List of works - Paul B Yu

A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation

scientific article published on 08 May 2020

A Selective Transforming Growth Factor-β Ligand Trap Attenuates Pulmonary Hypertension

scientific article published on 26 April 2016

A new class of small molecule inhibitor of BMP signaling

scientific article

ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension

scientific article published on 01 May 2020

ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A.

scientific article

Application of Drug Metabolism Studies in Chemical Structure Optimization for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP)

scientific article published on 24 April 2019

Augmentation of Smad-dependent BMP signaling in neural crest cells causes craniosynostosis in mice

scientific article published on June 2013

BMP type I receptor inhibition reduces heterotopic [corrected] ossification

scientific article

BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia

scientific article published on 30 July 2004

Bone Morphogenetic Protein 9 is a Mechanistic Biomarker of Portopulmonary Hypertension

scientific article published on 01 April 2019

Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells

scientific article published on 9 May 2005

Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells

scientific article published on 27 November 2007

Bone morphogenetic protein 6 and oxidized low-density lipoprotein synergistically recruit osteogenic differentiation in endothelial cells.

scientific article

Brief Report: Coordinated Modulation of Circulating miR-21 in HIV, HIV-Associated Pulmonary Arterial Hypertension, and HIV/Hepatitis C Virus Coinfection.

scientific article

C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation

scientific journal article

Career Development of Young Physician-Scientists in the Cardiovascular Sciences: Perspective and Advice From the Early Career Committee of the Cardiopulmonary, Critical Care, and Resuscitation Council of the American Heart Association

scientific article published on 01 May 2018

Changes in rodent abundance and weather conditions potentially drive hemorrhagic fever with renal syndrome outbreaks in Xi'an, China, 2005-2012.

scientific article

Circulating angiogenic modulatory factors predict survival and functional class in pulmonary arterial hypertension

scientific article published on April 2013

Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva.

scientific article published on 06 August 2008

Constitutively active ALK2 receptor mutants require type II receptor cooperation

scientific article published on 09 April 2013

Contributions of muscle-resident progenitor cells to homeostasis and disease

scientific article published on 10 October 2015

Delayed Microvascular Shear Adaptation in Pulmonary Arterial Hypertension. Role of Platelet Endothelial Cell Adhesion Molecule-1 Cleavage.

scientific article published on 13 January 2016

Development of an ALK2-biased BMP type I receptor kinase inhibitor

scientific article published on 30 April 2013

Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors

scientific article published on 06 September 2018

Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells.

scientific article published on 5 August 2010

Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells

scientific article (publication date: 2008)

Elafin in pulmonary arterial hypertension. Beyond targeting elastases

scientific article published on June 2015

Excess placental secreted frizzled-related protein 1 in maternal smokers impairs fetal growth

scientific article

Finding the Target: In Silico and Genetic Screening for Mechanistically Novel Drugs in Pulmonary Arterial Hypertension

scientific article published on 01 January 2019

HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression

scientific article

Hepcidin regulation by BMP signaling in macrophages is lipopolysaccharide dependent.

scientific article

Images in cardiovascular medicine. Left atrial-esophageal fistula after pulmonary vein isolation: a cautionary tale.

scientific article published in May 2007

Immunochemical properties of anti-Gal alpha 1-3Gal antibodies after sensitization with xenogeneic tissues

scientific article published on 01 March 1999

In Search of the Second Hit in Pulmonary Arterial Hypertension

scientific article published on 01 January 2019

Inhibition of bone morphogenetic protein 6 receptors ameliorates Sjögren's syndrome in mice

scientific article published on 19 February 2020

Inhibition of bone morphogenetic protein signal transduction prevents the medial vascular calcification associated with matrix Gla protein deficiency

scientific article

Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation ⬇️

scientific article published on March 10, 2011

Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis

scientific article published on 05 January 2012

Isolating pulmonary microvascular endothelial cells ex vivo: Implications for pulmonary arterial hypertension, and a caution on the use of commercial biomaterials

scientific article published on 27 February 2019

Macrophage migration inhibitory factor as a novel biomarker of portopulmonary hypertension

scientific article published on December 2016

Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification

scientific article published on 10 December 2019

NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension

scientific article published on 01 June 2018

Naturally occurring anti-alpha-galactosyl antibodies: relationship to xenoreactive anti-alpha-galactosyl antibodies

scientific article published on 01 September 1999

Oral administration of a bone morphogenetic protein type I receptor inhibitor prevents the development of anemia of inflammation

scientific article published on 17 October 2014

Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

scientific article

Pharmacologic Strategies for Assaying BMP Signaling Function

scientific article published on 01 January 2019

Prokaryotic expression, purification and activity assay of recombinant vascular endothelial growth factor.

scientific article published on September 2006

Room With a View

scientific article published on 01 August 2018

Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension.

scientific article published on 15 June 2015

Sensitization with xenogeneic tissues alters the heavy chain repertoire of human anti-Galalpha1-3Gal antibodies

scientific article published on 01 July 2005

Specificity and function of "natural" antibodies in immunodeficient subjects: clues to B cell lineage and development

scientific article published on 01 July 1997

Strategic Targeting of Multiple BMP Receptors Prevents Trauma-Induced Heterotopic Ossification

scientific article published on 15 July 2017

Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants

scientific article

Takotsubo cardiomyopathy complicated by cardiac tamponade: classic hemodynamic findings with a new disease

scientific article published on 01 September 2010

Targeting BMP signalling in cardiovascular disease and anaemia

scientific article

The Role of Bone Marrow-derived Cells in Pulmonary Arterial Hypertension. What Lies Beneath?

