List of works by Susan M. Lea

A Comparative Structure/Function Analysis of Two Type IV Pilin DNA Receptors Defines a Novel Mode of DNA Binding

scientific article published on 3 May 2016

A complex iron-calcium cofactor catalyzing phosphotransfer chemistry

scientific article published on September 2014

A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition

scientific article

A key centriole assembly interaction interface between human PLK4 and STIL appears to not be conserved in flies

scientific article published on 15 February 2017

A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi.

scientific article

A novel inhibitor of complement C5 provides structural insights into activation

A signal sequence suppressor mutant that stabilizes an assembled state of the twin arginine translocase.

scientific article published on 21 February 2017

A structural study of the interaction between the Dr haemagglutinin DraE and derivatives of chloramphenicol

scientific article

An aptamer that neutralizes R5 strains of human immunodeficiency virus type 1 blocks gp120-CCR5 interaction

scientific article

An atomic resolution model for assembly, architecture, and function of the Dr adhesins.

scientific article

An inhibitor of complement C5 provides structural insights into activation

scientific article published on 23 December 2019

Analysis of antigenic surfaces of proteins

scientific article published on 01 January 1995

Antigenic heterogeneity of a foot-and-mouth disease virus serotype in the field is mediated by very limited sequence variation at several antigenic sites.

scientific article published on March 1994

Architecture of the major component of the type III secretion system export apparatus

scientific article

Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9.

scientific article

Author Correction: Structure of the core of the type III secretion system export apparatus

scientific article published on 01 August 2018

Author Correction: Structures of the stator complex that drives rotation of the bacterial flagellum

scientific article published on 09 November 2020

Autoantibodies to CD59, CD55, CD46 or CD35 are not associated with atypical haemolytic uraemic syndrome (aHUS).

scientific article

Bifunctional Lipocalin Ameliorates Murine Immune Complex-induced Acute Lung Injury

scientific article

Biological activity, membrane-targeting modification, and crystallization of soluble human decay accelerating factor expressed in E. coli.

scientific article published in September 2004

Building a secreting nanomachine: a structural overview of the T3SS.

scientific article published on April 2014

Characterisation of Shigella Spa33 and Thermotoga FliM/N reveals a new model for C-ring assembly in T3SS.

scientific article published on 5 November 2015

Characterizing sequence variation in the VP1 capsid proteins of foot and mouth disease virus (serotype 0) with respect to virion structure

scientific article published in April 1998

Chicken TAP genes are polymorphic and co-evolve with the dominantly-expressed class I gene

article

Competition between antagonistic complement factors for a single protein on N. meningitidis rules disease susceptibility

scientific article

Complement Factor H: Using Atomic Resolution Structure to Illuminate Disease Mechanisms

Complement factor H: using atomic resolution structure to illuminate disease mechanisms

scientific article

Complement factor I in health and disease

scientific article

Complement regulation at the molecular level: The structure of decay-accelerating factor

scientific article

Correction: Design and Evaluation of Meningococcal Vaccines through Structure-Based Modification of Host and Pathogen Molecules

scientific article published on 17 January 2013

Cryo-EM structure and resistance landscape of M. tuberculosis MmpL3: An emergent therapeutic target

scholarly article

Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals

scholarly article

Crystal Structure and Functional Characterization of the Complement Regulator Mannose-binding Lectin (MBL)/Ficolin-associated Protein-1 (MAP-1)

scientific article

Crystal structure of Spa40, the specificity switch for theShigella flexneritype III secretion system

scientific article

Crystal structure of the Bacillus subtilis phosphodiesterase PhoD reveals an iron and calcium-containing active site

scientific article published on 12 September 2014

Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly

scientific article

Crystallization and preliminary X-ray analysis of three serotypes of foot-and-mouth disease virus

scientific article published in December 1992

Crystallization and preliminary X-ray diffraction analysis of a biologically active fragment of CD55

scientific article published on 01 June 1999

Crystallization and preliminary X-ray diffraction analysis of three EGF domains of EMR2, a 7TM immune-system molecule.

scientific article

Crystallization and preliminary crystallographic analysis of BbCRASP-1, a complement regulator-acquiring surface protein of Borrelia burgdorferi

scientific article

Crystallographic studies of human complement factor I

Decay-accelerating factor must bind both components of the complement alternative pathway C3 convertase to mediate efficient decay

scientific journal article

Deconvolution of fully overlapped reflections from crystals of foot-and-mouth disease virus O1 G67.

scientific article published in March 1995

Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen

scientific article

Delivering a toxic metal to the active site of urease

scholarly article

Design and Evaluation of Meningococcal Vaccines through Structure-Based Modification of Host and Pathogen Molecules

scientific article

Determination of the affinity and kinetic constants for the interaction between the human virus echovirus 11 and its cellular receptor, CD55.

scientific article published on November 1998

Determination of the structure of a decay accelerating factor-binding clinical isolate of echovirus 11 allows mapping of mutants with altered receptor requirements for infection

scientific article

Different modes of variation for each BG lineage suggest different functions

scientific article

Dimerization of complement factor H-related proteins modulates complement activation in vivo

scientific article

Dissecting the roles of VP0 cleavage and RNA packaging in picornavirus capsid stabilization: the structure of empty capsids of foot-and-mouth disease virus

scientific article published on December 1997

Distinct binding and immunogenic properties of the gonococcal homologue of meningococcal factor h binding protein

scientific article

ErpC, a member of the complement regulator-acquiring family of surface proteins fromBorrelia burgdorferi, possesses an architecture previously unseen in this protein family

scientific article

Erratum: Corrigendum: Three-dimensional reconstruction of the Shigella T3SS transmembrane regions reveals 12-fold symmetry and novel features throughout

scholarly article published in Nature Structural & Molecular Biology

Erratum: Structure of and influence of a tick complement inhibitor on human complement component 5

scholarly article published in Nature Immunology

EspM2 is a RhoA guanine nucleotide exchange factor

scientific article published on 21 December 2009

Expanding the Huntington’s disease research toolbox; validated subdomain protein constructs for biochemical and structural investigation of huntingtin

preprint

Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding

scientific article published on 10 April 2015

Expression, limited proteolysis and preliminary crystallographic analysis of IpaD, a component of the Shigella flexneri type III secretion system

scientific article published on 11 August 2006

Expression, purification, cocrystallization and preliminary crystallographic analysis of sucrose octasulfate/human complement regulator factor H SCRs 6-8.

scientific article published on 5 May 2007

Expression, purification, crystallization and preliminary crystallographic analysis of BipD, a component of the Burkholderia pseudomallei type III secretion system

scientific article published on 11 August 2006

Expression, purification, crystallization and preliminary crystallographic analysis of MxiH, a subunit of the Shigella flexneri type III secretion system needle

scientific article published on 28 February 2006

FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation.

scientific article

Factor H-related protein 5 interacts with pentraxin 3 and the extracellular matrix and modulates complement activation

scientific article

Factor I autoantibodies are associated with atypical haemolytic uraemic syndrome

scholarly article by David Kavanagh et al published August 2010 in Molecular Immunology

Factor I autoantibodies in patients with atypical hemolytic uremic syndrome: disease-associated or an epiphenomenon?

scientific article

Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands

scientific article

Functional analysis of the interdependence between DNA uptake sequence and its cognate ComP receptor during natural transformation in Neisseria species

scientific article

Further structural insights into the binding of complement factor H by complement regulator-acquiring surface protein 1 (CspA) ofBorrelia burgdorferi

scientific article

HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1

preprint

Helical Packing of Needles from Functionally Altered Shigella Type III Secretion Systems

article

Helical structure of the needle of the type III secretion system of Shigella flexneri

scientific article (publication date: 9 May 2003)

High resolution studies of the Afa/Dr adhesin DraE and its interaction with chloramphenicol

scientific article

High-resolution structures of bacterially expressed soluble human CD59

scientific article

His-384 Allotypic Variant of Factor H Associated with Age-related Macular Degeneration Has Different Heparin Binding Properties from the Non-disease-associated Form

scientific article published in Journal of Biological Chemistry

Human complement factor I glycosylation: structural and functional characterisation of the N-linked oligosaccharides.

scientific article published on 16 September 2006

Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1

scientific article published on 08 December 2021

Hydrophilic domain II of Escherichia coli Dr fimbriae facilitates cell invasion

scientific article

Identification and characterization of the ‘missing’ terminal enzyme for siroheme biosynthesis in α-proteobacteria

scientific article

Identification of Jagged1 as a novel ligand for CD46: An interaction required for normal induction and regulation of human TH1 responses

article

Identifying factors which enhance capacity to engage in clinical education among podiatry practitioners: an action research project

scientific article

Interactions of CD55 with non-C ligands

scientific article published in 2002

Interactions of CD55 with non-complement ligands

scientific article

Interactions of decay-accelerating factor (DAF) with haemagglutinating human enteroviruses: utilizing variation in primate DAF to map virus binding sites

scientific article published in March 2004

Intersubunit allosteric communication mediated by a conserved loop in the MCM helicase

scholarly article

Investigating the structure of the factor B vWF-A domain/CD55 protein-protein complex using DEER spectroscopy: successes and pitfalls

scientific article published on 9 October 2013

Mapping CD55 function. The structure of two pathogen-binding domains at 1.7 A

scientific article

Mechanism for the Hydrolysis of a Sulfur-Sulfur Bond Based on the Crystal Structure of the Thiosulfohydrolase SoxB

scientific article

Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex

scientific article published on 08 October 2021

Mechanism of thiosulfate oxidation in the SoxA family of cysteine-ligated cytochromes

scientific article published on 11 February 2015

Model of the equine rhinitis A virus capsid: identification of a major neutralizing immunogenic site

scientific article published in September 2003

Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex.

