List of works - Thomas Kaufmann

A novel TNFR1-triggered apoptosis pathway mediated by class IA PI3Ks in neutrophils.

scientific article

Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death

scientific article published on 15 November 2005

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

scientific article

BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice.

scientific article

BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals

scientific article published on 16 July 2019

BH3 mimetics efficiently induce apoptosis in mouse basophils and mast cells

scientific article published on 29 September 2017

BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella

scientific article

BOK displays cell death-independent tumor suppressor activity in non-small-cell lung carcinoma.

scientific article

BOK promotes chemical-induced hepatocarcinogenesis in mice

scientific article published on 11 December 2017

Balance between IL-3 and type Iinterferons and their interrelationship with FasL dictates lifespan and effector functions of human basophils.

scientific article

Basophils exhibit antibacterial activity through extracellular trap formation.

scientific article published on 4 June 2015

Bcl-2 family members: integrators of survival and death signals in physiology and pathology [corrected].

scientific article published on March 2004

Bcl-2 is a monomeric protein: prevention of homodimerization by structural constraints

scientific article

Bcl-w(edding) with mitochondria

scientific article published on January 2004

Bcl-x(S) induces an NGF-inhibitable cytochrome c release

scientific article

Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury

scientific journal article

Cancer caused by too much apoptosis--an intriguing contradiction?

scientific article published in April 2010

Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane

scientific journal article

Conformational control of Bax localization and apoptotic activity by Pro168.

scientific article

Consequences of the combined loss of BOK and BAK or BOK and BAX.

scientific article published on 06 June 2013

Correction: TNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP

scientific article published on 23 January 2020

Erratum: BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice

scholarly article published in Cell Death & Differentiation

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

scientific article

Fas death receptor signalling: roles of Bid and XIAP.

scientific article published on 30 September 2011

Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.

scientific article

FcɛRI cross-linking and IL-3 protect human basophils from intrinsic apoptotic stress

scientific article published on 23 July 2018

Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein

scientific article

Glucocorticoids ‘on air’ ⬇️

scientific article published on 01 February 2012

Hexokinase 3 enhances myeloid cell survival via non-glycolytic functions

scientific article published on 11 May 2022

IL-4 enhances survival of in vitro-differentiated mouse basophils through transcription-independent signaling downstream of PI3K.

scientific article

IVIG regulates the survival of human but not mouse neutrophils

scientific article

IgA Triggers Cell Death of Neutrophils When Primed by Inflammatory Mediators

scientific article published on 02 October 2020

Impact of BH3-mimetics on Human and Mouse Blood Leukocytes: A Comparative Study

scientific article published on 14 January 2020

Impact of inhibitor of apoptosis proteins on immune modulation and inflammation

scientific article

In Vitro Differentiation of Mouse Granulocytes

scientific article published on 01 January 2016

In vitro differentiation of near-unlimited numbers of functional mouse basophils using conditional Hoxb8.

scientific article published in January 2013

Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis.

scientific article published in February 2002

International EMBO Workshop on 'Model Organisms in Cell Death Research', Obergurgl (Austria).

scientific article published in August 2009

Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis

scientific article published on October 2016

Intracellular localization of the BCL-2 family member BOK and functional implications

scientific journal article

Is BOK required for apoptosis induced by endoplasmic reticulum stress?

scientific article published on 25 January 2016

Loss of BID Delays FASL-Induced Cell Death of Mouse Neutrophils and Aggravates DSS-Induced Weight Loss.

scientific article published on 28 February 2018

Loss of XIAP facilitates switch to TNFα-induced necroptosis in mouse neutrophils

scientific article published on 13 October 2016

Loss of the BH3-only protein Bid does not rescue RelA-deficient embryos from TNF-R1-mediated fatal hepatocyte destruction

scientific article

MEK/ERK-mediated phosphorylation of Bim is required to ensure survival of T and B lymphocytes during mitogenic stimulation.

scientific article published on July 2009

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

NADPH oxidase-independent formation of extracellular DNA traps by basophils

scientific article

NET formation can occur independently of RIPK3 and MLKL signaling

scientific article

Negative Regulation of BOK Expression by Recruitment of TRIM28 to Regulatory Elements in Its 3' Untranslated Region

Novel insights into mechanisms of food allergy and allergic airway inflammation using experimental mouse models

scientific article published on 29 October 2012

PU.1 supports TRAIL-induced cell death by inhibiting NF-κB-mediated cell survival and inducing DR5 expression.

scientific article published on 31 March 2017

Proapoptotic BH3-only protein Bid is essential for death receptor-induced apoptosis of pancreatic beta-cells.

scientific article published on 5 February 2008

Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim.

scientific article

Response: Does Bid Play a Role in the DNA Damage Response?

article

Role of TRAIL and the pro-apoptotic Bcl-2 homolog Bim in acetaminophen-induced liver damage

scientific article

Survival control of malignant lymphocytes by anti-apoptotic MCL-1.

scientific article

Switch from type II to I Fas/CD95 death signaling on in vitro culturing of primary hepatocytes

scientific article

TNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP

scientific article published on 20 September 2019

TRAIL enhances paracetamol-induced liver sinusoidal endothelial cell death in a Bim- and Bid-dependent manner

scientific article published on 20 December 2012

TREM-1 deficiency can attenuate disease severity without affecting pathogen clearance

scientific article published on 16 January 2014

Targeting disease by immunomodulation

scientific article published on February 2015

The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest

scientific article published on 01 April 2007

The BH3-only protein Puma plays an essential role in cytokine deprivation induced apoptosis of mast cells

scientific article

The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage

scientific journal article

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

article

The generation of neutrophils in the bone marrow is controlled by autophagy

scientific article

The membrane activity of BOK involves formation of large, stable toroidal pores and is promoted by cBID.

scientific article published on 8 January 2017

The tumor suppressor gene DAPK2 is induced by the myeloid transcription factors PU.1 and C/EBPα during granulocytic differentiation but repressed by PML-RARα in APL.

scientific article published on 13 September 2013

XIAP discriminates between type I and type II FAS-induced apoptosis

scientific article

XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation

scientific article published on 29 May 2014

List of works by Thomas Kaufmann

A novel TNFR1-triggered apoptosis pathway mediated by class IA PI3Ks in neutrophils.

Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice.

BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals

BH3 mimetics efficiently induce apoptosis in mouse basophils and mast cells

BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella

BOK displays cell death-independent tumor suppressor activity in non-small-cell lung carcinoma.

BOK promotes chemical-induced hepatocarcinogenesis in mice

Balance between IL-3 and type Iinterferons and their interrelationship with FasL dictates lifespan and effector functions of human basophils.

Basophils exhibit antibacterial activity through extracellular trap formation.

Bcl-2 family members: integrators of survival and death signals in physiology and pathology [corrected].

Bcl-2 is a monomeric protein: prevention of homodimerization by structural constraints

Bcl-w(edding) with mitochondria

Bcl-x(S) induces an NGF-inhibitable cytochrome c release

Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury

Cancer caused by too much apoptosis--an intriguing contradiction?

Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane

Conformational control of Bax localization and apoptotic activity by Pro168.

Consequences of the combined loss of BOK and BAK or BOK and BAX.

Correction: TNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP

Erratum: BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

Fas death receptor signalling: roles of Bid and XIAP.

Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.

FcɛRI cross-linking and IL-3 protect human basophils from intrinsic apoptotic stress

Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein

Glucocorticoids ‘on air’ ⬇️

Hexokinase 3 enhances myeloid cell survival via non-glycolytic functions

IL-4 enhances survival of in vitro-differentiated mouse basophils through transcription-independent signaling downstream of PI3K.

IVIG regulates the survival of human but not mouse neutrophils

IgA Triggers Cell Death of Neutrophils When Primed by Inflammatory Mediators

Impact of BH3-mimetics on Human and Mouse Blood Leukocytes: A Comparative Study

Impact of inhibitor of apoptosis proteins on immune modulation and inflammation

In Vitro Differentiation of Mouse Granulocytes

In vitro differentiation of near-unlimited numbers of functional mouse basophils using conditional Hoxb8.

Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis.

International EMBO Workshop on 'Model Organisms in Cell Death Research', Obergurgl (Austria).

Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis

Intracellular localization of the BCL-2 family member BOK and functional implications

Is BOK required for apoptosis induced by endoplasmic reticulum stress?

Loss of BID Delays FASL-Induced Cell Death of Mouse Neutrophils and Aggravates DSS-Induced Weight Loss.

Loss of XIAP facilitates switch to TNFα-induced necroptosis in mouse neutrophils

Loss of the BH3-only protein Bid does not rescue RelA-deficient embryos from TNF-R1-mediated fatal hepatocyte destruction

MEK/ERK-mediated phosphorylation of Bim is required to ensure survival of T and B lymphocytes during mitogenic stimulation.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

NADPH oxidase-independent formation of extracellular DNA traps by basophils

NET formation can occur independently of RIPK3 and MLKL signaling

Negative Regulation of BOK Expression by Recruitment of TRIM28 to Regulatory Elements in Its 3' Untranslated Region

Novel insights into mechanisms of food allergy and allergic airway inflammation using experimental mouse models

PU.1 supports TRAIL-induced cell death by inhibiting NF-κB-mediated cell survival and inducing DR5 expression.

Proapoptotic BH3-only protein Bid is essential for death receptor-induced apoptosis of pancreatic beta-cells.

Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim.

Response: Does Bid Play a Role in the DNA Damage Response?

Role of TRAIL and the pro-apoptotic Bcl-2 homolog Bim in acetaminophen-induced liver damage

Survival control of malignant lymphocytes by anti-apoptotic MCL-1.

Switch from type II to I Fas/CD95 death signaling on in vitro culturing of primary hepatocytes

TNFR2 induced priming of the inflammasome leads to a RIPK1-dependent cell death in the absence of XIAP

TRAIL enhances paracetamol-induced liver sinusoidal endothelial cell death in a Bim- and Bid-dependent manner

TREM-1 deficiency can attenuate disease severity without affecting pathogen clearance

Targeting disease by immunomodulation

The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest

The BH3-only protein Puma plays an essential role in cytokine deprivation induced apoptosis of mast cells

The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

The generation of neutrophils in the bone marrow is controlled by autophagy

The membrane activity of BOK involves formation of large, stable toroidal pores and is promoted by cBID.

The tumor suppressor gene DAPK2 is induced by the myeloid transcription factors PU.1 and C/EBPα during granulocytic differentiation but repressed by PML-RARα in APL.

XIAP discriminates between type I and type II FAS-induced apoptosis

XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation