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Authors whose works are in public domain in at least one jurisdiction

List of works by Roberta Fruttero

(Nitrooxyacyloxy)methyl esters of aspirin as novel nitric oxide releasing aspirins

scientific article published in August 2009

1,2,5-Oxadiazole analogues of leflunomide and related compounds

scientific article published on 03 November 2010

13C and 15N solution and solid-state nuclear magnetic resonance study of the intermolecular interactions in the 1 : 1 trimethoprim sulphamethoxazole complex

4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues

scientific article published on May 2010

6-Cyclohexylmethoxy-5-(cyano-NNO-azoxy)pyrimidine-4-amine: a new scaffold endowed with potent CDK2 inhibitory activity

scientific article published on 11 August 2013

A multi-photoresponsive molecular-hybrid for dual-modal photoinactivation of cancer cells

scholarly article in RSC Advances, vol. 4 no. 84, 2014

A new class of NO-donor H3-antagonists

scientific article published in May 2004

A new class of ibuprofen derivatives with reduced gastrotoxicity

scientific article

A new furoxan NO-donor rabeprazole derivative and related compounds

scientific article published in September 2003

A new series of amodiaquine analogues modified in the basic side chain with in vitro antileishmanial and antiplasmodial activity

scientific article published on 15 September 2009

A nitric oxide-donor furoxan moiety improves the efficacy of edaravone against early renal dysfunction and injury evoked by ischemia/reperfusion

scientific article

A novel hybrid aspirin-NO-releasing compound inhibits TNFalpha release from LPS-activated human monocytes and macrophages

scientific article published on 31 July 2008

A rapid screening for cytochrome P450 catalysis on new chemical entities: cytochrome P450 BM3 and 1,2,5-oxadiazole derivatives

scientific article published on 13 September 2012

Acyclic analogs of classical H2-antagonists: synthesis and activity of dialkylamioalkyl substituted ethers and oximes

Amodiaquine analogues containing NO-donor substructures: synthesis and their preliminary evaluation as potential tools in the treatment of cerebral malaria

scientific article published on 22 February 2011

Amphiphilic NO-Donor Antioxidants

scientific article published on 01 February 2007

Antiinflammatory, gastrosparing, and antiplatelet properties of new NO-donor esters of aspirin

scientific article (publication date: 27 February 2003)

Benzofurazanyl- and benzofuroxanyl-1,4-dihydropyridines: synthesis, structure and calcium entry blocker activity

Carnosine analogues containing NO-donor substructures: synthesis, physico-chemical characterization and preliminary pharmacological profile

scientific article published on 2 May 2012

Characterization of a new compound, S35b, as a guanylate cyclase activator in human platelets

scientific article published on 01 March 1992

Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells.

scientific article

Corrigendum: Designing Multitarget Anti-inflammatory Agents: Chemical Modulation of the Lumiracoxib Structure toward Dual Thromboxane Antagonists-COX-2 Inhibitors

scholarly article by Massimo Bertinaria et al published 26 November 2012 in ChemMedChem

Designing multitarget anti-inflammatory agents: chemical modulation of the lumiracoxib structure toward dual thromboxane antagonists-COX-2 inhibitors

scientific article

Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants.

scientific article published in December 2004

Dipole moments and electron distribution of furoxans and furazans

Doxorubicin-antioxidant co-drugs

scientific article published on 8 August 2013

Edaravone derivatives containing NO-donor functions

scientific article

Effect of the leaving group on the electrodic reduction mechanism of anti-Helicobacter pylori metronidazole derivatives, in aprotic and protic media.

scientific article published in June 2004

Electrochemical studies of biologically active arylazoxy compounds. The relationship between redox potentials and molluscicidal activities

Evidence of self-protonation on the electrodic reduction mechanism of an anti-Helicobacter pylori metronidazole isotere

Furazan and furoxan sulfonamides are strong α-carbonic anhydrase inhibitors and potential antiglaucoma agents

scientific article published on 17 June 2014

Furoxan analogues of the histamine H3-receptor antagonist imoproxifan and related furazan derivatives

scientific article published in August 2005

Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds

scientific article published on July 2006

Identification of 2,3-diaminophenazine and of o-benzoquinone dioxime as the major in vitro metabolites of benzofuroxan

scientific article

In vitro pharmacological evaluation of multitarget agents for thromboxane prostanoid receptor antagonism and COX-2 inhibition.

scientific article

Inhibition of human alpha-, beta- and gamma-thrombin by mono-, bis-, tris- and tetra-benzamidine structures: thermodynamic study

scientific article published in January 1992

Ionic Partition Diagram of the Zwitterionic Antihistamine Cetirizine

Leishmanicidal activities of novel synthetic furoxan and benzofuroxan derivatives

scientific article

Lipophilicity behaviour of the Zwitterionic antihistamine cetirizine in phosphatidylcholine liposomes/water systems

scientific article

Liposomal nitrooxy-doxorubicin: one step over caelyx in drug-resistant human cancer cells

scientific article

Liposome/water lipophilicity: methods, information content, and pharmaceutical applications

scientific article

Mechanism of action of novel NO-releasing furoxan derivatives of aspirin in human platelets

scientific article (publication date: June 2006)

