List of works - László Csanády

A new target for G protein signaling.

scientific article published on 11 September 2017

A novel kinetic assay of mitochondrial ATP-ADP exchange rate mediated by the ANT.

scientific article published on March 2009

A single active catalytic site is sufficient to promote transport in P-glycoprotein

scientific article published on 27 April 2016

Antagonistic regulation of native Ca2+- and ATP-sensitive cation channels in brain capillaries by nucleotides and decavanadate

scientific article published on June 2004

Application of rate-equilibrium free energy relationship analysis to nonequilibrium ion channel gating mechanisms

scientific article published on August 2009

Asymmetry of movements in CFTR's two ATP sites during pore opening serves their distinct functions.

scientific article published on 25 September 2017

CFTR channel gating: incremental progress in irreversible steps.

scientific article

CFTR gating: Invisible transitions made visible

scientific article published on 6 March 2017

Ca(2+)- and voltage-dependent gating of Ca(2+)- and ATP-sensitive cationic channels in brain capillary endothelium.

scientific article published on July 2003

Catalyst-like modulation of transition states for CFTR channel opening and closing: new stimulation strategy exploits nonequilibrium gating

scientific article published on 13 January 2014

Conformational changes in the catalytically inactive nucleotide-binding site of CFTR.

scientific article published on 10 June 2013

Cystic fibrosis drug ivacaftor stimulates CFTR channels at picomolar concentrations

scientific article published on 17 June 2019

Degenerate ABC composite site is stably glued together by trapped ATP.

scientific article published on May 2010

Electrophysiological, biochemical, and bioinformatic methods for studying CFTR channel gating and its regulation

scientific article published in January 2011

Enzyme activity and selectivity filter stability of ancient TRPM2 channels were simultaneously lost in early vertebrates

scientific article published on 02 April 2019

Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate

scientific article

Functional roles of nonconserved structural segments in CFTR's NH2-terminal nucleotide binding domain

scientific article

Identification of direct and indirect effectors of the transient receptor potential melastatin 2 (TRPM2) cation channel.

scientific article published on 22 July 2010

Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response to ATP binding at NBD2 ⬇️

scientific article published on October 1, 2010

Ion channels as targets to treat cystic fibrosis lung disease.

scientific article published on 25 October 2017

Mitoxantrone is expelled by the ABCG2 multidrug transporter directly from the plasma membrane.

scientific article published on 4 August 2010

Molecular Structure of the Human CFTR Ion Channel.

scientific article published on March 2017

Mutant cycles at CFTR's non-canonical ATP-binding site support little interface separation during gating ⬇️

scientific article

Obligate coupling of CFTR pore opening to tight nucleotide-binding domain dimerization

scientific article

Permeating proton found guilty in compromising TRPM2 channel activity

scientific article published on 01 May 2010

Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents

scientific article

Preferential phosphorylation of R-domain Serine 768 dampens activation of CFTR channels by PKA.

scientific article

Putative chanzyme activity of TRPM2 cation channel is unrelated to pore gating

scientific article

Rapid kinetic analysis of multichannel records by a simultaneous fit to all dwell-time histograms

scientific article

Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP-ribose-2'-phosphate.

scientific article

STRUCTURE, GATING, AND REGULATION OF THE CFTR ANION CHANNEL

scientific article published on 01 January 2019

Severed channels probe regulation of gating of cystic fibrosis transmembrane conductance regulator by its cytoplasmic domains

scientific article

Severed molecules functionally define the boundaries of the cystic fibrosis transmembrane conductance regulator's NH(2)-terminal nucleotide binding domain

scientific article

Simple binding of protein kinase A prior to phosphorylation allows CFTR anion channels to be opened by nucleotides

scientific article published on 17 August 2020

Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations.

scientific article

Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation.

scientific article

Structure-activity analysis of a CFTR channel potentiator: Distinct molecular parts underlie dual gating effects

scientific article

The ABC protein turned chloride channel whose failure causes cystic fibrosis

scientific article

The N-terminal transmembrane domain (TMD0) and a cytosolic linker (L0) of sulphonylurea receptor define the unique intrinsic gating of KATP channels

scientific article published on 3 August 2006

The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity

scientific journal article

The twain shall meet: channels, transporters and things between. Meeting on Membrane Transport in Flux: the Ambiguous Interface Between Channels and Pumps.

scientific article published on 5 September 2008

Thermodynamics of CFTR channel gating: a spreading conformational change initiates an irreversible gating cycle

scientific article

Timing of CFTR pore opening and structure of its transition state.

scientific article published on 22 October 2015

List of works by László Csanády

A new target for G protein signaling.

A novel kinetic assay of mitochondrial ATP-ADP exchange rate mediated by the ANT.

A single active catalytic site is sufficient to promote transport in P-glycoprotein

Antagonistic regulation of native Ca2+- and ATP-sensitive cation channels in brain capillaries by nucleotides and decavanadate

Application of rate-equilibrium free energy relationship analysis to nonequilibrium ion channel gating mechanisms

Asymmetry of movements in CFTR's two ATP sites during pore opening serves their distinct functions.

CFTR channel gating: incremental progress in irreversible steps.

CFTR gating: Invisible transitions made visible

Ca(2+)- and voltage-dependent gating of Ca(2+)- and ATP-sensitive cationic channels in brain capillary endothelium.

Catalyst-like modulation of transition states for CFTR channel opening and closing: new stimulation strategy exploits nonequilibrium gating

Conformational changes in the catalytically inactive nucleotide-binding site of CFTR.

Cystic fibrosis drug ivacaftor stimulates CFTR channels at picomolar concentrations

Degenerate ABC composite site is stably glued together by trapped ATP.

Electrophysiological, biochemical, and bioinformatic methods for studying CFTR channel gating and its regulation

Enzyme activity and selectivity filter stability of ancient TRPM2 channels were simultaneously lost in early vertebrates

Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate

Functional roles of nonconserved structural segments in CFTR's NH2-terminal nucleotide binding domain

Identification of direct and indirect effectors of the transient receptor potential melastatin 2 (TRPM2) cation channel.

Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response to ATP binding at NBD2 ⬇️

Ion channels as targets to treat cystic fibrosis lung disease.

Mitoxantrone is expelled by the ABCG2 multidrug transporter directly from the plasma membrane.

Molecular Structure of the Human CFTR Ion Channel.

Mutant cycles at CFTR's non-canonical ATP-binding site support little interface separation during gating ⬇️

Obligate coupling of CFTR pore opening to tight nucleotide-binding domain dimerization

Permeating proton found guilty in compromising TRPM2 channel activity

Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents

Preferential phosphorylation of R-domain Serine 768 dampens activation of CFTR channels by PKA.

Putative chanzyme activity of TRPM2 cation channel is unrelated to pore gating

Rapid kinetic analysis of multichannel records by a simultaneous fit to all dwell-time histograms

Ruling out pyridine dinucleotides as true TRPM2 channel activators reveals novel direct agonist ADP-ribose-2'-phosphate.

STRUCTURE, GATING, AND REGULATION OF THE CFTR ANION CHANNEL

Severed channels probe regulation of gating of cystic fibrosis transmembrane conductance regulator by its cytoplasmic domains

Severed molecules functionally define the boundaries of the cystic fibrosis transmembrane conductance regulator's NH(2)-terminal nucleotide binding domain

Simple binding of protein kinase A prior to phosphorylation allows CFTR anion channels to be opened by nucleotides

Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations.

Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation.

Structure-activity analysis of a CFTR channel potentiator: Distinct molecular parts underlie dual gating effects

The ABC protein turned chloride channel whose failure causes cystic fibrosis

The N-terminal transmembrane domain (TMD0) and a cytosolic linker (L0) of sulphonylurea receptor define the unique intrinsic gating of KATP channels

The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity

The twain shall meet: channels, transporters and things between. Meeting on Membrane Transport in Flux: the Ambiguous Interface Between Channels and Pumps.

Thermodynamics of CFTR channel gating: a spreading conformational change initiates an irreversible gating cycle

Timing of CFTR pore opening and structure of its transition state.