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List of works by Juan Bueren

A Short and Efficient Transduction Protocol for Mouse Hematopoietic Stem Cells with Lentiviral Vectors.

scientific article published on 17 August 2017

A common founder mutation in FANCA underlies the world's highest prevalence of Fanconi anemia in Gypsy families from Spain

scientific article published on 2 November 2004

A new approach to evaluate the total reserve of hematopoietic progenitors after acute irradiation

scientific article published in October 2004

A novel lentiviral vector targets gene transfer into human hematopoietic stem cells in marrow from patients with bone marrow failure syndrome and in vivo in humanized mice.

scientific article published on 23 November 2011

A protocol describing the genetic correction of somatic human cells and subsequent generation of iPS cells.

scientific article published on 11 March 2010

A simplified approach to improve the efficiency and safety of ex vivo hematopoietic gene therapy in fanconi anemia patients

scientific article published in February 2006

AM218, a new polyanionic polysaccharide, induces radioprotection in mice when administered shortly before irradiation

scientific article published on 01 January 1997

Adipose tissue-derived mesenchymal stem cells have in vivo immunosuppressive properties applicable for the control of the graft-versus-host disease

scientific article published on 27 July 2006

Adipose-derived mesenchymal stromal cells modulate experimental autoimmune arthritis by inducing an early regulatory innate cell signature.

scientific article published on 4 April 2016

Analysis of hematopoiesis in mice irradiated with 500 mGy of X rays at different stages of development

scientific article published on 01 September 1995

Application of the CFU-GM assay to predict acute drug-induced neutropenia: an international blind trial to validate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics

scientific article published on 25 July 2003

BCR-JAK2 drives a myeloproliferative neoplasm in transplanted mice.

scientific article

Bcr/Abl interferes with the Fanconi anemia/BRCA pathway: implications in the chromosomal instability of chronic myeloid leukemia cells

scientific article

Biochemical correction of X-CGD by a novel chimeric promoter regulating high levels of transgene expression in myeloid cells

scientific article

Biodistribution and Efficacy of Human Adipose-Derived Mesenchymal Stem Cells Following Intranodal Administration in Experimental Colitis.

scientific article

Brief report: impaired cell reprogramming in nonhomologous end joining deficient cells.

scientific article published in August 2013

Brief report: reduced expression of CD18 leads to the in vivo expansion of hematopoietic stem cells in mouse bone marrow.

scientific article published in October 2014

Chromosome fragility in patients with Fanconi anaemia: diagnostic implications and clinical impact

scientific article published on 07 January 2011

Conversion of human fibroblasts into monocyte-like progenitor cells

scientific article

Correction of SCID-X1 using an enhancerless Vav promoter.

scientific article published on 7 February 2011

Cytotoxic infection of hematopoietic stem and committed progenitor cells by the parvovirus minute virus of mice. Propagation of an acute myelosuppression in culture

scientific article published in January 1991

Detectable clonal mosaicism in blood as a biomarker of cancer risk in Fanconi anemia

scientific article published on 23 January 2017

Development of a web course on gene therapy by the international consortium of gene therapy

scientific article published on March 2014

Development of an in vitro model for the simultaneous study of the efficacy and hematotoxicity of antileukemic compounds.

scientific article

Development of lentiviral vectors with optimized transcriptional activity for the gene therapy of patients with Fanconi anemia

scientific article published in May 2010

Differential sensitivity to hyperthermia of mouse normal haemopoietic stem cells related to proliferation activity and organ source

scientific article published on 01 July 1987

Direct Conversion of Fibroblasts to Megakaryocyte Progenitors

scientific article

Down-regulated expression of hsa-miR-181c in Fanconi anemia patients: implications in TNFα regulation and proliferation of hematopoietic progenitor cells

scientific article published on 6 February 2012

Efficient engraftment of in utero transplanted mice with retrovirally transduced hematopoietic stem cells

scientific article

Engraftment and in vivo proliferation advantage of gene corrected mobilized CD34(+) cells from Fanconi anemia patients.