scientific article published on April 2016

The obligatory role of Activin A in the formation of heterotopic bone in Fibrodysplasia Ossificans Progressiva.

scientific article published on 16 June 2017

The traumatic bone: trauma-induced heterotopic ossification.

scientific article published on 15 June 2017

Transforming Growth Factor {beta} Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors

scientific article published on 18 February 2009

Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification.

scientific article published on November 2016

Up-regulation of the mammalian target of rapamycin complex 1 subunit Raptor by aldosterone induces abnormal pulmonary artery smooth muscle cell survival patterns to promote pulmonary arterial hypertension

scientific article published on 22 March 2016

Update in Pulmonary Vascular Disease 2016 and 2017

scientific article published on 01 July 2018

Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts.

scientific article

ΔNp63α-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells.

scientific article published on 14 December 2012

List of works by Paul B Yu

A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation

A Selective Transforming Growth Factor-β Ligand Trap Attenuates Pulmonary Hypertension

A new class of small molecule inhibitor of BMP signaling

ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension

ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A.

Application of Drug Metabolism Studies in Chemical Structure Optimization for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP)

Augmentation of Smad-dependent BMP signaling in neural crest cells causes craniosynostosis in mice

BMP type I receptor inhibition reduces heterotopic [corrected] ossification

BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia

Bone Morphogenetic Protein 9 is a Mechanistic Biomarker of Portopulmonary Hypertension

Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells

Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells

Bone morphogenetic protein 6 and oxidized low-density lipoprotein synergistically recruit osteogenic differentiation in endothelial cells.

Brief Report: Coordinated Modulation of Circulating miR-21 in HIV, HIV-Associated Pulmonary Arterial Hypertension, and HIV/Hepatitis C Virus Coinfection.

C-terminal domain (CTD) small phosphatase-like 2 modulates the canonical bone morphogenetic protein (BMP) signaling and mesenchymal differentiation via Smad dephosphorylation

Career Development of Young Physician-Scientists in the Cardiovascular Sciences: Perspective and Advice From the Early Career Committee of the Cardiopulmonary, Critical Care, and Resuscitation Council of the American Heart Association

Changes in rodent abundance and weather conditions potentially drive hemorrhagic fever with renal syndrome outbreaks in Xi'an, China, 2005-2012.

Circulating angiogenic modulatory factors predict survival and functional class in pulmonary arterial hypertension

Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva.

Constitutively active ALK2 receptor mutants require type II receptor cooperation

Contributions of muscle-resident progenitor cells to homeostasis and disease

Delayed Microvascular Shear Adaptation in Pulmonary Arterial Hypertension. Role of Platelet Endothelial Cell Adhesion Molecule-1 Cleavage.

Development of an ALK2-biased BMP type I receptor kinase inhibitor

Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors

Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells.

Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells

Elafin in pulmonary arterial hypertension. Beyond targeting elastases

Excess placental secreted frizzled-related protein 1 in maternal smokers impairs fetal growth

Finding the Target: In Silico and Genetic Screening for Mechanistically Novel Drugs in Pulmonary Arterial Hypertension

HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression

Hepcidin regulation by BMP signaling in macrophages is lipopolysaccharide dependent.

Images in cardiovascular medicine. Left atrial-esophageal fistula after pulmonary vein isolation: a cautionary tale.

Immunochemical properties of anti-Gal alpha 1-3Gal antibodies after sensitization with xenogeneic tissues

In Search of the Second Hit in Pulmonary Arterial Hypertension

Inhibition of bone morphogenetic protein 6 receptors ameliorates Sjögren's syndrome in mice

Inhibition of bone morphogenetic protein signal transduction prevents the medial vascular calcification associated with matrix Gla protein deficiency

Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation ⬇️

Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis

Isolating pulmonary microvascular endothelial cells ex vivo: Implications for pulmonary arterial hypertension, and a caution on the use of commercial biomaterials

Macrophage migration inhibitory factor as a novel biomarker of portopulmonary hypertension

Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification

NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension

Naturally occurring anti-alpha-galactosyl antibodies: relationship to xenoreactive anti-alpha-galactosyl antibodies

Oral administration of a bone morphogenetic protein type I receptor inhibitor prevents the development of anemia of inflammation

Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

Pharmacologic Strategies for Assaying BMP Signaling Function

Prokaryotic expression, purification and activity assay of recombinant vascular endothelial growth factor.

Room With a View

Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension.

Sensitization with xenogeneic tissues alters the heavy chain repertoire of human anti-Galalpha1-3Gal antibodies

Specificity and function of "natural" antibodies in immunodeficient subjects: clues to B cell lineage and development

Strategic Targeting of Multiple BMP Receptors Prevents Trauma-Induced Heterotopic Ossification

Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants

Takotsubo cardiomyopathy complicated by cardiac tamponade: classic hemodynamic findings with a new disease

Targeting BMP signalling in cardiovascular disease and anaemia

The Role of Bone Marrow-derived Cells in Pulmonary Arterial Hypertension. What Lies Beneath?

The obligatory role of Activin A in the formation of heterotopic bone in Fibrodysplasia Ossificans Progressiva.

The traumatic bone: trauma-induced heterotopic ossification.

Transforming Growth Factor {beta} Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors

Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification.

Up-regulation of the mammalian target of rapamycin complex 1 subunit Raptor by aldosterone induces abnormal pulmonary artery smooth muscle cell survival patterns to promote pulmonary arterial hypertension

Update in Pulmonary Vascular Disease 2016 and 2017

Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts.

ΔNp63α-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells.