List of works - Peter D. Mace

A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes

scientific article published in Nature Communications

A cryptic tubulin-binding domain links MEKK1 to curved tubulin protomers

scientific article published on 17 August 2020

Activation and specificity of human caspase-10.

scientific article published on September 2010

Asymmetric recruitment of cIAPs by TRAF2

scientific article

Bacterial expression and purification of the ovine type II bone morphogenetic protein receptor ectodomain

scientific article published on 12 August 2006

Caspase enzymology and activation mechanisms

scientific article published in January 2014

Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.

scientific article published on 24 May 2011

Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor

scientific article

Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP

scientific article

High resolution structures of the bone morphogenetic protein type II receptor in two crystal forms: implications for ligand binding

scientific article published on 10 November 2006

Live and let die: insights into pseudoenzyme mechanisms from structure

scientific article published on 5 August 2017

Molecular Mechanism of CCAAT-Enhancer Binding Protein Recruitment by the TRIB1 Pseudokinase

scientific article

Molecular Regulation of the Polycomb Repressive-Deubiquitinase

scientific article published on 22 October 2020

NSP-CAS Protein Complexes: Emerging Signaling Modules in Cancer

scientific article

NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling

scientific article

Noncovalent Ubiquitin Interactions Regulate the Catalytic Activity of Ubiquitin Writers.

scientific article published on 7 September 2016

Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity

scientific article

Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization

scientific article published on 10 March 2011

Structural Studies of ERK2 Protein Complexes

scientific article published in January 2017

Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter

scientific article published on 13 February 2024

Structural basis of autoregulatory scaffolding by apoptosis signal-regulating kinase 1.

scientific article published on 27 February 2017

Structural mechanisms in NLR inflammasome signaling.

scientific article

Structure and mechanism of a tripartite ATP-independent periplasmic TRAP transporter

scientific article published on 27 February 2023

Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation

scientific article published on 20 January 2016

Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

scientific article

Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors

scientific article

Structure-based mechanism of preferential complex formation by apoptosis signal-regulating kinases

scientific article published on 10 March 2020

Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment

scientific article

Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1

scientific article published on 25 September 2018

TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.

scientific article published on December 2009

The CARD plays a critical role in ASC foci formation and inflammasome signalling

scientific article published on February 2013

The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1.

scientific article

Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.

scientific article

When Worlds Collide-Mechanisms at the Interface between Phosphorylation and Ubiquitination.

scientific article published on 21 February 2017

List of works by Peter D. Mace

A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes

A cryptic tubulin-binding domain links MEKK1 to curved tubulin protomers

Activation and specificity of human caspase-10.

Asymmetric recruitment of cIAPs by TRAF2

Bacterial expression and purification of the ovine type II bone morphogenetic protein receptor ectodomain

Caspase enzymology and activation mechanisms

Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.

Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor

Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP

High resolution structures of the bone morphogenetic protein type II receptor in two crystal forms: implications for ligand binding

Live and let die: insights into pseudoenzyme mechanisms from structure

Molecular Mechanism of CCAAT-Enhancer Binding Protein Recruitment by the TRIB1 Pseudokinase

Molecular Regulation of the Polycomb Repressive-Deubiquitinase

NSP-CAS Protein Complexes: Emerging Signaling Modules in Cancer

NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling

Noncovalent Ubiquitin Interactions Regulate the Catalytic Activity of Ubiquitin Writers.

Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity

Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization

Structural Studies of ERK2 Protein Complexes

Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter

Structural basis of autoregulatory scaffolding by apoptosis signal-regulating kinase 1.

Structural mechanisms in NLR inflammasome signaling.

Structure and mechanism of a tripartite ATP-independent periplasmic TRAP transporter

Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation

Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors

Structure-based mechanism of preferential complex formation by apoptosis signal-regulating kinases

Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment

Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1

TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.

The CARD plays a critical role in ASC foci formation and inflammasome signalling

The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1.

Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.

When Worlds Collide-Mechanisms at the Interface between Phosphorylation and Ubiquitination.