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List of works by Shin-Ichiro Takahashi

A novel IRS-1-associated protein, DGKζ regulates GLUT4 translocation in 3T3-L1 adipocytes.

scientific article published on 14 October 2016

Amino acid regulation of gene transcription of rat insulin-like growth factor-binding protein-1.

scientific article

Analysis of insulin receptor substrate signaling dynamics on microstructured surfaces

scientific article published on 11 February 2015

Aspp2 negatively regulates body growth but not developmental timing by modulating IRS signaling in zebrafish embryos.

scientific article published on 19 December 2013

Branched-chain amino acid supplementation restores reduced insulinotropic activity of a low-protein diet through the vagus nerve in rats

scientific article published on 15 September 2017

Cell proliferation activities on skin fibroblasts from a short child with absence of one copy of the type 1 insulin-like growth factor receptor (IGF1R) gene and a tall child with three copies of the IGF1R gene

scientific article published in December 2003

Chapter Seven - When Phosphorylation Encounters Ubiquitination: A Balanced Perspective on IGF-1R Signaling

scientific article

Constitutive expression of insulin receptor substrate (IRS)-1 inhibits myogenic differentiation through nuclear exclusion of Foxo1 in L6 myoblasts ⬇️

scientific article

Creation of an autocrine model of insulin-like growth factor-I action in transfected FRTL-5 cells

scientific article published on June 1, 1992

Dietary protein deprivation decreases the serine phosphorylation of insulin receptor substrate-1 in rat skeletal muscle

scientific article published on April 2004

Dietary protein deprivation upregulates insulin signaling and inhibits gluconeogenesis in rat liver

scientific article published on 26 August 2010

Dietary restriction of single essential amino acids reduces plasma insulin-like growth factor-I (IGF-I) but does not affect plasma IGF-binding protein-1 in rats

scientific article published on 01 December 2000

Differential subcellular localization of insulin receptor substrates depends on C-terminal regions and importin beta

scientific article published in October 2008

Distinct modes of activation of phosphatidylinositol 3-kinase in response to cyclic adenosine 3', 5'-monophosphate or insulin-like growth factor I play different roles in regulation of cyclin D1 and p27Kip1 in FRTL-5 cells.

scientific article

Enhanced oxidative stress in GH-transgenic rat and acromegaly in humans

scientific article published on 25 February 2012

Familial dysautonomia (Riley-Day syndrome)

scientific article published on 01 March 1994

Familial short stature is associated with a novel dominant-negative heterozygous insulin-like growth factor 1 receptor (IGF1R) mutation

scientific article published on 30 September 2013

Familial short stature with IGF-I receptor gene anomaly.

scientific article published on 19 October 2011

Glucose deprivation attenuates sortilin levels in skeletal muscle cells

scientific article published on 13 December 2016

Growth hormone (GH) or insulin-like growth factor (IGF)-I represses 11beta-hydroxysteroid dehydrogenase type 1 (HSD1) mRNA expression in 3T3-L1 cells and its activity in their homogenates.

scientific article published on 7 April 2009

Growth hormone inhibition of glucose uptake in adipocytes occurs without affecting GLUT4 translocation through an insulin receptor substrate-2-phosphatidylinositol 3-kinase-dependent pathway

scientific article published on 2 January 2009

HSP90 interacting with IRS-2 is involved in cAMP-dependent potentiation of IGF-I signals in FRTL-5 cells

scientific journal article

Helicobacter pylori eradication therapy for gastric ulcer in elderly

scientific article published on November 2010

IGFBP-5 induces epithelial and fibroblast responses consistent with the fibrotic response.

scientific article published on August 2009

IGFBP5 induces cell adhesion, increases cell survival and inhibits cell migration in MCF-7 human breast cancer cells.

scientific article published on 10 February 2012

IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling

scientific article published on 11 April 2018

In vivo regulation of glycogen synthase kinase 3β activity in neurons and brains

scientific article published on 17 August 2017

Influence of fabrication errors on wölter mirror imaging performance

scientific article published on 01 December 1998

Insulin injection restored increased insulin receptor substrate (IRS)-2 protein during short-term protein restriction but did not affect reduced insulin-like growth factor (IGF)-I mRNA or increased triglyceride accumulation in the liver of rats.

scientific article

Insulin receptor substrate-1 (IRS-1) forms a ribonucleoprotein complex associated with polysomes

scientific article

Insulin receptor substrate-1 associates with small nucleolar RNA which contributes to ribosome biogenesis

scientific article published on 04 March 2014

Insulin receptor substrate-3 functions as transcriptional activator in the nucleus

scientific journal article

Insulin receptor substrate-3, interacting with Bcl-3, enhances p50 NF-kappaB activity

scientific article published on 11 March 2010

Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases.

scientific article published on 17 December 2010

Insulin-Like Growth Factor-l Potentiates Protein Synthesis Induced by Thyrotropin in FRTL-5 Cells: Comparison of Induction of Protein Synthesis and DNA Synthesis ⬇️

scientific article published on April 1, 1998

Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs.

scientific article

Integrator complex plays an essential role in adipose differentiation.

scientific article published on 21 March 2013

KIBRA suppresses apical exocytosis through inhibition of aPKC kinase activity in epithelial cells.

scientific article published on 14 April 2011

LST8 level controls basal p70 S6 kinase and Akt phosphorylations, and mTORC1 and mTORC2 negatively regulate each other by competing for association with LST8

scientific article published on 01 July 2012

LUBAC Formation Is Impaired in the Livers of Mice with MCD-Dependent Nonalcoholic Steatohepatitis.

scientific article published on 10 June 2015

Long-term hormonal regulation of the cAMP-specific phosphodiesterases in cultured FRTL-5 thyroid cells.

scientific article

Metformin rapidly increases insulin receptor activation in human liver and signals preferentially through insulin-receptor substrate-2.

scientific article published on March 2003

Microinjection of endogenous and exogenous proteins into primary cultures of rat hepatocytes and the degradation of the injected proteins

scientific article published in January 1989

Motility response to insulin-like growth factor-I (IGF-I) in MCF-7 cells is associated with IRS-2 activation and integrin expression

scientific article published on January 2004

Mutation at cleavage site of insulin-like growth factor receptor in a short-stature child born with intrauterine growth retardation.

scientific article published on 31 May 2005

Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity.

scientific article

Negative regulation of adipogenesis from human mesenchymal stem cells by Jun N-terminal kinase.

scientific article

New approach for the establishment of an hepatocyte cell line derived from rat early embryonic stem cells.

scientific article published on March 2003

Novel missense mutation in the IGF-I receptor L2 domain results in intrauterine and postnatal growth retardation.

scientific article published on August 2012

Novel repressor regulates insulin sensitivity through interaction with Foxo1

scientific article

PKCα suppresses 7,12-dimethylbenz[a]anthracene-induced skin tumor formation

scientific article published on 01 August 2012

Paraquat-induced oxidative stress represses phosphatidylinositol 3-kinase activities leading to impaired glucose uptake in 3T3-L1 adipocytes.

scientific article

Phosphatidylinositol 3-Kinase-Associated Protein (PI3KAP)/XB130 Crosslinks Actin Filaments through Its Actin Binding and Multimerization Properties In Vitro and Enhances Endocytosis in HEK293 Cells

scientific article

Phosphatidylinositol 3-Kinase-Binding Protein, PI3KAP/XB130, Is Required for cAMP-induced Amplification of IGF Mitogenic Activity in FRTL-5 Thyroid Cells ⬇️

scientific article published on April 11, 2012

Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation.

scientific article

Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity

scientific article published on 30 July 2010

Preoperative second-derivative of photoplethysmography measurement predicts the hemodynamic response to general anaesthesia induction

scientific article published in December 2009

Primary marginal zone lymphoma of the thymus accompanied by chromosomal anomaly 46,X,dup(X)(p11p22).

scientific article published in March 2002

Prolyl isomerase Pin1 negatively regulates AMP-activated protein kinase (AMPK) by associating with the CBS domain in the γ subunit

scientific article published on 14 August 2015

RNautophagy/DNautophagy possesses selectivity for RNA/DNA substrates

scientific article published in June 2015

Rapid increase in fibroblast growth factor 21 in protein malnutrition and its impact on growth and lipid metabolism - ERRATUM

scientific article published on 24 September 2015

Rapid increase in fibroblast growth factor 21 in protein malnutrition and its impact on growth and lipid metabolism.

scientific article published on 02 September 2015

Role of Pin1 protein in the pathogenesis of nonalcoholic steatohepatitis in a rodent model

scientific article

Roles of chondroitin sulfate proteoglycan 4 in fibrogenic/adipogenic differentiation in skeletal muscle tissues.

scientific article published on 28 August 2016

Runx1 promotes angiogenesis by downregulation of insulin-like growth factor-binding protein-3.

scientific article

Short term feedback regulation of cAMP in FRTL-5 thyroid cells. Role of PDE4D3 phosphodiesterase activation.

scientific article published on April 2000

Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation

scientific article published on 26 November 2013

Steroid hormones are novel nucleoside transport inhibitors by competition with nucleosides for their transporters

scientific article published on 12 December 2013

Supplemental arginine above the requirement during suckling causes obesity and insulin resistance in rats

scientific article published on 26 January 2016

The AP-1 complex regulates intracellular localization of insulin receptor substrate 1, which is required for insulin-like growth factor I-dependent cell proliferation

scientific article published on 11 March 2013

The Inner Nuclear Membrane Protein Nemp1 Is a New Type of RanGTP-Binding Protein in Eukaryotes

scientific journal article

The Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated Proteins

scientific article

The Short-Stature Homeobox-Containing Gene (shox/SHOX) Is Required for the Regulation of Cell Proliferation and Bone Differentiation in Zebrafish Embryo and Human Mesenchymal Stem Cells

scientific article

The Third International Congress of the GRS and the IGF Society, November 11-15, 2006, Kobe, Japan

scientific article published on 01 June 2007

The novel roles of liver for compensation of insulin resistance in human growth hormone transgenic rats

scientific article published on 17 August 2006

Thyroglobulin (Tg) activates MAPK pathway to induce thyroid cell growth in the absence of TSH, insulin and serum.

scientific article

Tissue-specific effects of protein malnutrition on insulin signaling pathway and lipid accumulation in growing rats

scientific article published on 13 March 2014

Triglyceride synthesis in hepatocytes isolated from rats fed a low-protein diet is enhanced independently of upregulation of insulin signaling

scientific article

Tumor necrosis factor (TNF)-α-induced repression of GKAP42 protein levels through cGMP-dependent kinase (cGK)-Iα causes insulin resistance in 3T3-L1 adipocytes

scientific article

USP15 attenuates IGF-I signaling by antagonizing Nedd4-induced IRS-2 ubiquitination

scientific article published on 23 January 2017

Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma.

scientific article published on 16 January 2017

Virtual pancreatoscopy of pancreatic cancer

scientific article published in March 2003

[Insulin-like growth factor-I controls animal growth]

scientific article published on 01 March 1996

[Legislation of MEXT guidelines for research involving recombinant DNA molecules]

scientific article published on 01 March 2004

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