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List of works by Xavier Iturrioz

A Time-Resolved FRET Cell-Based Binding Assay for the Apelin Receptor

scientific article published on 4 April 2017

A new strategy for treating hypertension by blocking the activity of the brain renin-angiotensin system with aminopeptidase A inhibitors

scientific article published on August 2014

Asp218 participates with Asp213 to bind a Ca2+ atom into the S1 subsite of aminopeptidase A: a key element for substrate specificity.

scientific article published in November 2008

Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes.

scientific article

Biased signaling favoring gi over β-arrestin promoted by an apelin fragment lacking the C-terminal phenylalanine

scientific article

By interacting with the C-terminal Phe of apelin, Phe255 and Trp259 in helix VI of the apelin receptor are critical for internalization.

scientific article published on 30 July 2010

Comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake".

scientific article published in February 2007

Contribution of molecular modeling and site-directed mutagenesis to the identification of two structural residues, Arg-220 and Asp-227, in aminopeptidase A.

scientific article published on 31 May 2002

Convenient Access to Fluorescent Probes by Chemoselective Acylation of Hydrazinopeptides: Application to the Synthesis of the First Far-Red Ligand for Apelin Receptor Imaging.

scientific article published on 18 December 2015

Corrigendum: Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes.

scientific article published on 22 July 2016

Development of original metabolically stable apelin-17 analogs with diuretic and cardiovascular effects.

scientific article published on 4 November 2016

Directed Molecular Evolution of an Engineered Gammaretroviral Envelope Protein with Dual Receptor Use Shows Stable Maintenance of Both Receptor Specificities.

scientific article published on 25 November 2015

Histidine 450 plays a critical role in catalysis and, with Ca2+, contributes to the substrate specificity of aminopeptidase A

scientific article published on 01 March 2000

Human brain aminopeptidase A: biochemical properties and distribution in brain nuclei

scientific article published in April 2008

Identification and pharmacological properties of E339-3D6, the first nonpeptidic apelin receptor agonist

scientific article

Involvement of arginine 878 together with Ca2+ in mouse aminopeptidase A substrate specificity for N-terminal acidic amino-acid residues

scientific article published on 6 September 2017

Loss-of-function point mutations associated with renal tubular dysgenesis provide insights about renin function and cellular trafficking

scientific article published on 29 October 2010

New structural insights into the apelin receptor: identification of key residues for apelin binding

scientific article published on 30 October 2014

PKCzetaII is a target for degradation through the tumour suppressor protein pVHL

scientific article

Phosphoprotein enriched in astrocytes-15 kDa expression inhibits astrocyte migration by a protein kinase C delta-dependent mechanism

scientific article

Phosphorylation is required for PMA- and cell-cycle-induced degradation of protein kinase Cdelta.

scientific article published on November 2002

Reciprocal regulation of plasma apelin and vasopressin by osmotic stimuli

scientific article published on 13 February 2008

Role of the Vasopressin/Apelin Balance and Potential Use of Metabolically Stable Apelin Analogs in Water Metabolism Disorders.

scientific article

SDHD Immunohistochemistry: A New Tool to ValidateSDHxMutations in Pheochromocytoma/Paraganglioma

scientific article published on 18 November 2014

Structure-activity relationship studies toward the discovery of selective apelin receptor agonists

scientific article published on 27 March 2014

Study of asparagine 353 in aminopeptidase A: characterization of a novel motif (GXMEN) implicated in exopeptidase specificity of monozinc aminopeptidases.

scientific article published on December 2001

Synthetic Modification within the "RPRL" Region of Apelin Peptides: Impact on Cardiovascular Activity and Stability to Neprilysin and Plasma Degradation.

scientific article

The apelinergic system: a perspective on challenges and opportunities in cardiovascular and metabolic disorders

scientific article published on 25 June 2019

The von Hippel-Lindau tumour-suppressor protein interaction with protein kinase Cdelta.

scientific article published on July 2006

Tyrosine kinase and mitogen-activated protein kinase/extracellularly regulated kinase differentially regulate intracellular calcium concentration responses to angiotensin II/III and bradykinin in rat cortical thick ascending limb

scientific article

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