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List of works by Cem Akin

17-Allylamino-17-demethoxygeldanamycin (17-AAG) is effective in down-regulating mutated, constitutively activated KIT protein in human mast cells

scientific article published on 9 October 2003

A clinicopathologic study of 24 cases of systemic mastocytosis involving the gastrointestinal tract and assessment of mucosal mast cell density in irritable bowel syndrome and asymptomatic patients

scientific article

A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib

scientific article published on 24 December 2003

A pilot study of nonmyeloablative allogeneic hematopoietic stem cell transplant for advanced systemic mastocytosis

scientific article published on 01 February 2006

Activity of imatinib in systemic mastocytosis with chronic basophilic leukemia and a PRKG2-PDGFRB fusion

scientific article published in January 2008

Advanced systemic mastocytosis: from molecular and genetic progress to clinical practice

scientific article

Aggressive systemic mastocytosis and related mast cell disorders: current treatment options and proposed response criteria

scientific article

Allogeneic hematopoietic cell transplantation in systemic mastocytosis: is there a high risk for veno-occlusive disease?

scientific article published on 17 December 2015

An immunohistochemical study of the bone marrow lesions of systemic mastocytosis: expression of stem cell factor by lesional mast cells

scientific article published on 01 August 2002

Analysis of the lineage relationship between mast cells and basophils using the c-kit D816V mutation as a biologic signature

scientific article published in June 2005

Analysis of the surface expression of c-kit and occurrence of the c-kit Asp816Val activating mutation in T cells, B cells, and myelomonocytic cells in patients with mastocytosis

scientific article published on 01 February 2000

Anaphylaxis after hymenoptera sting: is it venom allergy, a clonal disorder, or both?

scientific article published on 07 April 2015

Anaphylaxis and mast cell disease: what is the risk?

scientific article published in January 2010

Assessment of the extent of cutaneous involvement in children and adults with mastocytosis: relationship to symptomatology, tryptase levels, and bone marrow pathology

scientific article published in April 2003

Association of the Q576R polymorphism in the interleukin-4 receptor alpha chain with indolent mastocytosis limited to the skin

scientific article published on 01 August 2001

Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases

scientific article

Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI.

scientific article published on August 2003

Cladribine for mastocytosis: benefits and risks

scientific article published on 01 August 2015

Clinical presentation and markers of cutaneous versus systemic mastocytosis: the mastocytosis center at brigham and women's hospital in Boston

scientific article published on 8 April 2015

Clonality and molecular pathogenesis of mastocytosis.

scientific article

Consensus Opinion on Allogeneic Hematopoietic Cell Transplantation in Advanced Systemic Mastocytosis.

scientific article published on 27 April 2016

Current options in the treatment of mast cell mediator-related symptoms in mastocytosis

scientific article published in January 2006

Current treatment options in patients with mastocytosis: status in 2015 and future perspectives

scientific article

Cutaneous manifestations in patients with mastocytosis: Consensus report of the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European Academy of Allergology and Clinical Immunology

scientific article published on 15 October 2015

Cytogenetic abnormalities and their lack of relationship to the Asp816Val c-kit mutation in the pathogenesis of mastocytosis

scientific article published on 01 September 1998

Definitions, criteria and global classification of mast cell disorders with special reference to mast cell activation syndromes: a consensus proposal

scientific article published on 27 October 2011

Demonstration of an aberrant mast-cell population with clonal markers in a subset of patients with "idiopathic" anaphylaxis

scientific article

Demonstration that mast cells, T cells, and B cells bearing the activating kit mutation D816V occur in clusters within the marrow of patients with mastocytosis

scientific article published in November 2004

Diagnostic criteria and classification of mastocytosis in 2014.

scientific article published on May 2014

Effects of tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-kit

scientific article published in August 2003

Efficacy and Safety of Midostaurin in Advanced Systemic Mastocytosis

scientific article (publication date: 30 June 2016)

Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness

scientific article published on 3 April 2003

Elevated tryptase levels are associated with greater bone density in a cohort of patients with mastocytosis

scientific article published on 30 January 2006

Endocrine manifestations of systemic mastocytosis in bone.

scientific article published on 30 May 2016

Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene

scientific article published on 01 July 2002

FIP1L1/PDGFRA is a molecular marker of chronic eosinophilic leukaemia but not for systemic mastocytosis.

scientific article published in February 2007

Gene expression analysis in mastocytosis reveals a highly consistent profile with candidate molecular markers

scientific article

Genetic variants of ApoE account for variability of plasma low-density lipoprotein and apolipoprotein B levels in FHBL.

scientific article published in January 2005

Hematopoietic stem-cell transplantation for advanced systemic mastocytosis

scientific article

High serum corticotropin-releasing hormone (CRH) and bone marrow mast cell CRH receptor expression in a mastocytosis patient

scientific article published on 27 June 2014

How I treat patients with advanced systemic mastocytosis.

scientific article

Human mast cell apoptosis is regulated through Bcl-2 and Bcl-XL

scientific article published on 01 May 2001

IL-6 levels predict disease variant and extent of organ involvement in patients with mastocytosis

scientific article published on 01 May 2005

INTERACTIVE MEDICAL CASE. A Stinging Sensation

scientific article published in June 2015

Inhibition of murine splenic T lymphocyte proliferation by 2-deoxy-D-glucose-induced metabolic stress

scientific article published on 01 July 1994

International Working Group-Myeloproliferative Neoplasms Research and Treatment (IWG-MRT) & European Competence Network on Mastocytosis (ECNM) consensus response criteria in advanced systemic mastocytosis.

scientific article published on 16 January 2013

Itching without a rash

scientific article published on 01 March 2015

KIT D816V-associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia are distinct entities

scientific article published on 12 July 2007

KIT mutation analysis in mast cell neoplasms: recommendations of the European Competence Network on Mastocytosis

scientific article

Lenalidomide therapy in systemic mastocytosis.

scientific article published on 21 July 2008

Levels of mast-cell growth factors in plasma and in suction skin blister fluid in adults with mastocytosis: correlation with dermal mast-cell numbers and mast-cell tryptase

scientific article published on January 2002

Mast Cell Disorders

scientific article published in May 2016

Mast Cells, Mastocytosis, and Related Disorders

scientific article published on July 2015

Mast Cells, Mastocytosis, and Related Disorders

scientific article published on 01 November 2015

Mast cell activation disorders

scientific article published on May 2014

Mast cell activation syndrome: Proposed diagnostic criteria.

scientific article

Mast cell activation syndrome: a newly recognized disorder with systemic clinical manifestations

scientific article published on 28 May 2011

Mast cell activation syndromes

scientific article published on July 2013

Mast cell activation syndromes presenting as anaphylaxis

scientific article published on May 2015

Mast cell proliferative disorders: current view on variants recognized by the World Health Organization

scientific article published on October 2003

Mast cell sarcoma: a rare and potentially under-recognized diagnostic entity with specific therapeutic implications.

scientific article

Mast cells and eosinophils in mastocytosis, chronic eosinophilic leukemia, and non-clonal disorders

scientific article published on April 2012

Mastocytosis

scientific article published on 12 March 2014

Mastocytosis and allergy.

scientific article published on October 2007

Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts

scientific article published on 28 December 2016

Mastocytosis: advances in diagnosis and treatment.

scientific article published on July 2007

Mastocytosis: molecular mechanisms and clinical disease heterogeneity.

scientific article published in July 2001

Mastocytosis: update on pharmacotherapy and future directions

scientific article

Molecular diagnosis of mast cell disorders: a paper from the 2005 William Beaumont Hospital Symposium on Molecular Pathology

scientific article

Molecular remission and reversal of myelofibrosis in response to imatinib mesylate treatment in patients with the myeloproliferative variant of hypereosinophilic syndrome

scientific article

Multilineage hematopoietic involvement in systemic mastocytosis

scientific article published on 01 October 2003

On the way to targeted therapy of mast cell neoplasms: identification of molecular targets in neoplastic mast cells and evaluation of arising treatment concepts.

scientific article published in August 2004

Pathogenesis, clinical features, and treatment advances in mastocytosis.

scientific article published on January 2006

Pharmacological targeting of the KIT growth factor receptor: a therapeutic consideration for mast cell disorders ⬇️

scientific article published on 26 May 2008

Presumed choroidal and orbital mastocytosis

scientific article published in November 2001

Primary mast cell disorders in children

scientific article published on December 2013

Prolymphocytic leukemia: diagnosis and treatment. A case report

scientific article published on 01 November 1997

Proposed diagnostic algorithm for patients with suspected mastocytosis: a proposal of the European Competence Network on Mastocytosis.

scientific article published on 19 May 2014

Recent advances in mast cell clonality and anaphylaxis ⬇️

scientific article published on December 15, 2009

Refined diagnostic criteria and classification of mast cell leukemia (MCL) and myelomastocytic leukemia (MML): a consensus proposal

scientific article

Refinements in response criteria in systemic mastocytosis: reply to a proposal

scientific article published on 26 April 2010

Regression of urticaria pigmentosa in adult patients with systemic mastocytosis: correlation with clinical patterns of disease

scientific article published on 01 June 2002

Slowly progressive systemic mastocytosis with high mast-cell burden and no evidence of a non-mast-cell hematologic disorder: an example of a smoldering case?

scientific article published in July 2001

Soluble stem cell factor receptor (CD117) and IL-2 receptor alpha chain (CD25) levels in the plasma of patients with mastocytosis: relationships to disease severity and bone marrow pathology

scientific article published on 01 August 2000

Surrogate markers of disease in mastocytosis.

scientific article

Systemic mastocytosis

scientific article published on 01 January 2004

The Kit-activating mutation D816V enhances stem cell factor--dependent chemotaxis

scientific article published in August 2001

The Mastocytosis Society survey on mast cell disorders: patient experiences and perceptions

scientific article published on 3 December 2013

The Present Status of Public Health Education

scientific article published on 01 December 1940

The antitumor effect of bleomycin combined with bestatin against Ehrlich ascites carcinoma in mice

scientific article

The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations

scientific article published on March 2002

The classification of systemic mastocytosis should include mast cell leukemia (MCL) and systemic mastocytosis with a clonal hematologic non-mast cell lineage disease (SM-AHNMD)

scientific article published on August 2010

The identification and characterisation of novel KIT transcripts in aggressive mast cell malignancies and normal CD34+ cells

scientific article

The serum tryptase test: an emerging robust biomarker in clinical hematology.

scientific article

Thrombopoietin alone or in the presence of stem cell factor supports the growth of KIT(CD117)low/ MPL(CD110)+ human mast cells from hematopoietic progenitor cells

scientific article published on 01 April 2005

Treatment strategies in mastocytosis

scientific article published on 13 March 2014

Tryptase haplotype in mastocytosis: relationship to disease variant and diagnostic utility of total tryptase levels

scientific article

Tryptase is not cleared by the kidneys into the urine.

scientific article published on 24 November 2009

Tyrosine kinase inhibitors in the treatment of systemic mastocytosis.

scientific article published on 08 June 2011

Urticaria pigmentosa and mastocytosis: the role of immunophenotyping in diagnosis and determining response to treatment.

scientific article published on July 2006

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