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List of works by Joel M. Gottesfeld

8 Isolation of template active and inactive regions of chromatin

scientific article published on January 1, 1975

Accessibility of Nuclear Chromatin by DNA Binding Polyamides ⬇️

scientific article published on September 1, 2003

Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin

scientific article published on 15 January 2006

Assembly of transcriptionally active 5S RNA gene chromatin in vitro

scientific article published on 01 April 1982

Association of an RNA polymerase III transcription factor with a ribonucleoprotein complex recognized by autoimmune sera.

scientific article

Blocking transcription through a nucleosome with synthetic DNA ligands

scientific article published on 01 August 2002

Characterization of the DNA binding properties of the bHLH domain of Deadpan to single and tandem sites.

scientific article

Chromatin structure determines accessibility of a hairpin polyamide–chlorambucil conjugate at histone H4 genes in pancreatic cancer cells ⬇️

scientific article published on April 25, 2012

Chromosomal footprinting of transcriptionally active and inactive oocyte-type 5S RNA genes of Xenopus laevis

scientific article published in October 1990

Competition betweenXenopussatellite I sequences andPolIII genes for stable transcription complex formation ⬇️

scientific article published on October 25, 1984

Control of 5S RNA transcription in Xenopus somatic cell chromatin: activation with an oocyte extract.

scientific article published on January 1983

Control of gene expression in eukaryotic cells: lessons from class III genes.

scientific article published on June 1989

Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands

scientific article (publication date: 14 February 2003)

Cyclin L is an RS domain protein involved in pre-mRNA splicing

scientific article (publication date: 12 July 2002)

Development of histone deacetylase inhibitors as therapeutics for neurological disease

scientific article

Distribution of messenger RNA-coding sequences in fractionated chromatin

scientific article

Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA

scientific article

Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture

scientific article

Energetics and affinity of the histone octamer for defined DNA sequences

scientific article

Epigenetic therapy for Friedreich ataxia

scientific article

Evaluation of Histone Deacetylase Inhibitors as Therapeutics for Neurodegenerative Diseases ⬇️

scientific article published on January 1, 2011

Friedreich's ataxia induced pluripotent stem cells model intergenerational GAA⋅TTC triplet repeat instability

scientific article

Growth arrest of BCR-ABL positive cells with a sequence-specific polyamide-chlorambucil conjugate

scientific article

HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model

scientific article (publication date: 2008)

Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease.

scientific article

Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia.

scientific article published on 20 August 2006

Histone-DNA binding free energy cannot be measured in dilution-driven dissociation experiments

scientific article

Identifier sequences are transcribed specifically in brain.

scientific article published on March 1984

Importance of minor groove binding zinc fingers within the transcription factor IIIA-DNA complex

scientific article published on 01 December 1997

Improved Histone Deacetylase Inhibitors as Therapeutics for the Neurodegenerative Disease Friedreich's Ataxia: A New Synthetic Route

scientific article

Increasing frataxin gene expression with histone deacetylase inhibitors as a therapeutic approach for Friedreich's ataxia.

scientific article published on August 2013

Induced fit and "lock and key" recognition of 5S RNA by zinc fingers of transcription factor IIIA.

scientific article

Inhibition of DNA binding by human estrogen-related receptor 2 and estrogen receptor alpha with minor groove binding polyamides

scientific article

Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands ⬇️

scientific article published on October 27, 1998

Interaction of the RNA binding fingers of Xenopus transcription factor IIIA with specific regions of 5 S ribosomal RNA

scientific article

Introduction to the Thematic Minireview Series on Epigenetics ⬇️

scientific article published on March 24, 2011

Introduction to the Thematic Minireview Series: Chromatin and transcription

scientific article published in Journal of Biological Chemistry

Introduction to thematic minireview series: Development of human therapeutics based on induced pluripotent stem cell (iPSC) technology

scientific article published on 20 December 2013

Length-dependent CTG·CAG triplet-repeat expansion in myotonic dystrophy patient-derived induced pluripotent stem cells.

scientific article published on 9 August 2013

Mechanism of Action of 2-Aminobenzamide HDAC Inhibitors in Reversing Gene Silencing in Friedreich's Ataxia.

scientific article

Milestones in transcription and chromatin published in the Journal of Biological Chemistry

scientific article published on 01 February 2019

Minireview series on sirtuins: from biochemistry to health and disease

scientific article published on 18 October 2012

Minor groove DNA-protein contacts upstream of a tRNA gene detected with a synthetic DNA binding ligand

scientific article published on 01 March 1999

Mitotic repression of the transcriptional machinery.

scientific article published on June 1997

Novobiocin inhibits RNA polymerase III transcription in vitro by a mechanism distinct from DNA topoisomerase II.

scientific article

Nuclear extracts from globin-synthesizing cells enhance globin transcription in vitro

scientific article published in October 1985

Nucleosomes in solution exist as a mixture of twist-defect states

scientific article published in January 2005

Partial Purification of the Template-Active Fraction of Chromatin: A Preliminary Report ⬇️

scientific article published on June 1, 1974

Potent activity against K562 cells by polyamide-seco-CBI conjugates targeting histone H4 genes.

scientific article published on 11 November 2009

Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model ⬇️

scientific article (publication date: June 2011)

Protein and DNA requirements for the transcription factor IIIA-induced distortion of the 5 S rRNA gene promoter

scientific article published on 01 October 1996

Quantitative proteomic analysis identifies targets and pathways of a 2-aminobenzamide HDAC inhibitor in Friedreich's ataxia patient iPSC-derived neural stem cells.

scientific article

RNA as a transcriptional activator

scientific article published on 01 July 2003

RNA toxicity and missplicing in the common eye disease fuchs endothelial corneal dystrophy.

scientific article

Rationale for the Development of 2-Aminobenzamide Histone Deacetylase Inhibitors as Therapeutics for Friedreich Ataxia ⬇️

scientific article published on 04 July 2012

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

scientific article

Regulation of gene expression by small molecules

scientific article published in Nature

Regulation of gene expression with pyrrole-imidazole polyamides.

scientific article published in August 2004

Relative Contributions of the Zinc Fingers of Transcription Factor IIIA to the Energetics of DNA Binding

scientific article published on 01 November 1994

Repression of RNA polymerase II and III transcription during M phase of the cell cycle

scientific article published on December 1996

Repression of vertebrate RNA polymerase III transcription by DNA binding proteins located upstream from the transcription start site

scientific article published in July 1995

Role of DNA sequence in the binding specificity of synthetic basic-helix-loop-helix domains

scientific article published in January 2005

Role of Mismatch Repair Enzymes in GAA·TTC Triplet-repeat Expansion in Friedreich Ataxia Induced Pluripotent Stem Cells ⬇️

scientific article published on July 13, 2012

Selecting and isolating colonies of human induced pluripotent stem cells reprogrammed from adult fibroblasts.

scientific article published on 20 February 2012

Specific interaction of the first three zinc fingers of TFIIIA with the internal control region of the Xenopus 5 S RNA gene.

scientific article

The Effects of Pharmacological Inhibition of Histone Deacetylase 3 (HDAC3) in Huntington's Disease Mice

scientific article

The length of nucleosome-associated DNA is the same in both transcribed and nontranscribed regions of chromatin

scientific article published in Nature

Transcriptional profiling of isogenic Friedreich ataxia neurons and effect of an HDAC inhibitor on disease signatures

scientific article published on 14 December 2018

Translating HDAC inhibitors in Friedreich's ataxia.

scientific article published on 31 July 2016

Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model

scientific article

Zinc is required for folding and binding of a single zinc finger to DNA

scientific article published on 01 February 1991

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