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List of works by Wei-Jen Tang

A 1.3-Å Structure of Zinc-bound N-terminal Domain of Calmodulin Elucidates Potential Early Ion-binding Step

scientific article

A fluorimetric assay for real-time monitoring of adenylyl cyclase activity based on terbium norfloxacin

scientific article published on 13 June 2008

A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase

scientific article

ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics

scientific article

Adenylyl cyclases.

scientific article published in September 1992

An extended conformation of calmodulin induces interactions between the structural domains of adenylyl cyclase from Bacillus anthracis to promote catalysis

scientific article

Anthrax edema factor potency depends on mode of cell entry.

scientific article

Anthrax edema toxin cooperates with lethal toxin to impair cytokine secretion during infection of dendritic cells

scientific article published in April 2005

Anthrax edema toxin inhibits endothelial cell chemotaxis via Epac and Rap1

scientific article published on 09 May 2007

Anthrax edema toxin sensitizes DBA/2J mice to lethal toxin

scientific article published on 5 March 2007

Anthrax toxin-induced shock in rats is associated with pulmonary edema and hemorrhage

scientific article published on 23 December 2007

Anthrax toxins induce shock in rats by depressed cardiac ventricular function

scientific article

Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signaling

scientific article

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

scientific article

Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus

scholarly article

Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in mice

scientific article

Bacillus anthracis edema toxin impairs neutrophil actin-based motility

scientific article

Bis-halogen-anthraniloyl-substituted nucleoside 5'-triphosphates as potent and selective inhibitors of Bordetella pertussis adenylyl cyclase toxin

scientific article

Calcium dependence of the interaction between calmodulin and anthrax edema factor

scientific article published on 29 April 2003

Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.

scientific article

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice

scientific article

Cellular Functions and X-ray Structure of Anthrolysin O, a Cholesterol-dependent Cytolysin Secreted by Bacillus anthracis

scientific article

Chemical screening by mass spectrometry to identify inhibitors of anthrax lethal factor

scientific article

Comparison of three anthrax toxin neutralization assays

scientific article

Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme

scientific article

Construction of soluble adenylyl cyclase from human membrane-bound type 7 adenylyl cyclase

scientific article

Contributions of edema factor and protective antigen to the induction of protective immunity by Bacillus anthracis edema toxin as an intranasal adjuvant

scientific article

Coordinate regulation of G protein signaling via dynamic interactions of receptor and GAP

scientific article

Crystallization and preliminary X-ray study of the edema factor exotoxin adenylyl cyclase domain from Bacillus anthracis in the presence of its activator, calmodulin.

scientific article published on 21 November 2001

Cytidylyl and uridylyl cyclase activity of bacillus anthracis edema factor and Bordetella pertussis CyaA.

scientific article published on July 2010

Daughterless homodimer synergizes with Eyeless to induce Atonal expression and retinal neuron differentiation

scientific article

Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin

scientific article

Different Roles of N-Terminal and C-Terminal Domains in Calmodulin for Activation of Bacillus anthracis Edema Factor

scientific article published on 13 July 2015

Discovery of a small molecule that inhibits the interaction of anthrax edema factor with its cellular activator, calmodulin

scientific article

Distinct interactions of 2'- and 3'-O-(N-methyl)anthraniloyl-isomers of ATP and GTP with the adenylyl cyclase toxin of Bacillus anthracis, edema factor.

scientific article published on August 2009

Empirical valence bond simulations of the chemical mechanism of ATP to cAMP conversion by anthrax edema factor.

scientific article

Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme

scientific article published on 29 March 2018

Erratum: ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics

scientific article published on 11 July 2017

Expression and Purification of Soluble Adenylyl Cyclase from Escherichia coli

scientific article published on January 1, 2004

Expression and purification of recombinant adenylyl cyclases in Sf9 cells.

scientific article published on January 1994

Expression of alpha subunit of Gs in Escherichia coli

scientific article published in January 2002

Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues

scientific article published on October 2008

Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2

scientific article (publication date: February 2004)

Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling.

scientific article published on 25 January 2011

Identification of a structurally novel BTK mutation that drives ibrutinib resistance in CLL.

scientific article published on 10 September 2016

Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis

scientific article

Immunohistochemical evidence of ubiquitous distribution of the metalloendoprotease insulin-degrading enzyme (IDE; insulysin) in human non-malignant tissues and tumor cell lines

scientific article published on November 2008

In vivo epidermal migration requires focal adhesion targeting of ACF7

scientific article

Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 mono- and bis-(M)ANT-substituted nucleoside 5'-triphosphates

scientific article

Insights from Atomic-Resolution X-Ray Structures of Chemically Synthesized HIV-1 Protease in Complex with Inhibitors

scientific article

Insulin-degrading enzyme modulates the natriuretic peptide-mediated signaling response

scientific article

Interactions of Bordetella pertussis adenylyl cyclase toxin CyaA with calmodulin mutants and calmodulin antagonists: comparison with membranous adenylyl cyclase I.

scientific article published on 13 January 2012

Lethal and edema toxins of anthrax induce distinct hemodynamic dysfunction

scientific article published on 01 May 2007

Modular total chemical synthesis of a human immunodeficiency virus type 1 protease

scientific article

Modulation of the CXC chemokine receptor 4 agonist activity of ubiquitin through C-terminal protein modification

scientific article

Molecular Bases for the Recognition of Short Peptide Substrates and Cysteine-Directed Modifications of Human Insulin-Degrading Enzyme †

scientific article

Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-α, and Amylin by Human Insulin-Degrading Enzyme

scientific article

Molecular Basis of Catalytic Chamber-assisted Unfolding and Cleavage of Human Insulin by Human Insulin-degrading Enzyme

scientific article

Molecular Basis of Substrate Recognition and Degradation by Human Presequence Protease

scientific article

Molecular analysis of the interaction of Bordetella pertussis adenylyl cyclase with fluorescent nucleotides

scientific article published on 6 June 2007

Molecular analysis of the interaction of anthrax adenylyl cyclase toxin, edema factor, with 2'(3')-O-(N-(methyl)anthraniloyl)-substituted purine and pyrimidine nucleotides.

scientific article published on 4 December 2008

Noninvasive imaging technologies reveal edema toxin as a key virulence factor in anthrax

scientific article

Nucleotidyl cyclase activity of particulate guanylyl cyclase A: comparison with particulate guanylyl cyclases E and F, soluble guanylyl cyclase and bacterial adenylyl cyclases CyaA and edema factor

scientific article

Pathophysiology of anthrax

scientific article published on January 2009

Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities

scientific article

Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins

scientific article

Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme

scientific article

Previous exposure to delta9-tetrahydrocannibinol enhances locomotor responding to but not self-administration of amphetamine

scientific article

Protective role of Cys-178 against the inactivation and oligomerization of human insulin-degrading enzyme by oxidation and nitrosylation

scientific article

Protein-protein docking and analysis reveal that two homologous bacterial adenylyl cyclase toxins interact with calmodulin differently

scientific article published on 26 June 2008

Pseudomonas aeruginosa exoenzyme Y directly bundles actin filaments

scientific article published on 04 February 2020

Rapid Discovery and Characterization of Synthetic Neutralizing Antibodies against Anthrax Edema Toxin

scientific article published on 19 June 2019

Real-time analysis of ternary complex on particles: direct evidence for partial agonism at the agonist-receptor-G protein complex assembly step of signal transduction

scientific article

Reinvestigating the synthesis and efficacy of small benzimidazole derivatives as presequence protease enhancers

scientific article published on 01 October 2019

Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection

scientific article

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

scientific article (publication date: February 2009)

Spatial localization of bacteria controls coagulation of human blood by 'quorum acting'

scientific article published on December 2008

Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate.

scientific article

Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin

scientific article

Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin

scientific article

Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme

scientific article published on 07 July 2009

Structural determinants of ubiquitin-CXC chemokine receptor 4 interaction

scientific article published on 28 October 2011

Structure of anthrax edema factor-calmodulin-adenosine 5'-(alpha,beta-methylene)-triphosphate complex reveals an alternative mode of ATP binding to the catalytic site

scientific article

Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE

scientific article

Structure, function, and regulation of insulin-degrading enzyme

scientific article

Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.

scientific article

Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough

scientific article published on 3 April 2003

Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme

scientific article

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

scientific article

Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes Mellitus

scientific article

The C-terminal domain of human insulin degrading enzyme is required for dimerization and substrate recognition

scientific article published on 22 March 2006

The C2 catalytic domain of adenylyl cyclase contains the second metal ion (Mn2+) binding site

scientific article published on 01 November 1998

The adenylyl cyclase activity of anthrax edema factor

scientific article published on 26 June 2009

The amino terminus of varicella-zoster virus (VZV) glycoprotein E is required for binding to insulin-degrading enzyme, a VZV receptor

scientific article

The case for developing consensus standards for research in microbial pathogenesis: Bacillus anthracis toxins as an example

scientific article

The conserved asparagine and arginine are essential for catalysis of mammalian adenylyl cyclase

scientific article published on 01 May 1997

Three discrete regions of mammalian adenylyl cyclase form a site for Gsalpha activation

scientific article published in July 1997

Truncation and alanine-scanning mutants of type I adenylyl cyclase.

scientific article published on November 1995

Two Cytoplasmic Domains of Mammalian Adenylyl Cyclase Form a G- and Forskolin-activated Enzymein Vitro

scientific article published in Journal of Biological Chemistry

Ubiquitin is a novel substrate for human insulin-degrading enzyme

scientific article

Use of allostery to identify inhibitors of calmodulin-induced activation of Bacillus anthracis edema factor.

scientific article

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