scientific article published on 11 August 2017

Engraftment kinetics of human CD34+ cells from cord blood and mobilized peripheral blood co-transplanted into NOD/SCID mice

scientific article published on 01 February 2005

Epigenetic Alterations in Fanconi Anaemia: Role in Pathophysiology and Therapeutic Potential.

scientific article published on 14 October 2015

Ex vivo expansion and selection of retrovirally transduced bone marrow: an efficient methodology for gene-transfer to murine lympho-haemopoietic stem cells

scientific article published in May 1994

Ex vivo expansion of umbilical cord blood (UCB) CD34(+) cells alters the expression and function of alpha 4 beta 1 and alpha 5 beta 1 integrins

scientific article published on 01 October 2001

Exploring the link between MORF4L1 and risk of breast cancer

scientific article

Fanconi anaemia: from a monogenic disease to sporadic cancer ⬇️

scientific article published on April 1, 2011

Functional and phenotypic variations in human T cells subjected to retroviral-mediated gene transfer

scientific article published in March 2004

Gene therapy for Fanconi anemia: one step closer to the clinic.

scientific article published on February 2012

Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells.

scientific article

Generation of functional neutrophils from a mouse model of X-linked chronic granulomatous disorder using induced pluripotent stem cells

scientific article

Generation of iPSCs from genetically corrected Brca2 hypomorphic cells: implications in cell reprogramming and stem cell therapy

scientific article published in February 2014

Hematopoietic mobilization in mice increases the presence of bone marrow-derived hepatocytes via in vivo cell fusion

scientific article published in January 2006

Human Adipose-Derived Mesenchymal Stem Cells Modulate Experimental Autoimmune Arthritis by Modifying Early Adaptive T Cell Responses.

scientific article published on 22 July 2015

Immunoresponse against the transgene limits hematopoietic engraftment of mice transplanted in utero with virally transduced fetal liver.

scientific article

Improved Hematopoietic Gene Therapy in a Mouse Model of Fanconi Anemia Mediated by Mesenchymal Stromal Cells

scientific article published on 17 August 2017

In vitro and in vivo susceptibility of mouse megakaryocytic progenitors to strain i of parvovirus minute virus of mice.

scientific article

In vitro hematotoxicity of Aplidine on human bone marrow and cord blood progenitor cells

scientific article published in August 2001

In vitro toxicity of ET-743 and aplidine, two marine-derived antineoplastics, on human bone marrow haematopoietic progenitors. comparison with the clinical results

scientific article published in July 2002

In vitro toxicity of three new antitumoral drugs (trabectedin, aplidin, and kahalalide F) on hematopoietic progenitors and stem cells

scientific article published in November 2003

In vivo imaging of lung inflammation with neutrophil-specific 68Ga nano-radiotracer

scientific article published on 16 October 2017

Inhibitory effects of marine-derived DNA-binding anti-tumour tetrahydroisoquinolines on the Fanconi anaemia pathway

scientific article published on October 2013

Intralymphatic Administration of Adipose Mesenchymal Stem Cells Reduces the Severity of Collagen-Induced Experimental Arthritis

scientific article

Jun N-terminal kinase activity and early growth-response factor-1 gene expression are down-regulated in Fanconi anemia group A lymphoblasts.

scientific article published on 4 September 2003

Kinetic studies of pyruvate kinase during in vitro differentiation of GM-CFC haemopoietic precursor and bone marrow cells in mice

scientific article published on 01 April 1990

Latent hematopoietic stem cell toxicity associated with protracted drug administration

scientific article

Lentiviral Vector-Mediated Correction of a Mouse Model of Leukocyte Adhesion Deficiency Type I.

scientific article published on 08 April 2016

Lentiviral vector integration sites in human NOD/SCID repopulating cells

scientific article published in October 2006

Lentiviral-Mediated Gene Therapy in Fanconi Anemia-A Mice Reveals Long-Term Engraftment and Continuous Turnover of Corrected HSCs.

scientific article published on 29 September 2015

Lessons Learned from Two Decades of Clinical Trial Experience in Gene Therapy for Fanconi Anemia

scientific article published on 19 January 2017

Long-term skin regeneration in xenografts from iPSC teratoma-derived human keratinocytes.

scientific article published on 20 April 2016

Measles virus envelope pseudotyped lentiviral vectors transduce quiescent human HSCs at an efficiency without precedent

scientific article published on 24 October 2017

Mechanisms towards compensation of long-term haemopoietic injury in mice after 5 Gy irradiation: in vivo and in vitro enhancement of superoxide anion production by granulocytes

scientific article published on 01 August 1992

Mesenchymal stromal cells enhance the engraftment of hematopoietic stem cells in an autologous mouse transplantation model

scientific article published on 7 September 2015

Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs

scientific article

Mutations in ERCC4, encoding the DNA-repair endonuclease XPF, cause Fanconi anemia

scientific article

Non-homologous end-joining defect in fanconi anemia hematopoietic cells exposed to ionizing radiation

scientific article

Origin, functional role, and clinical impact of Fanconi anemia FANCA mutations

scientific article

Parvovirus infection suppresses long-term repopulating hematopoietic stem cells

scientific article

Perspectives on gene therapy for Fanconi anemia

article

Preserved long-term repopulation and differentiation properties of hematopoietic grafts subjected to ex vivo expansion with stem cell factor and interleukin 11

scientific article published on 01 May 1999

Prevalidation of a model for predicting acute neutropenia by colony forming unit granulocyte/macrophage (CFU-GM) assay.

scientific article published in December 2001

Production of humoral factors that stimulate spleen colony-forming units in mice irradiated with moderate doses of X rays

scientific article published on 01 April 1990

Prostaglandin E2 plays a key role in the immunosuppressive properties of adipose and bone marrow tissue-derived mesenchymal stromal cells.

scientific article published on 8 September 2010

Purging of leukemia-contaminated bone marrow grafts using suicide adenoviral vectors: an in vivo murine experimental model.

scientific article published in August 2003

Pyruvate kinase during in vitro differentiation of GM-CFC haemopoietic precursor in mice: modulation by L-alanine and L-phenylalanine

scientific article published on 01 June 1989

Quantitative PCR analysis reveals a high incidence of large intragenic deletions in the FANCA gene in Spanish Fanconi anemia patients.

scientific article

Radioprotection mediated by the haemopoietic stimulation conferred by AM5: a protein-associated polysaccharide

scientific article published on 01 July 1992

Reduced efficacy of mesenchymal stromal cells in preventing graft-versus-host disease in an in vivo model of haploidentical bone marrow transplant with leukemia

scientific article published on 4 October 2012

Regulatory elements of the vav gene drive transgene expression in hematopoietic stem cells from adult mice

scientific article published in April 2004

Residual damage of lymphohematopoietic repopulating cells after irradiation of mice at different stages of development

scientific article published on 01 January 2000

Residual haematopoietic damage in adult and 8 day-old mice exposed to 7 Gy of X-rays

scientific article published on 01 January 1993

Safe and Efficient Gene Therapy for Pyruvate Kinase Deficiency

scientific article

Safety of retroviral gene marking with a truncated NGF receptor

scientific article published on 01 April 2003

Stem cell gene therapy for fanconi anemia: report from the 1st international Fanconi anemia gene therapy working group meeting.

scientific article

Successful engraftment of gene-corrected hematopoietic stem cells in non-conditioned patients with Fanconi anemia

scientific article published on 09 September 2019

The mobilization of hematopoietic progenitors to peripheral blood is predictive of the hematopoietic syndrome after total or partial body irradiation of mice

scientific article published in February 2006

Therapeutic gene editing in CD34+ hematopoietic progenitors from Fanconi anemia patients.

scientific article published on 12 September 2017

Transforming and tumorigenic activity of JAK2 by fusion to BCR: molecular mechanisms of action of a novel BCR-JAK2 tyrosine-kinase

scientific article

Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases

scientific article published in February 2013

Transplantation of marrow cells from children with standard risk-acute lymphoblastic leukemia at the end of therapy into NOD/SCID mice for detecting residual leukemic cells with in vivo growth potential

scientific article published on 01 December 2003

Unraveling the role of FANCD2 in chronic myeloid leukemia

scientific article published on 06 February 2012

Use of CFU-GM assay for prediction of human maximum tolerated dose of a new antitumoral drug: Yondelis (ET-743).

scientific article published on October 2003

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