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List of works by Nuala Helsby

2-Amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT.

scientific article published on March 2004

A case-control study to assess the ability of the thymine challenge test to predict patients with severe to life threatening fluoropyrimidine-induced gastrointestinal toxicity

scientific article published on 12 December 2019

A high incidence of polymorphic CYP2C19 variants in archival blood samples from Papua New Guinea.

scientific article published on September 2008

A higher throughput assay for quantification of melphalan-induced DNA damage in peripheral blood mononuclear cells

scientific article published on 11 December 2019

A simple ex vivo bioassay for 5-FU transport into healthy buccal mucosal cells

scientific article published on 19 July 2019

Aerobic 2- and 4-nitroreduction of CB 1954 by human liver

scientific article published on 29 August 2005

Allantoin as A Biomarker of Inflammation in an Inflammatory Bowel Disease Mouse Model: NMR Analysis of Urine

scholarly article by Philippa A. Dryland et al published 3 June 2008 in The Open Bioactive Compounds Journal

Antimutagenic effects of wheat bran diet through modification of xenobiotic metabolising enzymes

scientific article

Association between the low-dose irinotecan regimen-induced occurrence of grade 4 neutropenia and genetic variants of UGT1A1 in patients with gynecological cancers.

scientific article

Aziridinyldinitrobenzamides: synthesis and structure-activity relationships for activation by E. coli nitroreductase.

scientific article published on June 2004

Bystander effects of bioreductive drugs: potential for exploiting pathological tumor hypoxia with dinitrobenzamide mustards.

scientific article published on June 2007

CYP2 family: physiological enzymes subset in GtoPdb v.2021.2

scientific article published on 25 June 2021

CYP2C19 and CYP2D6 genotypes in Pacific peoples

scientific article published on 15 June 2016

CYP2C19 genotype-phenotype discordance in patients with multiple myeloma leads to an acquired loss of drug-metabolising activity

scientific article published on 12 February 2014

Can in vitro drug metabolism studies with human tissue replace in vivo animal studies? ⬇️

scientific article published on August 2, 2005

Comparison of a thymine challenge test and endogenous uracil–dihydrouracil levels for assessment of fluoropyrimidine toxicity risk

scientific article published on 9 March 2021

Cross-Comparison of Exome Analysis, Next-Generation Sequencing of Amplicons, and the iPLEX(®) ADME PGx Panel for Pharmacogenomic Profiling

scientific article

Cyclophosphamide bioactivation pharmacogenetics in breast cancer patients

scientific article published on 10 June 2021

Cytochrome P450 (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

scientific article published on 16 September 2019

Cytochrome P450 in GtoPdb v.2021.2

scientific article published on 25 June 2021

DEVELOPMENT AND VALIDATION OF A HIGH PERFORMANCE LIQUID CHROMATOGRAPHY ASSAY FOR THE DETERMINATION OF A FLUORINATED ANALOGUE OF THALIDOMIDE, N-(2,6-DIOXOPIPERIDIN-3-YL)-3,4,5,6-TETRAFLUOROPHTHALAMIC ACID, AND LENALIDOMIDE

scientific article published on 7 January 2011

Do 5-fluorouracil therapies alter CYP2C19 metaboliser status?

scientific article published on 17 February 2010

Effect of nitroreduction on the alkylating reactivity and cytotoxicity of the 2,4-dinitrobenzamide-5-aziridine CB 1954 and the corresponding nitrogen mustard SN 23862: distinct mechanisms of bioreductive activation.

scientific article published on April 2003

Effects of quercetin on drug metabolizing enzymes and oxidation of 2',7-dichlorofluorescin in HepG2 cells

scientific article published on 01 December 1997

Evaluating aziridinyl nitrobenzamide compounds as leishmanicidal prodrugs

scientific article

Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin

scientific article

Hepatic cytochrome P450 CYP2C activity in psoriasis: studies using proguanil as a probe compound: Investigative reports

scientific article published on 01 March 1998

Hepatic nitroreduction, toxicity and toxicokinetics of the anti-tumour prodrug CB 1954 in mouse and rat

scientific article published in October 2007

High CYP2C19 phenotypic variability in gastrointestinal cancer patients

scientific article published on 27 November 2015

Hydrolysis of dinitrobenzamide phosphate prodrugs: the role of alkaline phosphatase

scientific article

Indirect regulation of CYP2C19 gene expression via DNA methylation.

scientific article published on 25 August 2017

Influence of mustard group structure on pathways of in vitro metabolism of anticancer N-(2-hydroxyethyl)-3,5-dinitrobenzamide 2-mustard prodrugs

scientific article published on 12 November 2007

Inhibition of mouse and human CYP 1A- and 2E1-dependent substrate metabolism by the isoflavonoids genistein and equol.

scientific article published on May 1998

Inter-individual variation in the metabolic activation of the antimalarial biguanides

scientific article published on May 1991

Intracellular activation of 4-hydroxycyclophosphamide into a DNA-alkylating agent in human leucocytes

scientific article published on 8 September 2021

Is the prevalence of CYP2C19 genetic variants different in Pacific people than in New Zealand Europeans?

scientific article published on 28 May 2010

Leaving group effects in reductively triggered fragmentation of 4-nitrobenzyl carbamates †

scientific article published in 2000

Metabolic activation of the antitumor drug 5-(Aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by NO synthases

scientific article published on 28 March 2008

Metabolism of thalidomide in liver microsomes of mice, rabbits, and humans

scientific article published on 9 April 2004

Metabolomic analysis identifies inflammatory and noninflammatory metabolic effects of genetic modification in a mouse model of Crohn's disease

scientific article published in April 2010

Metabolomic analysis reveals differences in urinary excretion of kiwifruit-derived metabolites in a mouse model of inflammatory bowel disease.

scientific article published on 29 September 2011

Molecular mechanisms of genetic variation and transcriptional regulation of CYP2C19 ⬇️

scientific article published on October 10, 2012

Nontargeted urinary metabolite profiling of a mouse model of Crohn's disease.

scientific article published in April 2009

Omeprazole-induced acute interstitial nephritis is not related to CYP2C19 genotype or CYP2C19 phenotype.

scientific article

Pharmacogenetics of drug-metabolizing enzymes: the prodrug hypothesis.

scientific article published on January 2012

Pharmacogenomics in Papua New Guineans: unique profiles and implications for enhancing drug efficacy while improving drug safety

scientific article published on 01 June 2018

Pheno- or genotype for the CYP2C19 drug metabolism polymorphism: the influence of disease.

scientific article published on January 2008

Preliminary Evidence for Enhanced Thymine Absorption: A Putative New Phenotype Associated With Fluoropyrimidine Toxicity in Cancer Patients

scientific article published on 01 August 2018

Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures.

scientific article published in March 2002

Regulation of cytosolic phospholipase A2 expression by cytokines in human amnion cells

scientific article published on May 1999

Severe 5-Fluorouracil-Associated Gastrointestinal Toxicity Unexplained by Dihydropyrimidine Dehydrogenase Deficiency and Renal Impairment: Should We Be Investigating Other Elimination Pathways to Assess the Risk of 5-Fluorouracil Toxicity?

scientific article published on 27 September 2021

Single-nucleotide polymorphisms and copy number variations of the FCGR2A and FCGR3A genes in healthy Japanese subjects.

scientific article published on 06 December 2013

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes

The Prevalence, Impact, and Risk Factors for Persistent Pain After Breast Cancer Surgery in a New Zealand Population

scientific article published on 01 September 2019

The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism--a panel study

scientific article

The association between heterozygosity for UGT1A1*6, UGT1A1*28, and variation in the serum total-bilirubin level in healthy young Japanese adults

scientific article published on 28 March 2013

The combined impact of CYP2C19 and CYP2B6 pharmacogenetics on cyclophosphamide bioactivation

scientific article published in December 2010

The importance of both CYP2C19 and CYP2B6 germline variations in cyclophosphamide pharmacokinetics and clinical outcomes

scientific article published on 22 July 2019

The importance of correct assignment of CYP2B6 genetic variants with respect to cyclophosphamide metabolizer status ⬇️

scientific article published on 25 March 2011

The isoflavones equol and genistein do not induce xenobiotic-metabolizing enzymes in mouse and in human cells

scientific article published on 01 June 1997

The multiple dose pharmacokinetics of proguanil

scientific article

The pharmacokinetics and activation of proguanil in man: consequences of variability in drug metabolism

scientific article published on October 1990

The preclinical pharmacokinetic disposition of a series of perforin-inhibitors as potential immunosuppressive agents

scientific article published on 26 August 2014

The relative systemic availability of ivermectin after administration as capsule, tablet, and oral solution

scientific article published in January 1988

The role of S-mephenytoin hydroxylase (CYP2C19) in the metabolism of the antimalarial biguanides

scientific article published in April 1995

Towards a test to predict 5-fluorouracil toxicity: Pharmacokinetic data for thymine and two sequential metabolites following oral thymine administration to healthy adult males.

scientific article

Trypanocidal activity of aziridinyl nitrobenzamide prodrugs

scientific article published on 2 August 2010

Unravelling the role of SNM1 in the DNA repair system of Trypanosoma brucei.

scientific article published on 21 March 2015

Using metabolomic analysis to understand inflammatory bowel diseases.

scientific article published on April 2011

Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs

scientific article published on 23 June 2021

Which CYP2B6 Variants Have Functional Consequences for Cyclophosphamide Bioactivation?

scientific article published on 8 December 2011

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