascular diseases.

scientific article published on February 2010

The low-density lipoprotein receptor–mTORC1 axis coordinates CD8+ T cell activation

scientific article published in 2022

The thyroid receptor modulator KB3495 reduces atherosclerosis independently of total cholesterol in the circulation in ApoE deficient mice

scientific article

Therapy and clinical trials: aggressive statin therapy versus combined and emerging approaches

scientific article

Translating the biology of adipokines in atherosclerosis and cardiovascular diseases: Gaps and open questions.

scientific article

Triglyceride-rich lipoproteins from normotrygliceridemic subjects and hyperlipidemic patients differently affect endothelial cell activation and gene expression patterns

scientific article published on 01 April 2007

Vinculin phosphorylation modulates endothelial cell permeability: a new target for cardiovascular disease?

scientific article published in 2022

[PCSK9 inhibitors and dyslipidemias: an update on clinical evidence]

scientific article published on 01 May 2014

List of works by Giuseppe Danilo Norata

-374 T/A RAGE polymorphism is associated with chronic kidney disease progression in subjects affected by nephrocardiovascular disease.

Anti-inflammatory and anti-atherogenic effects of cathechin, caffeic acid and trans-resveratrol in apolipoprotein E deficient mice

Antigen-Dependent and Antigen-Independent Pathways Modulate CD4 + CD28 null T-Cells During Atherosclerosis ⬇️

ApoE gene delivery inhibits severe hypercholesterolemia in newborn ApoE-KO mice

Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population

Cardiometabolic and immune factors associated with increased common carotid artery intima-media thickness and cardiovascular disease in patients with systemic lupus erythematosus.

Carotid intima-media thickness progression and risk of vascular events in people with diabetes: results from the PROG-IMT collaboration

Circulating CD4+CD25hiCD127lo regulatory T-Cell levels do not reflect the extent or severity of carotid and coronary atherosclerosis.

Circulating soluble receptor for advanced glycation end products is inversely associated with body mass index and waist/hip ratio in the general population

Class II phosphoinositide 3-kinases contribute to endothelial cells morphogenesis

Correction: Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration

Deficiency of the Long Pentraxin PTX3 Promotes Vascular Inflammation and Atherosclerosis

Dihydrotestosterone decreases tumor necrosis factor-alpha and lipopolysaccharide-induced inflammatory response in human endothelial cells.

Disease trends over time and CD4+CCR5+ T-cells expansion predict carotid atherosclerosis development in patients with systemic lupus erythematosus

Effect of Tie-2 conditional deletion of BDNF on atherosclerosis in the ApoE null mutant mouse.

Effect of the -420C/G variant of the resistin gene promoter on metabolic syndrome, obesity, myocardial infarction and kidney dysfunction.

Effect of the Toll-like receptor 4 (TLR-4) variants on intima-media thickness and monocyte-derived macrophage response to LPS

Effect of treatment with pravastatin or ezetimibe on endothelial function in patients with moderate hypercholesterolemia

Effects of PCSK9 variants on common carotid artery intima media thickness and relation to ApoE alleles.

Effects of fractalkine receptor variants on common carotid artery intima-media thickness

Emerging role of high density lipoproteins as a player in the immune system.

European lipoprotein club: report of the 35th ELC annual conference (Tutzing, 10th-13th September 2012).

Fibronectin extra domain A stabilises atherosclerotic plaques in apolipoprotein E and in LDL-receptor-deficient mice.

Fuel for thought: immunometabolism is a paradigm shift in understanding immunity in cardiovascular disease

Gene silencing approaches for the management of dyslipidaemia.

Genetically determined hypercholesterolaemia results into premature leucocyte telomere length shortening and reduced haematopoietic precursors

Genetically determined telomeres shortening is associated with carotid atherosclerosis progression and increased incidence of cardiovascular events

HDL and adaptive immunity: A tale of lipid rafts ⬇️

HDL in Immune-Inflammatory Responses: Implications beyond Cardiovascular Diseases

HDL in infectious diseases and sepsis

HDL in innate and adaptive immunity.

HDL3 induces cyclooxygenase-2 expression and prostacyclin release in human endothelial cells via a p38 MAPK/CRE-dependent pathway: effects on COX-2/PGI-synthase coupling

HDL: to treat or not to treat?

HDLs, immunity, and atherosclerosis.

High density lipoprotein cholesterol levels are an independent predictor of the progression of chronic kidney disease

High density lipoproteins and atherosclerosis: emerging aspects.

High-density lipoprotein subfraction 3 decreases ADAMTS-1 expression induced by lipopolysaccharide and tumor necrosis factor-alpha in human endothelial cells

High-density lipoprotein subfractions--what the clinicians need to know

High-density lipoproteins induce transforming growth factor-beta2 expression in endothelial cells.

Homozygous familial hypobetalipoproteinemia: two novel mutations in the splicing sites of apolipoprotein B gene and review of the literature

Hormonal control of trained immunity: aldosterone at the crossroad between activation of innate immunity and cardiovascular diseases

IDOL N342S Variant, Atherosclerosis Progression and Cardiovascular Disorders in the Italian General Population

Identification of seven loci affecting mean telomere length and their association with disease

Immunometabolic function of cholesterol in cardiovascular disease and beyond

Impact of systemic inflammation and autoimmune diseases on apoA-I and HDL plasma levels and functions

Increased atherosclerosis and vascular inflammation in APP transgenic mice with apolipoprotein E deficiency.

Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project

Inflammatory markers and extent and progression of early atherosclerosis: Meta-analysis of individual-participant-data from 20 prospective studies of the PROG-IMT collaboration

LOX-1 Inhibition in ApoE KO Mice Using a Schizophyllan-based Antisense Oligonucleotide Therapy

LOX-1, OxLDL, and atherosclerosis

Lack of ApoA-I in ApoEKO Mice Causes Skin Xanthomas, Worsening of Inflammation, and Increased Coronary Atherosclerosis in the Absence of Hyperlipidemia

Leonurine: a new comer in the natural compounds affecting atherosclerosis

Leptin:adiponectin ratio is an independent predictor of intima media thickness of the common carotid artery

Lipid lowering activity of drugs affecting cholesterol absorption.

Long pentraxin 3, a key component of innate immunity, is modulated by high-density lipoproteins in endothelial cells

Long pentraxin 3/tumor necrosis factor-stimulated gene-6 interaction: a biological rheostat for fibroblast growth factor 2-mediated angiogenesis

Long pentraxin 3: experimental and clinical relevance in cardiovascular diseases

Loss of voltage-gated hydrogen channel 1 expression reveals heterogeneous metabolic adaptation to intracellular acidification by T cells

Mannose Receptor Deficiency Impacts Bone Marrow and Circulating Immune Cells during High Fat Diet Induced Obesity

Markers of inflammation associated with plaque progression and instability in patients with carotid atherosclerosis

MiR-143/145 deficiency attenuates the progression of atherosclerosis in Ldlr-/-mice.

MicroRNAs and lipoproteins: A connection beyond atherosclerosis? ⬇️

Modified HDL: biological and physiopathological consequences.

Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation

New therapeutic principles for Familial Hypercholesterolemia

New therapeutic principles in dyslipidaemia: focus on LDL and Lp(a) lowering drugs ⬇️

Normative values for carotid intima media thickness and its progression: Are they transferrable outside of their cohort of origin?

Novel biotinylated bile acid amphiphiles: micellar aggregates formation and interaction with hepatocytes.

Novel concepts in HDL pharmacology.

Oxidised-HDL3 induces the expression of PAI-1 in human endothelial cells. Role of p38MAPK activation and mRNA stabilization

PCSK9 deficiency rewires heart metabolism and drives heart failure with preserved ejection fraction

PCSK9 inhibition for the treatment of hypercholesterolemia: promises and emerging challenges

PCSK9 inhibition in statin-intolerant HeFH patients: What's new?

PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling

Peak inflammation in atherosclerosis, primary biliary cirrhosis and autoimmune arthritis is counter-intuitively associated with regulatory T cell enrichment.

Pentraxin 3 (PTX3) plasma levels and carotid intima media thickness progression in the general population

Pentraxins and Atherosclerosis

Pharmacogenetics in cardiovascular disorders: an update on the principal drugs.

Plasma adiponectin levels in chronic kidney disease patients: relation with molecular inflammatory profile and metabolic status