List of works - Alyssa H. Hasty

A Crucial Role of Sterol Regulatory Element-binding Protein-1 in the Regulation of Lipogenic Gene Expression by Polyunsaturated Fatty Acids

scientific article published in Journal of Biological Chemistry

A decade of progress in adipose tissue macrophage biology

scientific article

A possible secondary immune response in adipose tissue during weight cycling: The ups and downs of yo-yo dieting

scientific article published on 08 January 2014

Aberrant accumulation of undifferentiated myeloid cells in the adipose tissue of CCR2-deficient mice delays improvements in insulin sensitivity.

scientific article

Abscisic acid ameliorates atherosclerosis by suppressing macrophage and CD4+ T cell recruitment into the aortic wall

scientific article

Absence of macrophage inflammatory protein-1{alpha} does not impact macrophage accumulation in adipose tissue of diet-induced obese mice

scientific article

Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice

scientific article

Activation of NF-κB drives the enhanced survival of adipose tissue macrophages in an obesogenic environment ⬇️

scientific article

Adipose Tissue is Enriched for Activated and Late-Differentiated CD8+ T Cells and Shows Distinct CD8+ Receptor Usage, Compared With Blood in HIV-Infected Persons

scientific article

Adipose tissue macrophages: Unique polarization and bioenergetics in obesity

scientific article published on 01 April 2020

Adipose tissue recruitment of leukocytes

scientific article published on June 2010

Administration of N-Acyl-Phosphatidylethanolamine Expressing Bacteria to Low Density Lipoprotein Receptor Mice Improves Indices of Cardiometabolic Disease

scientific article published in Scientific Reports

An Iron Refractory Phenotype in Obese Adipose Tissue Macrophages Leads to Adipocyte Iron Overload

scientific article published in 2022

Apolipoprotein E and Reverse Cholesterol Transport: The Role of Recycling in Plasma and Intracellular Lipid Trafficking

Atherosclerotic lesion formation and triglyceride storage in obese apolipoprotein AI-deficient mice.

scientific article

CC-chemokine receptor 7 (CCR7) deficiency alters adipose tissue leukocyte populations in mice.

scientific article

CCR2 deficiency leads to increased eosinophils, alternative macrophage activation, and type 2 cytokine expression in adipose tissue.

scientific article

CD8+ T cells regulate liver injury in obesity-related nonalcoholic fatty liver disease

scientific article published on 11 November 2019

Carbenoxolone treatment attenuates symptoms of metabolic syndrome and atherogenesis in obese, hyperlipidemic mice

scientific article published on 18 September 2007

Central nervous system neuropeptide Y signaling modulates VLDL triglyceride secretion.

scientific article published on 10 March 2008

Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs.

scientific article

Contributions of Innate Type 2 Inflammation to Adipose Function

scientific article published on 11 June 2018

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of L

scientific article published in May 2003

Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.

scientific article published on 30 September 2007

Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity, and insulin resistance.

scientific article published on 29 April 2008

Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice and reversal by a fish oil diet.

scientific article published on 15 October 2009

Deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein (UGRP)/glucose-6-phosphatase catalytic subunit-beta results in lowered plasma cholesterol and elevated glucagon

scientific article published on 5 October 2006

Diet-Induced Increases in Adiposity, but Not Plasma Lipids, Promote Macrophage Infiltration Into White Adipose Tissue

scientific article published on 01 March 2007

Dietary fish oil exerts hypolipidemic effects in lean and insulin sensitizing effects in obese LDLR-/- mice

scientific article published on 28 October 2009

Direct Effect of Cholesterol on Insulin Secretion: A Novel Mechanism for Pancreatic -Cell Dysfunction

scientific article published on 15 June 2007

Dual regulation of mouse Delta(5)- and Delta(6)-desaturase gene expression by SREBP-1 and PPARalpha

scientific article published in January 2002

Effects of vitamin E on oxidative stress and atherosclerosis in an obese hyperlipidemic mouse model.

scientific article published on 16 June 2006

Elevating adipose eosinophils in obese mice to physiologically normal levels does not rescue metabolic impairments.

scientific article published on 16 December 2017

Endoplasmic reticulum stress and hypertension - a new paradigm?

scientific article published on 15 October 2012

Extrinsic and Intrinsic Immunometabolism Converge: Perspectives on Future Research and Therapeutic Development for Obesity

scientific article published on 01 September 2019

Fat-water MRI is sensitive to local adipose tissue inflammatory changes in a diet-induced obesity mouse model at 15T

Fat-water MRI of a diet-induced obesity mouse model at 15.2T.

scientific article

Fish oil increases cholesterol storage in white adipose tissue with concomitant decreases in inflammation, hepatic steatosis, and atherosclerosis in mice

scientific article published on 01 July 2007

Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice

scientific journal article

Haematopoietic leptin receptor deficiency does not affect macrophage accumulation in adipose tissue or systemic insulin sensitivity

scientific article published on 22 December 2011

Hepatocyte-derived ApoE is more effective than non-hepatocyte-derived ApoE in remnant lipoprotein clearance

scientific article published on 27 January 2003

High CD8 T-Cell Receptor Clonality and Altered CDR3 Properties Are Associated With Elevated Isolevuglandins in Adipose Tissue During Diet-Induced Obesity

scientific article published on 04 September 2018

Hyaluronan accumulates with high-fat feeding and contributes to insulin resistance.

scientific article published on 24 January 2013

Impact of increased adipose tissue mass on inflammation, insulin resistance, and dyslipidemia

scientific article

Impact of macrophage inflammatory protein-1α deficiency on atherosclerotic lesion formation, hepatic steatosis, and adipose tissue expansion

scientific article

Impaired insulin signaling in the B10.D2-Hc0 H2d H2-T18c/oSnJ mouse model of complement factor 5 deficiency

scientific article published on 14 May 2019

Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages

scientific article

Inhibition of long-chain acyl coenzyme A synthetases during fatty acid loading induces lipotoxicity in macrophages

scientific article published on 13 August 2009

Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice

scientific article published in March 2004

Intracellular trafficking of recycling apolipoprotein E in Chinese hamster ovary cells

scientific article published on 13 March 2006

Iron homeostasis: a new job for macrophages in adipose tissue?

scientific article

Isolation of adipose tissue immune cells

scientific article published on 22 May 2013

Leptin requires canonical migratory signaling pathways for induction of monocyte and macrophage chemotaxis

scientific article published on 29 August 2007

Links between Immunologic Memory and Metabolic Cycling

scientific article published on 01 June 2018

Lipid and phospholipid profiling of biological samples using MALDI Fourier transform mass spectrometry

scientific article

Liver X receptor α-dependent iron handling in M2 macrophages: The missing link between cholesterol and intraplaque hemorrhage?

scientific article

Loss of CCR5 results in glucose intolerance in diet-induced obese mice

scientific article published on 13 August 2013

Loss of ovarian function in the VCD mouse-model of menopause leads to insulin resistance and a rapid progression into the metabolic syndrome.

scientific article published on 13 May 2009

MFe adipose tissue macrophages compensate for tissue iron perturbations in mice

scientific article published on 16 May 2018

Macrophage apolipoprotein A-I expression protects against atherosclerosis in ApoE-deficient mice and up-regulates ABC transporters.

scientific article published in October 2003

Macrophage infiltration into adipose tissue: initiation, propagation and remodeling.

scientific article published on January 2008

Macrophage-Targeted Therapeutics for Metabolic Disease

scientific article

Macrophage-derived apolipoprotein E ameliorates dyslipidemia and atherosclerosis in obese apolipoprotein E-deficient mice.

scientific article

Macrophages are essential for CTGF-mediated adult β-cell proliferation after injury

scientific article published on 19 May 2015

Mouse models of the metabolic syndrome

scientific article

Multiomics reveals persistence of obesity-associated immune cell phenotypes in adipose tissue during weight loss and weight regain in mice

scientific article published on 26 May 2022

Nitro-fatty acids reduce atherosclerosis in apolipoprotein E-deficient mice.

scientific article

Obesity Alters B Cell and Macrophage Populations in Brown Adipose Tissue

scientific article published on 18 September 2017

Obesity alters adipose tissue macrophage iron content and tissue iron distribution.

scientific article published on 15 October 2013

Obesity causes very low density lipoprotein clearance defects in low-density lipoprotein receptor-deficient mice

scientific article published on 05 April 2007

Obesity induced by a high-fat diet is associated with increased immune cell entry into the central nervous system.

scientific article published on 4 July 2013

Obesity potentiates development of fatty liver and insulin resistance, but not atherosclerosis, in high-fat diet-fed agouti LDLR-deficient mice

article

Obesity-induced reduction of adipose eosinophils is reversed with low-calorie dietary intervention

Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets

scientific article published on 5 May 2008

Palmitate induces apoptotic cell death and inflammasome activation in human placental macrophages

scientific article published on 09 December 2019

Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I

scientific journal article

Physiological expression of macrophage apoE in the artery wall reduces atherosclerosis in severely hyperlipidemic mice

scientific article published on 01 October 2002

Physiological relevance of apolipoprotein E recycling: studies in primary mouse hepatocytes

scientific article

Plasma insulin levels predict atherosclerotic lesion burden in obese hyperlipidemic mice

scientific article

Plasminogen activator inhibitor-1 modulates adipocyte differentiation.

scientific article published on 6 September 2005

Quantitation and cellular localization of 11β-HSD1 expression in murine thymus

article

Recombinant leptin promotes atherosclerosis and thrombosis in apolipoprotein E-deficient mice

scientific article published on 9 June 2005

Recycling of apolipoprotein E in mouse liver

scientific journal article

Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1.

scientific article

Regulation of S100B in white adipose tissue by obesity in mice

scientific article

Regulation of tissue iron homeostasis: the macrophage "ferrostat"

scientific article published on 30 January 2020

Retention of sedentary obese visceral white adipose tissue phenotype with intermittent physical activity despite reduced adiposity

scientific article

Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor.

scientific article published on 09 July 2001

Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis.

scientific article

Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes

scientific journal article

Striatal dopamine homeostasis is altered in mice following Roux-en-Y gastric bypass surgery.

scientific article

TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes

scientific article published on 4 December 2005

The recycling of apolipoprotein E in macrophages: influence of HDL and apolipoprotein A-I.

scientific article

The recycling of apolipoprotein E in primary cultures of mouse hepatocytes. Evidence for a physiologic connection to high density lipoprotein metabolism

scientific article published on 10 January 2003

The role of adipose tissue in mediating the beneficial effects of dietary fish oil

scientific article

The role of chemokines in recruitment of immune cells to the artery wall and adipose tissue

scientific article published on 21 December 2009

The role of lipolysis in mediating the proinflammatory effects of very low density lipoproteins in mouse peritoneal macrophages

scientific article published on 25 April 2006

The role of macrophage leptin receptor in aortic root lesion formation

scientific article published on 8 January 2008

Toll-like receptor 4 deficiency promotes the alternative activation of adipose tissue macrophages.

scientific article

Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes

scientific journal article

Weight cycling increases T-cell accumulation in adipose tissue and impairs systemic glucose tolerance.

scientific article published on 03 June 2013

What have we really learned about macrophage recruitment to adipose tissue?

scientific article published on January 2014

List of works by Alyssa H. Hasty

A Crucial Role of Sterol Regulatory Element-binding Protein-1 in the Regulation of Lipogenic Gene Expression by Polyunsaturated Fatty Acids

A decade of progress in adipose tissue macrophage biology

A possible secondary immune response in adipose tissue during weight cycling: The ups and downs of yo-yo dieting

Aberrant accumulation of undifferentiated myeloid cells in the adipose tissue of CCR2-deficient mice delays improvements in insulin sensitivity.

Abscisic acid ameliorates atherosclerosis by suppressing macrophage and CD4+ T cell recruitment into the aortic wall

Absence of macrophage inflammatory protein-1{alpha} does not impact macrophage accumulation in adipose tissue of diet-induced obese mice

Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice

Activation of NF-κB drives the enhanced survival of adipose tissue macrophages in an obesogenic environment ⬇️

Adipose Tissue is Enriched for Activated and Late-Differentiated CD8+ T Cells and Shows Distinct CD8+ Receptor Usage, Compared With Blood in HIV-Infected Persons

Adipose tissue macrophages: Unique polarization and bioenergetics in obesity

Adipose tissue recruitment of leukocytes

Administration of N-Acyl-Phosphatidylethanolamine Expressing Bacteria to Low Density Lipoprotein Receptor Mice Improves Indices of Cardiometabolic Disease

An Iron Refractory Phenotype in Obese Adipose Tissue Macrophages Leads to Adipocyte Iron Overload

Apolipoprotein E and Reverse Cholesterol Transport: The Role of Recycling in Plasma and Intracellular Lipid Trafficking

Atherosclerotic lesion formation and triglyceride storage in obese apolipoprotein AI-deficient mice.

CC-chemokine receptor 7 (CCR7) deficiency alters adipose tissue leukocyte populations in mice.

CCR2 deficiency leads to increased eosinophils, alternative macrophage activation, and type 2 cytokine expression in adipose tissue.

CD8+ T cells regulate liver injury in obesity-related nonalcoholic fatty liver disease

Carbenoxolone treatment attenuates symptoms of metabolic syndrome and atherogenesis in obese, hyperlipidemic mice

Central nervous system neuropeptide Y signaling modulates VLDL triglyceride secretion.

Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs.

Contributions of Innate Type 2 Inflammation to Adipose Function

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of L

Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.

Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity, and insulin resistance.

Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice and reversal by a fish oil diet.

Deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein (UGRP)/glucose-6-phosphatase catalytic subunit-beta results in lowered plasma cholesterol and elevated glucagon

Diet-Induced Increases in Adiposity, but Not Plasma Lipids, Promote Macrophage Infiltration Into White Adipose Tissue

Dietary fish oil exerts hypolipidemic effects in lean and insulin sensitizing effects in obese LDLR-/- mice

Direct Effect of Cholesterol on Insulin Secretion: A Novel Mechanism for Pancreatic -Cell Dysfunction

Dual regulation of mouse Delta(5)- and Delta(6)-desaturase gene expression by SREBP-1 and PPARalpha

Effects of vitamin E on oxidative stress and atherosclerosis in an obese hyperlipidemic mouse model.

Elevating adipose eosinophils in obese mice to physiologically normal levels does not rescue metabolic impairments.

Endoplasmic reticulum stress and hypertension - a new paradigm?

Extrinsic and Intrinsic Immunometabolism Converge: Perspectives on Future Research and Therapeutic Development for Obesity

Fat-water MRI is sensitive to local adipose tissue inflammatory changes in a diet-induced obesity mouse model at 15T

Fat-water MRI of a diet-induced obesity mouse model at 15.2T.

Fish oil increases cholesterol storage in white adipose tissue with concomitant decreases in inflammation, hepatic steatosis, and atherosclerosis in mice

Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice

Haematopoietic leptin receptor deficiency does not affect macrophage accumulation in adipose tissue or systemic insulin sensitivity

Hepatocyte-derived ApoE is more effective than non-hepatocyte-derived ApoE in remnant lipoprotein clearance

High CD8 T-Cell Receptor Clonality and Altered CDR3 Properties Are Associated With Elevated Isolevuglandins in Adipose Tissue During Diet-Induced Obesity

Hyaluronan accumulates with high-fat feeding and contributes to insulin resistance.

Impact of increased adipose tissue mass on inflammation, insulin resistance, and dyslipidemia

Impact of macrophage inflammatory protein-1α deficiency on atherosclerotic lesion formation, hepatic steatosis, and adipose tissue expansion

Impaired insulin signaling in the B10.D2-Hc0 H2d H2-T18c/oSnJ mouse model of complement factor 5 deficiency

Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages

Inhibition of long-chain acyl coenzyme A synthetases during fatty acid loading induces lipotoxicity in macrophages

Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice

Intracellular trafficking of recycling apolipoprotein E in Chinese hamster ovary cells

Iron homeostasis: a new job for macrophages in adipose tissue?

Isolation of adipose tissue immune cells

Leptin requires canonical migratory signaling pathways for induction of monocyte and macrophage chemotaxis

Links between Immunologic Memory and Metabolic Cycling

Lipid and phospholipid profiling of biological samples using MALDI Fourier transform mass spectrometry

Liver X receptor α-dependent iron handling in M2 macrophages: The missing link between cholesterol and intraplaque hemorrhage?

Loss of CCR5 results in glucose intolerance in diet-induced obese mice

Loss of ovarian function in the VCD mouse-model of menopause leads to insulin resistance and a rapid progression into the metabolic syndrome.

MFe adipose tissue macrophages compensate for tissue iron perturbations in mice

Macrophage apolipoprotein A-I expression protects against atherosclerosis in ApoE-deficient mice and up-regulates ABC transporters.

Macrophage infiltration into adipose tissue: initiation, propagation and remodeling.

Macrophage-Targeted Therapeutics for Metabolic Disease

Macrophage-derived apolipoprotein E ameliorates dyslipidemia and atherosclerosis in obese apolipoprotein E-deficient mice.

Macrophages are essential for CTGF-mediated adult β-cell proliferation after injury

Mouse models of the metabolic syndrome

Multiomics reveals persistence of obesity-associated immune cell phenotypes in adipose tissue during weight loss and weight regain in mice

Nitro-fatty acids reduce atherosclerosis in apolipoprotein E-deficient mice.

Obesity Alters B Cell and Macrophage Populations in Brown Adipose Tissue

Obesity alters adipose tissue macrophage iron content and tissue iron distribution.

Obesity causes very low density lipoprotein clearance defects in low-density lipoprotein receptor-deficient mice

Obesity induced by a high-fat diet is associated with increased immune cell entry into the central nervous system.

Obesity potentiates development of fatty liver and insulin resistance, but not atherosclerosis, in high-fat diet-fed agouti LDLR-deficient mice

Obesity-induced reduction of adipose eosinophils is reversed with low-calorie dietary intervention

Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets

Palmitate induces apoptotic cell death and inflammasome activation in human placental macrophages

Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I

Physiological expression of macrophage apoE in the artery wall reduces atherosclerosis in severely hyperlipidemic mice

Physiological relevance of apolipoprotein E recycling: studies in primary mouse hepatocytes

Plasma insulin levels predict atherosclerotic lesion burden in obese hyperlipidemic mice