List of works - Vincent Courdavault

A BAHD acyltransferase catalyzing 19-O-acetylation of tabersonine derivatives in roots of Catharanthus roseus enables combinatorial synthesis of monoterpene indole alkaloids.

scientific article published on 13 February 2018

A Biolistic-Mediated Virus-Induced Gene Silencing in Apocynaceae to Map Biosynthetic Pathways of Alkaloids

scientific article published on 01 January 2020

A TRP5/5-fluoroanthranilic acid counter-selection system for gene disruption in Candida guilliermondii.

scientific article published on 23 May 2012

A look inside an alkaloid multisite plant: the Catharanthus logistics.

scientific article published on 13 April 2014

A microbial supply chain for production of the anti-cancer drug vinblastine

scientific article published in 2022

A new series of vectors for constitutive, inducible or repressible gene expression in Candida guilliermondii.

scientific article published on 5 April 2014

A pair of tabersonine 16-hydroxylases initiates the synthesis of vindoline in an organ-dependent manner in Catharanthus roseus

scientific article published on 9 October 2013

A single gene encodes isopentenyl diphosphate isomerase isoforms targeted to plastids, mitochondria and peroxisomes in Catharanthus roseus.

scientific article published on 26 May 2012

A standardized toolkit for genetic engineering of CTG clade yeasts.

scientific article

A synthetic construct for genetic engineering of the emerging pathogenic yeast Candida auris

scientific article published on 20 November 2017

A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate.

scientific article

A type-B response regulator drives the expression of the hydroxymethylbutenyl diphosphate synthase gene in periwinkle

scientific article published on 11 August 2012

ALSV-Based Virus-Induced Gene Silencing in Apple Tree (Malus × domestica L.).

scientific article published on 01 January 2020

An NPF transporter exports a central monoterpene indole alkaloid intermediate from the vacuole.

scientific article published on 13 January 2017

An additional Meyerozyma guilliermondii IMH3 gene confers mycophenolic acid resistance in fungal CTG clade species.

scientific article published on 11 September 2016

An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis

scientific article

Antifungal activity of resveratrol derivatives against Candida species

scientific article published on 11 July 2014

Beyond the semi-synthetic artemisinin: metabolic engineering of plant-derived anti-cancer drugs

scientific article published on 13 December 2019

Biosynthetic Origin of E-Resveratrol Accumulation in Grape Canes during Postharvest Storage

scientific article published on 28 January 2015

Biotechnological potential of the fungal CTG clade species in the synthetic biology era.

scientific article

CHASE-Containing Histidine Kinase Receptors in Apple Tree: From a Common Receptor Structure to Divergent Cytokinin Binding Properties and Specific Functions.

scientific article published on 20 September 2017

CaaX-prenyltransferases are essential for expression of genes involvedin the early stages of monoterpenoid biosynthetic pathway in Catharanthus roseus cells.

scientific article published on April 2005

Candida guilliermondii: biotechnological applications, perspectives for biological control, emerging clinical importance and recent advances in genetics.

scientific article published on 25 April 2013

Cellular and Subcellular Compartmentation of the 2C-Methyl-D-Erythritol 4-Phosphate Pathway in the Madagascar Periwinkle

scientific article published on 07 April 2020

Characterization and subcellular localization of geranylgeranyl diphosphate synthase from Catharanthus roseus

scientific article published on 25 June 2011

Characterization of a second secologanin synthase isoform producing both secologanin and secoxyloganin allows enhanced de novo assembly of a Catharanthus roseus transcriptome. ⬇️

scientific article published on 19 August 2015

Characterization of a spermidine hydroxycinnamoyltransferase in Malus domestica highlights the evolutionary conservation of trihydroxycinnamoyl spermidines in pollen coat of core Eudicotyledons.

scientific article published on 12 September 2015

Characterization of an autonomously replicating sequence in Candida guilliermondii

scientific article published on 30 May 2013

Characterization of histidine-aspartate kinase HK1 and identification of histidine phosphotransfer proteins as potential partners in a Populus multistep phosphorelay.

scientific article

Characterization of the plastidial geraniol synthase from Madagascar periwinkle which initiates the monoterpenoid branch of the alkaloid pathway in internal phloem associated parenchyma

scientific article published on 24 October 2012

Chromosome-scale genomes throw light on plant drug biosynthesis

scientific article published in 2022

Class II Cytochrome P450 Reductase Governs the Biosynthesis of Alkaloids.

scientific article published on 29 September 2016

Composition and Tissue-Specific Distribution of Stilbenoids in Grape Canes Are Affected by Downy Mildew Pressure in the Vineyard

scientific article published on 16 September 2015

Cycloheximide as a tool to investigate protein import in peroxisomes: a case study of the subcellular localization of isoprenoid biosynthetic enzymes.

scientific article

Cytokinin and Ethylene Cell Signaling Pathways from Prokaryotes to Eukaryotes

scientific article published on 23 November 2020

De novo production of the plant-derived alkaloid strictosidine in yeast

scientific article

Deus ex Candida genetics: overcoming the hurdles for the development of a molecular toolbox in the CTG clade.

scientific article published on 27 January 2012

Developmental Methylome of the Medicinal Plant Catharanthus roseus Unravels the Tissue-Specific Control of the Monoterpene Indole Alkaloid Pathway by DNA Methylation

scientific article published on 21 August 2020

Discovery of a P450-catalyzed step in vindoline biosynthesis: a link between the aspidosperma and eburnamine alkaloids

scientific article published on 01 May 2015

Disrupting the methionine biosynthetic pathway in Candida guilliermondii: characterization of the MET2 gene as counter-selectable marker.

scientific article published on 24 April 2014

Disruption of Protein Mannosylation Affects Candida guilliermondii Cell Wall, Immune Sensing, and Virulence

scientific article (publication date: 2016)

Diversity and Evolution of Sensor Histidine Kinases in Eukaryotes

scientific article published on 01 January 2019

Drug-resistant cassettes for the efficient transformation of Candida guilliermondii wild-type strains.

scientific article published on 9 May 2011

Efficient gene targeting in a Candida guilliermondii non-homologous end-joining pathway-deficient strain

scientific article published on 5 March 2013

Emerging and emerged pathogenic Candida species: beyond the Candida albicans paradigm

scientific article

Engineered Microbes for Anticholinergics Production

scientific article published on 20 November 2020

Epidermis is a pivotal site of at least four secondary metabolic pathways in Catharanthus roseus aerial organs.

scientific article published on 2 December 2005

Field-Based Metabolomics of Vitis vinifera L. Stems Provides New Insights for Genotype Discrimination and Polyphenol Metabolism Structuring.

scientific article

Fluorescent protein fusions in Candida guilliermondii.

scientific article published on 23 July 2011

Folivory elicits a strong defense reaction in Catharanthus roseus: metabolomic and transcriptomic analyses reveal distinct local and systemic responses

scientific article published on 17 January 2017

Functional Divergence of Poplar Histidine-Aspartate Kinase HK1 Paralogs in Response to Osmotic Stress.

scientific article

Genome-wide identification and biochemical characterization of the UGT88F subfamily in Malus x domestica Borkh

scientific article published on 03 November 2018

Group X hybrid histidine kinase Chk1 is dispensable for stress adaptation, host-pathogen interactions and virulence in the opportunistic yeast Candida guilliermondii.

scientific article published on 09 May 2017

Hybrid histidine kinases in pathogenic fungi

scientific article

Identification of five B-type response regulators as members of a multistep phosphorelay system interacting with histidine-containing phosphotransfer partners of Populus osmosensor.

scientific article

Identifying Genes Involved in alkaloid Biosynthesis in <i>Vinca minor</i> Through Transcriptomics and Gene Co-Expression Analysis

scientific article published on 24 November 2020

Identifying Missing Biosynthesis Enzymes of Plant Natural Products

scientific article published on 21 January 2020

Illuminating fungal infections with bioluminescence.

scientific article

Improved gene co-expression network quality through expression dataset down-sampling and network aggregation

scientific article published on 08 October 2019

Innovative Tools and Strategies for Optimizing Yeast Cell Factories

scientific article published on 29 September 2020

Insights into B-type RR members as signaling partners acting downstream of HPt partners of HK1 in the osmotic stress response in Populus.

scientific article

Isolation of a cDNA encoding the alpha-subunit of CAAX-prenyltransferases from Catharanthus roseus and the expression of the active recombinant protein farnesyltransferase

scientific article published on January 2005

Mechanical stress rapidly induces E-resveratrol and E-piceatannol biosynthesis in grape canes stored as a freshly-pruned byproduct

scientific article

Megaviruses: An involvement in phytohormone receptor gene transfer in brown algae?

scientific article published on 19 April 2019

Metabolic engineering for plant natural products biosynthesis: new procedures, concrete achievements and remaining limits

scientific article published in 2021

Microbial cell factories for tetrahydroisoquinoline alkaloids production

scientific article published on 22 September 2020

Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle.

scientific article published on 3 May 2018

Molecular cloning and characterisation of two calmodulin isoforms of the Madagascar periwinkle Catharanthus roseus.

scientific article published on January 2011

Molecular cloning and functional characterization of Catharanthus roseus hydroxymethylbutenyl 4-diphosphate synthase gene promoter from the methyl erythritol phosphate pathway.

scientific article published on 13 December 2011

Molecular evolution of parsnip (Pastinaca sativa) membrane-bound prenyltransferases for linear and/or angular furanocoumarin biosynthesis ⬇️

scientific article published on 25 February 2016

New Insight into HPts as Hubs in Poplar Cytokinin and Osmosensing Multistep Phosphorelays: Cytokinin Pathway Uses Specific HPts

scientific article published on 11 December 2019

Optimization of the URA-blaster disruption system in Candida guilliermondii: efficient gene targeting using the URA3 marker.

scientific article published on 3 August 2012

Optimization of the transient transformation of Catharanthus roseus cells by particle bombardment and its application to the subcellular localization of hydroxymethylbutenyl 4-diphosphate synthase and geraniol 10-hydroxylase.

scientific article

Peroxisomal localisation of the final steps of the mevalonic acid pathway in planta

scientific article published on 8 June 2011

Phytochemical genomics of the Madagascar periwinkle: Unravelling the last twists of the alkaloid engine.

scientific article

Postharvest Treatment of Wood Biomass from a Large Collection of European Grape Varieties: Impact on the Selection of Polyphenol-Rich Byproducts

scientific article published in 2021

Prenylated Proteins Are Required for Methyl-Jasmonate-Induced Monoterpenoid Indole Alkaloids Biosynthesis in Catharanthus roseus

Proteins prenylated by type I protein geranylgeranyltransferase act positively on the jasmonate signalling pathway triggering the biosynthesis of monoterpene indole alkaloids in Catharanthus roseus.

scientific article published on 24 September 2008

Puzzling Out the Colchicine Biosynthetic Pathway

scientific article published on 09 November 2020

Ranking genome-wide correlation measurements improves microarray and RNA-seq based global and targeted co-expression networks

scientific article published on 18 July 2018

Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes

scientific article published on 25 June 2018

Setting-up a fast and reliable cytokinin biosensor based on a plant histidine kinase receptor expressed in Saccharomyces cerevisiae

scientific article published on 20 November 2018

Spatial distribution and hormonal regulation of gene products from methyl erythritol phosphate and monoterpene-secoiridoid pathways in Catharanthus roseus.

scientific article

Spatial organization of the vindoline biosynthetic pathway in Catharanthus roseus

scientific article published on 2 November 2010

Strictosidine activation in Apocynaceae: towards a "nuclear time bomb"? ⬇️

scientific article

Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity

scientific article published on 15 July 2016

Subcellular evidence for the involvement of peroxisomes in plant isoprenoid biosynthesis.

scientific article published on December 2011

Subcellular localization of the histidine kinase receptors Sln1p, Nik1p and Chk1p in the yeast CTG clade species Candida guilliermondii.

scientific article published on 8 February 2014

Synthesis of (-)-Melodinine K: A Case Study of Efficiency in Natural Product Synthesis

scientific article published on 29 July 2020

The <i>Vinca minor</i> genome highlights conserved evolutionary traits in monoterpene indole alkaloid synthesis

scientific article published in 2022

The Identification of Phytohormone Receptor Homologs in Early Diverging Fungi Suggests a Role for Plant Sensing in Land Colonization by Fungi

scientific article published on 31 January 2017

The subcellular localization of periwinkle farnesyl diphosphate synthase provides insight into the role of peroxisome in isoprenoid biosynthesis.

scientific article published on 27 August 2011

The subcellular organization of strictosidine biosynthesis in Catharanthus roseus epidermis highlights several trans-tonoplast translocations of intermediate metabolites.

scientific article published on 12 January 2011

Towards the Microbial Production of Plant-Derived Anticancer Drugs

scientific article published on 05 March 2020

Tracking the Origin and Evolution of Plant Metabolites

scientific article published on 04 September 2020

Transformation of Candida guilliermondii wild-type strains using the Staphylococcus aureus MRSA 252 ble gene as a phleomycin-resistant marker

scientific article published on 28 February 2013

Triple subcellular targeting of isopentenyl diphosphate isomerases encoded by a single gene

scientific article published on 5 September 2012

Turning up the Green Light

scientific article published on 29 December 2020

Two Tabersonine 6,7-Epoxidases Initiate Lochnericine-Derived Alkaloid Biosynthesis in ⬇️

scientific article published on 22 June 2018

Unlocking the diversity of alkaloids in Catharanthus roseus: nuclear localization suggests metabolic channeling in secondary metabolism

scientific article published on 12 March 2015

Vacuole-Targeted Proteins: Ins and Outs of Subcellular Localization Studies

scientific article published on 01 January 2018

Vineyard evaluation of stilbenoid-rich grape cane extracts against downy mildew: a large-scale study

scientific article published on 19 November 2018

Virus-Induced Gene Silencing: Hush Genes to Make Them Talk

scientific article published on 17 March 2020

Virus-induced gene silencing in Rauwolfia species.

scientific article published on 24 January 2017

Virus-induced gene silencing of the two squalene synthase isoforms of apple tree (Malus × domestica L.) negatively impacts phytosterol biosynthesis, plastid pigmentation and leaf growth

scientific article published on 27 March 2017

ZCT1 and ZCT2 transcription factors repress the activity of a gene promoter from the methyl erythritol phosphate pathway in Madagascar periwinkle cells.

scientific article published on 23 July 2014

[Towards bioproduction of anticancer drugs by yeast]

scientific article published on 22 May 2019

List of works by Vincent Courdavault

A BAHD acyltransferase catalyzing 19-O-acetylation of tabersonine derivatives in roots of Catharanthus roseus enables combinatorial synthesis of monoterpene indole alkaloids.

A Biolistic-Mediated Virus-Induced Gene Silencing in Apocynaceae to Map Biosynthetic Pathways of Alkaloids

A TRP5/5-fluoroanthranilic acid counter-selection system for gene disruption in Candida guilliermondii.

A look inside an alkaloid multisite plant: the Catharanthus logistics.

A microbial supply chain for production of the anti-cancer drug vinblastine

A new series of vectors for constitutive, inducible or repressible gene expression in Candida guilliermondii.

A pair of tabersonine 16-hydroxylases initiates the synthesis of vindoline in an organ-dependent manner in Catharanthus roseus

A single gene encodes isopentenyl diphosphate isomerase isoforms targeted to plastids, mitochondria and peroxisomes in Catharanthus roseus.

A standardized toolkit for genetic engineering of CTG clade yeasts.

A synthetic construct for genetic engineering of the emerging pathogenic yeast Candida auris

A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate.

A type-B response regulator drives the expression of the hydroxymethylbutenyl diphosphate synthase gene in periwinkle

ALSV-Based Virus-Induced Gene Silencing in Apple Tree (Malus × domestica L.).

An NPF transporter exports a central monoterpene indole alkaloid intermediate from the vacuole.

An additional Meyerozyma guilliermondii IMH3 gene confers mycophenolic acid resistance in fungal CTG clade species.

An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis

Antifungal activity of resveratrol derivatives against Candida species

Beyond the semi-synthetic artemisinin: metabolic engineering of plant-derived anti-cancer drugs

Biosynthetic Origin of E-Resveratrol Accumulation in Grape Canes during Postharvest Storage

Biotechnological potential of the fungal CTG clade species in the synthetic biology era.

CHASE-Containing Histidine Kinase Receptors in Apple Tree: From a Common Receptor Structure to Divergent Cytokinin Binding Properties and Specific Functions.

CaaX-prenyltransferases are essential for expression of genes involvedin the early stages of monoterpenoid biosynthetic pathway in Catharanthus roseus cells.

Candida guilliermondii: biotechnological applications, perspectives for biological control, emerging clinical importance and recent advances in genetics.

Cellular and Subcellular Compartmentation of the 2C-Methyl-D-Erythritol 4-Phosphate Pathway in the Madagascar Periwinkle

Characterization and subcellular localization of geranylgeranyl diphosphate synthase from Catharanthus roseus

Characterization of a second secologanin synthase isoform producing both secologanin and secoxyloganin allows enhanced de novo assembly of a Catharanthus roseus transcriptome. ⬇️

Characterization of a spermidine hydroxycinnamoyltransferase in Malus domestica highlights the evolutionary conservation of trihydroxycinnamoyl spermidines in pollen coat of core Eudicotyledons.

Characterization of an autonomously replicating sequence in Candida guilliermondii

Characterization of histidine-aspartate kinase HK1 and identification of histidine phosphotransfer proteins as potential partners in a Populus multistep phosphorelay.

Characterization of the plastidial geraniol synthase from Madagascar periwinkle which initiates the monoterpenoid branch of the alkaloid pathway in internal phloem associated parenchyma

Chromosome-scale genomes throw light on plant drug biosynthesis

Class II Cytochrome P450 Reductase Governs the Biosynthesis of Alkaloids.

Composition and Tissue-Specific Distribution of Stilbenoids in Grape Canes Are Affected by Downy Mildew Pressure in the Vineyard

Cycloheximide as a tool to investigate protein import in peroxisomes: a case study of the subcellular localization of isoprenoid biosynthetic enzymes.

Cytokinin and Ethylene Cell Signaling Pathways from Prokaryotes to Eukaryotes

De novo production of the plant-derived alkaloid strictosidine in yeast

Deus ex Candida genetics: overcoming the hurdles for the development of a molecular toolbox in the CTG clade.

Developmental Methylome of the Medicinal Plant Catharanthus roseus Unravels the Tissue-Specific Control of the Monoterpene Indole Alkaloid Pathway by DNA Methylation

Discovery of a P450-catalyzed step in vindoline biosynthesis: a link between the aspidosperma and eburnamine alkaloids

Disrupting the methionine biosynthetic pathway in Candida guilliermondii: characterization of the MET2 gene as counter-selectable marker.

Disruption of Protein Mannosylation Affects Candida guilliermondii Cell Wall, Immune Sensing, and Virulence

Diversity and Evolution of Sensor Histidine Kinases in Eukaryotes

Drug-resistant cassettes for the efficient transformation of Candida guilliermondii wild-type strains.

Efficient gene targeting in a Candida guilliermondii non-homologous end-joining pathway-deficient strain

Emerging and emerged pathogenic Candida species: beyond the Candida albicans paradigm

Engineered Microbes for Anticholinergics Production

Epidermis is a pivotal site of at least four secondary metabolic pathways in Catharanthus roseus aerial organs.

Field-Based Metabolomics of Vitis vinifera L. Stems Provides New Insights for Genotype Discrimination and Polyphenol Metabolism Structuring.

Fluorescent protein fusions in Candida guilliermondii.

Folivory elicits a strong defense reaction in Catharanthus roseus: metabolomic and transcriptomic analyses reveal distinct local and systemic responses

Functional Divergence of Poplar Histidine-Aspartate Kinase HK1 Paralogs in Response to Osmotic Stress.

Genome-wide identification and biochemical characterization of the UGT88F subfamily in Malus x domestica Borkh

Group X hybrid histidine kinase Chk1 is dispensable for stress adaptation, host-pathogen interactions and virulence in the opportunistic yeast Candida guilliermondii.

Hybrid histidine kinases in pathogenic fungi

Identification of five B-type response regulators as members of a multistep phosphorelay system interacting with histidine-containing phosphotransfer partners of Populus osmosensor.

Identifying Genes Involved in alkaloid Biosynthesis in <i>Vinca minor</i> Through Transcriptomics and Gene Co-Expression Analysis

Identifying Missing Biosynthesis Enzymes of Plant Natural Products

Illuminating fungal infections with bioluminescence.

Improved gene co-expression network quality through expression dataset down-sampling and network aggregation

Innovative Tools and Strategies for Optimizing Yeast Cell Factories

Insights into B-type RR members as signaling partners acting downstream of HPt partners of HK1 in the osmotic stress response in Populus.

Isolation of a cDNA encoding the alpha-subunit of CAAX-prenyltransferases from Catharanthus roseus and the expression of the active recombinant protein farnesyltransferase

Mechanical stress rapidly induces E-resveratrol and E-piceatannol biosynthesis in grape canes stored as a freshly-pruned byproduct

Megaviruses: An involvement in phytohormone receptor gene transfer in brown algae?

Metabolic engineering for plant natural products biosynthesis: new procedures, concrete achievements and remaining limits

Microbial cell factories for tetrahydroisoquinoline alkaloids production

Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle.

Molecular cloning and characterisation of two calmodulin isoforms of the Madagascar periwinkle Catharanthus roseus.

Molecular cloning and functional characterization of Catharanthus roseus hydroxymethylbutenyl 4-diphosphate synthase gene promoter from the methyl erythritol phosphate pathway.

Molecular evolution of parsnip (Pastinaca sativa) membrane-bound prenyltransferases for linear and/or angular furanocoumarin biosynthesis ⬇️

New Insight into HPts as Hubs in Poplar Cytokinin and Osmosensing Multistep Phosphorelays: Cytokinin Pathway Uses Specific HPts

Optimization of the URA-blaster disruption system in Candida guilliermondii: efficient gene targeting using the URA3 marker.

Optimization of the transient transformation of Catharanthus roseus cells by particle bombardment and its application to the subcellular localization of hydroxymethylbutenyl 4-diphosphate synthase and geraniol 10-hydroxylase.

Peroxisomal localisation of the final steps of the mevalonic acid pathway in planta

Phytochemical genomics of the Madagascar periwinkle: Unravelling the last twists of the alkaloid engine.

Postharvest Treatment of Wood Biomass from a Large Collection of European Grape Varieties: Impact on the Selection of Polyphenol-Rich Byproducts

Prenylated Proteins Are Required for Methyl-Jasmonate-Induced Monoterpenoid Indole Alkaloids Biosynthesis in Catharanthus roseus

Proteins prenylated by type I protein geranylgeranyltransferase act positively on the jasmonate signalling pathway triggering the biosynthesis of monoterpene indole alkaloids in Catharanthus roseus.

Puzzling Out the Colchicine Biosynthetic Pathway