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List of works by José María Gutiérrez

"Bad things come in small packages": predicting venom-induced coagulopathy in Bothrops atrox bites using snake ontogenetic parameters

scientific article published on 06 August 2019

12-HETE is a regulator of PGE2 production via COX-2 expression induced by a snake venom group IIA phospholipase A2 in isolated peritoneal macrophages

scientific article published on 04 December 2019

192. Action of Venom Metalloproteinases on Basement Membranes: Pathogenesis of Hemorrhage and Blistering in Snakebite Envenomings

scientific article published on 02 June 2012

A Call for Incorporating Social Research in the Global Struggle against Snakebite

scientific article published on 17 September 2015

A Comprehensive View of the Structural and Functional Alterations of Extracellular Matrix by Snake Venom Metalloproteinases (SVMPs): Novel Perspectives on the Pathophysiology of Envenoming

scientific article

A Lipidomic Perspective of the Action of Group IIA Secreted Phospholipase A2 on Human Monocytes: Lipid Droplet Biogenesis and Activation of Cytosolic Phospholipase A2α

scientific article published on 10 June 2020

A Lys49 phospholipase A(2) homologue from Bothrops asper snake venom induces proliferation, apoptosis and necrosis in a lymphoblastoid cell line

scientific article

A Lys49 phospholipase A2, isolated from Bothrops asper snake venom, induces lipid droplet formation in macrophages which depends on distinct signaling pathways and the C-terminal region

scientific article published on 24 December 2012

A Lys49-PLA2 myotoxin of Bothrops asper triggers a rapid death of macrophages that involves autocrine purinergic receptor signaling.

scientific article

A Snake Venom-Secreted Phospholipase A2 Induces Foam Cell Formation Depending on the Activation of Factors Involved in Lipid Homeostasis.

scientific article published on 14 June 2018

A Synthetic Biology approach for consistent production of plant-made recombinant polyclonal antibodies against snake venom toxins.

scientific article published on 29 August 2017

A catalytically-inactive snake venom Lys49 phospholipase A₂ homolog induces expression of cyclooxygenase-2 and production of prostaglandins through selected signaling pathways in macrophages

scientific article published on 14 February 2013

A cellular deficiency of gangliosides causes hypersensitivity to Clostridium perfringens phospholipase C.

scientific article

A comparison of in vitro methods for assessing the potency of therapeutic antisera against the venom of the coral snake Micrurus nigrocinctus

scientific article published on 01 April 1997

A group IIA-secreted phospholipase A2 from snake venom induces lipid body formation in macrophages: the roles of intracellular phospholipases A2 and distinct signaling pathways

scientific article published on 08 April 2011

A multi-sectorial approach for addressing the problem of snakebite envenoming in Honduras

scientific article published on 21 January 2019

A multicomponent strategy to improve the availability of antivenom for treating snakebite envenoming

scientific article

A neutralizing recombinant single chain antibody, scFv, against BaP1, A P-I hemorrhagic metalloproteinase from Bothrops asper snake venom.

scientific article published on 2 June 2014

A new method for the detection of phospholipase A2 variants: Identification of isozymes in the venoms of newborn and adult Bothrops asper (terciopelo) snakes

scientific article published on 01 January 1988

A novel pentameric phospholipase A 2 myotoxin (PophPLA 2 ) from the venom of the pit viper Porthidium ophryomegas

scholarly article by Julio Vindas published in October 2018

A novel pentameric phospholipase A myotoxin (PophPLA) from the venom of the pit viper Porthidium ophryomegas

scientific article published in 2018

A pan-specific antiserum produced by a novel immunization strategy shows a high spectrum of neutralization against neurotoxic snake venoms

scientific article published on 09 July 2020

A phospholipase A2 from Bothrops asper snake venom activates neutrophils in culture: Expression of cyclooxygenase-2 and PGE2 biosynthesis

article

A potent antihemorrhagin in the serum of the non-poisonous water snake Natrix tessellata: isolation, characterization and mechanism of neutralization

article

A randomized blinded clinical trial of two antivenoms, prepared by caprylic acid or ammonium sulphate fractionation of IgG, in Bothrops and Porthidium snake bites in Colombia: correlation between safety and biochemical characteristics of antivenoms

scientific article published on 01 June 1999

A randomized double-blind clinical trial of two antivenoms in patients bitten by Bothrops atrox in Colombia

scientific article published on 01 November 1996

A representative metalloprotease induces PGE2 synthesis in fibroblast-like synoviocytes via the NF-κB/COX-2 pathway with amplification by IL-1β and the EP4 receptor

scientific article published on 24 February 2020

A transdisciplinary approach to snakebite envenoming

scientific article published in March 2022

Ability of six Latin American antivenoms to neutralize the venom of mapanáequis (Bothrops atrox) from Antioquia and Chocó(Colombia)

scientific article published on 01 June 1995

Ability of the phospholipase A2 inhibitor Varespladib to abrogate or delay lethality induced by neurotoxic snake venoms

scientific article published on 01 April 2020

Activation of cellular functions in macrophages by venom secretory Asp-49 and Lys-49 phospholipases A(2).

scientific article published in October 2005

Activity of hemorrhagic metalloproteinase BaH-1 and myotoxin II from Bothrops asper snake venom on capillary endothelial cells in vitro.

scientific article published on April 1994

Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue-damaging activities

scientific article

Amino acid sequence of a myotoxic Lys49-phospholipase A2 homologue from the venom of Cerrophidion (Bothrops) godmani

scientific article published in May 1998

An Asp49 phospholipase A2 from snake venom induces cyclooxygenase-2 expression and prostaglandin E2 production via activation of NF-κB, p38MAPK, and PKC in macrophages

scientific article

An MTT-based method for the in vivo quantification of myotoxic activity of snake venoms and its neutralization by antibodies

scientific article published in May 1993

An alternative in vitro method for testing the potency of the polyvalent antivenom produced in Costa Rica

scientific article published on 01 January 1988

An electrophoretic study on phospholipase A2 isoenzymes in the venoms of Central American crotaline snakes

scientific article published on 01 August 1992

An improved technique for the assessment of venom-induced haemorrhage in a murine model

scientific article published on 9 October 2017

An in vitro α-neurotoxin-nAChR binding assay correlates with lethality and in vivo neutralization of a large number of elapid neurotoxic snake venoms from four continents

scientific article published on 28 August 2020

An interactive database for the investigation of high-density peptide microarray guided interaction patterns and antivenom cross-reactivity

scientific article published on 24 June 2020

Analgesic effect of morphine and tramadol in standard toxicity assays in mice injected with venom of the snake Bothrops asper

scientific article published on 27 September 2018

Analysis of wound exudates reveals differences in the patterns of tissue damage and inflammation induced by the venoms of Daboia russelii and Bothrops asper in mice

scientific article published on 08 August 2020

Anti-human erythrocyte antibodies in horse-derived antivenoms used in the treatment of snakebite envenomations

scientific article published on 20 February 2006

Antibiotic therapy for snakebite envenoming

scientific article published on 03 February 2020

Antibody neutralization of a myotoxin from the venom of Bothrops asper (terciopelo)

scientific article published on 01 January 1987

Antibody-mediated neutralization and binding-reversal studies on α-neurotoxins from micrurus nigrocinctus nigrocinctus (coral snake) venom

scientific article published on 01 March 1996

Anticomplementary activity of equine whole IgG antivenoms: comparison of three fractionation protocols

scientific article published in January 2005

Anticomplementary activity of horse IgG and F(ab')2 antivenoms.

scientific article published on 20 January 2014

Antiplasmodial effect of the venom of Crotalus durissus cumanensis, crotoxin complex and Crotoxin B

scientific article published on 31 July 2012

Antivenom for snakebite envenoming in Sri Lanka: the need for geographically specific antivenom and improved efficacy.

scientific article published on 20 February 2013

Antivenomic assessment of the immunological reactivity of EchiTAb-Plus-ICP, an antivenom for the treatment of snakebite envenoming in sub-Saharan Africa

scientific article

Antivenomic characterization of two antivenoms against the venom of the taipan, Oxyuranus scutellatus, from Papua New Guinea and Australia

scientific article

Antivenomics of Atropoides mexicanus and Atropoides picadoi snake venoms: Relationship to the neutralization of toxic and enzymatic activities

scientific article published on 30 September 2010

Antivenomics: A Proteomics Tool for Studying the Immunoreactivity of Antivenoms

Antivenoms for Snakebite Envenomings ⬇️

scientific article published on October 1, 2011

Antivenoms for the treatment of snakebite envenomings: the road ahead

scientific article published on 23 March 2011

Appraisal of antivenom production in public laboratories in Latin America during the first semester of 2020: The impact of COVID-19

scientific article published on 17 June 2021

Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect

scientific article published on 23 March 2017

Assessing a 6-h endpoint observation time in the lethality neutralization assay used to evaluate the preclinical efficacy of snake antivenoms

scientific article published in November 2021

Assessing the preclinical efficacy of antivenoms: from the lethality neutralization assay to antivenomics

scientific article

Assessment of metalloproteinase inhibitors clodronate and doxycycline in the neutralization of hemorrhage and coagulopathy induced by Bothrops asper snake venom

scientific article published on 5 September 2008

Assessment of snake antivenom purity by comparing physicochemical and immunochemical methods

scientific article published on 26 November 2012

Assessment of the viral safety of antivenoms fractionated from equine plasma.

scientific article

BITES AND ENVENOMATIONS BY COLUBRID SNAKES IN MEXICO AND CENTRAL AMERICA

scientific article published on 14 October 2002

Backbone flexibility controls the activity and specificity of a protein-protein interface – specificity in snake venom metalloproteases (SVMPs).

scientific article published on 19 April 2011

Backbone flexibility controls the activity and specificity of a protein-protein interface: specificity in snake venom metalloproteases

scientific article

Basement membrane degradation and inflammation play a role in the pulmonary hemorrhage induced by a P-III snake venom metalloproteinase

scientific article published in July 2021

Biochemical and biological characterization of Bothriechis schlegelii snake venoms from Colombia and Costa Rica

scientific article published on 19 July 2016

Biochemical and biological characterization of ecuadorian pitviper venoms (genera Bothriechis, Bothriopsis, Bothrops and Lachesis)

scientific article published on 01 June 1996

Biochemical and biological characterization of two serine proteinases from Colombian Crotalus durissus cumanensis snake venom

scientific article

Biochemical and pharmacological similarities between the venoms of newborn Crotalus durissus durissus and adult Crotalus durissus terrificus rattlesnakes

scientific article

Biological and biochemical activities of Vipera berus (European viper) venom

scientific article published on 01 June 1993

Blood flow is required for rapid endothelial cell damage induced by a snake venom hemorrhagic metalloproteinase

scientific article published on 09 December 2005

Body distribution of Bothrops asper (terciopelo) snake venom myotoxin and its relationship to pathological changes

scientific article published on 01 January 1988

Bothrops asper Hemorrhagic Proteinases

Bothrops asper Metalloproteinase BaP1

Bothrops asper and Bothrops jararaca snake venoms trigger microbicidal functions of peritoneal leukocytes in vivo.

scientific article published in October 2001

Bothrops asper hemorrhagic proteinases

Bothrops asper metalloproteinase BaP1 is inhibited by alpha(2)-macroglobulin and mouse serum and does not induce systemic hemorrhage or coagulopathy

scientific article

Bothrops asper snake venom and its metalloproteinase BaP-1 activate the complement system. Role in leucocyte recruitment.

scientific article published on January 2000

Bothrops asper: beauty and peril in the neotropics

scientific article published on 18 June 2009

Bothrops snake myotoxins induce a large efflux of ATP and potassium with spreading of cell damage and pain

scientific article

Calcium plays a key role in the effects induced by a snake venom Lys49 phospholipase A2 homologue on a lymphoblastoid cell line

scientific article published on 21 November 2005

Caprylic acid fractionation of hyperimmune horse plasma: Description of a simple procedure for antivenom production

article

Case Report: Hemothorax in Envenomation by the Viperid Snake Bothrops asper

scientific article published on 01 March 2019

Cellular pathology induced by snake venom phospholipase A2 myotoxins and neurotoxins: common aspects of their mechanisms of action.

scientific article published on September 2008

Changes in myofibrillar components after skeletal muscle necrosis induced by a myotoxin isolated from the venom of the snake Bothrops asper

scientific article published in February 1990

Characterization of 'basparin A,' a prothrombin-activating metalloproteinase, from the venom of the snake Bothrops asper that inhibits platelet aggregation and induces defibrination and thrombosis

scientific article

Characterization of a novel snake venom component: Kazal-type inhibitor-like protein from the arboreal pitviper Bothriechis schlegelii

scientific article published on 10 March 2016

Characterization of events associated with apoptosis/anoikis induced by snake venom metalloproteinase BaP1 on human endothelial cells

scientific article

Characterization of the local tissue damage induced by LHF-II, a metalloproteinase with weak hemorrhagic activity isolated from Lachesis muta muta snake venom

scientific article published on 01 September 1999

Chemical modification of histidine and lysine residues of myotoxic phospholipases A2 isolated from Bothrops asper and Bothrops godmani snake venoms: effects on enzymatic and pharmacological properties

scientific article published in February 1997

Circumstances and Consequences of Snakebite Envenomings: A Qualitative Study in South-Eastern Costa Rica

scientific article published on 11 January 2020

Cleavage of the NH2-Terminal Octapeptide of Bothrops asper Myotoxic Lysine-49 Phospholipase A2 Reduces Its Membrane-Destabilizing Effect

scientific article published on 01 August 1994

Clinical and laboratory alterations in horses during immunization with snake venoms for the production of polyvalent (Crotalinae) antivenom

article

Coagulopathy induced by viperid snake venoms in a murine model: Comparison of standard coagulation tests and rotational thromboelastometry

scientific article published in July 2022

Coagulotoxic effects by brown snake (Pseudonaja) and taipan (Oxyuranus) venoms, and the efficacy of a new antivenom

scientific article published on 22 March 2019

Combined venom gland cDNA sequencing and venomics of the New Guinea small-eyed snake, Micropechis ikaheka

scientific article published on 8 August 2014

Combined venomics, venom gland transcriptomics, bioactivities, and antivenomics of two Bothrops jararaca populations from geographic isolated regions within the Brazilian Atlantic rainforest

scientific article published on 9 May 2015

Comparative proteomic analysis of the venom of the taipan snake, Oxyuranus scutellatus, from Papua New Guinea and Australia: Role of neurotoxic and procoagulant effects in venom toxicity

article

Comparative study of the cytolytic activity of snake venoms from African spitting cobras (Naja spp., Elapidae) and its neutralization by a polyspecific antivenom

scientific article published on 8 September 2011

Comparative study of the efficacy and safety of two polyvalent, caprylic acid fractionated [IgG and F(ab')2] antivenoms, in Bothrops asper bites in Colombia

scientific article

Comparative study of the venoms of three subspecies of Lachesis muta (bushmaster) from Brazil, Colombia and Costa Rica

article

Comparative study on coagulant, defibrinating, fibrinolytic and fibrinogenolytic activities of Costa Rican crotaline snake venoms and their neutralization by a polyvalent antivenom

scientific article published in January 1989

Comparative study on the ability of IgG and Fab sheep antivenoms to neutralize local hemorrhage, edema and myonecrosis induced by Bothrops asper (terciopelo) snake venom

scientific article published on 01 February 2000

Comparison between IgG and F(ab′)2 polyvalent antivenoms: neutralization of systemic effects induced by Bothrops asper venom in mice, extravasation to muscle tissue, and potential for induction of adverse reactions

scientific article published on 01 June 2001

Comparison of the adjuvant activity of aluminum hydroxide and calcium phosphate on the antibody response towards Bothrops asper snake venom

scientific article published on 19 March 2013

Comparison of the effect of Crotalus simus and Crotalus durissus ruruima venoms on the equine antibody response towards Bothrops asper venom: Implications for the production of polyspecific snake antivenoms

article

Comparison of venom composition and biological activities of the subspecies Crotalus lepidus lepidus, Crotalus lepidus klauberi and Crotalus lepidus morulus from Mexico

scientific article

Computational biology in Costa Rica: the role of a small country in the global context of bioinformatics

scientific article

Confronting the neglected problem of snake bite envenoming: the need for a global partnership

scientific article

Correction: Poor Regenerative Outcome after Skeletal Muscle Necrosis Induced by Bothrops asper Venom: Alterations in Microvasculature and Nerves

scientific article published on 21 July 2011

Critical role of TLR2 and MyD88 for functional response of macrophages to a group IIA-secreted phospholipase A2 from snake venom

scientific article

Cross-reactivity and cross-immunomodulation between venoms of the snakes Bothrops asper, Crotalus simus and Lachesis stenophrys, and its effect in the production of polyspecific antivenom for Central America

scientific article published on 9 August 2017

Cross-reactivity, antivenomics, and neutralization of toxic activities of Lachesis venoms by polyspecific and monospecific antivenoms

scientific article published on 07 August 2017

Cross-recognition of a pit viper (Crotalinae) polyspecific antivenom explored through high-density peptide microarray epitope mapping

scientific article published on 14 July 2017

Crystallization and preliminary X-ray diffraction analysis of suramin, a highly charged polysulfonated napthylurea, complexed with a myotoxic PLA2 from Bothrops asper venom.

scientific article published in December 2004

Crystallization and preliminary diffraction data of two myotoxins isolated from the venoms of Bothrops asper (Terciopelo) and Bothrops nummifer (jumping viper).

scientific article published on August 1993

Current challenges for confronting the public health problem of snakebite envenoming in Central America

scientific article published on 06 March 2014

Current technology for the industrial manufacture of snake antivenoms

scientific article published on 28 June 2018

Cytotoxicity induced in myotubes by a Lys49 phospholipase A2 homologue from the venom of the snake Bothrops asper: evidence of rapid plasma membrane damage and a dual role for extracellular calcium

scientific article

Cytotoxicity of snake venom Lys49 PLA2-like myotoxin on rat cardiomyocytes ex vivo does not involve a direct action on the contractile apparatus

scientific article published on 30 September 2021

DNase activity in Costa Rican crotaline snake venoms: Quantification of activity and identification of electrophoretic variants

scientific article published on 01 January 1991

Danger in the reef: Proteome, toxicity, and neutralization of the venom of the olive sea snake, Aipysurus laevis

scientific article published on 11 July 2015

Defining the pathogenic threat of envenoming by south african shield-nosed and coral snakes (genus aspidelaps), and revealing the likely efficacy of available antivenom

article

Delayed LY333013 (Oral) and LY315920 (Intravenous) Reverse Severe Neurotoxicity and Rescue Juvenile Pigs from Lethal Doses of (Eastern Coral Snake) Venom

scholarly article by Matthew R Lewin et al published 17 November 2018 in Toxins

Delayed Oral LY333013 Rescues Mice from Highly Neurotoxic, Lethal Doses of Papuan Taipan (Oxyuranus scutellatus) Venom

scientific article published on 20 September 2018

Dermonecrosis caused by a spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib

scientific article published in 2024

Detection of proteins antigenically related to Bothrops asper myotoxin in crotaline snake venoms

scientific article published on 01 January 1987

Development and validation of a reverse phase HPLC method for the determination of caprylic acid in formulations of therapeutic immunoglobulins and its application to antivenom production

scientific article published on 17 April 2009

Development of a chicken-derived antivenom against the taipan snake (Oxyuranus scutellatus) venom and comparison with an equine antivenom

scientific article published on 29 June 2016

Development of a new polyspecific antivenom for snakebite envenoming in Sri Lanka: Analysis of its preclinical efficacy as compared to a currently available antivenom

scientific article published on 6 October 2016

Development of immunoassays for determination of circulating venom antigens during envenomations by coral snakes (Micrurus species)

article

Differential procoagulant effects of saw-scaled viper (Serpentes: Viperidae: Echis) snake venoms on human plasma and the narrow taxonomic ranges of antivenom efficacies.

scientific article published on 25 August 2017

Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes

scientific article published in 2023

Dissociation of enzymatic and pharmacological properties of piratoxins-I and -III, two myotoxic phospholipases A2 from Bothrops pirajai snake venom

scientific article published in March 2001

Dissociation of enzymatic and toxic activities by the use of antibodies

scientific article published on 01 January 1990

Efectos proteolitico, hemorragico y mionecrotico de los venenos de serpientes costarricenses de los generos Bothrops, Crotalus y Lachesis

scientific article published on 01 January 1980

Effect of Bothrops asper (Fer-De-Lance) snake venom on erythrocyte membrane. A comparative study

scientific article published on February 1, 1992

Effect of calcineurin inhibitors on myotoxic activity of crotoxin and Bothrops asper phospholipase A2 myotoxins in vivo and in vitro.

scientific article

Effect of geographical variation of Echis ocellatus, Naja nigricollis and Bitis arietans venoms on their neutralization by homologous and heterologous antivenoms

scientific article published on 5 October 2015

Effect of premedication with subcutaneous adrenaline on the pharmacokinetics and immunogenicity of equine whole IgG antivenom in a rabbit model

scientific article published on 15 April 2017

Effect of preservatives on IgG aggregation, complement-activating effect and hypotensive activity of horse polyvalent antivenom used in snakebite envenomation

scientific article

Effect of storage temperature on the stability of the liquid polyvalent antivenom produced in Costa Rica

scientific article published on 01 January 1990

Effect of the metalloproteinase inhibitor batimastat in the systemic toxicity induced by Bothrops asper snake venom: understanding the role of metalloproteinases in envenomation

scientific article published in March 2004

Effect of the phospholipase A2 inhibitor Varespladib, and its synergism with crotalic antivenom, on the neuromuscular blockade induced by Crotalus durissus terrificus venom (with and without crotamine) in mouse neuromuscular preparations

scientific article published in July 2022

Effect of various Viperidae and Crotalidae snake venoms on endothelial cells in vitro.

scientific article published on December 1994

Effectiveness of batimastat, a synthetic inhibitor of matrix metalloproteinases, in neutralizing local tissue damage induced by BaP1, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper

scientific article published on 01 July 2000

Effects of Bothrops asper (terciopelo) myotoxin III, a basic phospholipase A2, on liposomes and mouse gastrocnemius muscle

scientific article published in February 1993

Effects of Bothrops asper snake venom on lymphatic vessels: insights into a hidden aspect of envenomation

scientific article

Effects of Bothrops asper snake venom on the expression of cyclooxygenases and production of prostaglandins by peritoneal leukocytes in vivo, and by isolated neutrophils and macrophages in vitro.

