List of works - Jean-Pierre Brion

3D imaging in the postmortem human brain with CLARITY and CUBIC

scientific article published on 01 January 2018

A 4R tauopathy develops without amyloid deposits in aged cat brains

scientific article published on 14 June 2019

A neuronal aging pattern unique to humans and common chimpanzees

scientific article

A subset of calretinin-positive neurons are abnormal in Alzheimer's disease

scientific article published in January 1994

Accelerated human mutant tau aggregation by knocking out murine tau in a transgenic mouse model

scientific article published on February 2011

Adult neural precursor cells form connexin-dependent networks that improve their survival

scientific article published in October 2015

Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a “P301L” tau knockin mouse

Alzheimer's disease and tau proteins

scientific article published in November 1986

Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits

scientific article

Amyloid precursor protein reduction enhances the formation of neurofibrillary tangles in a mutant tau transgenic mouse model

scientific article published on 5 April 2017

Amyloid-β pathology enhances pathological fibrillary tau seeding induced by Alzheimer PHF in vivo

scientific article published on 01 January 2019

Astrocytes are an early target in osmotic demyelination syndrome

scientific article

Astrocytic calcium/zinc binding protein S100A6 over expression in Alzheimer's disease and in PS1/APP transgenic mice models

article

Bimodal modulation of tau protein phosphorylation and conformation by extracellular Zn2+ in human-tau transfected cells

scientific article

Biological Models in Frontotemporal Dementias

scientific article published on 01 January 2008

Calcineurin (phosphatase 2B) is present in neurons containing neurofibrillary tangles and in a subset of senile plaques in Alzheimer's disease.

scientific article published in March 1995

Calcium-mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid-beta accumulation.

scientific article published on 3 November 2006

Cell cycle S phase markers are expressed in cerebral neuron nuclei of cats infected by the Feline Panleukopenia Virus.

scientific article published on 10 November 2016

Cell surface targeting of VPAC1 receptors: evidence for implication of a quality control system and the proteasome

scientific article published on 8 April 2008

Central role and mechanisms of β-cell dysfunction and death in friedreich ataxia-associated diabetes

scientific article published on December 2012

Characterisation of cytoskeletal abnormalities in mice transgenic for wild-type human tau and familial Alzheimer's disease mutants of APP and presenilin-1.

scientific article published in February 2004

Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brains

scientific article

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

scientific article

Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission

scientific article published on 23 March 2017

Degeneration of phrenic motor neurons induces long-term diaphragm deficits following mid-cervical spinal contusion in mice

scientific article published on 23 November 2012

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

scientific journal article

Deletion of murine tau gene increases tau aggregation in a human mutant tau transgenic mouse model

scientific article published on August 2010

Developmental changes in tau phosphorylation: fetal tau is transiently phosphorylated in a manner similar to paired helical filament-tau characteristic of Alzheimer's disease.

scientific article published in December 1993

Developmental expression and localization of glycogen synthase kinase-3beta in rat brain

scientific article published in June 1999

Distribution of the phosphorylated microtubule-associated protein tau in developing cortical neurons

scientific article published in December 1994

Early axonopathy preceding neurofibrillary tangles in mutant tau transgenic mice

scientific article

Early phrenic motor neuron loss and transient respiratory abnormalities after unilateral cervical spinal cord contusion

scientific article published on June 2013

Enhanced signaling downstream of ribonucleic Acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets.

scientific article

Epigenetic control of aquaporin 1 expression by the amyloid precursor protein

scientific article published on 17 August 2009

Epigenetic induction of EGR-1 expression by the amyloid precursor protein during exposure to novelty

scientific article

Expression of Tau protein and Tau mRNA in the cerebellum during axonal outgrowth

scientific article published on 01 January 1990

Expression of tau mRNA and soluble tau isoforms in affected and non-affected brain areas in Alzheimer's disease.

scientific article published in October 2004

Expression of transferrin receptor 1, proliferating cell nuclear antigen, p27(Kip1) and calbindin in the fetal and neonatal feline cerebellar cortex

scientific article

Expression of vasoactive intestinal peptide and related receptors in overcirculation-induced pulmonary hypertension in piglets.

scientific article

Generation of a monoclonal antibody to the carboxy-terminal domain of tau by immunization with the amino-terminal domain of the amyloid precursor protein

scientific article published in December 1996

Glial cells identified by anti-alpha-albumin (anti-GFA) in human pineal gland.

scientific article

Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase

scientific article published in November 1992

Glycogen synthase kinase-3beta and the p25 activator of cyclin dependent kinase 5 increase pausing of mitochondria in neurons

scientific article published on 6 March 2010

Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain

scientific article published on 15 February 2017

Heparin treatment increases 9-kb MAP2 mRNA levels in neuronal cell cultures

scientific article

Heterotopic brain tissue in the scalp

scientific article published on 01 July 1995

High-Molecular-Weight Paired Helical Filaments from Alzheimer Brain Induces Seeding of Wild-Type Mouse Tau into an Argyrophilic 4R Tau Pathology in Vivo

scientific article published on 3 August 2016

Identification of feline panleukopenia virus proteins expressed in Purkinje cell nuclei of cats with cerebellar hypoplasia.

scientific article published on 16 November 2012

Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration

scientific article

Increased misfolding and truncation of tau in APP/PS1/tau transgenic mice compared to mutant tau mice

scientific article

Increased tau phosphorylation but absence of formation of neurofibrillary tangles in mice double transgenic for human tau and Alzheimer mutant (M146L) presenilin-1.

scientific article published in January 2002

Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology

scientific article published on 8 January 2014

Interaction between a MAPT variant causing frontotemporal dementia and mutant APP affects axonal transport.

scientific article published on 5 April 2018

Isolation of cDNAs coding for epitopes shared by microtubule-associated proteins and neurofibrillary tangle in Alzheimer's disease

scientific article

Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice

scientific article published on 28 September 2012

Level of PICALM, a key component of clathrin-mediated endocytosis, is correlated with levels of phosphotau and autophagy-related proteins and is associated with tau inclusions in AD, PSP and Pick disease

scientific article published on 31 May 2016

Levels of kinesin light chain and dynein intermediate chain are reduced in the frontal cortex in Alzheimer's disease: implications for axoplasmic transport.

scientific article

Lithium chloride increases the production of amyloid-beta peptide independently from its inhibition of glycogen synthase kinase 3.

scientific article published on 13 July 2005

Lithium reduces tau phosphorylation: effects in living cells and in neurons at therapeutic concentrations.

scientific article published on April 1999

Lithium treatment arrests the development of neurofibrillary tangles in mutant tau transgenic mice with advanced neurofibrillary pathology

scientific article

Mint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease

scientific article (publication date: June 1999)

Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice.

scientific article published on 7 December 2015

Modulation of tau pathology in tau transgenic models

scientific article published on August 2010

Motor deficit in a tauopathy model is induced by disturbances of axonal transport leading to dying-back degeneration and denervation of neuromuscular junctions

scientific article published on 10 August 2015

Multifaceted role of galectin-3 on human glioblastoma cell motility

scientific article

Mutant presenilin 1 proteins induce cell death and reduce tau-dependent processes outgrowth.

scientific article published on December 2003

Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation

scientific article published on 01 March 1999

Neurodegenerative changes including altered tau phosphorylation and neurofilament immunoreactivity in mice transgenic for the serine/threonine kinase Mos.

scientific article published in March 1996

Neurofibrillary tangles and Alzheimer's disease.

scientific article

Neuropathology of iatrogenic Creutzfeldt-Jakob disease and immunoassay of French cadaver-sourced growth hormone batches suggest possible transmission of tauopathy and long incubation periods for the transmission of Abeta pathology

scientific article

New aspects of the pathology of neurodegenerative disorders as revealed by ubiquitin antibodies

scientific article published on 01 January 1989

Osmotic Stress-Induced Defective Glial Proteostasis Contributes to Brain Demyelination after Hyponatremia Treatment

scientific article published on 25 January 2017

Overexpression of the astrocyte glutamate transporter GLT1 exacerbates phrenic motor neuron degeneration, diaphragm compromise, and forelimb motor dysfunction following cervical contusion spinal cord injury.

scientific article

PART is part of Alzheimer disease

scientific article

Perikaryal neurofilament phosphorylation in axotomized and 6-OH-dopamine-lesioned CNS neurons

scientific article published in September 1990

Phosphorylation of tau protein is not affected in mice lacking apolipoprotein E

scientific article published on 01 November 1995

Phrenic motor neuron degeneration compromises phrenic axonal circuitry and diaphragm activity in a unilateral cervical contusion model of spinal cord injury

article

Quantitative assessment of the density of neurofibrillary tangles and senile plaques in senile dementia of the Alzheimer type. Comparison of immunocytochemistry with a specific antibody and Bodian's protargol method

scientific article published in January 1987

Rapamycin ester analog CCI-779/Temsirolimus alleviates tau pathology and improves motor deficit in mutant tau transgenic mice

scientific article published in January 2015

Rating of the lesions in senile dementia of the Alzheimer type: concordance between laboratories. A European multicenter study under the auspices of EURAGE.

scientific article published in July 1990

Re-induction of hyponatremia after rapid overcorrection of hyponatremia reduces mortality in rats

scientific article published on 15 July 2009

Regional oligodendrocytopathy and astrocytopathy precede myelin loss and blood-brain barrier disruption in a murine model of osmotic demyelination syndrome

scientific article published on 23 November 2017

Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts

scientific article published on 15 February 2013

Sex-regulated gene dosage effect of PPARα on synaptic plasticity

article

Subcellular structural plasticity caused by the absence of the fast Ca(2+) buffer calbindin D-28k in recurrent collaterals of cerebellar Purkinje neurons

scientific article published on 5 November 2014

Synaptophysin and chromogranin A immunoreactivities in senile plaques of Alzheimer's disease

scientific article published in January 1991

Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate

scientific article published on 12 June 2016

The active form of glycogen synthase kinase-3beta is associated with granulovacuolar degeneration in neurons in Alzheimer's disease.

scientific article published on 29 November 2001

The complex relationship between soluble and insoluble tau in tauopathies revealed by efficient dephosphorylation and specific antibodies

scientific article published in November 2002

The function of the microtubule-associated protein tau is variably modulated by graded changes in glycogen synthase kinase-3β activity

scientific article published on 01 January 2000

The lipid phosphatase Synaptojanin 1 undergoes a significant alteration in expression and solubility and is associated with brain lesions in Alzheimer's disease

scientific article published on 03 June 2020

The long term adenoviral expression of the human amyloid precursor protein shows different secretase activities in rat cortical neurons and astrocytes.

scientific article published in October 1998

The pathology of the neuronal cytoskeleton in Alzheimer's disease

scientific article published on November 10, 1992

Transplantation of human cortex with Alzheimer's disease into rat occipital cortex; a model for the study of Alzheimer disease

scientific article published in April 1984

Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase.

scientific article published on July 2005

Ultrastructural Analysis of Thalamus Damages in a Mouse Model of Osmotic-Induced Demyelination

scientific article published on 02 May 2019

Vaccination with Sarkosyl insoluble PHF-tau decrease neurofibrillary tangles formation in aged tau transgenic mouse model: a pilot study.

scientific article

de novo MAPT mutation G335A causes severe brain atrophy, 3R and 4R PHF-tau pathology and early onset frontotemporal dementia

scientific article published on 29 June 2020

List of works by Jean-Pierre Brion

3D imaging in the postmortem human brain with CLARITY and CUBIC

A 4R tauopathy develops without amyloid deposits in aged cat brains

A neuronal aging pattern unique to humans and common chimpanzees

A subset of calretinin-positive neurons are abnormal in Alzheimer's disease

Accelerated human mutant tau aggregation by knocking out murine tau in a transgenic mouse model

Adult neural precursor cells form connexin-dependent networks that improve their survival

Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a “P301L” tau knockin mouse

Alzheimer's disease and tau proteins

Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits

Amyloid precursor protein reduction enhances the formation of neurofibrillary tangles in a mutant tau transgenic mouse model

Amyloid-β pathology enhances pathological fibrillary tau seeding induced by Alzheimer PHF in vivo

Astrocytes are an early target in osmotic demyelination syndrome

Astrocytic calcium/zinc binding protein S100A6 over expression in Alzheimer's disease and in PS1/APP transgenic mice models

Bimodal modulation of tau protein phosphorylation and conformation by extracellular Zn2+ in human-tau transfected cells

Biological Models in Frontotemporal Dementias

Calcineurin (phosphatase 2B) is present in neurons containing neurofibrillary tangles and in a subset of senile plaques in Alzheimer's disease.

Calcium-mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid-beta accumulation.

Cell cycle S phase markers are expressed in cerebral neuron nuclei of cats infected by the Feline Panleukopenia Virus.

Cell surface targeting of VPAC1 receptors: evidence for implication of a quality control system and the proteasome

Central role and mechanisms of β-cell dysfunction and death in friedreich ataxia-associated diabetes

Characterisation of cytoskeletal abnormalities in mice transgenic for wild-type human tau and familial Alzheimer's disease mutants of APP and presenilin-1.

Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brains

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission

Degeneration of phrenic motor neurons induces long-term diaphragm deficits following mid-cervical spinal contusion in mice

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

Deletion of murine tau gene increases tau aggregation in a human mutant tau transgenic mouse model

Developmental changes in tau phosphorylation: fetal tau is transiently phosphorylated in a manner similar to paired helical filament-tau characteristic of Alzheimer's disease.

Developmental expression and localization of glycogen synthase kinase-3beta in rat brain

Distribution of the phosphorylated microtubule-associated protein tau in developing cortical neurons

Early axonopathy preceding neurofibrillary tangles in mutant tau transgenic mice

Early phrenic motor neuron loss and transient respiratory abnormalities after unilateral cervical spinal cord contusion

Enhanced signaling downstream of ribonucleic Acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets.

Epigenetic control of aquaporin 1 expression by the amyloid precursor protein

Epigenetic induction of EGR-1 expression by the amyloid precursor protein during exposure to novelty

Expression of Tau protein and Tau mRNA in the cerebellum during axonal outgrowth

Expression of tau mRNA and soluble tau isoforms in affected and non-affected brain areas in Alzheimer's disease.

Expression of transferrin receptor 1, proliferating cell nuclear antigen, p27(Kip1) and calbindin in the fetal and neonatal feline cerebellar cortex

Expression of vasoactive intestinal peptide and related receptors in overcirculation-induced pulmonary hypertension in piglets.

Generation of a monoclonal antibody to the carboxy-terminal domain of tau by immunization with the amino-terminal domain of the amyloid precursor protein

Glial cells identified by anti-alpha-albumin (anti-GFA) in human pineal gland.

Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase

Glycogen synthase kinase-3beta and the p25 activator of cyclin dependent kinase 5 increase pausing of mitochondria in neurons

Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain

Heparin treatment increases 9-kb MAP2 mRNA levels in neuronal cell cultures

Heterotopic brain tissue in the scalp

High-Molecular-Weight Paired Helical Filaments from Alzheimer Brain Induces Seeding of Wild-Type Mouse Tau into an Argyrophilic 4R Tau Pathology in Vivo

Identification of feline panleukopenia virus proteins expressed in Purkinje cell nuclei of cats with cerebellar hypoplasia.

Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration

Increased misfolding and truncation of tau in APP/PS1/tau transgenic mice compared to mutant tau mice

Increased tau phosphorylation but absence of formation of neurofibrillary tangles in mice double transgenic for human tau and Alzheimer mutant (M146L) presenilin-1.

Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology

Interaction between a MAPT variant causing frontotemporal dementia and mutant APP affects axonal transport.

Isolation of cDNAs coding for epitopes shared by microtubule-associated proteins and neurofibrillary tangle in Alzheimer's disease

Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice

Level of PICALM, a key component of clathrin-mediated endocytosis, is correlated with levels of phosphotau and autophagy-related proteins and is associated with tau inclusions in AD, PSP and Pick disease

Levels of kinesin light chain and dynein intermediate chain are reduced in the frontal cortex in Alzheimer's disease: implications for axoplasmic transport.

Lithium chloride increases the production of amyloid-beta peptide independently from its inhibition of glycogen synthase kinase 3.

Lithium reduces tau phosphorylation: effects in living cells and in neurons at therapeutic concentrations.

Lithium treatment arrests the development of neurofibrillary tangles in mutant tau transgenic mice with advanced neurofibrillary pathology

Mint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease

Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice.

Modulation of tau pathology in tau transgenic models

Motor deficit in a tauopathy model is induced by disturbances of axonal transport leading to dying-back degeneration and denervation of neuromuscular junctions

Multifaceted role of galectin-3 on human glioblastoma cell motility

Mutant presenilin 1 proteins induce cell death and reduce tau-dependent processes outgrowth.

Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation

Neurodegenerative changes including altered tau phosphorylation and neurofilament immunoreactivity in mice transgenic for the serine/threonine kinase Mos.

Neurofibrillary tangles and Alzheimer's disease.

Neuropathology of iatrogenic Creutzfeldt-Jakob disease and immunoassay of French cadaver-sourced growth hormone batches suggest possible transmission of tauopathy and long incubation periods for the transmission of Abeta pathology

New aspects of the pathology of neurodegenerative disorders as revealed by ubiquitin antibodies

Osmotic Stress-Induced Defective Glial Proteostasis Contributes to Brain Demyelination after Hyponatremia Treatment

Overexpression of the astrocyte glutamate transporter GLT1 exacerbates phrenic motor neuron degeneration, diaphragm compromise, and forelimb motor dysfunction following cervical contusion spinal cord injury.

PART is part of Alzheimer disease

Perikaryal neurofilament phosphorylation in axotomized and 6-OH-dopamine-lesioned CNS neurons

Phosphorylation of tau protein is not affected in mice lacking apolipoprotein E

Phrenic motor neuron degeneration compromises phrenic axonal circuitry and diaphragm activity in a unilateral cervical contusion model of spinal cord injury

Quantitative assessment of the density of neurofibrillary tangles and senile plaques in senile dementia of the Alzheimer type. Comparison of immunocytochemistry with a specific antibody and Bodian's protargol method

Rapamycin ester analog CCI-779/Temsirolimus alleviates tau pathology and improves motor deficit in mutant tau transgenic mice