List of works - Oliver Limbo

ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair.

scientific article

ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling

scientific article published on 3 March 2014

BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint

scientific article published on 2 August 2010

Brc1 Promotes the Focal Accumulation and SUMO Ligase Activity of Smc5-Smc6 During Replication Stress

scientific article published on 03 January 2019

Critical Function of γH2A in S-Phase

scientific article published on 14 September 2015

Critical functions of Rpa3/Ssb3 in S-phase DNA damage responses in fission yeast.

scientific article

Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination

scientific article

Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

scientific article published on 15 June 2020

Lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks in the polynucleotide kinase/phosphatase mutant of fission yeast

scientific article published on 18 September 2017

Molecular basis of chromatin remodeling by Rhp26, a yeast CSB ortholog

scientific article published on 13 March 2019

Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair

scientific article

Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

scientific article

Mre11 complex links sister chromatids to promote repair of a collapsed replication fork

scientific article published on 13 August 2018

Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks

scientific article

Mre11-Rad50-dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1.

scientific article

Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair

scientific article

Phosphorylation-regulated binding of Ctp1 to Nbs1 is critical for repair of DNA double-strand breaks

scientific article

RNase H eliminates R-loops that disrupt DNA replication but is nonessential for efficient DSB repair

scientific article published on 05 April 2018

Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif

scientific article

Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.

scientific article

Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins

scientific article published in 2024

Tolerance of deregulated G1/S transcription depends on critical G1/S regulon genes to prevent catastrophic genome instability.

scientific article published on 18 December 2014

Tonoplast-localized Abc2 Transporter Mediates Phytochelatin Accumulation in Vacuoles and Confers Cadmium Tolerance ⬇️

scientific article published on October 11, 2010

List of works by Oliver Limbo

ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair.

ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling

BRCT domain interactions with phospho-histone H2A target Crb2 to chromatin at double-strand breaks and maintain the DNA damage checkpoint

Brc1 Promotes the Focal Accumulation and SUMO Ligase Activity of Smc5-Smc6 During Replication Stress

Critical Function of γH2A in S-Phase

Critical functions of Rpa3/Ssb3 in S-phase DNA damage responses in fission yeast.

Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination

Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

Lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks in the polynucleotide kinase/phosphatase mutant of fission yeast

Molecular basis of chromatin remodeling by Rhp26, a yeast CSB ortholog

Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair

Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

Mre11 complex links sister chromatids to promote repair of a collapsed replication fork

Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks

Mre11-Rad50-dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1.

Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair

Phosphorylation-regulated binding of Ctp1 to Nbs1 is critical for repair of DNA double-strand breaks

RNase H eliminates R-loops that disrupt DNA replication but is nonessential for efficient DSB repair

Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif

Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.

Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins

Tolerance of deregulated G1/S transcription depends on critical G1/S regulon genes to prevent catastrophic genome instability.

Tonoplast-localized Abc2 Transporter Mediates Phytochelatin Accumulation in Vacuoles and Confers Cadmium Tolerance ⬇️