scientific article published on 19 January 2009

Effects of PI and PIII Snake Venom Haemorrhagic Metalloproteinases on the Microvasculature: A Confocal Microscopy Study on the Mouse Cremaster Muscle

scientific article

Effects of a myotoxic phospholipase A2 isolated from Bothrops asper venom on skeletal muscle sarcoplasmic reticulum

article

Effects of aqueous extract of Casearia sylvestris (Flacourtiaceae) on actions of snake and bee venoms and on activity of phospholipases A2.

scientific article

Effects of chemical modifications of crotoxin B, the phospholipase A(2) subunit of crotoxin from Crotalus durissus terrificus snake venom, on its enzymatic and pharmacological activities

scientific article published in September 2001

Effects of neutrophil depletion in the local pathological alterations and muscle regeneration in mice injected with Bothrops jararaca snake venom

Effects on cultured mammalian cells of myotoxin III, a phospholipase A2 isolated from Bothrops asper (terciopelo) venom.

scientific article published on November 1993

Efficacy and safety of two whole IgG polyvalent antivenoms, refined by caprylic acid fractionation with or without β-propiolactone, in the treatment of Bothrops asper bites in Colombia

scientific article published on 12 May 2006

Efficacy of IgG and F(ab′)2 Antivenoms to Neutralize Snake Venom-induced Local Tissue Damage as Assessed by the Proteomic Analysis of Wound Exudate

scientific article published on 15 November 2011

Elapid venom toxins: multiple recruitments of ancient scaffolds

scientific article published in January 1999

Emerging therapeutic alternatives for snakebite envenoming

scientific article published on 10 July 2019

Engineered nanoparticles bind elapid snake venom toxins and inhibit venom-induced dermonecrosis

scientific article published on 04 October 2018

Envenomations by Bothrops and Crotalus snakes induce the release of mitochondrial alarmins

scientific article

Enzyme immunoassays for detection and quantification of venoms of Sri Lankan snakes: Application in the clinical setting

scientific article published on 05 October 2020

Epidemiology of snakebites in Colombia (2008-2016)

scientific article published on 16 December 2020

Epidemiology of snakebites in El Salvador (2014-2019)

scientific article published on 30 July 2020

Equine antibodies to Bothrops asper myotoxin II: isolation from polyvalent antivenom and neutralizing ability

scientific article published on 01 January 1990

Estudio comparativo de los venenos de serpiente Cascabel (Crotalus durissus durissus) de ejemplares adultos y recien nacidos

article

Estudio ultraestructural de la mionecrosis inducida en raton por el veneno de terciopelo (Bothrops asper) de Costa Rica

scientific article published on 01 January 1981

Evaluacion de la capacidad de cuatro antivenenos comerciales para neutralizar el veneno de la serpiente Bothrops asper (terciopelo) de Costa Rica

scientific article published on 01 September 1995

Evaluation of the preclinical efficacy of four antivenoms, distributed in sub-Saharan Africa, to neutralize the venom of the carpet viper, Echis ocellatus, from Mali, Cameroon, and Nigeria

scientific article

Experimental myonecrosis induced by the venoms of South American Micrurus (coral snakes)

scientific article published on October 1, 1992

Experimental pathology of local tissue damage induced by Bothrops asper snake venom

scientific article published on 18 March 2009

Experimental pathophysiology of systemic alterations induced by Bothrops asper snake venom

scientific article

Exploration of immunoglobulin transcriptomes from mice immunized with three-finger toxins and phospholipases A2 from the Central American coral snake, Micrurus nigrocinctus

scientific article published on 24 January 2017

Exploration of immunoglobulin transcriptomes from mice immunized with three-finger toxins and phospholipases A2 from the Central American coral snake, Micrurus nigrocinctus

Exploration of immunoglobulin transcriptomes from mice immunized with three-finger toxins and phospholipases A2 from the Central American coral snake, Micrurus nigrocinctus

Exploring the venom of the forest cobra snake: Toxicovenomics and antivenom profiling of Naja melanoleuca

scientific article published in September 2016

Extracts of Renealmia alpinia (Rottb.) MAAS Protect against Lethality and Systemic Hemorrhage Induced by Bothrops asper Venom: Insights from a Model with Extract Administration before Venom Injection

scientific article published on 30 April 2015

Factors associated with adverse reactions induced by caprylic acid-fractionated whole IgG preparations: comparison between horse, sheep and camel IgGs

scientific article published on 23 September 2005

Feeding behavior and venom toxicity of coral snake Micrurus nigrocinctus (Serpentes: Elapidae) on its natural prey in captivity

scientific article published in August 2004

First crotoxin-like phospholipase A(2) complex from a New World non-rattlesnake species: nigroviriditoxin, from the arboreal Neotropical snake Bothriechis nigroviridis

scientific article published on 28 November 2014

First look into the venom of Roatan Island's critically endangered coral snake Micrurus ruatanus: Proteomic characterization, toxicity, immunorecognition and neutralization by an antivenom

article

Freeze-dried EchiTAb+ICP antivenom formulated with sucrose is more resistant to thermal stress than the liquid formulation stabilized with sorbitol

scientific article published on 3 May 2017

Freeze-dried snake antivenoms formulated with sorbitol, sucrose or mannitol: Comparison of their stability in an accelerated test

scientific article published on 01 August 2014

From Fangs to Pharmacology: The Future of Snakebite Envenoming Therapy

scientific article published on 22 June 2016

Functional analysis of DM64, an antimyotoxic protein with immunoglobulin-like structure from Didelphis marsupialis serum

scientific article

Geographic and ontogenic variability in the venom of the neotropical rattlesnake Crotalus durissus: pathophysiological and therapeutic implications

scientific article published on 01 March 2002

Geographical variability of the venoms of four populations of Bothrops asper from Panama: Toxicological analysis and neutralization by a polyvalent antivenom

scientific article published on 07 April 2017

Global Availability of Antivenoms: The Relevance of Public Manufacturing Laboratories

scientific article published on 24 December 2018

Guest editor's foreword

Hemorrhage Caused by Snake Venom Metalloproteinases: A Journey of Discovery and Understanding

scientific article

Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage

scientific article

Hemorrhagic and procoagulant P-III snake venom metalloproteinases differ in their binding to the microvasculature of mouse cremaster muscle

scientific article published on 12 February 2020

Hemostatic effects induced by Thalassophryne nattereri fish venom: a model of endothelium-mediated blood flow impairment

article

High resolution analysis of snake venom metalloproteinase (SVMP) peptide bond cleavage specificity using proteome based peptide libraries and mass spectrometry

scientific article

High-resolution crystal structure of the snake venom metalloproteinase BaP1 complexed with a peptidomimetic: insight into inhibitor binding

scientific article

High-throughput immuno-profiling of mamba (Dendroaspis) venom toxin epitopes using high-density peptide microarrays

scientific article

Histopathological and biochemical alterations induced by intramuscular injection of Bothrops asper (terciopelo) venom in mice

scientific article published on 01 January 1989

Homogenates of skeletal muscle injected with snake venom inhibit myogenic differentiation in cell culture

article

Horse IgG isotypes and cross-neutralization of two snake antivenoms produced in Brazil and Costa Rica

article

Human heterophilic antibodies against equine immunoglobulins: assessment of their role in the early adverse reactions to antivenom administration

scientific article published on 18 June 2008

Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants

scientific article published in May 2003

Identification of new snake venom metalloproteinase inhibitors using compound screening and rational Peptide design

scientific article

Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene.

scientific article published on August 2000

Immune Response Towards Snake Venoms ⬇️

scientific article published on October 1, 2011

Immunochemical and biological characterization of monoclonal antibodies against BaP1, a metalloproteinase from Bothrops asper snake venom

scientific article published on 30 July 2010

Immunochemical characterization of Micrurus nigrocinctus nigrocinctus venom with monoclonal and polyclonal antibodies

scientific article published on 01 June 1994

Immunoglobulin G and F(ab′)2 polyvalent antivenoms do not differ in their ability to neutralize hemorrhage, edema and myonecrosis induced by Bothrops asper (terciopelo) snake venom

scientific article published on 01 November 1997

Immunological profile of antivenoms: preclinical analysis of the efficacy of a polyspecific antivenom through antivenomics and neutralization assays

scientific article published on 28 February 2014

Immunological studies on BaH1 and BaP1, two hemorrhagic metalloproteinases from the venom of the snake Bothrops asper

scientific article published on 01 August 1995

Impact of regional variation in Bothrops asper snake venom on the design of antivenoms: integrating antivenomics and neutralization approaches

scientific article published in January 2010

Improving antivenom availability and accessibility: science, technology, and beyond

scientific article published on 03 March 2012

Improving the control of snakebite envenomation in Latin America and the Caribbean: a discussion on pending issues

scientific article published on 01 December 2018

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scientific article published on October 1995

In vitro antiplasmodial activity of phospholipases A2 and a phospholipase homologue isolated from the venom of the snake Bothrops asper

scientific article published on 14 December 2012

In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies

scientific article published in Nature Communications

Increased infectivity of Staphylococcus aureus in an experimental model of snake venom-induced tissue damage

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Increments in cytokines and matrix metalloproteinases in skeletal muscle after injection of tissue-damaging toxins from the venom of the snake Bothrops asper

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Increments in serum cytokine and nitric oxide levels in mice injected with Bothrops asper and Bothrops jararaca snake venoms

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Inequality: span the global divide

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Infectious Complications Following Snakebite by Bothrops lanceolatus in Martinique: A Case Series

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Inhibition of Toxic Activities ofVenom and Other Crotalid Snake Venoms by a Novel Neutralizing Mixture

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Inhibition of enzymatic activities of Bothrops asper snake venom and docking analysis of compounds from plants used in Central America to treat snakebite envenoming

scientific article published on 07 October 2021

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Inhibition of the hemorrhagic activity of Bothrops asper venom by a novel neutralizing mixture

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Innovative Immunization Strategies for Antivenom Development

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Instituto Butantan and Instituto Clodomiro Picado: A long-standing partnership in science, technology, and public health

scientific article published in October 2021

Integrated "omics" profiling indicates that miRNAs are modulators of the ontogenetic venom composition shift in the Central American rattlesnake, Crotalus simus simus

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Interaction of snake venom metalloproteinases with type IV collagen: Role of the different domains in target biding

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Intramuscular administration of antivenoms in experimental envenomation by Bothrops asper: comparison between Fab and IgG

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Intravenous administration of equine-derived whole IgG antivenom does not induce early adverse reactions in non-envenomed horses and cows

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Isolation and biochemical, functional and structural characterization of a novel L-amino acid oxidase from Lachesis muta snake venom

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Isolation and characterization of a metalloproteinase with weak hemorrhagic activity from the venom of the snake Bothrops asper (terciopelo)

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Isolation and characterization of basic myotoxic phospholipases A2 from Bothrops godmani (Godman's pit viper) snake venom

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Isolation and characterization of four medium-size disintegrins from the venoms of Central American viperid snakes of the genera Atropoides, Bothrops, Cerrophidion and Crotalus

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Isolation and characterization of synergistic hemorrhagins from the venom of the snake Bothrops asper

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Isolation and partial characterization of a myotoxin from the venom of the snake Bothrops nummifer

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Isolation from a polyvalent antivenom of antibodies to a myotoxin in Bothrops asper snake venom

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Isolation of a galactose-binding lectin from the venom of the snake Bothrops godmani (Godmann's pit viper)

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Isolation of a myotoxin from Bothrops asper venom: partial characterization and action on skeletal muscle

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Lachesis stenophrys venom reduces the equine antibody response towards Bothrops asper venom used as co-immunogen in the production of polyspecific snake antivenom

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Lemnitoxin, the major component of Micrurus lemniscatus coral snake venom, is a myotoxic and pro-inflammatory phospholipase A2.

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Local and systemic pathophysiological alterations induced by a serine proteinase from the venom of the snake Bothrops jararacussu

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Local tissue damage induced by BaP1, a metalloproteinase isolated from Bothrops asper (Terciopelo) snake venom

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Membrane independent activation of fibroblast proMMP-2 by snake venom: novel roles for venom proteinases

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Mionecrosis, hemorragia y edema inducidos por el veneno de Bothrops asper en ratón blanco

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MmTX1 and MmTX2 from coral snake venom potently modulate GABAA receptor activity

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Modulation of the susceptibility of human erythrocytes to snake venom myotoxic phospholipases A(2): role of negatively charged phospholipids as potential membrane binding sites

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Mortality due to snakebite envenomation in Costa Rica (1993–2006)

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Muscle Tissue Damage Induced by the Venom of Bothrops asper: Identification of Early and Late Pathological Events through Proteomic Analysis

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Myonecrosis induced in mice by a basic myotoxin isolated from the venom of the snake Bothrops nummifer (jumping viper) from Costa Rica

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Myotoxic and cytolytic activities of dimeric Lys49 phospholipase A2 homologues are reduced, but not abolished, by a pH-induced dissociation

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Myotoxin II from Bothrops asper (Terciopelo) venom is a lysine-49 phospholipase A2.

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Nephrotoxicity induced by the venom of Hypnale hypnale from Sri Lanka: Studies on isolated perfused rat kidney and renal tubular cell lines

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Neutralization of Bothrops mattogrossensis snake venom from Bolivia: experimental evaluation of llama and donkey antivenoms produced by caprylic acid precipitation

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Neutralization of crotaline snake venoms from Central and South America by antivenoms produced in Brazil and Costa Rica

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Neutralization of four Peruvian Bothrops sp. snake venoms by polyvalent antivenoms produced in Perú and Costa Rica: preclinical assessment

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Neutralization of hyaluronidase and indirect hemolytic activities of Costa Rican snake venoms by a polyvalent antivenom

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Neutralization of local effects of the terciopelo (Bothrops asper) venom by blood serum of the colubrid snake Clelia clelia

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Neutralization of myotoxic phospholipases A2 from the venom of the snake Bothrops asper by monoclonal antibodies

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Neutralization of proteolytic and hemorrhagic activities of Costa Rican snake venoms by a polyvalent antivenom

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Neutralization of the neuromuscular inhibition of venom and taipoxin from the taipan (Oxyuranus scutellatus) by F(ab')2 and whole IgG antivenoms

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Neutralization, by a monospecific Bothrops lanceolatus antivenom, of toxic activities induced by homologous and heterologous Bothı́rops snake venoms

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Neutralizing properties of LY315920 toward snake venom group I and II myotoxic phospholipases A2

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Neutrophils do not contribute to local tissue damage, but play a key role in skeletal muscle regeneration, in mice injected with Bothrops asper snake venom

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Novel Catalytically-Inactive PII Metalloproteinases from a Viperid Snake Venom with Substitutions in the Canonical Zinc-Binding Motif

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Novel Snakebite Therapeutics Must Be Tested in Appropriate Rescue Models to Robustly Assess Their Preclinical Efficacy

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Novel alternatives for improving the therapy of snakebite envenomings

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Novel insights into capillary vessel basement membrane damage by snake venom hemorrhagic metalloproteinases: a biochemical and immunohistochemical study

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Omics meets biology: application to the design and preclinical assessment of antivenoms

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Ontogenetic changes in the venom of the snake Lachesis muta stenophrys (bushmaster) from Costa Rica

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Ontogenetic variability of Bothrops atrox and Bothrops asper snake venoms from Colombia

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Oral Microbiota of the Snake Bothrops lanceolatus in Martinique

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PLOS Neglected Tropical Diseases broadens its coverage of envenomings caused by animal bites and stings

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Paediatric snakebite envenoming: recognition and management of cases

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Paediatric snakebite envenoming: the world's most neglected 'Neglected Tropical Disease'?

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Pan-African polyspecific antivenom produced by caprylic acid purification of horse IgG: an alternative to the antivenom crisis in Africa

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Pan-American Lancehead Pit-Vipers: Coagulotoxic Venom Effects and Antivenom Neutralisation of and Geographical Variants

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Pathogenesis of myonecrosis induced by crude venom and a myotoxin of Bothrops asper

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Pathogenic mechanisms underlying adverse reactions induced by intravenous administration of snake antivenoms

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Pathological alterations induced by neuwiedase, a metalloproteinase isolated from Bothrops neuwiedi snake venom

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Pathological and biochemical changes induced in mice after intramuscular injection of venom from newborn specimens of the snake Bothrops asper (Terciopelo).

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Pathological changes induced by BaH1, a hemorrhagic proteinase isolated from Bothrops asper (Terciopelo) snake venom, on mouse capillary blood vessels

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Peptidomimetic hydroxamate metalloproteinase inhibitors abrogate local and systemic toxicity induced by Echis ocellatus (saw-scaled) snake venom

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Pharmacokinetic-pharmacodynamic relationships of immunoglobulin therapy for envenomation

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Pharmacokinetics of whole IgG equine antivenom: Comparison between normal and envenomed rabbits

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Pharmacological modulation of edema induced by Lys-49 and Asp-49 myotoxic phospholipases A2 isolated from the venom of the snake Bothrops asper (terciopelo).

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Pharmacological modulation of hyperalgesia induced by Bothrops asper (terciopelo) snake venom

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Pharmacological study of edema induced by venom of the snake Bothrops asper (terciopelo) in mice

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Phospholipase A(2) enhances the endothelial cell detachment effect of a snake venom metalloproteinase in the absence of catalysis

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Phospholipases A2 from viperidae snake venoms: how do they induce skeletal muscle damage?

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Phospholipases A2: Unveiling the secrets of a functionally versatile group of snake venom toxins ⬇️

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Phylovenomics of Daboia russelii across the Indian subcontinent. Bioactivities and comparative in vivo neutralization and in vitro third-generation antivenomics of antivenoms against venoms from India, Bangladesh and Sri Lanka

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Physicochemical characterization of commercial freeze-dried snake antivenoms

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Polymorphonuclear neutrophil leukocytes in snakebite envenoming

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Poor regenerative outcome after skeletal muscle necrosis induced by Bothrops asper venom: alterations in microvasculature and nerves

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Preclinical Evaluation of the Efficacy of Antivenoms for Snakebite Envenoming: State-of-the-Art and Challenges Ahead

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Preclinical assessment of a polyspecific antivenom against the venoms of Cerrophidion sasai, Porthidium nasutum and Porthidium ophryomegas: Insights from combined antivenomics and neutralization assays

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Preclinical assessment of the ability of polyvalent (Crotalinae) and anticoral (Elapidae) antivenoms produced in Costa Rica to neutralize the venoms of North American snakes

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Preclinical assessment of the efficacy of a new antivenom (EchiTAb-Plus-ICP) for the treatment of viper envenoming in sub-Saharan Africa

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Preclinical assessment of the neutralizing capacity of antivenoms produced in six Latin American countries against medically-relevant Bothrops snake venoms

scientific article published on 16 July 2010

Preclinical assessment of the neutralizing efficacy of snake antivenoms in Latin America and the Caribbean: A review

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Preclinical efficacy against toxic activities of medically relevant Bothrops sp. (Serpentes: Viperidae) snake venoms by a polyspecific antivenom produced in Mexico

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Preclinical efficacy of Australian antivenoms against the venom of the small-eyed snake, Micropechis ikaheka, from Papua New Guinea: an antivenomics and neutralization study

scientific article published on 28 June 2014

Preclinical evaluation of caprylic acid-fractionated IgG antivenom for the treatment of Taipan (Oxyuranus scutellatus) envenoming in Papua New Guinea

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Preclinical evaluation of the neutralizing ability of a monospecific antivenom for the treatment of envenomings by Bothrops lanceolatus in Martinique

scholarly article by Dabor Resiere et al published June 2018 in Toxicon

Preclinical evaluation of three polyspecific antivenoms against the venom of Echis ocellatus: Neutralization of toxic activities and antivenomics

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Priority Actions and Progress to Substantially and Sustainably Reduce the Mortality, Morbidity and Socioeconomic Burden of Tropical Snakebite

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Profiling the venom gland transcriptomes of Costa Rican snakes by 454 pyrosequencing

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Pros and cons of different therapeutic antibody formats for recombinant antivenom development

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Protease Activity Profiling of Snake Venoms Using High-Throughput Peptide Screening

scholarly article by Konstantinos Kalogeropoulos et al published 19 March 2019 in Toxins

Proteomic Analysis of Human Blister Fluids Following Envenomation by Three Snake Species in India: Differential Markers for Venom Mechanisms of Action.

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Proteomic analysis of Bothrops pirajai snake venom and characterization of BpirMP, a new P-I metalloproteinase

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Proteomic and biological characterization of the venom of the redtail coral snake, Micrurus mipartitus (Elapidae), from Colombia and Costa Rica

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Proteomic and functional profiling of the venom of Bothrops ayerbei from Cauca, Colombia, reveals striking interspecific variation with Bothrops asper venom

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Proteomic and toxinological characterization of the venom of the South African Ringhals cobra Hemachatus haemachatus

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Proteomic, toxicological and immunogenic characterization of Mexican west-coast rattlesnake (Crotalus basiliscus) venom and its immunological relatedness with the venom of Central American rattlesnake (Crotalus simus).

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Proteomics and antivenomics of Papuan black snake (Pseudechis papuanus) venom with analysis of its toxicological profile and the preclinical efficacy of Australian antivenoms

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Proteomics of Wound Exudate in Snake Venom-Induced Pathology: Search for Biomarkers To Assess Tissue Damage and Therapeutic Success

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Publisher Correction: In vivo neutralization of dendrotoxin-mediated neurotoxicity of black mamba venom by oligoclonal human IgG antibodies

scientific article published in Nature Communications

Pulmonary hemorrhage induced by jararhagin, a metalloproteinase from Bothrops jararaca snake venom

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Purification and characterization of BaH4, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper

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Purification and characterization of myotoxin IV, a phospholipase A2 variant, from Bothrops asper snake venom

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Purification of IgG and albumin from human plasma by aqueous two phase system fractionation

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Purification of equine whole IgG snake antivenom by using an aqueous two phase system as a primary purification step

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Quantitation by enzyme-immunoassay of antibodies against bothrops myotoxins in four commercially-available antivenoms

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Reducing the impact of snakebite envenoming in Latin America and the Caribbean: achievements and challenges ahead

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Role of TNF-alpha, IL-1beta and IL-6 in the local tissue damage induced by Bothrops asper snake venom: an experimental assessment in mice

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Role of collagens and perlecan in microvascular stability: exploring the mechanism of capillary vessel damage by snake venom metalloproteinases

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Role of cyclooxygenases in oedema-forming activity of bothropic venoms

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Role of enzymatic activity in muscle damage and cytotoxicity induced by Bothrops asper Asp49 phospholipase A2 myotoxins: are there additional effector mechanisms involved?

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Role of nitric oxide in the local and systemic pathophysiological effects induced by Bothrops asper snake venom in mice

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Role of the animal model on the pharmacokinetics of equine-derived antivenoms

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Role of the snake venom toxin jararhagin in proinflammatory pathogenesis: in vitro and in vivo gene expression analysis of the effects of the toxin

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Second generation snake antivenomics: Comparing immunoaffinity and immunodepletion protocols

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Secretory phospholipases A(2) isolated from Bothrops asper and from Crotalus durissus terrificus snake venoms induce distinct mechanisms for biosynthesis of prostaglandins E2 and D2 and expression of cyclooxygenases

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Selecting key toxins for focused development of elapid snake antivenoms and inhibitors guided by a Toxicity Score

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Severe snakebite envenomation in French Guiana: When antivenom is not available

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Signaling pathways involved in zymosan phagocytosis induced by two secreted phospholipases A2 isolated from Bothrops asper snake venom in macrophages

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Site mutation of residues in a loop surrounding the active site of a PI snake venom metalloproteinase abrogates its hemorrhagic activity

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Skeletal Muscle Necrosis and Regeneration after Injection of BaH1, A Hemorrhagic Metalloproteinase Isolated from the Venom of the Snake Bothrops asper (Terciopelo)

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Skeletal muscle degeneration and regeneration after injection of bothropstoxin-II, a phospholipase A2 isolated from the venom of the snake Bothrops jararacussu ⬇️

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Skeletal muscle degeneration induced by venom phospholipases A2: insights into the mechanisms of local and systemic myotoxicity

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Skeletal muscle necrosis and regeneration after injection of Thalassophryne nattereri (niquim) fish venom in mice

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Skeletal muscle necrosis induced by a phospholipase A2 isolated from the venom of the coral snake Micrurus nigrocinctus nigrocinctus

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Skeletal muscle regeneration after myonecrosis induced by Bothrops asper (terciopelo) venom

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Skin pathology induced by snake venom metalloproteinase: acute damage, revascularization, and re-epithelization in a mouse ear model

scientific article published in May 2008

Snake population venomics and antivenomics of Bothrops atrox: Paedomorphism along its transamazonian dispersal and implications of geographic venom variability on snakebite management

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Snake venom components enhance pain upon subcutaneous injection: an initial examination of spinal cord mediators

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Snake venom metalloproteinases: structure/function relationships studies using monoclonal antibodies

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Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide

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Snake venomics and antivenomics of Bothrops atrox venoms from Colombia and the Amazon regions of Brazil, Perú and Ecuador suggest the occurrence of geographic variation of venom phenotype by a trend towards paedomorphism

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Snake venomics and antivenomics of Bothrops colombiensis, a medically important pitviper of the Bothrops atrox-asper complex endemic to Venezuela: Contributing to its taxonomy and snakebite management

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Snake venomics and antivenomics of Protobothrops mucrosquamatus and Viridovipera stejnegeri from Taiwan: Keys to understand the variable immune response in horses

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Snake venomics and antivenomics of the arboreal neotropical pitvipers Bothriechis lateralis and Bothriechis schlegelii

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Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming

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Snake venomics and toxicological profiling of the arboreal pitviper Bothriechis supraciliaris from Costa Rica.

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Snake venomics of African spitting cobras: toxin composition and assessment of congeneric cross-reactivity of the pan-African EchiTAb-Plus-ICP antivenom by antivenomics and neutralization approaches

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Snake venomics of Bothriechis nigroviridis reveals extreme variability among palm pitviper venoms: different evolutionary solutions for the same trophic purpose

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Snake venomics of Central American pitvipers: clues for rationalizing the distinct envenomation profiles of Atropoides nummifer and Atropoides picadoi

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Snake venomics of Lachesis muta rhombeata and genus-wide antivenomics assessment of the paraspecific immunoreactivity of two antivenoms evidence the high compositional and immunological conservation across Lachesis

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Snake venomics of Micrurus alleni and Micrurus mosquitensis from the Caribbean region of Costa Rica reveals two divergent compositional patterns in New World elapids.

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Snake venomics of monocled cobra (Naja kaouthia) and investigation of human IgG response against venom toxins

scientific article published on 11 March 2015

Snake venomics of the Central American rattlesnake Crotalus simus and the South American Crotalus durissus complex points to neurotoxicity as an adaptive paedomorphic trend along Crotalus dispersal in South America

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Snake venomics of the Lesser Antillean pit vipers Bothrops caribbaeus and Bothrops lanceolatus: correlation with toxicological activities and immunoreactivity of a heterologous antivenom

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Snake venomics of the South and Central American Bushmasters. Comparison of the toxin composition of Lachesis muta gathered from proteomic versus transcriptomic analysis

Snake venomics of the pit vipers Porthidium nasutum, Porthidium ophryomegas, and Cerrophidion godmani from Costa Rica: Toxicological and taxonomical insights

scientific article published on 23 December 2011

Snakebite Envenoming in Children: A Neglected Tropical Disease in a Costa Rican Pediatric Tertiary Care Center

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Snakebite envenomation in the Caribbean: The role of medical and scientific cooperation

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Snakebite envenoming

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Snakebite envenoming

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Snakebite envenoming from a global perspective: Towards an integrated approach

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Snakebite envenoming from an Ecohealth perspective

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Snakebite envenoming in French Guiana: Assessment of the preclinical efficacy against the venom of Bothrops atrox of two polyspecific antivenoms

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Snakebite envenoming in children: A neglected tropical disease in a Costa Rican pediatric tertiary care center

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Snakebite envenoming in different national contexts: Costa Rica, Sri Lanka, and Nigeria

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Snakebite mortality in Costa Rica.

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Snakebites are associated with poverty, weather fluctuations, and El Niño

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Stability of equine IgG antivenoms obtained by caprylic acid precipitation: towards a liquid formulation stable at tropical room temperature

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Stability, distribution and use of antivenoms for snakebite envenomation in Latin America: report of a workshop

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Standardization of assays for testing the neutralizing ability of antivenoms

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Strengthening antivenom production in Central and South American public laboratories: report of a workshop

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Structural and functional characterization of BnSP-7, a Lys49 myotoxic phospholipase A(2) homologue from Bothrops neuwiedi pauloensis venom

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Structural and functional characterization of myotoxin I, a Lys49 phospholipase A(2) homologue from Bothrops moojeni (Caissaca) snake venom.

scientific article published in January 2000

Structural and functional characterization of myotoxin I, a Lys49 phospholipase A2 homologue from the venom of the snake Bothrops atrox

scientific article published in July 2004

Structural and functional properties of BaTX, a new Lys49 phospholipase A2 homologue isolated from the venom of the snake Bothrops alternatus

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Structural basis for phospholipase A2-like toxin inhibition by the synthetic compound Varespladib (LY315920)

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Structure of a Lys49-Phospholipase A2 homologue isolated from the venom of Bothrops nummifer (jumping viper)

scientific article published on 01 February 1999

Structure of a calcium-independent phospholipase-like myotoxic protein from Bothrops asper venom

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Study of the design and analytical properties of the lethality neutralization assay used to estimate antivenom potency against Bothrops asper snake venom

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Substitutions of residues in a loop surrounding the active site of a P-I snake venom metalloproteinase abrogates its hemorrhagic activity

scientific article published on 01 April 2020

Synergism between basic Asp49 and Lys49 phospholipase A2 myotoxins of viperid snake venom in vitro and in vivo

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Systemic and local myotoxicity induced by snake venom group II phospholipases A2: comparison between crotoxin, crotoxin B and a Lys49 PLA2 homologue

scientific article published on 29 August 2007

Systemic cytokine response in children bitten by snakes in Costa Rica

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Systemic effects induced by the venom of the snake Bothrops caribbaeus in a murine model