Mesomeric dipole moments. Part 12

Michael addition of Grignard reagents to tetraethyl ethenylidenebisphosphonate

article

Mitochondrial-targeting nitrooxy-doxorubicin: a new approach to overcome drug resistance

scientific article published on 7 December 2012

Molecular factors influencing retention on immobilized artifical membranes (IAM) compared to partitioning in liposomes and n-octanol

scientific article

Molecular-Dynamics and NMR Investigation of the Property Space of the Zwitterionic Antihistamine Cetirizine

Multitarget drugs: Focus on the NO-donor hybrid drugs

Multitarget drugs: synthesis and preliminary pharmacological characterization of zileuton analogues endowed with Dual 5-LO inhibitor and NO-dependent activities

scientific article published on September 2010

N-Substituted analogues of S-nitroso-N-acetyl-D,L-penicillamine: chemical stability and prolonged nitric oxide mediated vasodilatation in isolated rat femoral arteries

scientific article published in February 1999

NO donor and biological properties of different benzofuroxans

scientific article published in June 1999

NO release regulated by doxorubicin as the green light-harvesting antenna

scientific article published on 21 May 2020

NO-Donor COX-2 Inhibitors. New Nitrooxy-Substituted 1,5-Diarylimidazoles Endowed with COX-2 Inhibitory and Vasodilator Properties

scientific article published on 03 March 2007

NO-Donor Phenols: A New Class of Products Endowed with Antioxidant and Vasodilator Properties

scientific article published on 01 May 2006

NO-donor melatonin derivatives: synthesis and in vitro pharmacological characterization

scientific article published on 01 April 2007

NO-donor thiacarbocyanines as multifunctional agents for Alzheimer's disease

scientific article published on 3 June 2015

New 1,4-dihydropyridines endowed with NO-donor and calcium channel agonist properties

scientific article published on May 2004

New Nitric Oxide or Hydrogen Sulfide Releasing Aspirins

scientific article published on 06 July 2011

New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold

scientific article published on 03 January 2012

New potential uroselective NO-donor alpha1-antagonists

scientific article published in August 2003

New praziquantel derivatives containing NO-donor furoxans and related furazans as active agents against Schistosoma mansoni

scientific article

New tetrahydroisoquinoline-based P-glycoprotein modulators: decoration of the biphenyl core gives selective ligands

scientific article published on 03 April 2018

Nicorandil analogues containing NO-donor furoxans and related furazans

scientific article

Nitric Oxide Donor β2-Agonists: Furoxan Derivatives Containing the Fenoterol Moiety and Related Furazans

scientific article published on 11 September 2007

Nitric oxide donor doxorubicins accumulate into Doxorubicin-resistant human colon cancer cells inducing cytotoxicity

scientific article published on 4 April 2011

Nitroanilines are the reduction products of benzofuroxan system by oxyhemoglobin (HbO2 2+).

scientific article published in October 2001

Nitrooxyacyl derivatives of salicylic acid: aspirin-like molecules that covalently inactivate cyclooxygenase-1.

scientific article published on 5 January 2011

Nitrooxymethyl-substituted analogues of celecoxib: synthesis and pharmacological characterization

scientific article published in March 2009

Nitrooxymethyl-substituted analogues of rofecoxib: synthesis and pharmacological characterization

scientific article published in May 2010

No-Mimetic Furoxans: Arylsulphonylfuroxans and Related Compounds

scientific article published on 01 October 1993

Non-imidazole histamine NO-donor H3-antagonists

scientific article published in June 2005

Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents.

scientific article published on 16 January 2013

Novel antioxidant agents deriving from molecular combination of Vitamin C and NO-donor moieties

scientific article

Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors

scientific article

On the self-condensation of aminoguanidine leading to 1,1,4,10,10-pentaamino-2,3,5,6,8,9-hexaazadeca-1,3,5,7,9-pentaene (structure elucidation through X-ray powder diffraction)

Oximation of acetyl(hydroxyimino)acetone: nuclear magnetic resonance spectroscopic, chemical, and X-ray crystallographic studies of the reaction products

Phenylsulfonylfuroxans as modulators of multidrug-resistance-associated protein-1 and P-glycoprotein

scientific article published on August 2010

Physicochemical Profiling of Sartans: A Detailed Study of Ionization Constants and Distribution Coefficients

Physicochemical profile and in vitro permeation behavior of a new class of non-steroidal anti-inflammatory drug candidates

scientific article published on 25 March 2010

Platelet antiaggregatory effects and haemodynamic activity of two terfuroxan isomer pairs

scientific article

Reversed-phase high-performance liquid chromatographic study of the lipophilicity of a series of analogues of the antibiotic “calvatic acid”

S35b, a new phenylsulfonylfuroxan compound, inhibits thrombin-induced synthesis of platelet-activating factor and prostacyclin in human endothelial cells

scientific article published on 01 November 1993

Searching for balanced hybrid NO-donor 1,4-dihydropyridines with basic properties.

scientific article

Searching for new NO-donor aspirin-like molecules: Furoxanylacyl derivatives of salicylic acid and related furazans

scientific article published on 16 August 2011

Searching for new NO-donor aspirin-like molecules: a new class of nitrooxy-acyl derivatives of salicylic acid

scientific article

Structural investigation of Ca 2+ antagonists benzofurazanyl and benzofuroxanyl-1,4-dihydropyridines

Structure-Property Relationships in the Basicity and Lipophilicity of Arylalkylamine Oxides

Structure-antioxidant activity relationships in a series of NO-donor phenols

scientific article published in September 2008

Studies of the potential genotoxic effects of furoxans: the case of CAS 1609 and of the water-soluble analogue of CHF 2363.

scientific article published on 13 February 2008

Studies on agents with mixed NO-dependent and calcium channel antagonistic vasodilating activities.

scientific article published in February 2001

Studies on agents with mixed NO-dependent vasodilating and beta-blocking activities

scientific article published in December 1997

Synthesis and Biological Evaluation of N(2) -Substituted 2,4-Diamino-6-cyclohexylmethoxy-5-nitrosopyrimidines and Related 5-Cyano-NNO-azoxy Derivatives as Cyclin-Dependent Kinase 2 (CDK2) Inhibitors

scientific article

Synthesis and Biological Evaluation of the First Example of NO-Donor Histone Deacetylase Inhibitor

scientific article

Synthesis and anti-Helicobacter pylori properties of NO-donor/metronidazole hybrids and related compounds

Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy)pyrazole derivatives

scientific article published on 05 April 2011

Synthesis and preliminary biological profile of new NO-donor tolbutamide analogues

scientific article published on 11 April 2012

Synthesis and preliminary pharmacological characterisation of a new class of nitrogen-containing bisphosphonates (N-BPs).

scientific article published in March 2010

Synthesis and vasodilating properties of N-alkylamide derivatives of 4-amino-3-furoxancarboxylic acid and related azo derivatives.

scientific article published in September 2003

Synthesis and voltage-clamp studies of methyl 1,4-dihydro-2, 6-dimethyl-5-nitro-4-(benzofurazanyl)pyridine-3-carboxylate racemates and enantiomers and of their benzofuroxanyl analogues.

scientific article published on April 1999

Synthesis of NO-donor bisphosphonates and their in-vitro action on bone resorption.

scientific article published on March 2005

Synthesis of new bicyclic analogues of glutamic acid

Synthesis of some novel organic nitrates and comparative in vitro study of their vasodilator profile

scientific article

Synthesis physicochemical profile and PAMPA study of new NO-donor edaravone co-drugs

scientific article published on 08 December 2011

Synthesis, Physicochemical Characterization, and Biological Activities of New Carnosine Derivatives Stable in Human Serum As Potential Neuroprotective Agents

scientific article published on 23 December 2010

Synthesis, chiral HPLC resolution and configuration assignment of 1-phenylglyceryl trinitrate stereomers

scientific article published on 01 June 2006

The Furoxan System: Design of Selective Nitric Oxide (NO) Donor Inhibitors of COX-2 Endowed with Anti-Aggregatory and Vasodilating Activities

scientific article published on 01 July 2005

The Lipophilicity Behavior of Three Catechol-O-methyltransferase (COMT) Inhibitors and Simple Analogues

scientific article (publication date: 2006)

The relationship between redox potentials and substituent constants in biologically active arylazoxy compounds

The role of fluorine in stabilizing the bioactive conformation of dihydroorotate dehydrogenase inhibitors ⬇️

scientific article published on November 10, 2012

Thermolysis of 4-(2-azido-3-nitrophenyl)-1,4-dihydropyridines as source of β-carboline derivatives and some related compounds

Thymopentin down-regulates both activity and expression of iNOS in blood cells of Sézary syndrome patients

scientific article published on 18 June 2012

Tuning the Hydrophobicity of a Mitochondria-Targeted NO Photodonor

scientific article published on 08 May 2018

Unsymmetrically substituted furoxans. Part 19. Methyl and phenylfuroxansulfonic acids and related sulfonamides

Water Soluble Furoxan Derivatives as NO Prodrugs

scientific article published on 01 February 1997

Water-Soluble Nitric-Oxide-Releasing Acetylsalicylic Acid (ASA) Prodrugs

scientific article published on 10 June 2013

[3-(1H-imidazol-4-yl)propyl]guanidines containing furoxan moieties: a new class of H3-antagonists endowed with NO-donor properties

scientific article published in April 2003

α1-Adrenoceptor Blocking Activity of Some Ring-open Analogues of Prazosin

scientific article published on 01 October 1994

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