List of works - Shijun Wen

Advances in the studies of roles of Rho/Rho-kinase in diseases and the development of its inhibitors.

scientific article published on 25 October 2013

Berberine protects homocysteic acid-induced HT-22 cell death: involvement of Akt pathway.

scientific article

Carvedilol attenuates 6-hydroxydopamine-induced cell death in PC12 cells: involvement of Akt and Nrf2/ARE pathways

scientific article published on 21 June 2014

Chemotherapy induces tumor immune evasion by upregulation of programmed cell death ligand 1 expression in bone marrow stromal cells

scientific article published on 28 December 2016

Deubiquitinase inhibition of 19S regulatory particles by 4-arylidene curcumin analog AC17 causes NF-κB inhibition and p53 reactivation in human lung cancer cells.

scientific article published on 21 May 2013

Discovery of a novel rhein-SAHA hybrid as a multi-targeted anti-glioblastoma drug

scientific article published on 14 August 2019

Domino Carbopalladation/C-H Activation as a Quick Access to Polycyclic Frameworks

scientific article published on 10 January 2018

Effective inhibition of nasopharyngeal carcinoma in vitro and in vivo by targeting glycolysis with oxamate

scientific article published on 27 August 2013

Elimination of stem-like cancer cell side-population by auranofin through modulation of ROS and glycolysis

scientific article published on 24 January 2018

Glyceraldehyde-3-phosphate dehydrogenase promotes cancer growth and metastasis through upregulation of SNAIL expression.

scientific article published on 18 November 2016

Heterocyclic Iodoniums for the Assembly of Oxygen-Bridged Polycyclic Heteroarenes with Water as the Oxygen Source

scientific article published on 27 July 2018

ITD mutation in FLT3 tyrosine kinase promotes Warburg effect and renders therapeutic sensitivity to glycolytic inhibition

scientific article

Impact of Nrf2 on tumor growth and drug sensitivity in oncogenic K-ras-transformed cells in vitro and in vivo

scientific article published on 5 April 2018

Inhibition of cancer growth in vitro and in vivo by a novel ROS-modulating agent with ability to eliminate stem-like cancer cells.

scientific article published on 22 June 2017

Macrolactamization versus macrolactonization: total synthesis of FK228, the depsipeptide histone deacetylase inhibitor.

scientific article

Mild Cu(I)-catalyzed cascade reaction of cyclic diaryliodoniums, sodium azide, and alkynes: efficient synthesis of triazolophenanthridines

scientific article published on 22 October 2014

Mining expression and prognosis of topoisomerase isoforms in non-small-cell lung cancer by using Oncomine and Kaplan-Meier plotter

scientific article

New Mild and Simple Approach to Isothiocyanates: A Class of Potent Anticancer Agents.

scientific article

Novel combination of histone methylation modulators with therapeutic synergy against acute myeloid leukemia in vitro and in vivo

scientific article

Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis

scientific article published on 21 October 2015

Palladium catalyzed dual C-H functionalization of indoles with cyclic diaryliodoniums, an approach to ring fused carbazole derivatives

scientific article published on 01 December 2014

Pantothenic acid biosynthesis in the parasite Toxoplasma gondii: a target for chemotherapy.

scientific article

Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening

scientific article

Pd catalyzed insertion of alkynes into cyclic diaryliodoniums: a direct access to multi-substituted phenanthrenes

scientific article published in September 2015

REV-ERBa Regulates CYP7A1 through Repression of Liver Receptor Homolog-1.

scientific article published on 13 December 2017

Regulation of stem-like cancer cells by glutamine through β-catenin pathway mediated by redox signaling

scientific article

Relayed Regioselective Alkynylation/Olefination of Unsymmetrical Cyclic Diaryliodonium Species Catalyzed by Cu and Pd: Affording Fluorescent Cytotoxic Benzoxazoles

scientific article published on 30 October 2015

Synergy between Auranofin and Celecoxib against Colon Cancer In Vitro and In Vivo through a Novel Redox-Mediated Mechanism

scientific article published on 03 July 2019

Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives

scientific article published on 05 February 2018

Synthesis and evaluation of multifunctional ferulic and caffeic acid dimers for Alzheimer's disease.

scientific article published on 17 August 2016

Synthesis of N-acyl-N,O-acetals mediated by titanium ethoxide

scientific article published on 5 December 2013

Targeting cancer cell mitochondria as a therapeutic approach

scientific article published on January 2013

Targeting cancer cell mitochondria as a therapeutic approach: recent updates

scientific article published on 21 June 2017

The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor

scientific article

The histone deacetylase inhibitors vorinostat and romidepsin downmodulate IL-10 expression in cutaneous T-cell lymphoma cells.

scientific article

Three-component Pd/Cu-catalyzed cascade reactions of cyclic iodoniums, alkynes, and boronic acids: an approach to methylidenefluorenes

scientific article published on 17 April 2014

Total synthesis of azumamide A and azumamide E, evaluation as histone deacetylase inhibitors, and design of a more potent analogue

scientific article published on 21 February 2007

Total synthesis of cyclomarin C

scientific article published on 01 August 2004

Xc- inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism

scientific article

List of works by Shijun Wen

Advances in the studies of roles of Rho/Rho-kinase in diseases and the development of its inhibitors.

