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List of works by Masaharu Seno

A Novel Combination Cancer Therapy with Iron Chelator Targeting Cancer Stem Cells via Suppressing Stemness

scientific article published on 03 February 2019

A Novel Model of Meibomian Gland Dysfunction Induced with Complete Freund's Adjuvant in Rabbits

scientific article published on 09 February 2017

A betacellulin mutant promotes differentiation of pancreatic acinar AR42J cells into insulin-producing cells with low affinity of binding to ErbB1.

scientific article

A cancer stem cell model as the point of origin of cancer-associated fibroblasts in tumor microenvironment.

scientific article

A hybrid protein between IFN-gamma and IL-2.

scientific article

A model of cancer stem cells derived from mouse induced pluripotent stem cells

scientific article

A sensitive enzyme immunoassay for human basic fibroblast growth factor

scientific article published on 01 February 1991

A simple method to induce differentiation of murine bone marrow mesenchymal cells to insulin-producing cells using conophylline and betacellulin-delta4.

scientific article published on 15 May 2008

Acidic amorphous silica prepared from iron oxide of bacterial origin

scientific article

Anti-angiogenic effect of an insertional fusion protein of human basic fibroblast growth factor and ribonuclease-1.

scientific article published on 24 June 2005

Anti-tumor effect in an in vivo model by human-derived pancreatic RNase with basic fibroblast growth factor insertional fusion protein through antiangiogenic properties

scientific article published on 09 October 2006

Betacellulin improves glucose metabolism by promoting conversion of intraislet precursor cells to beta-cells in streptozotocin-treated mice

scientific article published in September 2003

Blood and Cancer: Cancer Stem Cells as Origin of Hematopoietic Cells in Solid Tumor Microenvironments

scientific article published on 22 May 2020

Cancer stem cells maintain a hierarchy of differentiation by creating their niche

scientific article

Cancer-inducing niche: the force of chronic inflammation

scientific article published in 2022

Carboxyl-terminal structure of basic fibroblast growth factor significantly contributes to its affinity for heparin

scientific article published on 01 March 1990

Characterization of bio-nanocapsule as a transfer vector targeting human hepatocyte carcinoma by disulfide linkage modification

scientific article published on 28 December 2006

Characterization of cancer stem-like cells derived from mouse induced pluripotent stem cells transformed by tumor-derived extracellular vesicles

scientific article

Chlorotoxin-Fc fusion inhibits release of MMP-2 from pancreatic cancer cells.

scientific article published on 06 January 2014

Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin

scientific journal article

Conophylline and betacellulin-delta4: an effective combination of differentiation factors for pancreatic beta cells

scientific article published on 16 February 2007

Conversion of Stem Cells to Cancer Stem Cells: Undercurrent of Cancer Initiation

scientific article published on 11 March 2019

Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells

scientific article

Cripto-1 enhances the canonical Wnt/β-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors.

scientific article

Cripto-1 induces apoptosis in HC-11 mouse mammary epithelial cells

scientific article published on 01 February 2000

Cytokine Expression and Macrophage Localization in Xenograft and Allograft Tumor Models Stimulated with Lipopolysaccharide

scientific article published on 23 April 2018

Delivery of sodium borocaptate to glioma cells using immunoliposome conjugated with anti-EGFR antibodies by ZZ-His.

scientific article

Denatured and reversibly cationized p53 readily enters cells and simultaneously folds to the functional protein in the cells

scientific article published in May 2006

Detection and localization of Cripto-1 binding in mouse mammary epithelial cells and in the mouse mammary gland using an immunoglobulin-cripto-1 fusion protein

scientific article published on 01 January 2002

Development of 111In-labeled liposomes for vulnerable atherosclerotic plaque imaging

scientific article

Development of an epidermal growth factor derivative with EGFR blocking activity

scientific article

Development of bionanocapsules targeting brain tumors.

scientific article published on 27 June 2007

Different pancreatic cancer microenvironments convert iPSCs into cancer stem cells exhibiting distinct plasticity with altered gene expression of metabolic pathways

scientific article published on 21 January 2022

E-selectin targeting to visualize tumors in vivo

scientific article published on 01 March 2010

Efficient drug delivery of Paclitaxel glycoside: a novel solubility gradient encapsulation into liposomes coupled with immunoliposomes preparation

scientific article

Engineered bio-nanocapsules, the selective vector for drug delivery system.

scientific article

Enhanced internalization of ErbB2 in SK-BR-3 cells with multivalent forms of an artificial ligand ⬇️

scientific article published on November 1, 2011

Eosinophil cationic protein enhances cardiomyocyte differentiation of P19CL6 embryonal carcinoma cells by stimulating the FGF receptor signaling pathway.

scientific article

Eosinophil cationic protein enhances stabilization of β-catenin during cardiomyocyte differentiation in P19CL6 embryonal carcinoma cells

scientific article published on 28 December 2012

Epidermal growth factor receptor-dependent cytotoxicity for human squamous carcinoma cell lines of a conjugate composed of human EGF and RNase 1.

scientific article

Establishment of monoclonal antibodies against human acidic fibroblast growth factor

scientific article

Exogenous Cripto-1 Suppresses Self-Renewal of Cancer Stem Cell Model

scientific article published on 26 October 2018

Expression of cDNA encoding human basic fibroblast growth factor in E. coli

scientific article published on 01 July 1987

Expression of human immunoglobulin E epsilon chain cDNA in E. coli.

scientific article

Expression of modified bFGF cDNAs in mammalian cells

scientific article published on January 1991

Extracellular matrix modulates insulin production during differentiation of AR42J cells: Functional role of Pax6 transcription factor ⬇️

scientific article published on January 1, 2011

First Report of Cucumber mosaic virus in Sweet Cherry in the People's Republic of China

scientific article published on 01 November 2010

Gene therapy of liver tumors with human liver-specific nanoparticles.

scientific article published on 22 September 2006

Genes expressed during the differentiation of pancreatic AR42J cells into insulin-secreting cells

scientific article published on 01 February 1999

Hematopoietic Cells Derived from Cancer Stem Cells Generated from Mouse Induced Pluripotent Stem Cells

scientific article published on 29 December 2019

High epiregulin expression in human U87 glioma cells relies on IRE1α and promotes autocrine growth through EGF receptor

scientific article

Human betacellulin structure modeled from other members of EGF family

scientific article

Human betacellulin, a member of the EGF family dominantly expressed in pancreas and small intestine, is fully active in a monomeric form

scientific article published on January 1996

Human eosinophil cationic protein enhances stress fiber formation in Balb/c 3T3 fibroblasts and differentiation of rat neonatal cardiomyocytes

scientific article

Hydrogen peroxide and endothelin-1 are novel activators of betacellulin ectodomain shedding.

scientific article published on October 2006

Identification of caveolin-1 as a potential causative factor in the generation of trastuzumab resistance in breast cancer cells.

scientific article published on 21 June 2013

Identification of the motility-related protein (MRP-1), recognized by monoclonal antibody M31-15, which inhibits cell motility ⬇️

scientific article published on December 1, 1991

Insertional-fusion of basic fibroblast growth factor endowed ribonuclease 1 with enhanced cytotoxicity by steric blockade of inhibitor interaction.

scientific article

Intracellular delivery of glutathione S-transferase-fused proteins into mammalian cells by polyethylenimine-glutathione conjugates

scientific article

Intracellular delivery of proteins into mammalian living cells by polyethylenimine-cationization.

scientific article published on February 2005

Involvement of MAPK signaling molecules and Runx2 in the NELL1-induced osteoblastic differentiation

scientific article published on 17 December 2007

Metastasis Model of Cancer Stem Cell-Derived Tumors

scientific article published on 21 August 2020

Metastasis of Cancer Stem Cells Developed in the Microenvironment of Hepatocellular Carcinoma

scientific article published on 23 August 2019

Monoclonal antibodies against human basic fibroblast growth factor

scientific article published on 01 April 1989

Nano-micrometer-architectural acidic silica prepared from iron oxide of Leptothrix ochracea origin.

scientific article

Nanoparticles for the delivery of genes and drugs to human hepatocytes

scientific article published on 29 June 2003

Novel and simple loading procedure of cisplatin into liposomes and targeting tumor endothelial cells.

scientific article

Nucleotide sequence encoding human pancreatic ribonuclease

scientific article

Nucleotide sequence of rat basic fibroblast growth factor cDNA ⬇️

scientific article published on June 10, 1988

Optimization of bacterial plasmid transformation using nanomaterials based on the Yoshida effect

scientific article (publication date: 2010)

Paclitaxel and Sorafenib: The Effective Combination of Suppressing the Self-Renewal of Cancer Stem Cells

scientific article published on 26 May 2020

Practical Liposomal Formulation for Taxanes with Polyethoxylated Castor Oil and Ethanol with Complete Encapsulation Efficiency and High Loading Efficiency.

scientific article

Preparation of potent cytotoxic ribonucleases by cationization: enhanced cellular uptake and decreased interaction with ribonuclease inhibitor by chemical modification of carboxyl groups

scientific article (publication date: 26 June 2001)

Production of biologically active IgG hinge-tag soluble epidermal growth factor receptors (ErbB).

scientific article

Promotion of beta-cell regeneration by betacellulin in ninety percent-pancreatectomized rats

scientific article published in December 2001

Protein transduction assisted by polyethylenimine-cationized carrier proteins.

scientific article published on June 2005

Reversal of streptozotocin-induced hyperglycemia by continuous supply of betacellulin in mice

scientific article published in August 2008

Reversal of streptozotocin-induced hyperglycemia by transplantation of pseudoislets consisting of beta cells derived from ductal cells

scientific article published in June 2004

Revisiting Cancer Stem Cells as the Origin of Cancer-Associated Cells in the Tumor Microenvironment: A Hypothetical View from the Potential of iPSCs

scientific article published on 04 April 2020

Smad2 functions as a co-activator of canonical Wnt/beta-catenin signaling pathway independent of Smad4 through histone acetyltransferase activity of p300.

scientific article published on 18 May 2008

Solution structure of betacellulin, a new member of EGF-family ligands

scientific article

Spherical self-organizing map as a helpful tool to identify category-specific cell surface markers.

scientific article published on 13 September 2008

Stabilizing basic fibroblast growth factor using protein engineering

scientific article published on 01 March 1988

Steering target selectivity and potency by fragment-based de novo drug design

scientific article published on 26 August 2013

Studies on the betacellulin receptor in pancreatic AR42J cells

scientific article published in June 1998

Synthesis of hepatitis B virus e antigen in E. coli

scientific article

Targeting Glioblastoma Cells Expressing CD44 with Liposomes Encapsulating Doxorubicin and Displaying Chlorotoxin-IgG Fc Fusion Protein

scientific article published on 26 February 2018

Targeting activated lymphocytes with an entirely human immunotoxin analogue: human pancreatic RNase1-human IL-2 fusion.

scientific article published in June 2000

The EGF-CFC family: novel epidermal growth factor-related proteins in development and cancer.

scientific article

Three-dimensional crystal structure of human eosinophil cationic protein (RNase 3) at 1.75 A resolution

scientific article published in July 2000

Three-dimensional structure of human RNase 1 delta N7 at 1.9 A resolution

scientific article

Tissue-specific expression of pancreatic-type RNases and RNase inhibitor in humans

scientific article published on 01 April 1997

Transient cell proliferation with polyethylenimine-cationized N-terminal domain of simian virus 40 large T-antigen.

scientific article published on January 2008

‘Crystal lattice engineering,’ an approach to engineer protein crystal contacts by creating intermolecular symmetry: Crystallization and structure determination of a mutant human RNase 1 with a hydrophobic interface of leucines

scientific article

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