List of works - Ken R Bracke

A comparative study of matrix remodeling in chronic models for COPD; mechanistic insights into the role of TNF-α.

scientific article

Accumulation of dendritic cells and increased CCL20 levels in the airways of patients with chronic obstructive pulmonary disease

scientific article

Aggravation of Allergic Airway Inflammation by Cigarette Smoke in Mice Is CD44-Dependent

scientific article

Airway Surface Dehydration Aggravates Cigarette Smoke-Induced Hallmarks of COPD in Mice.

scientific article published on 12 June 2015

Altered cigarette smoke-induced lung inflammation due to ablation of Grx1

scientific article

Association of innate defense proteins BPIFA1 and BPIFB1 with disease severity in COPD.

scientific article published on 19 December 2017

Asthma inflammatory phenotypes show differential microRNA expression in sputum

scientific article published in May 2016

B cells in chronic obstructive pulmonary disease: moving to center stage.

scientific article

Bone morphogenetic protein 6 (BMP-6) modulates lung function, pulmonary iron levels and cigarette smoke-induced inflammation

scientific article published on 12 December 2018

CCR7 modulates pulmonary and lymph node inflammatory responses in cigarette smoke-exposed mice

scientific article published in December 2009

COPD is associated with reduced pulmonary interstitial expression of pentraxin-3.

scientific article published on 15 September 2011

Characterization and Quantification of Innate Lymphoid Cell Subsets in Human Lung

scientific article

Chronic cigarette smoke exposure induces microbial and inflammatory shifts and mucin changes in the murine gut.

scientific article published in June 2015

Chronic rejection pathology after orthotopic lung transplantation in mice: the development of a murine BOS model and its drawbacks

scientific article

Cigarette smoke and the terminal ileum: increased autophagy in murine follicle-associated epithelium and Peyer's patches

scientific article published on 24 December 2011

Cigarette smoke extract induces a phenotypic shift in epithelial cells; involvement of HIF1α in mesenchymal transition.

scientific article

Cigarette smoke induces PTX3 expression in pulmonary veins of mice in an IL-1 dependent manner

scientific article published on 4 October 2010

Cigarette smoke-induced pulmonary emphysema in scid-mice. Is the acquired immune system required?

scientific article

Cigarette smoke-induced pulmonary inflammation and emphysema are attenuated in CCR6-deficient mice

scientific article published in October 2006

Cigarette smoke-induced pulmonary inflammation, but not airway remodelling, is attenuated in chemokine receptor 5-deficient mice

scientific article published in October 2007

Cigarette smoking alters epithelial apoptosis and immune composition in murine GALT.

scientific article

Comment on “Cigarette Smoke-Induced Pulmonary Inflammation Is TLR4/MyD88 and IL-1R1/MyD88 Signaling Dependent”

scientific article published on 01 May 2008

Concomitant inhalation of cigarette smoke and aerosolized protein activates airway dendritic cells and induces allergic airway inflammation in a TLR-independent way.

scientific article published on 27 July 2009

Correction: Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD.

scientific article published on 9 January 2017

DPP4, the Middle East Respiratory Syndrome Coronavirus Receptor, is Upregulated in Lungs of Smokers and Chronic Obstructive Pulmonary Disease Patients

scientific article

Different regulation of cigarette smoke induced inflammation in upper versus lower airways

scientific article published on 23 July 2010

Different roles for human lung dendritic cell subsets in pulmonary immune defense mechanisms

scientific article published on 20 April 2006

Effects of vagus nerve stimulation on pro- and anti-inflammatory cytokine induction in patients with refractory epilepsy

scientific article published on 15 July 2009

Elevated GDF-15 contributes to pulmonary inflammation upon cigarette smoke exposure.

scientific article published in February 2017

Elucidating COPD pathogenesis by large-scale genetic analyses.

scientific article

End-stage cystic fibrosis lung disease is characterised by a diverse inflammatory pattern: an immunohistochemical analysis.

scientific article published on 10 January 2017

Enhanced deposition of low-molecular-weight hyaluronan in lungs of cigarette smoke-exposed mice

scientific article published on 12 August 2009

Enhanced pulmonary leptin expression in patients with severe COPD and asymptomatic smokers.

