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List of works by Michael J. Hendzel

A key role for poly(ADP-ribose) polymerase 3 in ectodermal specification and neural crest development

scientific article

A requirement for polymerized actin in DNA double-strand break repair

scientific article

A small molecule inhibitor of polycomb repressive complex 1 inhibits ubiquitin signaling at DNA double-strand breaks

scientific article published on 30 July 2013

ATM-dependent DNA damage-independent mitotic phosphorylation of H2AX in normally growing mammalian cells.

scientific article

Association of ATM activation and DNA repair with induced radioresistance after low-dose irradiation

scientific article

Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents

scientific article published on 11 April 2007

BCL10 is recruited to sites of DNA damage to facilitate DNA double-strand break repair

scientific article published in January 2016

BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair

scientific article

Characterization and comparison of protein complexes initiated by the intracellular domain of individual Notch paralogs.

scientific article published on 23 March 2011

Characterization of the histone H2A.Z-1 and H2A.Z-2 isoforms in vertebrates

scientific article

Characterizing fluorescence recovery curves for nuclear proteins undergoing binding events

scientific article published in November 2004

Chromatin condensation is not associated with apoptosis

scientific article published on 01 September 1998

Conference Scene: epigenetics eh! The first formal meeting of the Canadian epigenetics community

scientific article published on 01 August 2011

Conversations between chromatin modifications and DNA double strand break repair: a commentary

scientific article published on 27 August 2013

Core histone hyperacetylation impacts cooperative behavior and high-affinity binding of histone H1 to chromatin

scientific article published on 01 June 2010

Core histones H2B and H4 are mobilized during infection with herpes simplex virus 1.

scientific article published on 12 October 2011

Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting

scientific article published in May 2015

DEAD Box 1 Facilitates Removal of RNA and Homologous Recombination at DNA Double-Strand Breaks.

scientific article published on 22 August 2016

DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair

scientific article

Distinct dynamics and distribution of histone methyl-lysine derivatives in mouse development

scientific article published in December 2004

Emerging roles of eraser enzymes in the dynamic control of protein ADP-ribosylation

scientific article published on 12 March 2019

Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR

scientific article

Epigenetic regulation of centromere formation and kinetochore function.

scientific article published on August 2006

Epigenetics regulate centromere formation and kinetochore function.

scientific article published on August 2008

F-actin-dependent insolubility of chromatin-modifying components

scientific article published on 13 April 2004

Fixation-dependent organization of core histones following DNA fluorescent in situ hybridization

scientific article published on 01 July 1997

G2 histone methylation is required for the proper segregation of chromosomes.

scientific article published on 28 July 2009

Germline mutations in BAP1 impair its function in DNA double-strand break repair

scientific article

H1 family histones in the nucleus. Control of binding and localization by the C-terminal domain

scientific article

H2A.Bbd: an X-chromosome-encoded histone involved in mammalian spermiogenesis

scientific article

Immunofluorescence of Histone Proteins

scientific article published in January 2017

Impaired in vivo binding of MeCP2 to chromatin in the absence of its DNA methyl-binding domain

scientific article published on 4 April 2013

Improved transfection efficiency of an aliphatic lipid substituted 2 kDa polyethylenimine is attributed to enhanced nuclear association and uptake in rat bone marrow stromal cell.

scientific article

Increased Ser-10 phosphorylation of histone H3 in mitogen-stimulated and oncogene-transformed mouse fibroblasts

scientific article published on August 1999

Investigation of PARP-1, PARP-2, and PARG interactomes by affinity-purification mass spectrometry

scientific article

Linker histones are mobilized during infection with herpes simplex virus type 1.

scientific article published on 25 June 2008

Mechanotransduction from the ECM to the genome: are the pieces now in place?

scientific article published on August 2008

Methylation of MRE11 regulates its nuclear compartmentalization

scientific article published on 9 July 2005

Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation

scientific article (publication date: November 1997)

Modeling transcription factor binding events to DNA using a random walker/jumper representation on a 1D/2D lattice with different affinity sites

scientific article published on 21 November 2007

Modelling the compartmentalization of splicing factors

scientific article

Molecular Basis for K63-Linked Ubiquitination Processes in Double-Strand DNA Break Repair: A Focus on Kinetics and Dynamics.

scientific article published on 3 June 2017

Notch signaling as a therapeutic target for breast cancer treatment?

scientific article published on 31 May 2011

Nuclear distribution of histone deacetylase: a marker enzyme for the internal nuclear matrix

scientific article published on 01 April 1992

Nucleoplasmic beta-actin exists in a dynamic equilibrium between low-mobility polymeric species and rapidly diffusing populations.

scientific article

Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients

scientific article

PARP-3 associates with polycomb group bodies and with components of the DNA damage repair machinery.

scientific article

PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites

scientific article

Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage.

scientific article

Pin1 promotes histone H1 dephosphorylation and stabilizes its binding to chromatin

scientific article published on 07 October 2013

Poly(ADP-ribose) glycohydrolase is a component of the FMRP-associated messenger ribonucleoparticles.

scientific article

Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks

scientific article published on 04 July 2019

Poly(ADP-ribosyl)ation-dependent Transient Chromatin Decondensation and Histone Displacement following Laser Microirradiation

scientific article published on 11 November 2015

Polycomb group proteins in the DNA damage response: a link between radiation resistance and "stemness".

scientific article

Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes

scientific article published on 23 November 2020

Probing nuclear ultrastructure by electron spectroscopic imaging

scientific article published on 01 April 1996

Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples.

scientific article

Proteomic investigation of phosphorylation sites in poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase

scientific article

Quantitative analysis of CBP- and P300-induced histone acetylations in vivo using native chromatin.

scientific article published in November 2003

Quantitative analysis reveals asynchronous and more than DSB-associated histone H2AX phosphorylation after exposure to ionizing radiation.

scientific article published on March 2006

RHAMM is a centrosomal protein that interacts with dynein and maintains spindle pole stability

scientific article

RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor Recruitment

scientific article

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

scientific article

RYBP Is a K63-Ubiquitin-Chain-Binding Protein that Inhibits Homologous Recombination Repair.

scientific article published in January 2018

Reprogramming progeria fibroblasts re-establishes a normal epigenetic landscape.

scientific article

Synthesis and biological testing of novel pyridoisothiazolones as histone acetyltransferase inhibitors

scientific article published on 2 February 2011

The CD20 calcium channel is localized to microvilli and constitutively associated with membrane rafts: antibody binding increases the affinity of the association through an epitope-dependent cross-linking-independent mechanism.

scientific article published on 19 February 2004

The F-act's of nuclear actin.

scientific article published on 04 May 2014

The PAX3 paired domain and homeodomain function as a single binding module in vivo to regulate subnuclear localization and mobility by a mechanism that requires base-specific recognition

scientific article published on 17 July 2010

The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice

scientific journal article

The cytotoxicity of gamma-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition.

scientific article published on 06 August 2009

The differential mobilization of histones H3.1 and H3.3 by herpes simplex virus 1 relates histone dynamics to the assembly of viral chromatin

scientific article

The expanding role of poly(ADP-ribose) metabolism: current challenges and new perspectives.

scientific article

The gamma-H2A.X: is it just a surrogate marker of double-strand breaks or much more?

scientific article published on January 2008

The oncogenic potential of Jumonji D2 (JMJD2/KDM4) histone demethylase overexpression

scientific article published on 05 December 2012

The relationship between histone H3 phosphorylation and acetylation throughout the mammalian cell cycle.

scientific article published on August 2006

The transcription coactivator CBP is a dynamic component of the promyelocytic leukemia nuclear body

scientific article published on March 2001

The transcriptional regulator CBP has defined spatial associations within interphase nuclei.

scientific article

Trichostatin A decreases the levels of MeCP2 expression and phosphorylation and increases its chromatin binding affinity

scientific article

Using FRAP and mathematical modeling to determine the in vivo kinetics of nuclear proteins.

scientific article

Using quantitative imaging microscopy to define the target substrate specificities of histone post-translational-modifying enzymes.

scientific article published in August 2005

Visualization of miniSOG Tagged DNA Repair Proteins in Combination with Electron Spectroscopic Imaging (ESI).

scientific article published on 24 September 2015

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