scientific article published on 10 April 2001

Molecular basis for Jagged-1/Serrate ligand recognition by the Notch receptor

scientific article published on 21 January 2013

Molecular basis for redox control by the human cystine/glutamate antiporter system xc−

scientific article published on 08 December 2021

Molecular basis for redox control by the human cystine/glutamate antiporter system xc−

preprint

Molecular dissection of interactions between components of the alternative pathway of complement and decay accelerating factor (CD55).

scientific article published on 9 November 2004

Molecular footprints reveal the impact of the protective HLA-A*03 allele in hepatitis C virus infection

scientific article

Molecular model of a type III secretion system needle: Implications for host-cell sensing

scientific article

Molecular structure of the intact bacterial flagellar basal body

scientific article published on 30 April 2021

Mutational analyses of the BbCRASP-1 protein of Borrelia burgdorferi identify residues relevant for the architecture and binding of host complement regulators FHL-1 and factor H

scientific article published on 09 January 2009

Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates

scientific article

Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies

scientific article

Nonameric structures of the cytoplasmic domain of FlhA and SctV in the context of the full-length protein

scholarly article

Nonfunctional variant 3 factor H binding proteins as meningococcal vaccine candidates

scientific article

Notch receptor-ligand binding and activation: insights from molecular studies

scientific article

On the state of crystallography at the dawn of the electron microscopy revolution

scientific article

Polymorphisms in the Human Inhibitory Signal-regulatory Protein   Do Not Affect Binding to Its Ligand CD47

scientific article

Putting the structure into complement

scientific article

Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT

scientific article (publication date: December 2004)

Rev binds specifically to a purine loop in the SL1 region of the HIV-1 leader RNA

scientific article (publication date: 10 October 2003)

SAS-6 oligomerization: the key to the centriole?

scientific article published on 19 September 2011

SIMPLE 3.0. Stream single-particle cryo-EM analysis in real time

scientific article published on 03 October 2020

SIMPLE 3.0. Stream single-particle cryo-EM analysis in real time

scientific article published on 07 November 2020

Self-chaperoning of the type III secretion system needle tip proteins IpaD and BipD.

scientific article published on 31 October 2006

Semaphorin-7A is an erythrocyte receptor for P. falciparum merozoite-specific TRAP homolog, MTRAP

scientific article (publication date: 2012)

SepL resembles an aberrant effector in binding to a class 1 type III secretion chaperone and carrying an N-terminal secretion signal

scientific article published on 10 September 2010

Shigella flexneri Spa15 Crystal Structure Verified in Solution by Double Electron Electron Resonance

scientific article

Specific DNA recognition mediated by a type IV pilin

scientific article

Specificity and mechanism of assembly of C4b binding protein

Structural Analysis Uncovers Lipid-Binding Properties of Notch Ligands

scientific article

Structural Basis for Mitotic Centrosome Assembly in Flies

scientific article published on June 2017

Structural Basis for Recognition of the Pore-Forming Toxin Intermedilysin by Human Complement Receptor CD59

scientific article

Structural Insights into Notch Receptor-Ligand Interactions

Structural analysis of substrate binding by the TatBC component of the twin-arginine protein transport system

scholarly article

Structural and Functional Characterization of the Bacterial Type III Secretion Export Apparatus

scientific article

Structural and Functional Studies on the N-terminal Domain of the Shigella Type III Secretion Protein MxiG

scientific article

Structural and functional characteristics of MBL/Ficolin-associated Protein-1 (MAP-1)

Structural and functional characterization of a novel T cell receptor co-regulatory protein complex, CD97-CD55

scientific article

Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands

scientific article published on June 2017

Structural and functional insights into the interaction of echoviruses and decay-accelerating factor

scientific article published on 4 November 2005

Structural basis for complement factor H linked age-related macular degeneration

scientific article

Structural basis for complement factor I control and its disease-associated sequence polymorphisms

scientific article

Structural basis for specificity and promiscuity in a carrier protein/enzyme system from the sulfur cycle

scientific article

Structural basis for therapeutic inhibition of complement C5

scientific article

Structural basis of antifolate recognition and transport by PCFT

scholarly article

Structural basis of cholesterol binding by a novel clade of dendritic cell modulators from ticks.

scientific article published on 22 November 2017

Structural biology of Tat protein transport

scientific article published on 05 April 2014

Structural characterization of an anti-gp120 RNA aptamer that neutralizes R5 strains of HIV-1.

scientific article

Structural comparison of two strains of foot-and-mouth disease virus subtype O1 and a laboratory antigenic variant, G67.

scientific article published in June 1995

Structural findings in complement factor H-related proteins unravel the pathogenesis of C3 glomerulopathy

Structure and function of a family of tick-derived complement inhibitors targeting properdin

scientific article published on 14 January 2022

Structure and mechanism of the proton-driven motor that powers type 9 secretion and gliding motility

scientific article published on 11 January 2021

Structure of Foot-and-mouth disease virus serotype A10 61 alone and complexed with oligosaccharide receptor: receptor conservation in the face of antigenic variation

scientific article

Structure of a major immunogenic site on foot-and-mouth disease virus

scientific article

Structure of and influence of a tick complement inhibitor on human complement component 5

scientific article

Structure of human complement C8, a precursor to membrane attack

scientific article

Structure of the TatC core of the twin-arginine protein transport system

scientific article

Structure of the core of the type III secretion system export apparatus

scientific article published on 02 July 2018

Structure-based design of chimeric antigens for multivalent protein vaccines.

scientific article

Structure-function mapping of BbCRASP-1, the key complement factor H and FHL-1 binding protein of Borrelia burgdorferi.

scientific article

Structures of CD200/CD200 Receptor Family and Implications for Topology, Regulation, and Evolution

scientific article

Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction

scientific article

Structures of SALSA/DMBT1 SRCR domains reveal the conserved ligand-binding mechanism of the ancient SRCR fold

scientific article published on 25 February 2020

Structures of the Shigella flexneri Type 3 Secretion System Protein MxiC Reveal Conformational Variability Amongst Homologues

scientific article

Structures of the Type IX Secretion/Gliding Motility Motor from across the Phylum

scholarly article

Structures of the Type IX Secretion/gliding motility motor from across the phylum Bacteroidetes

scholarly article

Structures of the rat complement regulator CrrY

scientific article

Structures of the stator complex that drives rotation of the bacterial flagellum

scientific article published on 14 September 2020

Symmetry mismatch in the MS-ring of the bacterial flagellar rotor explains the structural coordination of secretion and rotation

scientific article published on 13 April 2020

TatBC, TatB, and TatC form structurally autonomous units within the twin arginine protein transport system of Escherichia coli

scientific article published on 30 July 2007

Tetartohedral twinning could happen to you too

scientific article published on 16 March 2012

The CD46-Jagged1 interaction is critical for human TH1 immunity

scientific article

The Escherichia coli Cell Division Protein and Model Tat Substrate SufI (FtsP) Localizes to the Septal Ring and Has a Multicopper Oxidase-Like Structure

scientific article

The S. Typhi effector StoD is an E3/E4 ubiquitin ligase which binds K48- and K63-linked diubiquitin

scientific article published on 29 May 2019

The Salmonella type III secretion system inner rod protein PrgJ is partially folded.

scientific article

The Structure of OMCI, a Novel Lipocalin Inhibitor of the Complement System

scientific article

The Structure of an Injectisome Export Gate Demonstrates Conservation of Architecture in the Core Export Gate between Flagellar and Virulence Type III Secretion Systems

scientific article published on 25 June 2019

The centrosome-specific phosphorylation of Cnn by Polo/Plk1 drives Cnn scaffold assembly and centrosome maturation.

scientific article

The characterization of weak protein-protein interactions: evidence from DEER for the trimerization of a von Willebrand Factor A domain in solution.

scientific article

The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in flies

scientific article published on 23 May 2015

The structure and antigenicity of a type C foot-and-mouth disease virus

scientific article

The structure and function of a foot-and-mouth disease virus-oligosaccharide receptor complex.

scientific article

The structure of an immunodominant loop on foot and mouth disease virus, serotype O1, determined under reducing conditions

scientific article published on January 1994

The structure of echovirus type 12 bound to a two-domain fragment of its cellular attachment protein decay-accelerating factor (CD 55)

scientific article

The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion

scientific article published on 10 March 2020

The type III needle and the damage done

scientific article

Three-dimensional reconstruction of the Shigella T3SS transmembrane regions reveals 12-fold symmetry and novel features throughout

scientific article

Timing is everything: the regulation of type III secretion

scientific article published on 31 December 2009

Towards a structural basis for complement factor H linked age-related macular degeneration

Two cross-reactive monoclonal antibodies recognize overlapping epitopes on Neisseria meningitidis factor H binding protein but have different functional properties

Type 9 secretion system structures reveal a new protein transport mechanism

scientific article published in Nature

What's the point of the type III secretion system needle?

scholarly article

With phases: how two wrongs can sometimes make a right

scientific article

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