scientific article

Eosinophils in the spotlight: Eosinophilic airway inflammation in nonallergic asthma

scientific article

Exacerbation of cigarette smoke-induced pulmonary inflammation by Staphylococcus aureus enterotoxin B in mice

scientific article published on 27 May 2011

Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers: implications for autoimmunity in rheumatoid arthritis

scientific article

GDF-15 in Pulmonary and Critical Care Medicine

scientific article published on 01 June 2019

Genome-wide association analysis identifies six new loci associated with forced vital capacity

scientific article

Heritability and genome-wide association study of diffusing capacity of the lung

scientific article published on 15 September 2018

Immunological diversity in phenotypes of chronic lung allograft dysfunction: a comprehensive immunohistochemical analysis.

scientific article published on 7 November 2016

Increased T-regulatory cells in lungs and draining lymph nodes in a murine model of COPD

scientific article published on 01 March 2010

Increased levels of enzymes involved in local estradiol synthesis in chronic obstructive pulmonary disease

scientific article published on 8 December 2016

Inflammasomes in respiratory disease: from bench to bedside.

scientific article published on May 2014

Investigation of 5-HT4 receptors in bronchial hyperresponsiveness in cigarette smoke-exposed mice.

scientific article published on 31 October 2013

Lymphoid follicles in (very) severe COPD: beneficial or harmful?

scientific article published on July 2009

Matrix metalloproteinase-12 and cathepsin D expression in pulmonary macrophages and dendritic cells of cigarette smoke-exposed mice

scientific article

MicroRNA Profiling Reveals a Role for MicroRNA-218-5p in the Pathogenesis of Chronic Obstructive Pulmonary Disease.

scientific article

MicroRNA expression in induced sputum of smokers and patients with chronic obstructive pulmonary disease

scientific article published on 29 October 2010

MicroRNA miR-22 drives T(H)17 responses in emphysema.

scientific article published on October 2015

MicroRNAs as future therapeutic targets in COPD?

scientific article published on 25 May 2017

Murine TLR4 is implicated in cigarette smoke-induced pulmonary inflammation

scientific article published on 29 August 2006

New insights into the immunology of chronic obstructive pulmonary disease.

scientific article published on September 2011

Non-coding RNAs in the pathogenesis of COPD.

scientific article published on 20 May 2015

Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD

scientific article published on 15 December 2016

Peripheral Artery Disease in Patients with Chronic Obstructive Pulmonary Disease.

scientific article published in January 2017

Physicochemical and biological evaluation of cationic polymethacrylates as vectors for gene delivery

scientific article published in March 2003

Placental growth factor inhibition targets pulmonary angiogenesis and represents a novel therapy for hepatopulmonary syndrome in mice

scientific article

Plasmacytoid dendritic cells in pulmonary lymphoid follicles of patients with COPD.

scientific article

Reduced Frizzled Receptor 4 Expression Prevents WNT/β-Catenin-driven Alveolar Lung Repair in Chronic Obstructive Pulmonary Disease.

scientific article published on 28 February 2017

Reply: Direct Detection of Circulating MicroRNAs Unveiled the Absence of MicroRNA-218-5p in Smoker Subjects.

scientific article

Role of B Cell-Activating Factor in Chronic Obstructive Pulmonary Disease

scientific article published on 12 August 2015

Role of CXCL13 in cigarette smoke-induced lymphoid follicle formation and chronic obstructive pulmonary disease

scientific article published in August 2013

Role of IL-1α and the Nlrp3/caspase-1/IL-1β axis in cigarette smoke-induced pulmonary inflammation and COPD.

scientific article

Role of activin-A in cigarette smoke-induced inflammation and COPD.

scientific article published on 14 November 2013

Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema

scientific article

Role of lymphotoxin-alpha in cigarette smoke-induced inflammation and lymphoid neogenesis

scientific article published on 22 January 2009

Role of the nitric oxide-soluble guanylyl cyclase pathway in obstructive airway diseases.

scientific article published on 17 July 2014

Role of the tachykinin NK1 receptor in a murine model of cigarette smoke-induced pulmonary inflammation.

scientific article

Role of tumour necrosis factor-alpha receptor p75 in cigarette smoke-induced pulmonary inflammation and emphysema

scientific article published on 15 March 2006

Selective accumulation of langerhans-type dendritic cells in small airways of patients with COPD.

scientific article

Smoke decreases reversible oxidations S-glutathionylation and S-nitrosylation in mice

TNF alpha receptor genotype influences smoking-induced muscle-fibre-type shift and atrophy in mice

scientific article published on 29 February 2008

Targeted therapy with inhaled corticosteroids in COPD according to blood eosinophil counts

scientific article published on 16 April 2015

Targeting immune pathways for therapy in asthma and chronic obstructive pulmonary disease.

scientific article published on December 2014

The Effect of Cigarette Smoke Exposure on the Development of Inflammation in Lungs, Gut and Joints of TNFΔARE Mice

scientific article published on 2 November 2015

The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD

scientific article published on 14 March 2022

The role of ChemR23 in the induction and resolution of cigarette smoke-induced inflammation

scientific article

The role of interleukin-6 in pulmonary and systemic manifestations in a murine model of chronic obstructive pulmonary disease

scientific article published in October 2010

The role of soluble guanylyl cyclase in chronic obstructive pulmonary disease

scientific article published in October 2013

Transforming growth factor-β superfamily in obstructive lung diseases. more suspects than TGF-β alone.

scientific article

microRNA profiling in lung tissue and bronchoalveolar lavage of cigarette smoke-exposed mice and in COPD patients: a translational approach.

scientific article published on 9 October 2017

List of works by Ken R Bracke

A comparative study of matrix remodeling in chronic models for COPD; mechanistic insights into the role of TNF-α.

Accumulation of dendritic cells and increased CCL20 levels in the airways of patients with chronic obstructive pulmonary disease

Aggravation of Allergic Airway Inflammation by Cigarette Smoke in Mice Is CD44-Dependent

Airway Surface Dehydration Aggravates Cigarette Smoke-Induced Hallmarks of COPD in Mice.

Altered cigarette smoke-induced lung inflammation due to ablation of Grx1

Association of innate defense proteins BPIFA1 and BPIFB1 with disease severity in COPD.

Asthma inflammatory phenotypes show differential microRNA expression in sputum

B cells in chronic obstructive pulmonary disease: moving to center stage.

Bone morphogenetic protein 6 (BMP-6) modulates lung function, pulmonary iron levels and cigarette smoke-induced inflammation

CCR7 modulates pulmonary and lymph node inflammatory responses in cigarette smoke-exposed mice

COPD is associated with reduced pulmonary interstitial expression of pentraxin-3.

Characterization and Quantification of Innate Lymphoid Cell Subsets in Human Lung

Chronic cigarette smoke exposure induces microbial and inflammatory shifts and mucin changes in the murine gut.

Chronic rejection pathology after orthotopic lung transplantation in mice: the development of a murine BOS model and its drawbacks

Cigarette smoke and the terminal ileum: increased autophagy in murine follicle-associated epithelium and Peyer's patches

Cigarette smoke extract induces a phenotypic shift in epithelial cells; involvement of HIF1α in mesenchymal transition.

Cigarette smoke induces PTX3 expression in pulmonary veins of mice in an IL-1 dependent manner

Cigarette smoke-induced pulmonary emphysema in scid-mice. Is the acquired immune system required?

Cigarette smoke-induced pulmonary inflammation and emphysema are attenuated in CCR6-deficient mice

Cigarette smoke-induced pulmonary inflammation, but not airway remodelling, is attenuated in chemokine receptor 5-deficient mice

Cigarette smoking alters epithelial apoptosis and immune composition in murine GALT.

Comment on “Cigarette Smoke-Induced Pulmonary Inflammation Is TLR4/MyD88 and IL-1R1/MyD88 Signaling Dependent”

Concomitant inhalation of cigarette smoke and aerosolized protein activates airway dendritic cells and induces allergic airway inflammation in a TLR-independent way.

Correction: Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD.

DPP4, the Middle East Respiratory Syndrome Coronavirus Receptor, is Upregulated in Lungs of Smokers and Chronic Obstructive Pulmonary Disease Patients

Different regulation of cigarette smoke induced inflammation in upper versus lower airways

Different roles for human lung dendritic cell subsets in pulmonary immune defense mechanisms

Effects of vagus nerve stimulation on pro- and anti-inflammatory cytokine induction in patients with refractory epilepsy

Elevated GDF-15 contributes to pulmonary inflammation upon cigarette smoke exposure.

Elucidating COPD pathogenesis by large-scale genetic analyses.

End-stage cystic fibrosis lung disease is characterised by a diverse inflammatory pattern: an immunohistochemical analysis.

Enhanced deposition of low-molecular-weight hyaluronan in lungs of cigarette smoke-exposed mice

Enhanced pulmonary leptin expression in patients with severe COPD and asymptomatic smokers.

Eosinophils in the spotlight: Eosinophilic airway inflammation in nonallergic asthma

Exacerbation of cigarette smoke-induced pulmonary inflammation by Staphylococcus aureus enterotoxin B in mice

Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers: implications for autoimmunity in rheumatoid arthritis

GDF-15 in Pulmonary and Critical Care Medicine

Genome-wide association analysis identifies six new loci associated with forced vital capacity

Heritability and genome-wide association study of diffusing capacity of the lung

Immunological diversity in phenotypes of chronic lung allograft dysfunction: a comprehensive immunohistochemical analysis.

Increased T-regulatory cells in lungs and draining lymph nodes in a murine model of COPD

Increased levels of enzymes involved in local estradiol synthesis in chronic obstructive pulmonary disease

Inflammasomes in respiratory disease: from bench to bedside.

Investigation of 5-HT4 receptors in bronchial hyperresponsiveness in cigarette smoke-exposed mice.

Lymphoid follicles in (very) severe COPD: beneficial or harmful?

Matrix metalloproteinase-12 and cathepsin D expression in pulmonary macrophages and dendritic cells of cigarette smoke-exposed mice

MicroRNA Profiling Reveals a Role for MicroRNA-218-5p in the Pathogenesis of Chronic Obstructive Pulmonary Disease.

MicroRNA expression in induced sputum of smokers and patients with chronic obstructive pulmonary disease

MicroRNA miR-22 drives T(H)17 responses in emphysema.

MicroRNAs as future therapeutic targets in COPD?

Murine TLR4 is implicated in cigarette smoke-induced pulmonary inflammation

New insights into the immunology of chronic obstructive pulmonary disease.

Non-coding RNAs in the pathogenesis of COPD.

Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD

Peripheral Artery Disease in Patients with Chronic Obstructive Pulmonary Disease.

Physicochemical and biological evaluation of cationic polymethacrylates as vectors for gene delivery

Placental growth factor inhibition targets pulmonary angiogenesis and represents a novel therapy for hepatopulmonary syndrome in mice

Plasmacytoid dendritic cells in pulmonary lymphoid follicles of patients with COPD.

Reduced Frizzled Receptor 4 Expression Prevents WNT/β-Catenin-driven Alveolar Lung Repair in Chronic Obstructive Pulmonary Disease.

Reply: Direct Detection of Circulating MicroRNAs Unveiled the Absence of MicroRNA-218-5p in Smoker Subjects.

Role of B Cell-Activating Factor in Chronic Obstructive Pulmonary Disease

Role of CXCL13 in cigarette smoke-induced lymphoid follicle formation and chronic obstructive pulmonary disease

Role of IL-1α and the Nlrp3/caspase-1/IL-1β axis in cigarette smoke-induced pulmonary inflammation and COPD.

Role of activin-A in cigarette smoke-induced inflammation and COPD.

Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema

Role of lymphotoxin-alpha in cigarette smoke-induced inflammation and lymphoid neogenesis

Role of the nitric oxide-soluble guanylyl cyclase pathway in obstructive airway diseases.

Role of the tachykinin NK1 receptor in a murine model of cigarette smoke-induced pulmonary inflammation.

Role of tumour necrosis factor-alpha receptor p75 in cigarette smoke-induced pulmonary inflammation and emphysema

Selective accumulation of langerhans-type dendritic cells in small airways of patients with COPD.

Smoke decreases reversible oxidations S-glutathionylation and S-nitrosylation in mice

TNF alpha receptor genotype influences smoking-induced muscle-fibre-type shift and atrophy in mice

Targeted therapy with inhaled corticosteroids in COPD according to blood eosinophil counts

Targeting immune pathways for therapy in asthma and chronic obstructive pulmonary disease.

The Effect of Cigarette Smoke Exposure on the Development of Inflammation in Lungs, Gut and Joints of TNFΔARE Mice

The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD

The role of ChemR23 in the induction and resolution of cigarette smoke-induced inflammation

The role of interleukin-6 in pulmonary and systemic manifestations in a murine model of chronic obstructive pulmonary disease

The role of soluble guanylyl cyclase in chronic obstructive pulmonary disease