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Systemic vascular leakage induced in mice by Russell's viper venom from Pakistan

scientific article published in Scientific Reports

THE NEED FOR AN INTEGRATED APPROACH IN CONFRONTING SNAKEBITE ENVENOMING IN LATIN AMERICA: THE RELEVANCE OF ENDOGENOUS SCIENTIFIC AND TECHNOLOGICAL RESEARCH

The C-terminal region of a Lys49 myotoxin mediates Ca2+ influx in C2C12 myotubes

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The Global Snake Bite Initiative: an antidote for snake bite

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The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming

scientific article published on 29 June 2021

The ability of specific antivenom and low temperature to inhibit the myotoxicity and neuromuscular block induced by Micrurus nigrocinctus venom

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The amino acid sequence of a myotoxic phospholipase from the venom of Bothrops asper

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The analgesics morphine and tramadol do not alter the acute toxicity induced by Bothrops asper snake venom in mice

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The effect of myotoxins isolated from Bothrops snake venoms on multilamellar liposomes: relationship to phospholipase A2, anticoagulant and myotoxic activities

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The lethality test used for estimating the potency of antivenoms against Bothrops asper snake venom: Pathophysiological mechanisms, prophylactic analgesia, and a surrogate in vitro assay

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The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms

scientific article published on 23 August 2017

The need for full integration of snakebite envenoming within a global strategy to combat the neglected tropical diseases: the way forward

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The paraspecific neutralisation of snake venom induced coagulopathy by antivenoms

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The phospholipase A2 homologues of snake venoms: biological activities and their possible adaptive roles

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The struggle of neglected scientific groups: ten years of NeTropica efforts to promote research in tropical diseases in Central America

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The venom of Bothrops asper from Guatemala: toxic activities and neutralization by antivenoms

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Third-generation antivenomics analysis of the preclinical efficacy of Bothrofav® antivenom towards Bothrops lanceolatus venom

scientific article published on 29 December 2018

Thrombocytopenia and platelet hypoaggregation induced by Bothrops asper snake venom

scholarly article by Mónica Soto et al published 2005 in Thrombosis and Haemostasis

Thrombocytopenia and platelet hypoaggregation induced by Bothrops asper snake venom. Toxins involved and their contribution to metalloproteinase-induced pulmonary hemorrhage

scientific article

Tissue localization and extracellular matrix degradation by PI, PII and PIII snake venom metalloproteinases: clues on the mechanisms of venom-induced hemorrhage

scientific article

Tissue pathology induced by snake venoms: How to understand a complex pattern of alterations from a systems biology perspective?

scientific article published on 20 August 2009

Toxicity of Bothrops sp snake venoms from Ecuador and preclinical assessment of the neutralizing efficacy of a polyspecific antivenom from Costa Rica

article

Toxicovenomics and antivenom profiling of the Eastern green mamba snake (Dendroaspis angusticeps).

scientific article

Trends in snakebite envenomation therapy: scientific, technological and public health considerations

scientific article

Turbidity of hyperimmune equine antivenom: The role of phenol and serum lipoproteins

scientific article published on 01 January 1993

Two color morphs of the pelagic yellow-bellied sea snake, Pelamis platura, from different locations of Costa Rica: snake venomics, toxicity, and neutralization by antivenom

scientific article published on 3 April 2014

Two phospholipase A2 inhibitors from the plasma of Cerrophidion (Bothrops) godmani which selectively inhibit two different group-II phospholipase A2 myotoxins from its own venom: isolation, molecular cloning and biological properties.

scientific article published on March 2000

Ultrastructural alterations in mouse capillary blood vessels after experimental injection of venom from the snake Bothrops asper (Terciopelo).

scientific article published on October 1992

Understanding and confronting snakebite envenoming: The harvest of cooperation

scientific article

Understanding structural and functional aspects of PII snake venom metalloproteinases: characterization of BlatH1, a hemorrhagic dimeric enzyme from the venom of Bothriechis lateralis

scientific article published on 21 January 2014

Understanding the Snake Venom Metalloproteinases: An Interview with Jay Fox and José María Gutiérrez

scientific article published on 16 January 2017

Unresolved issues in the understanding of the pathogenesis of local tissue damage induced by snake venoms

scientific article published on 23 April 2018

Unveiling the nature of black mamba (Dendroaspis polylepis) venom through venomics and antivenom immunoprofiling: Identification of key toxin targets for antivenom development

scientific article published on 14 February 2015

Using geographical information systems to identify populations in need of improved accessibility to antivenom treatment for snakebite envenoming in Costa Rica

scientific article

Varespladib (LY315920) and Methyl Varespladib (LY333013) Abrogate or Delay Lethality Induced by Presynaptically Acting Neurotoxic Snake Venoms

scientific article published on 20 February 2020

Varespladib (LY315920) inhibits neuromuscular blockade induced by Oxyuranus scutellatus venom in a nerve-muscle preparation

scientific article published on 01 September 2020

Venom Composition and Diet of the Cantil Agkistrodon bilineatus howardgloydi (Serpentes: Viperidae)

article by Alejandro Solorzano et al published December 1999 in Southwestern Naturalist

Venom from Russia: Venomics, Bioactivities and Preclinical Assessment of Microgen Antivenom

scientific article published on 01 February 2019

Venom of Bothrops asper from Mexico and Costa Rica: Intraspecific variation and cross-neutralization by antivenoms

scientific article published on 18 November 2011

Venom of the Coral Snake Micrurus clarki: Proteomic Profile, Toxicity, Immunological Cross-Neutralization, and Characterization of a Three-Finger Toxin.

scientific article published on 05 May 2016

Venom of the crotaline snake Atropoides nummifer (jumping viper) from Guatemala and Honduras: comparative toxicological characterization, isolation of a myotoxic phospholipase A2 homologue and neutralization by two antivenoms

scientific article published on 01 June 2001

Venomic and antivenomic analyses of the Central American coral snake, Micrurus nigrocinctus (Elapidae).

scientific article published on 25 February 2011

Venomics and antivenomics of Bothrops erythromelas from five geographic populations within the Caatinga ecoregion of northeastern Brazil

scientific article

Venomics of New World pit vipers: genus-wide comparisons of venom proteomes across Agkistrodon

scientific article

Venomous animals in a changing world

scientific article published on 5 April 2022

Venomous snakes of Costa Rica: biological and medical implications of their venom proteomic profiles analyzed through the strategy of snake venomics

scientific article

Venoms of Micrurus coral snakes: Evolutionary trends in compositional patterns emerging from proteomic analyses.

scientific article published on 15 September 2016

Venoms, poisons and toxins: evolution and impact of amazing molecules

scientific article published on 12 January 2020

Venoms, venomics, antivenomics

scientific article published on 20 March 2009

Viperid Envenomation Wound Exudate Contributes to Increased Vascular Permeability via a DAMPs/TLR-4 Mediated Pathway

scientific article

Why is Skeletal Muscle Regeneration Impaired after Myonecrosis Induced by Viperid Snake Venoms?

scientific article

Why myotoxin-containing snake venoms possess powerful nucleotidases?

scientific article published on 19 December 2012

Wound exudate as a proteomic window to reveal different mechanisms of tissue damage by snake venom toxins

scientific article published in November 2009

[Biomedical research in Revista de Biologia Tropical]

scientific article published on 01 September 2002

[Local effects induced by Micrurus nigrocinctus venom in white mice (author's transl)]

scientific article published in January 1980

[Situation of public laboratories manufacturing antivenoms in Latin AmericaA situação dos laboratórios públicos produtores de soros antivenenos na América Latina]

scientific article published on 19 November 2019

[Understanding snake venoms: 50 years of research in Latin America]

scientific article published on 01 June 2002

p-Bromophenacyl bromide modification of Bothrops asper myotoxin II, a lysine-49 phospholipase A2, affects its pharmacological activities

scientific article published in September 1993

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