List of works - Wendy Noble

A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies

scientific article published on 7 May 2018

A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response

scientific article published on 03 January 2019

A role for tau at the synapse in Alzheimer's disease pathogenesis.

scientific article published on 25 September 2013

ALS/FTD-associated FUS activates GSK-3β to disrupt the VAPB-PTPIP51 interaction and ER-mitochondria associations.

scientific article published on 14 July 2016

Advances in tau-based drug discovery.

scientific article

Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss

scientific article

Ammon's Horn 2 (CA2) of the Hippocampus: A Long-Known Region with a New Potential Role in Neurodegeneration

scientific article published on 05 June 2018

Anti-inflammatory impact of minocycline in a mouse model of tauopathy.

scientific article published on 12 October 2010

Astrocytes and neuroinflammation in Alzheimer's disease.

scientific article published in October 2014

Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture.

scientific article

Astrocytic C-X-C motif chemokine ligand-1 mediates β-amyloid-induced synaptotoxicity

scientific article published on 28 December 2021

Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer's disease.

scientific article

Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production

scientific article

Cdk5 is a key factor in tau aggregation and tangle formation in vivo

scientific article

Challenges in neurodegeneration research ⬇️

scientific article published on March 10, 2010

Characterisation of tau in the human and rodent enteric nervous system under physiological conditions and in tauopathy

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

scientific article

Co-localization of cholesterol, apolipoprotein E and fibrillar Abeta in amyloid plaques

scientific article

Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression

scientific article

Considerations for future tau-targeted therapeutics: can they deliver?

scientific article published on 29 October 2019

Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer's disease

scientific article published on 18 May 2016

Cytokine expression during allergen-induced late nasal responses: IL-4 and IL-5 mRNA is expressed early (at 6 h) predominantly by eosinophils

article

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease.

scientific article

Dynamic association of tau with neuronal membranes is regulated by phosphorylation

scientific article

Evidence that the presynaptic vesicle protein CSPalpha is a key player in synaptic degeneration and protection in Alzheimer's disease

scientific article published on 29 January 2015

Functional Implications of Glycogen Synthase Kinase‐3‐Mediated Tau Phosphorylation ⬇️

scientific article published on July 11, 2011

Inhibition of glycogen synthase kinase-3 by BTA-EG4 reduces tau abnormalities in an organotypic brain slice culture model of Alzheimer's disease

scientific article

Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo

scientific article

Intracellular and extracellular roles for tau in neurodegenerative disease.

scientific article published on January 2014

Kinase activities increase during the development of tauopathy in htau mice

scientific article published in October 2007

Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein

scientific article published on 05 December 2019

LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer's disease brains

scientific article published on 08 May 2019

Linking amyloid and tau pathology in Alzheimer's disease: the role of membrane cholesterol in Abeta-mediated tau toxicity.

scientific article published in August 2009

Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or Aβ production

scientific article

Mediators of tau phosphorylation in the pathogenesis of Alzheimer's disease

scientific article

Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures.

scientific article published on 16 March 2017

Minocycline at 2 Different Dosages vs Placebo for Patients With Mild Alzheimer Disease: A Randomized Clinical Trial

scientific article published on 18 November 2019

Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease.

scientific article

Molecular motors implicated in the axonal transport of tau and alpha-synuclein

scientific article

Neurodegeneration as an RNA disorder ⬇️

scientific article published on October 10, 2012

Organotypic slice cultures from transgenic mice as disease model systems

scientific article published in December 2002

Physiological release of endogenous tau is stimulated by neuronal activity.

scientific article published on 15 February 2013

Preparation of organotypic brain slice cultures for the study of Alzheimer's disease.

scientific article

Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease

scientific article published on 12 April 2013

Roles of tau protein in health and disease

scientific article

Sleep well to slow Alzheimer's progression?

scientific article

Synaptic Localisation of Tau

scientific article published on 01 January 2019

Tackling gaps in developing life-changing treatments for dementia

scientific article published on 24 June 2019

Tau phosphorylation affects its axonal transport and degradation

scientific article published on 17 April 2013

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

scientific article published on 24 February 2009

Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate

scientific article published on 12 June 2016

The ER-Mitochondria Tethering Complex VAPB-PTPIP51 Regulates Autophagy.

scientific article published on 18 January 2017

The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity

scientific article published on 06 March 2019

The importance of tau phosphorylation for neurodegenerative diseases

scientific article published on July 2013

The microtubule-associated protein tau is also phosphorylated on tyrosine

scientific article published on January 2009

Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase.

scientific article published on July 2005

Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau.

scientific article published on 7 July 2011

Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain

scientific article published on 31 March 2016

α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production

scientific article

List of works by Wendy Noble

A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies

A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response

A role for tau at the synapse in Alzheimer's disease pathogenesis.

ALS/FTD-associated FUS activates GSK-3β to disrupt the VAPB-PTPIP51 interaction and ER-mitochondria associations.

Advances in tau-based drug discovery.

Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss

Ammon's Horn 2 (CA2) of the Hippocampus: A Long-Known Region with a New Potential Role in Neurodegeneration

Anti-inflammatory impact of minocycline in a mouse model of tauopathy.

Astrocytes and neuroinflammation in Alzheimer's disease.

Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture.

Astrocytic C-X-C motif chemokine ligand-1 mediates β-amyloid-induced synaptotoxicity

Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer's disease.

Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production

Cdk5 is a key factor in tau aggregation and tangle formation in vivo

Challenges in neurodegeneration research ⬇️

Characterisation of tau in the human and rodent enteric nervous system under physiological conditions and in tauopathy

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

Co-localization of cholesterol, apolipoprotein E and fibrillar Abeta in amyloid plaques

Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression

Considerations for future tau-targeted therapeutics: can they deliver?

Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer's disease

Cytokine expression during allergen-induced late nasal responses: IL-4 and IL-5 mRNA is expressed early (at 6 h) predominantly by eosinophils

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease.

Dynamic association of tau with neuronal membranes is regulated by phosphorylation

Evidence that the presynaptic vesicle protein CSPalpha is a key player in synaptic degeneration and protection in Alzheimer's disease

Functional Implications of Glycogen Synthase Kinase‐3‐Mediated Tau Phosphorylation ⬇️

Inhibition of glycogen synthase kinase-3 by BTA-EG4 reduces tau abnormalities in an organotypic brain slice culture model of Alzheimer's disease

Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo

Intracellular and extracellular roles for tau in neurodegenerative disease.

Kinase activities increase during the development of tauopathy in htau mice

Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein

LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer's disease brains

Linking amyloid and tau pathology in Alzheimer's disease: the role of membrane cholesterol in Abeta-mediated tau toxicity.

Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or Aβ production

Mediators of tau phosphorylation in the pathogenesis of Alzheimer's disease

Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures.

Minocycline at 2 Different Dosages vs Placebo for Patients With Mild Alzheimer Disease: A Randomized Clinical Trial

Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease.

Molecular motors implicated in the axonal transport of tau and alpha-synuclein

Neurodegeneration as an RNA disorder ⬇️

Organotypic slice cultures from transgenic mice as disease model systems

Physiological release of endogenous tau is stimulated by neuronal activity.

Preparation of organotypic brain slice cultures for the study of Alzheimer's disease.

Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease

Roles of tau protein in health and disease

Sleep well to slow Alzheimer's progression?

Synaptic Localisation of Tau

Tackling gaps in developing life-changing treatments for dementia

Tau phosphorylation affects its axonal transport and degradation

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate

The ER-Mitochondria Tethering Complex VAPB-PTPIP51 Regulates Autophagy.

The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity

The importance of tau phosphorylation for neurodegenerative diseases

The microtubule-associated protein tau is also phosphorylated on tyrosine

Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase.

Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau.

Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain

α-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production