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List of works by Philippa Saunders

A Role for Androgens in Epithelial Proliferation and Formation of Glands in the Mouse Uterus

scientific article published on 10 March 2016

A Role for the orphan nuclear receptor estrogen-related receptor alpha in endometrial stromal cell decidualization and expression of genes implicated in energy metabolism.

scientific article

A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis

scholarly article

A computational model of lipopolysaccharide-induced nuclear factor kappa B activation: a key signalling pathway in infection-induced preterm labour.

scientific article

A developmentally regulated chaperone complex for the endoplasmic reticulum of male haploid germ cells

scientific article

A human DAZ transgene confers partial rescue of the mouse Dazl null phenotype

scientific article

A novel mouse model of endometriosis mimics human phenotype and reveals insights into the inflammatory contribution of shed endometrium

scientific article

A pilot randomised double blind controlled trial of the efficacy of purified fatty acids for the treatment of women with endometriosis-associated pain (PurFECT): study protocol.

scientific article published on 25 April 2018

A role for selective androgen response elements in the development of the epididymis and the androgen control of the 5α reductase II gene

scientific article published on 13 July 2012

Androgen receptor signalling in peritubular myoid cells is essential for normal differentiation and function of adult Leydig cells

scientific article published on 09 June 2011

Androgen-Induced Relaxation of Uterine Myocytes Is Mediated by Blockade of Both Ca(2+) Flux and MLC Phosphorylation

scientific article published on 11 January 2016

Androgens and androgen receptor: Above and beyond

scientific article published on 24 February 2018

Androgens and endometrium: New insights and new targets.

scientific article published on 15 September 2017

Androgens in pregnancy: roles in parturition

scientific article

Androgens regulate scarless repair of the endometrial "wound" in a mouse model of menstruation.

scientific article

Animal models of endometriosis: Replicating the aetiology and symptoms of the human disorder

scientific article published on 06 April 2018

Attenuated sex steroid receptor expression in fallopian tube of women with ectopic pregnancy

scientific article

Blastocyst Oestrogen Synthesis and the Maternal Recognition of Pregnancy ⬇️

scientific article published on January 1, 1978

Cellular localisation of messenger RNAs in rat testis: application of digoxigenin-labelled ribonucleotide probes to embedded tissue.

scientific article published in August 1993

Chlamydia trachomatis infection of human endometrial stromal cells induces defective decidualisation and chemokine release.

scientific article

Cloning of oestrogen receptor beta from Old and New World primates: identification of splice variants and functional analysis.

scientific article published on June 2004

Colocalization of mRNA and protein using in situ hybridization and immunohistochemistry in testicular tissue

scientific article published on 01 December 1995

Computer models to study uterine activation at labour.

scientific article published on 17 June 2013

Control of inhibin production by primate granulosa cells

scientific article published on 01 October 1989

Cortisol regulates the paracrine action of macrophages by inducing vasoactive gene expression in endometrial cells.

scientific article published on 23 December 2015

D2 receptor, a missing exon

scientific article published in Nature

Dehydroepiandrosterone enhances decidualization in women of advanced reproductive age.

scientific article published in February 2018

Deletion of the androgen receptor in adipose tissue in male mice elevates retinol binding protein 4 and reveals independent effects on visceral fat mass and on glucose homeostasis.

scientific article published on 13 March 2012

Detection of germ cell-derived proteins in testicular interstitial fluid: potential for monitoring spermatogenesis in vivo

scientific journal article

Development and function of the adult generation of Leydig cells in mice with Sertoli cell-selective or total ablation of the androgen receptor.

scientific article published on 26 May 2005

Development and validation of a new monoclonal antibody to mammalian aromatase.

scientific article published in January 2002

Development of steroid signaling pathways during primordial follicle formation in the human fetal ovary

scientific article published on 23 March 2011

Differential Expression of Estrogen Receptor-α and -β and Androgen Receptor in the Ovaries of Marmosets and Humans

scientific article published on 01 October 2000

Differential Expression of Estrogen Receptors α and β in the Reproductive Tractsof Adult Male Dogs and Cats1

scientific article published on 01 April 2002

Differential Regulation of Cyclic Adenosine 3′,5′-Monophosphate (cAMP) Response Element-Binding Protein and cAMP Response Element Modulator Messenger Ribonucleic Acid Transcripts by Follicle-Stimulating Hormone and Androgen in the Adult Rat Testi

scientific article published on 01 April 1994

Differential expression of two estrogen receptor beta isoforms in the human fetal testis during the second trimester of pregnancy.

scientific article

Differential hormonal regulation of estrogen receptors ERalpha and ERbeta and androgen receptor expression in rat efferent ductules.

scientific article

Differential patterns of expression of DAX-1 and steroidogenic factor-1 (SF-1) in the fetal rat testis

scientific journal article

Do Phthalates Affect Steroidogenesis by the Human Fetal Testis? Exposure of Human Fetal Testis Xenografts to Di-n-Butyl Phthalate

scientific article published on 11 January 2012

Do heat stress and deficits in DNA repair pathways have a negative impact on male fertility?

scientific article published on 05 January 2008

EP2 receptor antagonism reduces peripheral and central hyperalgesia in a preclinical mouse model of endometriosis

scientific article published on 10 March 2017

ERbeta isoform expression in colorectal carcinoma: an in vivo and in vitro study of clinicopathological and molecular correlates.

scientific article

ERbeta1 and the ERbeta2 splice variant (ERbetacx/beta2) are expressed in distinct cell populations in the adult human testis.

scientific article

ERβ-dependent effects on uterine endothelial cells are cell specific and mediated via Sp1.

scientific article published on 11 June 2013

Effect of Neonatal Gonadotropin-Releasing Hormone Antagonist Administration on Sertoli Cell Number and Testicular Development in the Marmoset: Comparison with the Rat1

article

Effect of ovariectomy on adipose tissue of mice in the absence of estrogen receptor alpha (ERalpha): a potential role for estrogen receptor beta (ERbeta).

scientific article published in November 2002

Effects of Roxb. and L. in an In Vitro Intestinal Inflammation Model Using Immune Cells and Caco-2

scientific article published on 20 November 2018

Elevated peritoneal expression and estrogen regulation of nociceptive ion channels in endometriosis

scientific article

Endo-immunology: interactions between the immune and endocrine systems. Introduction.

scientific article published on 19 November 2010

Endocrine disruption of oestrogen action and female reproductive tract cancers

scientific article

Endometrial Intracrinology--generation of an estrogen-dominated microenvironment in the secretory phase of women.

scientific article published on 6 September 2013

Endometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders

scientific article published on 22 October 2018

Endometrial apoptosis and neutrophil infiltration during menstruation exhibits spatial and temporal dynamics that are recapitulated in a mouse model.

scientific article published on 12 December 2017

Enobosarm (GTx-024) Modulates Adult Skeletal Muscle Mass Independently of the Androgen Receptor in the Satellite Cell Lineage

scientific article

Establishment of long-term monolayer cultures of somatic cells from human fetal testes and expansion of peritubular myoid cells in the presence of androgen.

scientific article published on 20 January 2010

Estradiol is a critical mediator of macrophage-nerve cross talk in peritoneal endometriosis.

scientific article

Estrogen receptor (ER) agonists differentially regulate neuroangiogenesis in peritoneal endometriosis via the repellent factor SLIT3.

scientific article

Estrogen receptor beta, but not estrogen receptor alpha, is present in the vascular endothelium of the human and nonhuman primate endometrium.

scientific article

Estrogen receptor related beta is expressed in human endometrium throughout the normal menstrual cycle.

scientific article published on 04 September 2008

Estrogen receptor-α and -β immunoreactivity and mRNA in neurons of sensory and autonomic ganglia and spinal cord

scientific article published on 01 May 2001

Estrogen-dependent regulation of human uterine natural killer cells promotes vascular remodelling via secretion of CCL2.

scientific article

Estrogens in testis biology.

scientific article

Evidence for a dynamic role for mononuclear phagocytes during endometrial repair and remodelling.

scientific article

Evidence from a mouse model that epithelial cell migration and mesenchymal-epithelial transition contribute to rapid restoration of uterine tissue integrity during menstruation

scientific article published on 22 January 2014

Evidence of androgen action in endometrial and ovarian cancers

scientific article published on 12 March 2014

Expression cloning of a rat testicular transcript abundant in germ cells, which contains two leucine zipper motifs.

scientific article published on November 1997

Expression of cytochrome P450 17alpha-hydroxylase/C17-20 lyase in the fetal rat testis is reduced by maternal exposure to exogenous estrogens

scientific article published on 01 March 1996

Expression of estrogen receptor ESR1 and its 46-kDa variant in the gubernaculum testis

scientific journal article

Expression of oestrogen receptor beta (ER beta) in multiple rat tissues visualised by immunohistochemistry

scientific article published on 01 September 1997

Expression of oestrogen receptor beta (ER beta) occurs in multiple cell types, including some germ cells, in the rat testis

scientific article published on 01 March 1998

Expression of oestrogen receptor beta (ERbeta1) protein in human breast cancer biopsies

scientific article

FSH receptor mRNA is expressed stage-dependently during rat spermatogenesis

scientific article published on 01 April 1992

Germ cell differentiation in the marmoset (Callithrix jacchus) during fetal and neonatal life closely parallels that in the human.

scientific article published on 11 August 2008

Germ cell transplantation—a fertile field

scientific article published on 01 January 2000

Germ cell-somatic cell interactions during spermatogenesis.

scientific article published on January 2003

Gonadal effects of a mouse Denys-Drash syndrome mutation.

scientific article published in October 2005

Haploinsufficiency of the germ cell-specific nuclear RNA binding protein hnRNP G-T prevents functional spermatogenesis in the mouse.

scientific article published on 18 June 2008

Hormone receptor dynamics in a receptive human endometrium.

scientific article published on February 2009

Human HSD17B1 expression masculinizes transgenic female mice.

scientific article

Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation

scientific article

Hypoxyprobe™ reveals dynamic spatial and temporal changes in hypoxia in a mouse model of endometrial breakdown and repair

scientific article published on 19 January 2016

Identification of a novel missense mutation that is as damaging to DAX-1 repressor function as a nonsense mutation.

scientific article published in March 2003

Identification of androgen receptor phosphorylation in the primate ovary in vivo.

scientific article

Immune cell and transcriptomic analysis of the human decidua in term and preterm parturition.

scientific article published on 18 August 2017

Immune cells and preterm labour: do invariant NKT cells hold the key?

scientific article published on 14 January 2015

Immunoexpression of Aquaporin-1 in the Efferent Ducts of the Rat and Marmoset Monkey during Development, Its Modulation by Estrogens, and Its Possible Role in Fluid Resorption

article

Immunoexpression of the Steroidogenic Enzymes 3-Beta Hydroxysteroid Dehydrogenase and 17 α-hydroxylase, C17,20 Lyase and the Receptor for Luteinizing Hormone (LH) in the Fetal Rat Testis Suggests That the Onset of Leydig Cell Steroid Production Is I

scientific article published on 01 February 1998

Immunohistochemical Profiling of Germ Cells Within the Human Fetal Testis: Identification of Three Subpopulations

scientific article published on 18 August 2004

Immunolocalisation of androgen receptor to interstitial cells in fetal rat testes and to mesenchymal and epithelial cells of associated ducts

scientific article published on 01 November 1995

Immunolocalisation of oestrogen receptor-α within the testis and excurrent ducts of the rat and marmoset monkey from perinatal life to adulthood

scientific article published on 01 June 1997

Immunoprofiling of human uterine mast cells identifies three phenotypes and expression of ERβ and glucocorticoid receptor.

scientific article

Impact of a mild scrotal heat stress on DNA integrity in murine spermatozoa

scientific article published on 01 April 2005

In silico analysis identifies a novel role for androgens in the regulation of human endometrial apoptosis.

scientific article

Induction of progesterone receptor immunoexpression in stromal tissue throughout the male reproductive tract after neonatal oestrogen treatment of rats

scientific article published on 01 June 2000

Infertility in a Transgenic Rat Due to Impairment of Cytoplasmic Elimination and Sperm Release from the Sertoli Cells ⬇️

scientific article published on July 1, 1995

Inflammatory events in endometrial adenocarcinoma.

scientific article published on 20 April 2010

Intergenerational transmission of postpartum hemorrhage risk: analysis of 2 Scottish birth cohorts

scientific article published on 8 January 2014

Intra-testicular injection of adenoviral constructs results in Sertoli cell-specific gene expression and disruption of the seminiferous epithelium.

scientific article published on 27 October 2008

Intracrine Androgens Enhance Decidualization and Modulate Expression of Human Endometrial Receptivity Genes

scientific article published on 28 January 2016

Intratubular germ cell neoplasia of the human testis: heterogeneous protein expression and relation to invasive potential.

scientific article

Investigation of the potential role of the germ cell complement in control of the expression of transferrin mRNA in the prepubertal and adult rat testis.

scientific article

Laparoscopic Surgery: A New Technique to Induce Endometriosis in a Mouse Model.

scientific article published on 18 March 2016

Localization of estrogen receptor beta protein expression in adult human bone.

scientific article

Localization of inhibin/activin subunit mRNAs during the luteal phase in the primate ovary

scientific article published on 01 June 1993

Localization of mRNAs by in-situ hybridization to the residual body at stages IX-X of the cycle of the rat seminiferous epithelium: fact or artefact?

scientific article published on June 1994

Localization of the sites of synthesis and action of prolactin by immunocytochemistry and in-situ hybridization within the human utero-placental unit

scientific article published on 01 December 1991

Low-dose dexamethasone as a treatment for women with heavy menstrual bleeding: protocol for response-adaptive randomised placebo-controlled dose-finding parallel group trial (DexFEM).

scientific article

Macrophage-derived insulin-like growth factor-1 is a key neurotrophic and nerve-sensitizing factor in pain associated with endometriosis

scientific article published on 10 July 2019

Male fertility and strategies for fertility preservation following childhood cancer treatment.

scientific article published on 03 March 2009

Male infertility and DNA damage in Doppel knockout and prion protein/Doppel double-knockout mice

scientific article

Marmoset spermatogenesis: organizational similarities to the human

scientific article published on 01 October 2000

Maternal oestrogen/xenoestrogen exposure alters expression of steroidogenic factor-1 (SF-1/Ad4BP) in the fetal rat testis

scientific article published on 01 March 1997

Mitochondrial cytochrome C oxidase II messenger ribonucleic acid is expressed in pachytene spermatocytes at high levels and in a stage-dependent manner during spermatogenesis in the rat.

scientific article published on January 1993

Modelling germ cell development in vitro.

scientific article published on August 2008

Modulation of ER alpha transcriptional activity by the orphan nuclear receptor ERR beta and evidence for differential effects of long- and short-form splice variants.

scientific article

Mouse models of male infertility.

scientific article

Nature of the spermatogenic arrest in Dazl -/- mice.

scientific article published in September 2001

New concepts for an old problem: the diagnosis of endometrial hyperplasia

scientific article

New insights into the role of androgens in wolffian duct stabilization in male and female rodents.

scientific article published on 8 January 2009

Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells

scientific article

Oestrogen receptor beta (ER beta).

scientific article published in September 1998

Oestrogen receptor beta and neoadjuvant therapy with tamoxifen: prediction of response and effects of treatment.

scientific article published on May 2006

Ontogeny of anti-Mullerian hormone, 3β-hydroxysteroid dehydrogenase and androgen receptor expression during ovine fetal gonadal development

article

Partial purification and characterization of chorionic gonadotrophin in plasma and in culture medium of trophoblast cells from the marmoset monkey (Callithrix jacchus)

article

Pituitary adenylate cyclase activating polypeptide can regulate testicular germ cell protein synthesis in vitro

scientific journal article

Point mutations detected in the androgen receptor gene of three men with partial androgen insensitivity syndrome

scientific article published on September 1, 1992

Possible function of carbohydrate on glycoproteins secreted by the pig uterus during pregnancy.

scientific article

Pregnancy in obese mice protects selectively against visceral adiposity and is associated with increased adipocyte estrogen signalling

scientific article

RNA binding protein Musashi1 is expressed in sertoli cells in the rat testis from fetal life to adulthood.

scientific article published in February 2002

Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells

scientific article published on 06 September 2018

Rate of replenishment and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages

scientific article published on 01 June 2020

Regulation of Inhibin Subunit Gene Expression by FSH and Estradiol in Cultured Rat Granulosa Cells

article

Regulation of androgen action during establishment of pregnancy

scientific article

Regulation of the germ stem cell niche as the foundation for adult spermatogenesis: a role for miRNAs?

scientific article published on 06 April 2014

Relationship between expression of sex steroid receptors and structure of the seminal vesicles after neonatal treatment of rats with potent or weak estrogens

scientific article

Relevant human tissue resources and laboratory models for use in endometriosis research.

scientific article

Reply of the Authors

scientific article published on 15 August 2013

Reply: Expression of oestrogen receptor beta proteins in human breast cancer biopsies.

scientific article

Repurposing dichloroacetate for the treatment of women with endometriosis

scientific article published on 02 December 2019

Repurposing simvastatin as a therapy for preterm labor: evidence from preclinical models

scientific article published on 12 October 2018

Research Priorities for Endometriosis

scientific article published on 30 June 2016

Retinoic Acid signalling and the control of meiotic entry in the human fetal gonad

scientific article

SULFATION PATHWAYS: A role for steroid sulphatase in intracrine regulation of endometrial decidualisation

scientific article published on 02 May 2018

SULFATION PATHWAYS: Contribution of intracrine oestrogens to the aetiology of endometriosis

scientific article published on 01 August 2018

Selective ablation of the androgen receptor in mouse sertoli cells affects sertoli cell maturation, barrier formation and cytoskeletal development

scientific article (publication date: 2010)

Selective androgen receptor modulators (SARMs) have specific impacts on the mouse uterus

scientific article published on 01 September 2019

Selective progesterone receptor modulator (SPRM) ulipristal acetate (UPA) and its effects on the human endometrium.

scientific article

Selective progesterone receptor modulators (SPRMs): progesterone receptor action, mode of action on the endometrium and treatment options in gynecological therapies

scientific article published on 03 May 2016

Smooth muscle cell-specific knockout of androgen receptor: a new model for prostatic disease.

scientific article published on 5 July 2011

Stage-Specific expression of rat transition protein 2 mrna and possible localization to the chromatoid body of step 7 spermatids by in situ hybridization using a nonradioactive riboprobe

scientific article published on 01 December 1992

Steroids Regulate CXCL4 in the Human Endometrium During Menstruation to Enable Efficient Endometrial Repair

scientific article

TGFβ1 attenuates expression of prolactin and IGFBP-1 in decidualized endometrial stromal cells by both SMAD-dependent and SMAD-independent pathways

scientific article

Targeting colony stimulating factor-1 receptor signalling to treat ectopic pregnancy

scientific article published on 24 September 2020

Testicular expression of inhibin and activin subunits and follistatin in the rat and human fetus and neonate and during postnatal development in the rat

scientific article published on 01 May 1997

Testosterone and spermatogenesis. Identification of stage-specific, androgen-regulated proteins secreted by adult rat seminiferous tubules ⬇️

scientific article published on March 1, 1992

The ERβ5 splice variant increases oestrogen responsiveness of ERαpos Ishikawa cells

scientific article published on 01 February 2020

The Effect of a Sertoli Cell-Selective Knockout of the Androgen Receptor on Testicular Gene Expression in Prepubertal Mice

article

The Role of Androgens in Sertoli Cell Proliferation and Functional Maturation: Studies in Mice with Total or Sertoli Cell-Selective Ablation of the Androgen Receptor

scientific article published on 10 March 2005

The Skeleton: The New Controller of Male Fertility?

scientific article published on 01 March 2011

The antiestrogen ICI 182,780 decreases the expression of estrogen receptor-alpha but has no effect on estrogen receptor-beta and androgen receptor in rat efferent ductules

scientific article

The critical time window for androgen-dependent development of the Wolffian duct in the rat.

scientific article published on 12 April 2007

The impact of 27-hydroxycholesterol on endometrial cancer proliferation.

scientific article published on 25 January 2018

The importance of the macrophage within the human endometrium.

scientific article published on 29 October 2012

The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis

scientific article

The peritoneum is both a source and target of TGF-β in women with endometriosis.

scientific article

The tumour-suppressor protein ASPP1 is nuclear in human germ cells and can modulate ratios of CD44 exon V5 spliced isoforms in vivo.

scientific article

Top ten endometriosis research priorities in the UK and Ireland

scientific article published on 18 May 2017

Transforming growth factor-β induced Warburg-like metabolic reprogramming may underpin the development of peritoneal endometriosis.

scientific article

Xenografting of human fetal testis tissue: a new approach to study fetal testis development and germ cell differentiation.

scientific article

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