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List of works by Lars Plate

"Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates

scientific article published on 21 December 2017

Apoptolidin family glycomacrolides target leukemia through inhibition of ATP synthase

scientific article published on 02 December 2021

Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue

scientific article published on 18 May 2016

Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether

scientific article published on 31 May 2019

Comparative Multiplexed Interactomics of SARS-CoV-2 and Homologous Coronavirus Nonstructural Proteins Identifies Unique and Shared Host-Cell Dependencies

scientific article published on 02 December 2020

Comparative multiplexed interactomics of SARS-CoV-2 and homologous coronavirus non-structural proteins identifies unique and shared host-cell dependencies

scientific article published on 14 July 2020

Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation Using Targeted RNA Sequencing

scientific article published on 13 March 2019

Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation using Targeted RNA-sequencing

Dengue and Zika virus infection are impaired by small molecule ER proteostasis regulator 147 in an ATF6-independent manner

scientific article published on 16 May 2020

Determinants of Ligand Affinity and Heme Reactivity in H-NOX Domains

scientific article

Hyaluronan-tethered opioid depots: synthetic strategies and release kinetics in vitro and in vivo

scientific article

Methodology to probe subunit interactions in ribonucleotide reductases

scientific article published on December 2008

Modulating protein quality control

scientific article published on 20 July 2016

Nitric oxide modulates bacterial biofilm formation through a multicomponent cyclic-di-GMP signaling network

scientific article published on 26 April 2012

Nitric oxide-sensing H-NOX proteins govern bacterial communal behavior

scientific article published on 07 October 2013

Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients.

scientific article published in September 2017

Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins

scientific article published on 07 August 2018

Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis

scientific article published in Nature Communications

Phosphorylation-dependent derepression by the response regulator HnoC in the Shewanella oneidensis nitric oxide signaling network

scientific article

Premature Activation of Immune Transcription Programs in Autoimmune-Predisposed Mouse Embryonic Stem Cells and Blastocysts

scientific article published on 11 August 2020

Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein

Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein

scientific article published on 16 May 2019

Regulated in Development and DNA Damage Response 1 Deficiency Impairs Autophagy and Mitochondrial Biogenesis in Articular Cartilage and Increases the Severity of Experimental Osteoarthritis

scientific article published on 23 March 2017

Regulating Secretory Proteostasis through the Unfolded Protein Response: From Function to Therapy

scientific article

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.

scientific article published on 20 July 2016

The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer.

scientific article

The unfolded protein response regulator ATF6 promotes mesodermal differentiation.

scientific article published on 13 February 2018

Thyroglobulin interactome profiling defines altered proteostasis topology associated with thyroid dyshormonogenesis

scientific article published on 18 November 2020

Toward 'omic scale metabolite profiling: a dual separation-mass spectrometry approach for coverage of lipid and central carbon metabolism

scientific article published on 03 July 2013

Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain

scientific article

Use of a semisynthetic epitope to probe histidine kinase activity and regulation

scientific article published on 9 October 2009

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