List of works - Justin A. MacDonald

A Potential New Tool for Managing Clostridium difficile Infection

scientific article published on 18 February 2013

A Small Molecule Pyrazolo[3,4-d]Pyrimidinone Inhibitor of Zipper-Interacting Protein Kinase Suppresses Calcium Sensitization of Vascular Smooth Muscle

scientific article published on 13 October 2015

A strategy for the rapid identification of phosphorylation sites in the phosphoproteome

scientific article published in April 2002

A tale of two threonines: myosin phosphatase inhibition and calcium sensitization of smooth muscle.

scientific article

Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis

scientific article published on 18 March 2012

Assessment of endothelin and copeptin as biomarkers for vasovagal syncope

scientific article published on 7 December 2015

Biochemical and structural aspects of the ATP-binding domain in inflammasome-forming human NLRP proteins

scientific article

C-terminal repeat domain kinase I phosphorylates Ser2 and Ser5 of RNA polymerase II C-terminal domain repeats

scientific article published on 26 March 2004

Ca2+-independent contraction of longitudinal ileal smooth muscle is potentiated by a zipper-interacting protein kinase pseudosubstrate peptide.

scientific article published on 18 June 2009

Characterization of protein kinase pathways responsible for Ca2+ sensitization in rat ileal longitudinal smooth muscle

scientific article published on 26 July 2007

Chemical genetics of zipper-interacting protein kinase reveal myosin light chain as a bona fide substrate in permeabilized arterial smooth muscle

scientific article published on 31 August 2011

Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome

scientific article published on 13 April 2010

Coimmunopurification of phosphorylated bacterial- and plant-type phosphoenolpyruvate carboxylases with the plastidial pyruvate dehydrogenase complex from developing castor oil seeds.

scientific article

Cross-talk between Rho-associated kinase and cyclic nucleotide-dependent kinase signaling pathways in the regulation of smooth muscle myosin light chain phosphatase

scientific article published on 4 September 2012

Differential effects of salvinorin A on endotoxin-induced hypermotility and neurogenic ion transport in mouse ileum

scientific article

Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase

scientific article published in March 2001

ERK and p38MAPK pathways regulate myosin light chain phosphatase and contribute to Ca2+ sensitization of intestinal smooth muscle contraction.

scientific article published in January 2015

Effects of nitric oxide and reactive oxygen species on HIF-1α stabilization following clostridium difficile toxin exposure of the Caco-2 epithelial cell line

scientific article published on 27 August 2013

Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor

scientific article

Glycation of wood frog (Rana sylvatica) hemoglobin and blood proteins: in vivo and in vitro studies

scientific article

Guest editorial & introduction to the special issue

scientific article published on 01 June 2011

Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury

scientific article

Identification of a 115kDa MAP-kinase activated by freezing and anoxic stresses in the marine periwinkle, Littorina littorea

scientific article published on 30 March 2006

Identification of the linker histone H1 as a protein kinase Cε-binding protein in vascular smooth muscle

scientific article published in 2004

Improving upon the in vitro biological activity of antithrombotic disulfides

scientific article published on 01 September 2004

In situ Analysis of Smoothelin-like 1 and Calmodulin Interactions in Smooth Muscle Cells by Proximity Ligation

article

Inhibition of zipper-interacting protein kinase function in smooth muscle by a myosin light chain kinase pseudosubstrate peptide

scientific article published on 10 January 2007

Integrin-linked kinase is responsible for Ca2+-independent myosin diphosphorylation and contraction of vascular smooth muscle

scientific article published on December 2005

Intrarectal instillation of Clostridium difficile toxin A triggers colonic inflammation and tissue damage: development of a novel and efficient mouse model of Clostridium difficile toxin exposure

scientific article

Intrinsically disordered N-terminus of calponin homology-associated smooth muscle protein (CHASM) interacts with the calponin homology domain to enable tropomyosin binding

scientific journal article

MAPKs represent novel therapeutic targets for gastrointestinal motility disorders

scientific article

Mapping and functional characterization of the murine smoothelin-like 1 promoter

scientific article

Mitogen-activated protein kinase pathways contribute to hypercontractility and increased Ca2+ sensitization in murine experimental colitis

scientific article published on 3 February 2009

Mitogen-activated protein kinases and selected downstream targets display organ-specific responses in the hibernating ground squirrel

article

Modulation of smooth muscle contractility by CHASM, a novel member of the smoothelin family of proteins

scientific article

NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations

scientific article published on 22 August 2016

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis

scientific article

Network analysis of TCGA and GTEx gene expression datasets for identification of trait-associated biomarkers in human cancer

scientific article published on 07 February 2022

Novel contributions of the smoothelin-like 1 protein in vascular smooth muscle contraction and its potential involvement in myogenic tone

scientific article published on April 2014

Opportunities to Target Specific Contractile Abnormalities with Smooth Muscle Protein Kinase Inhibitors

scientific article

Parasitic helminths: a pharmacopeia of anti-inflammatory molecules.

scientific article published on 15 December 2008

Phosphorylation of telokin by cyclic nucleotide kinases and the identification of in vivo phosphorylation sites in smooth muscle

article

Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase

scientific article published on August 2002

Prostate-apoptosis response-4 phosphorylation in vascular smooth muscle

scientific journal article

Protein phosphatase type-1 from skeletal muscle of the freeze-tolerant wood frog

scientific article published in January 2002

Proteomic Analysis of Calcium/Calmodulin-dependent Protein Kinase I and IVin VitroSubstrates Reveals Distinct Catalytic Preferences

scientific article published in Journal of Biological Chemistry

Purification and characterization of fructose bisphosphate aldolase from the ground squirrel, Spermophilus lateralis: enzyme role in mammalian hibernation

scientific article published in December 2002

Purification of Smooth Muscle Myosin Phosphatase Using a Thiophosphorylated Myosin Light-Chain-Affinity Resin

scientific article published on 01 January 2007

Reassessment of the cold-labile nature of phosphofructokinase from a hibernating ground squirrel

scientific article published in September 2001

Regulation of Ground Squirrel Na+K+-ATPase Activity by Reversible Phosphorylation during Hibernation

scientific article published on 01 January 1999

Site-specific phosphorylation and point mutations of telokin modulate its Ca2+-desensitizing effect in smooth muscle

scientific article

Smooth muscle myosin phosphatase-associated kinase induces Ca2+ sensitization via myosin phosphatase inhibition

scientific article

Smooth muscle phenotypic plasticity in mechanical obstruction of the small intestine.

scientific article published on July 2008

Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides

scientific article

Smoothelin-like 1 deletion enhances myogenic reactivity of mesenteric arteries with alterations in PKC and myosin phosphatase signaling

scientific article published in Scientific Reports

Solution structure of the calponin homology (CH) domain from the smoothelin-like 1 protein: a unique apocalmodulin-binding mode and the possible role of the C-terminal type-2 CH-domain in smooth muscle relaxation

scientific article

Staurosporine inhibition of zipper-interacting protein kinase contractile effects in gastrointestinal smooth muscle

scientific article published on 01 February 2007

Structure-activity relationships for selected sulfur-rich antithrombotic compounds

scientific article published in July 2000

Targeting hypoxia-inducible factor-1 (HIF-1) signaling in therapeutics: implications for the treatment of inflammatory bowel disease

scientific article published on January 2009

Temperature and phosphate effects on allosteric phenomena of phosphofructokinase from a hibernating ground squirrel (Spermophilus lateralis).

scientific article published in January 2005

The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin-1β.

scientific article published on 30 July 2012

The P2Y6 receptor mediates Clostridium difficile toxin-induced CXCL8/IL-8 production and intestinal epithelial barrier dysfunction

scientific article published on 22 November 2013

The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter

scientific article

The contribution of protein kinase C and CPI-17 signaling pathways to hypercontractility in murine experimental colitis.

scientific article

The effect of hibernation on protein phosphatases from ground squirrel organs

scientific article published on 13 October 2007

The muscle fatty acid binding protein of spadefoot toad (Scaphiopus couchii)

scientific article published in March 2000

The myosin phosphatase targeting protein (MYPT) family: a regulated mechanism for achieving substrate specificity of the catalytic subunit of protein phosphatase type 1δ.

scientific article published on February 2011

The regulation of smooth muscle contractility by zipper-interacting protein kinase

scientific article published on January 2007

The role of the calponin homology domain of smoothelin-like 1 (SMTNL1) in myosin phosphatase inhibition and smooth muscle contraction

scientific article

Tissue-selective alternate promoters guide NLRP6 expression

scientific article published on 29 December 2020

Tools and protocol for quantification of myosin phosphorylation with MRM-MS.

scientific article published on 17 May 2018

Two domains of the smoothelin-like 1 protein bind apo- and calcium-calmodulin independently

scientific article published on 4 June 2014

Vitamin D₃ metabolites enhance the NLRP3-dependent secretion of IL-1β from human THP-1 monocytic cells

scientific article published on May 2015

cAMP-dependent protein kinase from brown adipose tissue: temperature effects on kinetic properties and enzyme role in hibernating ground squirrels

article

List of works by Justin A. MacDonald

A Potential New Tool for Managing Clostridium difficile Infection

A Small Molecule Pyrazolo[3,4-d]Pyrimidinone Inhibitor of Zipper-Interacting Protein Kinase Suppresses Calcium Sensitization of Vascular Smooth Muscle

A strategy for the rapid identification of phosphorylation sites in the phosphoproteome

A tale of two threonines: myosin phosphatase inhibition and calcium sensitization of smooth muscle.

Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis

Assessment of endothelin and copeptin as biomarkers for vasovagal syncope

Biochemical and structural aspects of the ATP-binding domain in inflammasome-forming human NLRP proteins

C-terminal repeat domain kinase I phosphorylates Ser2 and Ser5 of RNA polymerase II C-terminal domain repeats

Ca2+-independent contraction of longitudinal ileal smooth muscle is potentiated by a zipper-interacting protein kinase pseudosubstrate peptide.

Characterization of protein kinase pathways responsible for Ca2+ sensitization in rat ileal longitudinal smooth muscle

Chemical genetics of zipper-interacting protein kinase reveal myosin light chain as a bona fide substrate in permeabilized arterial smooth muscle

Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome

Coimmunopurification of phosphorylated bacterial- and plant-type phosphoenolpyruvate carboxylases with the plastidial pyruvate dehydrogenase complex from developing castor oil seeds.

Cross-talk between Rho-associated kinase and cyclic nucleotide-dependent kinase signaling pathways in the regulation of smooth muscle myosin light chain phosphatase

Differential effects of salvinorin A on endotoxin-induced hypermotility and neurogenic ion transport in mouse ileum

Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase

ERK and p38MAPK pathways regulate myosin light chain phosphatase and contribute to Ca2+ sensitization of intestinal smooth muscle contraction.

Effects of nitric oxide and reactive oxygen species on HIF-1α stabilization following clostridium difficile toxin exposure of the Caco-2 epithelial cell line

Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor

Glycation of wood frog (Rana sylvatica) hemoglobin and blood proteins: in vivo and in vitro studies

Guest editorial & introduction to the special issue

Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury

Identification of a 115kDa MAP-kinase activated by freezing and anoxic stresses in the marine periwinkle, Littorina littorea

Identification of the linker histone H1 as a protein kinase Cε-binding protein in vascular smooth muscle

Improving upon the in vitro biological activity of antithrombotic disulfides

In situ Analysis of Smoothelin-like 1 and Calmodulin Interactions in Smooth Muscle Cells by Proximity Ligation

Inhibition of zipper-interacting protein kinase function in smooth muscle by a myosin light chain kinase pseudosubstrate peptide

Integrin-linked kinase is responsible for Ca2+-independent myosin diphosphorylation and contraction of vascular smooth muscle

Intrarectal instillation of Clostridium difficile toxin A triggers colonic inflammation and tissue damage: development of a novel and efficient mouse model of Clostridium difficile toxin exposure

Intrinsically disordered N-terminus of calponin homology-associated smooth muscle protein (CHASM) interacts with the calponin homology domain to enable tropomyosin binding

MAPKs represent novel therapeutic targets for gastrointestinal motility disorders

Mapping and functional characterization of the murine smoothelin-like 1 promoter

Mitogen-activated protein kinase pathways contribute to hypercontractility and increased Ca2+ sensitization in murine experimental colitis

Mitogen-activated protein kinases and selected downstream targets display organ-specific responses in the hibernating ground squirrel

Modulation of smooth muscle contractility by CHASM, a novel member of the smoothelin family of proteins

NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis

Network analysis of TCGA and GTEx gene expression datasets for identification of trait-associated biomarkers in human cancer

Novel contributions of the smoothelin-like 1 protein in vascular smooth muscle contraction and its potential involvement in myogenic tone

Opportunities to Target Specific Contractile Abnormalities with Smooth Muscle Protein Kinase Inhibitors

Parasitic helminths: a pharmacopeia of anti-inflammatory molecules.

Phosphorylation of telokin by cyclic nucleotide kinases and the identification of in vivo phosphorylation sites in smooth muscle

Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase

Prostate-apoptosis response-4 phosphorylation in vascular smooth muscle

Protein phosphatase type-1 from skeletal muscle of the freeze-tolerant wood frog

Proteomic Analysis of Calcium/Calmodulin-dependent Protein Kinase I and IVin VitroSubstrates Reveals Distinct Catalytic Preferences

Purification and characterization of fructose bisphosphate aldolase from the ground squirrel, Spermophilus lateralis: enzyme role in mammalian hibernation

Purification of Smooth Muscle Myosin Phosphatase Using a Thiophosphorylated Myosin Light-Chain-Affinity Resin

Reassessment of the cold-labile nature of phosphofructokinase from a hibernating ground squirrel

Regulation of Ground Squirrel Na+K+-ATPase Activity by Reversible Phosphorylation during Hibernation

Site-specific phosphorylation and point mutations of telokin modulate its Ca2+-desensitizing effect in smooth muscle

Smooth muscle myosin phosphatase-associated kinase induces Ca2+ sensitization via myosin phosphatase inhibition

Smooth muscle phenotypic plasticity in mechanical obstruction of the small intestine.

Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides

Smoothelin-like 1 deletion enhances myogenic reactivity of mesenteric arteries with alterations in PKC and myosin phosphatase signaling

Solution structure of the calponin homology (CH) domain from the smoothelin-like 1 protein: a unique apocalmodulin-binding mode and the possible role of the C-terminal type-2 CH-domain in smooth muscle relaxation

Staurosporine inhibition of zipper-interacting protein kinase contractile effects in gastrointestinal smooth muscle

Structure-activity relationships for selected sulfur-rich antithrombotic compounds

Targeting hypoxia-inducible factor-1 (HIF-1) signaling in therapeutics: implications for the treatment of inflammatory bowel disease

Temperature and phosphate effects on allosteric phenomena of phosphofructokinase from a hibernating ground squirrel (Spermophilus lateralis).

The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin-1β.

The P2Y6 receptor mediates Clostridium difficile toxin-induced CXCL8/IL-8 production and intestinal epithelial barrier dysfunction

The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter

The contribution of protein kinase C and CPI-17 signaling pathways to hypercontractility in murine experimental colitis.

The effect of hibernation on protein phosphatases from ground squirrel organs

The muscle fatty acid binding protein of spadefoot toad (Scaphiopus couchii)

The myosin phosphatase targeting protein (MYPT) family: a regulated mechanism for achieving substrate specificity of the catalytic subunit of protein phosphatase type 1δ.

The regulation of smooth muscle contractility by zipper-interacting protein kinase

The role of the calponin homology domain of smoothelin-like 1 (SMTNL1) in myosin phosphatase inhibition and smooth muscle contraction

Tissue-selective alternate promoters guide NLRP6 expression

Tools and protocol for quantification of myosin phosphorylation with MRM-MS.

Two domains of the smoothelin-like 1 protein bind apo- and calcium-calmodulin independently

Vitamin D₃ metabolites enhance the NLRP3-dependent secretion of IL-1β from human THP-1 monocytic cells

cAMP-dependent protein kinase from brown adipose tissue: temperature effects on kinetic properties and enzyme role in hibernating ground squirrels