Berberine protects homocysteic acid-induced HT-22 cell death: involvement of Akt pathway.

Carvedilol attenuates 6-hydroxydopamine-induced cell death in PC12 cells: involvement of Akt and Nrf2/ARE pathways

Chemotherapy induces tumor immune evasion by upregulation of programmed cell death ligand 1 expression in bone marrow stromal cells

Deubiquitinase inhibition of 19S regulatory particles by 4-arylidene curcumin analog AC17 causes NF-κB inhibition and p53 reactivation in human lung cancer cells.

Discovery of a novel rhein-SAHA hybrid as a multi-targeted anti-glioblastoma drug

Domino Carbopalladation/C-H Activation as a Quick Access to Polycyclic Frameworks

Effective inhibition of nasopharyngeal carcinoma in vitro and in vivo by targeting glycolysis with oxamate

Elimination of stem-like cancer cell side-population by auranofin through modulation of ROS and glycolysis

Glyceraldehyde-3-phosphate dehydrogenase promotes cancer growth and metastasis through upregulation of SNAIL expression.

Heterocyclic Iodoniums for the Assembly of Oxygen-Bridged Polycyclic Heteroarenes with Water as the Oxygen Source

ITD mutation in FLT3 tyrosine kinase promotes Warburg effect and renders therapeutic sensitivity to glycolytic inhibition

Impact of Nrf2 on tumor growth and drug sensitivity in oncogenic K-ras-transformed cells in vitro and in vivo

Inhibition of cancer growth in vitro and in vivo by a novel ROS-modulating agent with ability to eliminate stem-like cancer cells.

Macrolactamization versus macrolactonization: total synthesis of FK228, the depsipeptide histone deacetylase inhibitor.

Mild Cu(I)-catalyzed cascade reaction of cyclic diaryliodoniums, sodium azide, and alkynes: efficient synthesis of triazolophenanthridines

Mining expression and prognosis of topoisomerase isoforms in non-small-cell lung cancer by using Oncomine and Kaplan-Meier plotter

New Mild and Simple Approach to Isothiocyanates: A Class of Potent Anticancer Agents.

Novel combination of histone methylation modulators with therapeutic synergy against acute myeloid leukemia in vitro and in vivo

Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis

Palladium catalyzed dual C-H functionalization of indoles with cyclic diaryliodoniums, an approach to ring fused carbazole derivatives

Pantothenic acid biosynthesis in the parasite Toxoplasma gondii: a target for chemotherapy.

Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening

Pd catalyzed insertion of alkynes into cyclic diaryliodoniums: a direct access to multi-substituted phenanthrenes

REV-ERBa Regulates CYP7A1 through Repression of Liver Receptor Homolog-1.

Regulation of stem-like cancer cells by glutamine through β-catenin pathway mediated by redox signaling

Relayed Regioselective Alkynylation/Olefination of Unsymmetrical Cyclic Diaryliodonium Species Catalyzed by Cu and Pd: Affording Fluorescent Cytotoxic Benzoxazoles

Synergy between Auranofin and Celecoxib against Colon Cancer In Vitro and In Vivo through a Novel Redox-Mediated Mechanism

Synthesis and biological evaluation of 20-epi-amino-20-deoxysalinomycin derivatives

Synthesis and evaluation of multifunctional ferulic and caffeic acid dimers for Alzheimer's disease.

Synthesis of N-acyl-N,O-acetals mediated by titanium ethoxide

Targeting cancer cell mitochondria as a therapeutic approach

Targeting cancer cell mitochondria as a therapeutic approach: recent updates

The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor

The histone deacetylase inhibitors vorinostat and romidepsin downmodulate IL-10 expression in cutaneous T-cell lymphoma cells.

Three-component Pd/Cu-catalyzed cascade reactions of cyclic iodoniums, alkynes, and boronic acids: an approach to methylidenefluorenes

Total synthesis of azumamide A and azumamide E, evaluation as histone deacetylase inhibitors, and design of a more potent analogue

Total synthesis of cyclomarin C

Xc- inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanism