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List of works by Metello Innocenti

Abi1 is essential for the formation and activation of a WAVE2 signalling complex

scientific article

Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes

article

An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine

scientific article

CDC25(Mm)/Ras-GRF1 regulates both Ras and Rac signaling pathways

scientific article published on October 1999

CLIC4 is regulated by RhoA-mDia2 signaling through Profilin-1 binding to modulate filopodia length

Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1

scientific article (publication date: 19 October 2001)

Flat clathrin lattices are dynamic actin-controlled hubs for clathrin-mediated endocytosis and signalling of specific receptors

scientific article published on 13 July 2017

Initiation of lamellipodia and ruffles involves cooperation between mDia1 and the Arp2/3 complex.

scientific article published on 8 September 2015

Interplay between N-WASP and CK2 optimizes clathrin-mediated endocytosis of EGFR.

scientific article

Invadosomes - shaping actin networks to follow mechanical cues

scientific article published on June 2016

Knockout of the Arp2/3 complex in epidermis causes a psoriasis-like disease hallmarked by hyperactivation of transcription factor Nrf2.

scientific article published on 7 November 2017

Mechanisms through which Sos-1 coordinates the activation of Ras and Rac.

scientific article

New insights into the formation and the function of lamellipodia and ruffles in mesenchymal cell migration.

scientific article published on 7 March 2018

New nuclear and perinuclear functions of formins.

scientific article published on December 2016

PFA fixation enables artifact-free super-resolution imaging of the actin cytoskeleton and associated proteins

scientific article published on 4 July 2016

Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1.

scientific article

Profilin 1 binding couples chloride intracellular channel protein CLIC4 to RhoA-mDia2 signaling and filopodium formation

scientific article published in Journal of Biological Chemistry

Proteomic analyses uncover a new function and mode of action for mouse homolog of Diaphanous 2 (mDia2)

scientific article

Quantitative Proteomics Illuminates a Functional Interaction between mDia2 and the Proteasome

scientific article published on 21 October 2016

Rapid Remodeling of Invadosomes by Gi-coupled Receptors: DISSECTING THE ROLE OF Rho GTPases.

scientific article

Regulation of actin dynamics by WASP and WAVE family proteins.

scientific article published on June 2004

Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement

scientific article

SMIFH2 has effects on Formins and p53 that perturb the cell cytoskeleton

scientific article

Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation.

scientific article

The chloride intracellular channel protein CLIC4 inhibits filopodium formation induced by constitutively active mutants of formin mDia2

scientific article published on 07 March 2020

WASP-related proteins, Abi1 and Ena/VASP are required for Listeria invasion induced by the Met receptor

scientific article published on 15 March 2005

WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2.

scientific article

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