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List of works by David D Roberts

A combinatorial approach for targeted delivery using small molecules and reversible masking to bypass nonspecific uptake in vivo

scientific article

A function-blocking CD47 antibody modulates extracellular vesicle-mediated intercellular signaling between breast carcinoma cells and endothelial cells

scientific article published on 29 November 2017

ATP binding to hemoglobin response gene 1 protein is necessary for regulation of the mating type locus in Candida albicans

scientific article

Activate Rac to rescue new vessels

scientific article published on 01 February 2011

Activated CD47 regulates multiple vascular and stress responses: implications for acute kidney injury and its management

scientific article

Age-dependent regulation of skeletal muscle mitochondria by the thrombospondin-1 receptor CD47.

scientific article

Alpha4beta1 integrin mediates selective endothelial cell responses to thrombospondins 1 and 2 in vitro and modulates angiogenesis in vivo

scientific article published on 29 December 2003

Antisense targeting of CD47 enhances human cytotoxic T-cell activity and increases survival of mice bearing B16 melanoma when combined with anti-CTLA4 and tumor irradiation

scientific article published on 18 October 2019

Arginine-induced germ tube formation in Candida albicans is essential for escape from murine macrophage line RAW 264.7.

scientific article published on 2 February 2009

Autotaxin signaling via lysophosphatidic acid receptors contributes to vascular endothelial growth factor-induced endothelial cell migration.

scientific article

Blockade of CD47 increases survival of mice exposed to lethal total body irradiation

scientific article

Blockade of thrombospondin-1-CD47 interactions prevents necrosis of full thickness skin grafts

scientific article

Blocking Thrombospondin-1/CD47 Signaling Alleviates Deleterious Effects of Aging on Tissue Responses to Ischemia

article

CD47

article

CD47 Expression in Natural Killer Cells Regulates Homeostasis and Modulates Immune Response to Lymphocytic Choriomeningitis Virus

scientific article published on 20 December 2018

CD47 Promotes Protective Innate and Adaptive Immunity in a Mouse Model of Disseminated Candidiasis

scientific article published on 26 May 2015

CD47 Receptor Globally Regulates Metabolic Pathways That Control Resistance to Ionizing Radiation

scientific article

CD47 applies the brakes to angiogenesis via vascular endothelial growth factor receptor-2.

scientific article

CD47 deficiency confers cell and tissue radioprotection by activation of autophagy

scientific article

CD47 in the tumor microenvironment limits cooperation between antitumor T-cell immunity and radiotherapy

scientific article

CD47 signaling pathways controlling cellular differentiation and responses to stress

scientific article published on 24 February 2015

CD47 signaling regulates the immunosuppressive activity of VEGF in T cells

scientific article

CD47-dependent immunomodulatory and angiogenic activities of extracellular vesicles produced by T cells.

scientific article published on 2 June 2014

CD47-dependent regulation of H₂S biosynthesis and signaling in T cells

scientific article published on 08 January 2015

CD47: a new target in cardiovascular therapy.

scientific article published on 10 January 2008

CD63, MHC class 1, and CD47 identify subsets of extracellular vesicles containing distinct populations of noncoding RNAs.

scientific article published on 7 February 2018

Candida albicans ISW2 Regulates Chlamydospore Suspensor Cell Formation and Virulence In Vivo in a Mouse Model of Disseminated Candidiasis

scientific article

Candida albicans heme oxygenase and its product CO contribute to pathogenesis of candidemia and alter systemic chemokine and cytokine expression

scientific article

Combination of anthracyclines and anti-CD47 therapy inhibit invasive breast cancer growth while preventing cardiac toxicity by regulation of autophagy

scientific article published on 28 July 2018

Comprehensive characterization of heat shock protein 27 phosphorylation in human endothelial cells stimulated by the microbial dithiole thiolutin

scientific article published on 23 August 2008

Conformational analysis of an alpha3beta1 integrin-binding peptide from thrombospondin-1: implications for antiangiogenic drug design

scientific article

Dietary fat overcomes the protective activity of thrombospondin-1 signaling in the Apc(Min/+) model of colon cancer

scientific article published on 30 May 2016

Differential effects of ABT-510 and a CD36-binding peptide derived from the type 1 repeats of thrombospondin-1 on fatty acid uptake, nitric oxide signaling, and caspase activation in vascular cells.

scientific article

Differential expression of S100C in thyroid lesions

scientific article published in April 2004

Differential interactions of thrombospondin-1, -2, and -4 with CD47 and effects on cGMP signaling and ischemic injury responses.

scientific article

Differential intolerance to loss of function and missense mutations in genes that encode human matricellular proteins

scientific article published on 07 January 2021

Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity

scientific article

Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells.

scientific article published on 23 July 2009

Divergent modulation of normal and neoplastic stem cells by thrombospondin-1 and CD47 signaling

scientific article published on 6 May 2016

Dur3 is the major urea transporter in Candida albicans and is co-regulated with the urea amidolyase Dur1,2

scientific article

Endogenous thrombospondin-1 regulates leukocyte recruitment and activation and accelerates death from systemic candidiasis

scientific article

Endoplasmic Reticulum Stress Protein GRP78 Modulates Lipid Metabolism to Control Drug Sensitivity and Antitumor Immunity in Breast Cancer

scientific article published on October 2016

Endothelial nitric oxide synthase limits host immunity to control disseminated Candida albicans infections in mice ⬇️

scientific article published on 31 October 2019

Enhancing cardiovascular dynamics by inhibition of thrombospondin-1/CD47 signaling.

scientific article published on October 2008

Extracellular Matrix and Redox Signaling in Cellular Responses to Stress

scientific article

Fibronectin-based masking molecule blocks platelet adhesion

scientific article

Functional regulation of T lymphocytes by modulatory extracellular matrix proteins.

scientific article published on June 2004

Guanylyl cyclase-dependent chemotaxis of endothelial cells in response to nitric oxide gradients

scientific article published on 17 November 2005

Hbr1 Activates and Represses Hyphal Growth in Candida albicans and Regulates Fungal Morphogenesis under Embedded Conditions

scientific article published on 3 June 2015

Heme oxygenase in Candida albicans is regulated by hemoglobin and is necessary for metabolism of exogenous heme and hemoglobin to alpha-biliverdin

scientific article published on 13 November 2003

Hemoglobin is an effective inducer of hyphal differentiation in Candida albicans

scientific article published on 01 February 2007

Identification of novel beta1 integrin binding sites in the type 1 and type 2 repeats of thrombospondin-1.

scientific article

Imaging Candida Infections in the Host.

scientific article published on January 2016

Increasing Survival of Ischemic Tissue by Targeting CD47

article

Induction of a high affinity fibronectin receptor in Candida albicans by caspofungin: requirements for beta (1,6) glucans and the developmental regulator Hbr1p.

scientific article published in March 2007

Inhibitory signaling through signal regulatory protein-α is not sufficient to explain the antitumor activities of CD47 antibodies

scientific article published on 24 August 2012

MRI confirms loss of blood-brain barrier integrity in a mouse model of disseminated candidiasis

scientific article

Metabolomic Analysis Reveals Unique Biochemical Signatures Associated with Protection from Radiation Induced Lung Injury by Lack of cd47 Receptor Gene Expression

scientific article published on 08 October 2019

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

scientific article published on 23 November 2018

Mitochondria directly donate their membrane to form autophagosomes during a novel mechanism of parkin-associated mitophagy.

scientific article published on 27 March 2014

Modulation of angiogenesis by dithiolethione-modified NSAIDs and valproic acid.

scientific article published on 12 March 2007

Molecular regulation of tumor angiogenesis and perfusion via redox signaling

scientific article

NOS Inhibition Modulates Immune Polarization and Improves Radiation-Induced Tumor Growth Delay

scientific article published on 19 May 2015

Natural Killer Cell Recruitment and Activation Are Regulated by CD47 Expression in the Tumor Microenvironment

scientific article published on 30 July 2019

Nitric oxide and its gatekeeper thrombospondin-1 in tumor angiogenesis.

scientific article published on February 2007

Nitric oxide in wound-healing.

scientific article

Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1.

scientific article

Novel dithiolethione-modified nonsteroidal anti-inflammatory drugs in human hepatoma HepG2 and colon LS180 cells.

scientific article published on 10 March 2009

Positive feedback between vascular endothelial growth factor-A and autotaxin in ovarian cancer cells

scientific article published on March 2008

Programmable multivalent display of receptor ligands using peptide nucleic acid nanoscaffolds.

scientific article

Protein expression profiling in the spectrum of renal cell carcinomas.

scientific article

Proteomic identification of new biomarkers and application in thyroid cytology

scientific article published on 01 September 2006

Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors

scientific article published on 05 July 2019

Radioprotection in normal tissue and delayed tumor growth by blockade of CD47 signaling

scientific article

Recognition of the N-terminal modules of thrombospondin-1 and thrombospondin-2 by alpha6beta1 integrin.

scientific article published on 8 August 2003

Regulation of cellular redox signaling by matricellular proteins in vascular biology, immunology, and cancer

scientific article

Regulation of integrin function by CD47 ligands. Differential effects on alpha vbeta 3 and alpha 4beta1 integrin-mediated adhesion

scientific article published on 5 September 2002

Regulation of nitric oxide signalling by thrombospondin 1: implications for anti-angiogenic therapies

scientific article published on 05 February 2009

Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow.

scientific article published on 04 April 2014

Ribosomal RNA processing in Candida albicans.

scientific article published on 25 October 2011

Secreted Thrombospondin-1 Regulates Macrophage Interleukin-1β Production and Activation through CD47.

scientific article published on 27 January 2016

Signaling and stress: The redox landscape in NOS2 biology

scientific article (publication date: October 2015)

Silencing of directional migration in roundabout4 knockdown endothelial cells

scientific article

TSG-6 binds via its CUB_C domain to the cell-binding domain of fibronectin and increases fibronectin matrix assembly

scientific journal article

The N-terminal module of thrombospondin-1 interacts with the link domain of TSG-6 and enhances its covalent association with the heavy chains of inter-alpha-trypsin inhibitor.

scientific article

The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: a new feature of nitrogen oxide signaling

scientific article published on July 2006

The bell-shaped curve for peroxynitrite-mediated oxidation and nitration of NO/O2-* is alive and well.

scientific article published on August 2010

The biphasic nature of nitric oxide responses in tumor biology.

scientific article published on July 2006

The role of CD47 in pathogenesis and treatment of renal ischemia reperfusion injury

scientific article published on 03 November 2018

Therapeutic Targeting of CD47 to Modulate Tissue Responses to Ischemia and Radiation.

scientific article

Therapeutic opportunities for targeting the ubiquitous cell surface receptor CD47

scientific article

Therapeutic targeting of the thrombospondin-1 receptor CD47 to treat liver cancer.

scientific article published on 18 March 2015

Thrombospondin 1 and vasoactive agents indirectly alter tumor blood flow.

scientific article

Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cells

scientific article

Thrombospondin-1 and CD47 limit cell and tissue survival of radiation injury.

scientific article published on 11 September 2008

Thrombospondin-1 and CD47 regulate blood pressure and cardiac responses to vasoactive stress

scientific article published on 21 January 2009

Thrombospondin-1 and CD47 signaling regulate healing of thermal injury in mice.

scientific article

Thrombospondin-1 antagonizes nitric oxide-stimulated vascular smooth muscle cell responses

scientific article published on 27 May 2006

Thrombospondin-1 inhibition of vascular smooth muscle cell responses occurs via modulation of both cAMP and cGMP.

scientific article

Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47.

scientific article

Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner

scientific article

Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake

scientific article

Thrombospondin-1 interactions regulate eicosanoid metabolism and signaling in cancer-related inflammation

scientific article published on 01 September 2018

Thrombospondin-1 is a CD47-dependent endogenous inhibitor of hydrogen sulfide signaling in T cell activation

scientific article published on 13 March 2013

Thrombospondin-1 is a major activator of TGF-beta in fibrotic renal disease in the rat in vivo.

scientific article published in February 2004

Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide-mediated vascular smooth muscle relaxation

scientific article published on 2 November 2006

Thrombospondin-1/CD47 blockade following ischemia-reperfusion injury is tissue protective.

scientific article published on December 2009

Thrombospondin-1: an extracellular message delivered by macrophages that promotes aortic aneurysms

scientific article published in July 2015

Thrombospondins: Purification of human platelet thrombospondin-1.

scientific article published on 6 November 2017

Tipping off endothelial tubes: nitric oxide drives tip cells

scientific article published on 16 December 2014

Treatment of liver ischemia-reperfusion injury by limiting thrombospondin-1/CD47 signaling

scientific article

Trichostatin A and 5-aza-2'-deoxycytidine switch S1P from an inhibitor to a stimulator of motility through epigenetic regulation of S1P receptors.

scientific article published on 26 December 2006

Type I collagen is a molecular target for inhibition of angiogenesis by endogenous thrombospondin-1

scientific article published on 01 January 2006

Urea amidolyase (DUR1,2) contributes to virulence and kidney pathogenesis of Candida albicans

scientific article

Versican-thrombospondin-1 binding in vitro and colocalization in microfibrils induced by inflammation on vascular smooth muscle cells.

scientific article

sFRP-1 binds via its netrin-related motif to the N-module of thrombospondin-1 and blocks thrombospondin-1 stimulation of MDA-MB-231 breast carcinoma cell adhesion and migration.

scientific article

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