List of works - Naoya Yahagi

A Crucial Role of Sterol Regulatory Element-binding Protein-1 in the Regulation of Lipogenic Gene Expression by Polyunsaturated Fatty Acids

scientific article published in Journal of Biological Chemistry

A candidate functional SNP rs7074440 in TCF7L2 alters gene expression through C-FOS in hepatocytes.

scientific article published on 13 January 2018

A case of fatal pneumonia caused by Legionella pneumophila serogroup 6 developed after drowning in a public bath

scientific article published on February 1997

A key role of nuclear factor Y in the refeeding response of fatty acid synthase in adipocytes

scientific article published on 9 March 2017

A transcription factor of lipid synthesis, sterol regulatory element-binding protein (SREBP)-1a causes G(1) cell-cycle arrest after accumulation of cyclin-dependent kinase (cdk) inhibitors.

scientific article published on 27 July 2007

Ablation of Elovl6 protects pancreatic islets from high-fat diet-induced impairment of insulin secretion

scientific article published on 02 June 2014

Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis.

scientific article published in September 2009

Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement

scientific article published on 25 November 2010

Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia

scientific article published on 01 July 2000

Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr(-/-) mouse model

scientific article

Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status

scientific journal article

Administration of angiotensin II, but not catecholamines, induces accumulation of lipids in the rat heart

scientific article

Apolipoprotein C-II deficiency with no rare variant in the APOC2 gene

scientific article published on 7 March 2013

Apoptotic cell death in atherosclerotic plaques of hyperlipidemic knockout mice

scientific article published on 01 December 1997

Asialoglycoprotein receptor deficiency in mice lacking the major receptor subunit. Its obligate requirement for the stable expression of oligomeric receptor.

scientific article

CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα.

scientific article published on 16 December 2016

Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity

scientific article

Circulating malondialdehyde-modified LDL-related variables and coronary artery stenosis in asymptomatic patients with type 2 diabetes

scientific article

Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs.

scientific article

Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma

scientific article published in June 2005

Comparison of the Framingham risk score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and maximum carotid intima-media thickness for predicting coronary artery ste

scientific article published on 8 April 2014

Corrigendum: Glycogen shortage during fasting triggers liver–brain–adipose neurocircuitry to facilitate fat utilization

scientific article published in December 2013

Cost-effectiveness of a New Opportunistic Screening Strategy for Walk-in Fingertip HbA1c Testing at Community Pharmacies in Japan.

scientific article published on 23 April 2018

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of L

scientific article published in May 2003

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling

scientific article published on May 2003

Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.

scientific article published on 30 September 2007

Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity, and insulin resistance.

scientific article published on 29 April 2008

Detection of Transgenes in Gene Delivery Model Mice by Adenoviral Vector Using ddPCR

scientific article published on 08 June 2019

Dicer has a crucial role in the early stage of adipocyte differentiation, but not in lipid synthesis, in 3T3-L1 cells

scientific article published on 26 March 2012

Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice

scientific article

Diversity of voltage-gated sodium channels in the ascidian larval nervous system

scientific article published in August 2000

Dual regulation of mouse Delta(5)- and Delta(6)-desaturase gene expression by SREBP-1 and PPARalpha

scientific article published in January 2002

Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene

scientific journal article

Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry.

scientific article published on 16 September 2017

Elimination of cholesterol ester from macrophage foam cells by adenovirus-mediated gene transfer of hormone-sensitive lipase.

scientific article

Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding β-Cell Mass and Increasing Insulin Secretory Capacity.

scientific article

Elovl6 promotes nonalcoholic steatohepatitis

scientific article published on 01 December 2012

Embryonic lethality and defective neural tube closure in mice lacking squalene synthase.

scientific article published in October 1999

FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products.

scientific article

Glucocorticoid receptor suppresses gene expression of Rev-erbα (Nr1d1) through interaction with the CLOCK complex

scientific article published on 01 February 2019

Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice

scientific journal article

Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement

scientific article published in December 2003

Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes.

scientific article published on 18 September 2014

Hepatic Control of Energy Metabolism via the Autonomic Nervous System.

scientific article

High mobility group protein-B1 interacts with sterol regulatory element-binding proteins to enhance their DNA binding

scientific article

Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lep ob/ob mice.

scientific article published on 18 July 2009

Hormone-sensitive lipase is involved in hepatic cholesteryl ester hydrolysis.

scientific article

Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system

scientific article published on 13 June 2016

Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol: a potential role in adipocyte lipolysis

scientific journal article

Identification of human ELOVL5 enhancer regions controlled by SREBP

scientific article published on 28 August 2015

In vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding protein-1c expression

scientific article

Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver

scientific article (publication date: September 2006)

Inhibition of ubiquitin ligase F-box and WD repeat domain-containing 7α (Fbw7α) causes hepatosteatosis through Krüppel-like factor 5 (KLF5)/peroxisome proliferator-activated receptor γ2 (PPARγ2) pathway but not SREBP-1c protein in mice

scientific article published on 12 September 2011

Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice

scientific article published in March 2004

Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression.

scientific article published on 17 September 2016

KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting.

scientific article published on 17 August 2016

Lipolysis in the absence of hormone-sensitive lipase: evidence for a common mechanism regulating distinct lipases

scientific article published in December 2002

Macrophage Elovl6 Deficiency Ameliorates Foam Cell Formation and Reduces Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice

scientific article published on 04 August 2011

Malondialdehyde-modified LDL-related variables are associated with diabetic kidney disease in type 2 diabetes

scientific article published on 26 May 2018

MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice. ⬇️

scientific article published on January 2013

MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo

scientific article

Mouse Elovl-6 promoter is an SREBP target

scientific article published on 28 January 2008

Novel mutations in the microsomal triglyceride transfer protein gene causing abetalipoproteinemia

scientific article published on 01 August 2000

Nuclear SREBP-1a causes loss of pancreatic beta-cells and impaired insulin secretion

scientific article

Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism

scientific article published on 26 March 2019

Overexpressed lipoprotein lipase protects against atherosclerosis in apolipoprotein E knockout mice

scientific article published on 01 September 1999

Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets

scientific article published on 5 May 2008

Polyunsaturated fatty acids selectively suppress sterol regulatory element-binding protein-1 through proteolytic processing and autoloop regulatory circuit.

scientific article

Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements

scientific article

Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver

scientific article published on 12 February 2007

Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin.

scientific article

Role of Hormone-sensitive Lipase in Leptin-Promoted Fat Loss and Glucose Lowering

scientific article published on 12 April 2017

SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes.

scientific article

SREBP-1-independent regulation of lipogenic gene expression in adipocytes.

scientific article published on 24 April 2007

SREBPs suppress IRS-2-mediated insulin signalling in the liver

scientific article published on 14 March 2004

Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide

scientific article

Selective peroxisome proliferator-activated receptor-α modulator K-877 efficiently activates the peroxisome proliferator-activated receptor-α pathway and improves lipid metabolism in mice.

scientific article published on 13 January 2017

Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor.

scientific article published on 09 July 2001

Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy

scientific article published on 14 September 2015

Sterol Regulatory Element–Binding Protein-1 Determines Plasma Remnant Lipoproteins and Accelerates Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice

scientific article published on 05 May 2011

Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes

scientific journal article

Sterol regulatory element-binding protein-1 is regulated by glucose at the transcriptional level.

scientific article

Sterol regulatory element-binding proteins activate insulin gene promoter directly and indirectly through synergy with BETA2/E47.

scientific article published on 29 July 2005

Suppression of the pancreatic duodenal homeodomain transcription factor-1 (Pdx-1) promoter by sterol regulatory element-binding protein-1c (SREBP-1c).

scientific article published on 7 June 2011

TFE3 controls lipid metabolism in adipose tissue of male mice by suppressing lipolysis and thermogenesis

scientific article published on 24 July 2013

TFE3 inhibits myoblast differentiation in C2C12 cells via down-regulating gene expression of myogenin.

scientific article published on 2 December 2012

TFE3 regulates muscle metabolic gene expression, increases glycogen stores, and enhances insulin sensitivity in mice

scientific article

TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes

scientific article published on 4 December 2005

Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity

scientific article

The LDL receptor is the major pathway for beta-VLDL uptake by mouse peritoneal macrophages

scientific article

The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice

scientific article published on 19 May 2009

Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT1

scientific article published on 19 December 2019

Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance

scientific article published on 01 June 2018

Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: pleiotropic effects on CD36 expression and HDL.

scientific article

[Gene therapy for hyperlipoproteinemia]

scientific article published on 01 March 2001

p53 Activation in Adipocytes of Obese Mice ⬇️

scientific article published on May 6, 2003

p53 involvement in the pathogenesis of fatty liver disease.

scientific article published on 25 February 2004

List of works by Naoya Yahagi

A Crucial Role of Sterol Regulatory Element-binding Protein-1 in the Regulation of Lipogenic Gene Expression by Polyunsaturated Fatty Acids

A candidate functional SNP rs7074440 in TCF7L2 alters gene expression through C-FOS in hepatocytes.

A case of fatal pneumonia caused by Legionella pneumophila serogroup 6 developed after drowning in a public bath

A key role of nuclear factor Y in the refeeding response of fatty acid synthase in adipocytes

A transcription factor of lipid synthesis, sterol regulatory element-binding protein (SREBP)-1a causes G(1) cell-cycle arrest after accumulation of cyclin-dependent kinase (cdk) inhibitors.

Ablation of Elovl6 protects pancreatic islets from high-fat diet-induced impairment of insulin secretion

Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis.

Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement

Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia

Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr(-/-) mouse model

Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status

Administration of angiotensin II, but not catecholamines, induces accumulation of lipids in the rat heart

Apolipoprotein C-II deficiency with no rare variant in the APOC2 gene

Apoptotic cell death in atherosclerotic plaques of hyperlipidemic knockout mice

Asialoglycoprotein receptor deficiency in mice lacking the major receptor subunit. Its obligate requirement for the stable expression of oligomeric receptor.

CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα.

Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity

Circulating malondialdehyde-modified LDL-related variables and coronary artery stenosis in asymptomatic patients with type 2 diabetes

Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs.

Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma

Comparison of the Framingham risk score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and maximum carotid intima-media thickness for predicting coronary artery ste

Corrigendum: Glycogen shortage during fasting triggers liver–brain–adipose neurocircuitry to facilitate fat utilization

Cost-effectiveness of a New Opportunistic Screening Strategy for Walk-in Fingertip HbA1c Testing at Community Pharmacies in Japan.

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of L

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling

Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.

Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity, and insulin resistance.

Detection of Transgenes in Gene Delivery Model Mice by Adenoviral Vector Using ddPCR

Dicer has a crucial role in the early stage of adipocyte differentiation, but not in lipid synthesis, in 3T3-L1 cells

Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice

Diversity of voltage-gated sodium channels in the ascidian larval nervous system

Dual regulation of mouse Delta(5)- and Delta(6)-desaturase gene expression by SREBP-1 and PPARalpha

Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene

Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry.

Elimination of cholesterol ester from macrophage foam cells by adenovirus-mediated gene transfer of hormone-sensitive lipase.

Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding β-Cell Mass and Increasing Insulin Secretory Capacity.

Elovl6 promotes nonalcoholic steatohepatitis

Embryonic lethality and defective neural tube closure in mice lacking squalene synthase.

FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products.

Glucocorticoid receptor suppresses gene expression of Rev-erbα (Nr1d1) through interaction with the CLOCK complex

Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice

Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement

Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes.

Hepatic Control of Energy Metabolism via the Autonomic Nervous System.

High mobility group protein-B1 interacts with sterol regulatory element-binding proteins to enhance their DNA binding

Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lep ob/ob mice.

Hormone-sensitive lipase is involved in hepatic cholesteryl ester hydrolysis.

Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system

Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol: a potential role in adipocyte lipolysis

Identification of human ELOVL5 enhancer regions controlled by SREBP

In vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding protein-1c expression

Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver

Inhibition of ubiquitin ligase F-box and WD repeat domain-containing 7α (Fbw7α) causes hepatosteatosis through Krüppel-like factor 5 (KLF5)/peroxisome proliferator-activated receptor γ2 (PPARγ2) pathway but not SREBP-1c protein in mice

Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice

Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression.

KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting.

Lipolysis in the absence of hormone-sensitive lipase: evidence for a common mechanism regulating distinct lipases

Macrophage Elovl6 Deficiency Ameliorates Foam Cell Formation and Reduces Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice

Malondialdehyde-modified LDL-related variables are associated with diabetic kidney disease in type 2 diabetes

MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice. ⬇️

MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo

Mouse Elovl-6 promoter is an SREBP target

Novel mutations in the microsomal triglyceride transfer protein gene causing abetalipoproteinemia

Nuclear SREBP-1a causes loss of pancreatic beta-cells and impaired insulin secretion

Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism

Overexpressed lipoprotein lipase protects against atherosclerosis in apolipoprotein E knockout mice

Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets

Polyunsaturated fatty acids selectively suppress sterol regulatory element-binding protein-1 through proteolytic processing and autoloop regulatory circuit.

Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements

Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver

Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin.

Role of Hormone-sensitive Lipase in Leptin-Promoted Fat Loss and Glucose Lowering

SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes.

SREBP-1-independent regulation of lipogenic gene expression in adipocytes.

SREBPs suppress IRS-2-mediated insulin signalling in the liver

Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide

Selective peroxisome proliferator-activated receptor-α modulator K-877 efficiently activates the peroxisome proliferator-activated receptor-α pathway and improves lipid metabolism in mice.

Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor.

Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy