List of works - Alexander Egle

A complementary role of multiparameter flow cytometry and high-throughput sequencing for minimal residual disease detection in chronic lymphocytic leukemia: an European Research Initiative on CLL study.

scientific article published on 7 December 2015

A modified scoring of the NCCN-IPI is more accurate in the elderly and is improved by albumin and β2 -microglobulin

scientific article published on 19 September 2014

A phase 2 study of rituximab plus lenalidomide for mucosa-associated lymphoid tissue lymphoma

scientific article published on 22 November 2016

Actinomycin D induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia

article by Olaf Merkel et al published 1 June 2012 in Leukemia

An uncommon cause of anaemia: Sheehan's syndrome

scientific article published on 7 December 2010

Analysis of Bcl-2 protein expression in chronic lymphocytic leukemia. A comparison of three semiquantitation techniques

scientific article published on 01 February 2000

Anti-Hu Antibody Associated Paraneoplastic Cerebellar Degeneration in Head and Neck Cancer.

scientific article published on 22 December 2015

Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation.

scientific article

Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation

scientific article published on August 2010

Autoimmune hemolysis accompanied by thrombopenia: consumption or myelodysplasia?

scientific article

Azacitidine in patients with WHO-defined AML – Results of 155 patients from the Austrian Azacitidine Registry of the AGMT-Study Group ⬇️

scientific article published on April 29, 2013

B-859-35, a new drug with anti-tumor activity reverses multi-drug resistance.

scientific article published on April 1991

B-cell receptor usage correlates with the sensitivity to CD40 stimulation and the occurrence of CD4+ T-cell clonality in chronic lymphocytic leukemia.

scientific article published on 24 April 2015

B-cell-specific IRF4 deletion accelerates chronic lymphocytic leukemia development by enhanced tumor immune evasion

scientific article published on 01 November 2019

BIRC3 Expression Predicts CLL Progression and Defines Treatment Sensitivity via Enhanced NF-κB Nuclear Translocation

scientific article published on 28 November 2018

Bcl-2 proteins in development, health, and disease of the hematopoietic system.

scientific article published on 16 February 2016

Bid-ding for mercy: twisted killer in action.

scientific article published in July 2013

Bim is a suppressor of Myc-induced mouse B cell leukemia

scholarly article

C-Reactive Protein and Neutrophil/Lymphocytes Ratio: Prognostic Indicator for Doubling overall survival Prediction in Pancreatic Cancer Patients

scientific article published on 25 October 2019

C-reactive protein level is a prognostic indicator for survival and improves the predictive ability of the R-IPI score in diffuse large B-cell lymphoma patients.

scientific article

CD1d expression on chronic lymphocytic leukemia B cells affects disease progression and induces T cell skewing in CD8 positive and CD4CD8 double negative T cells

scientific article published on July 2016

CD4+ T cells, but not non-classical monocytes, are dispensable for the development of chronic lymphocytic leukemia in the TCL1-tg murine model.

scientific article published on 2 November 2015

CXCL12-induced VLA-4 activation is impaired in trisomy 12 chronic lymphocytic leukemia cells: a role for CCL21.

scientific article

CYP39A1 polymorphism is associated with toxicity during intensive induction chemotherapy in patients with advanced head and neck cancer

scientific article

Casein Kinase 1 is a Therapeutic Target in Chronic Lymphocytic Leukemia.

scientific article published on 9 January 2018

Chemotherapy-induced augmentation of T cells expressing inhibitory receptors is reversed by treatment with lenalidomide in chronic lymphocytic leukemia

scientific article published on 21 February 2014

Chronic lymphocytic leukaemia induces an exhausted T cell phenotype in the TCL1 transgenic mouse model.

scientific article published on 4 May 2015

Clinical aspects of 2009 pandemic influenza A (H1N1) virus infection in Austria

scientific article

Clonal evolution and heterogeneity in metastatic head and neck cancer-An analysis of the Austrian Study Group of Medical Tumour Therapy study group

scientific article published on 22 February 2018

Clonal evolution in relapsed and refractory diffuse large B-cell lymphoma is characterized by high dynamics of subclones

scientific article published on 6 June 2016

Cobas ampliprep/cobas TaqMan HIV-1 v2.0 assay: consequences at the cohort level

scientific article

Complete remission of Waldenström macroglobulinemia with azacitidine and rituximab

scientific article published on 05 July 2011

Complications of 5-azacytidine: Three cases of severe ischemic colitis in elderly patients with myelodysplastic syndrome

scientific article published on 15 October 2013

Constitutive expression of Fas (Apo-1/CD95) ligand on multiple myeloma cells: a potential mechanism of tumor-induced suppression of immune surveillance

scientific article published on 01 July 1997

DNA Methylation Signatures Predicting Bevacizumab Efficacy in Metastatic Breast Cancer.

scientific article

Depletion of CLL-associated patrolling monocytes and macrophages controls disease development and repairs immune dysfunction in vivo

scientific article published on 2 November 2015

Development of CLL in the TCL1 transgenic mouse model is associated with severe skewing of the T-cell compartment homologous to human CLL.

scientific article published on 24 May 2011

Differential bone marrow homing capacity of VLA-4 and CD38 high expressing chronic lymphocytic leukemia cells

scientific article

Differential sensitivity of CD4+ and CD8+ T lymphocytes to the killing efficacy of Fas (Apo-1/CD95) ligand+ tumor cells in B chronic lymphocytic leukemia ⬇️

scientific article published on June 1, 1998

Drug-induced apoptosis is associated with enhanced Fas (Apo-1/CD95) ligand expression but occurs independently of Fas (Apo-1/CD95) signaling in human T-acute lymphatic leukemia cells

scientific article published on 01 August 1997

Durable remissions with venetoclax monotherapy in secondary AML refractory to hypomethylating agents and high expression of BCL-2 and/or BIM

scientific article published on 28 February 2019

Establishment and validation of a novel risk model for estimating time to first treatment in 120 patients with chronic myelomonocytic leukaemia

scientific article published on 30 January 2018

Evaluation of circulating cell-free DNA as a molecular monitoring tool in patients with metastatic cancer

scientific article published on 09 December 2019

Exome sequencing of the TCL1 mouse model for CLL reveals genetic heterogeneity and dynamics during disease development

article

Expression levels of CD38 in T cells predict course of disease in male patients with B-chronic lymphocytic leukemia

scientific article published on 6 July 2006

Expression of Apo-1/Fas (CD95), Bcl-2, Bax and Bcl-x in myeloma cell lines: relationship between responsiveness to anti-Fas mab and p53 functional status

scientific article published on 01 May 1997

Expression of functional interleukin-15 receptor and autocrine production of interleukin-15 as mechanisms of tumor propagation in multiple myeloma

scientific article published on 01 January 2000

Fludarabine and rituximab with escalating doses of lenalidomide followed by lenalidomide/rituximab maintenance in previously untreated chronic lymphocytic leukaemia (CLL): the REVLIRIT CLL-5 AGMT phase I/II study

scientific article published on 04 June 2018

Fludarabine modulates composition and function of the T cell pool in patients with chronic lymphocytic leukaemia

scientific article

Fluorouracil and Dihydropyrimidine Dehydrogenase Genotyping

scientific article published on 09 May 2016

How does lenalidomide target the chronic lymphocytic leukemia microenvironment?

scientific article

IL-10 serum levels in B-cell chronic lymphocytic leukaemia

scientific article published on 01 July 1996

ILK Induction in Lymphoid Organs by a TNFα-NF-κB-Regulated Pathway Promotes the Development of Chronic Lymphocytic Leukemia.

scientific article published on 2 February 2016

Increased body mass index is associated with improved overall survival in diffuse large B-cell lymphoma

scientific article published on 3 December 2013

Independent Prognostic Value of Serum Markers in Diffuse Large B-Cell Lymphoma in the Era of the NCCN-IPI.

scientific article

Influence of body mass index on survival in indolent and mantle cell lymphomas: analysis of the StiL NHL1 trial

scientific article

Inhibition of cell proliferation, protein kinase C, and phorbol ester-induced fos expression by the dihydropyridine derivative B859-35.

scientific article published on November 1991

Initial evaluation of the Roche COBAS TaqMan HIV-1 v2.0 assay for determining viral load in HIV-infected individuals.

scientific article published in January 2009

Interdependent regulation of p53 and miR-34a in chronic lymphocytic leukemia

scientific article published on 03 July 2010

Intermittent low-dose bevacizumab in hereditary hemorrhagic telangiectasia : A case report.

scientific article

Ixazomib-Thalidomide-Dexamethasone for induction therapy followed by Ixazomib maintenance treatment in patients with relapsed/refractory multiple myeloma

scientific article published on 27 September 2019

Kasabach-Merritt phenomenon in hepatic angiosarcoma

scientific article published on 24 July 2014

Lenalidomide in combination with vorinostat and dexamethasone for the treatment of relapsed/refractory peripheral T cell lymphoma (PTCL): report of a phase I/II trial

scientific article

Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy

scientific article published on 23 January 2015

Liver toxicity during temozolomide chemotherapy caused by Chinese herbs. ⬇️

scientific article

Lysine residue at position 22 of the AID protein regulates its class switch activity.

scientific article

Microenvironment-induced CD44v6 promotes early disease progression in chronic lymphocytic leukemia

scientific article published on 19 January 2018

Milestones in Chronic Lymphocytic Leukemia: An exciting decade of progress-10th anniversary of memo

scientific article

Mimicking the microenvironment in chronic lymphocytic leukaemia - where does the journey go?

article by Daniela Asslaber et al published 4 December 2012 in British Journal of Haematology

Modulation of Apo-1/Fas (CD95)-induced programmed cell death in myeloma cells by interferon-alpha 2

scientific article published on 01 December 1996

Molecular and cellular mechanisms of CLL: novel therapeutic approaches.

scientific article published on 02 June 2009

Molecular responses and chromosomal aberrations in patients with polycythemia vera treated with peg-proline-interferon alpha-2b.

scientific article

NCCN-IPI score-independent prognostic potential of pretreatment uric acid levels for clinical outcome of diffuse large B-cell lymphoma patients

scientific article

Novel models for prediction of benefit and toxicity with FOLFIRINOX treatment of pancreatic cancer using clinically available parameters

scientific article published in PLoS ONE

Old and new news in CLL: "It's the pathway, stupid!".

scientific article published in August 2014

On the role and significance of Fas (Apo-1/CD95) ligand (FasL) expression in immune privileged tissues and cancer cells using multiple myeloma as a model

scientific article published on 01 November 1998

PKCbeta is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKCbeta as a therapeutic target in chronic lymphocytic leukemia.

scientific article

Pleural decortication of a marginal zone lymphoma

scientific article published on 22 November 2013

Plitidepsin: a potential new treatment for relapsed/refractory multiple myeloma

scientific article published on 16 August 2018

Prognostic score in patients with recurrent or metastatic carcinoma of the head and neck treated with cetuximab and chemotherapy

scientific article

Protein kinase c-β-dependent activation of NF-κB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo.

scientific article

Quality of life in patients with relapsed/refractory multiple myeloma during ixazomib-thalidomide-dexamethasone induction and ixazomib maintenance therapy and comparison to the general population

scientific article published on 26 September 2019

RNA editing contributes to epitranscriptome diversity in chronic lymphocytic leukemia

scientific article published on 30 July 2020

Raltegravir in pregnancy: a case series presentation

scientific article published on 01 June 2011

Red blood cell alloimmunization in 184 patients with myeloid neoplasms treated with azacitidine - A retrospective single center experience.

scientific article published on 9 May 2017

Regulatory T cells predict the time to initial treatment in early stage chronic lymphocytic leukemia

scientific article published on 18 November 2010

Remission maintenance treatment options in chronic lymphocytic leukemia

scientific article published on 10 August 2018

Riding the 2-edged sword

scientific article published on 01 June 2010

Ristocetin-induced platelet aggregation for monitoring of bleeding tendency in CLL treated with ibrutinib

scientific article published on 2 December 2016

Rituximab maintenance overcomes the negative prognostic factor of obesity in CLL: Subgroup analysis of the international randomized AGMT CLL-8a mabtenance trial

scientific article published on 19 March 2019

Rituximab maintenance versus observation alone in patients with chronic lymphocytic leukaemia who respond to first-line or second-line rituximab-containing chemoimmunotherapy: final results of the AGMT CLL-8a Mabtenance randomised trial.

scientific article published on 16 June 2016

Ropeginterferon alfa-2b, a novel IFNα-2b, induces high response rates with low toxicity in patients with polycythemia vera

scientific article

Stromal cell protein kinase C-β inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance

scientific article published on 01 January 2020

Subversion of the Bcl-2 life/death switch in cancer development and therapy.

scientific article published in January 2005

TCL1 transgenic mice as a model for CD49d-high chronic lymphocytic leukemia

scientific article published on 21 February 2020

TIGIT expressing CD4+T cells represent a tumor-supportive T cell subset in chronic lymphocytic leukemia

scientific article published on 21 September 2017

TNF cytokine family: more BAFF-ling complexities

scientific article (publication date: 11 December 2001)

Targeting proliferation of chronic lymphocytic leukemia (CLL) cells through KCa3.1 blockade

scientific article published on 20 January 2014

The AKT1 isoform plays a dominant role in the survival and chemoresistance of chronic lymphocytic leukaemia cells

scientific article published on 6 July 2015

The clinical significance of fibrinogen plasma levels in patients with diffuse large B cell lymphoma.

scientific article published on 7 December 2015

The effect of IgVH mutational status on the induction of apoptosis by rituximab in patients with heavily pretreated B-cell chronic lymphocytic leukemia: evidence from a clinical phase I/II trial

scientific article published on 01 September 2006

The influence of FCGR2A and FCGR3A polymorphisms on the survival of patients with recurrent or metastatic squamous cell head and neck cancer treated with cetuximab.

scientific article published on 18 July 2017

The significance of pretreatment anemia in the era of R-IPI and NCCN-IPI prognostic risk assessment tools: a dual-center study in diffuse large B-cell lymphoma patients.

scientific article published on 13 February 2015

Treatment of aggressive B-cell lymphoma in elderly patients: influence of single nucleotide polymorphisms affecting pharmacodynamics of chemotherapeutics.

scientific article published on 25 June 2014

Treatment with brentuximab vedotin plus bendamustine in unselected patients with CD30-positive aggressive lymphomas

scientific article published on 10 January 2020

Update on squamous cell carcinoma of the head and neck: ASCO annual meeting 2017.

scientific article published on 20 October 2017

Use of romiplostim allows for hepatitis C therapy in a HIV/HCV coinfected patient

scientific article

VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia

scientific article published on 20 November 2003

Viral infections and their management in patients with chronic lymphocytic leukemia.

scientific article published on 03 January 2013

microRNA-34a expression correlates with MDM2 SNP309 polymorphism and treatment-free survival in chronic lymphocytic leukemia

scientific article published on 20 January 2010

p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa.

scientific article published on 9 May 2013

List of works by Alexander Egle

A complementary role of multiparameter flow cytometry and high-throughput sequencing for minimal residual disease detection in chronic lymphocytic leukemia: an European Research Initiative on CLL study.

A modified scoring of the NCCN-IPI is more accurate in the elderly and is improved by albumin and β2 -microglobulin

A phase 2 study of rituximab plus lenalidomide for mucosa-associated lymphoid tissue lymphoma

Actinomycin D induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia

An uncommon cause of anaemia: Sheehan's syndrome

Analysis of Bcl-2 protein expression in chronic lymphocytic leukemia. A comparison of three semiquantitation techniques

Anti-Hu Antibody Associated Paraneoplastic Cerebellar Degeneration in Head and Neck Cancer.

Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation.

Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation

Autoimmune hemolysis accompanied by thrombopenia: consumption or myelodysplasia?

Azacitidine in patients with WHO-defined AML – Results of 155 patients from the Austrian Azacitidine Registry of the AGMT-Study Group ⬇️

B-859-35, a new drug with anti-tumor activity reverses multi-drug resistance.

B-cell receptor usage correlates with the sensitivity to CD40 stimulation and the occurrence of CD4+ T-cell clonality in chronic lymphocytic leukemia.

B-cell-specific IRF4 deletion accelerates chronic lymphocytic leukemia development by enhanced tumor immune evasion

BIRC3 Expression Predicts CLL Progression and Defines Treatment Sensitivity via Enhanced NF-κB Nuclear Translocation

Bcl-2 proteins in development, health, and disease of the hematopoietic system.

Bid-ding for mercy: twisted killer in action.

Bim is a suppressor of Myc-induced mouse B cell leukemia

C-Reactive Protein and Neutrophil/Lymphocytes Ratio: Prognostic Indicator for Doubling overall survival Prediction in Pancreatic Cancer Patients

C-reactive protein level is a prognostic indicator for survival and improves the predictive ability of the R-IPI score in diffuse large B-cell lymphoma patients.

CD1d expression on chronic lymphocytic leukemia B cells affects disease progression and induces T cell skewing in CD8 positive and CD4CD8 double negative T cells

CD4+ T cells, but not non-classical monocytes, are dispensable for the development of chronic lymphocytic leukemia in the TCL1-tg murine model.

CXCL12-induced VLA-4 activation is impaired in trisomy 12 chronic lymphocytic leukemia cells: a role for CCL21.

CYP39A1 polymorphism is associated with toxicity during intensive induction chemotherapy in patients with advanced head and neck cancer

Casein Kinase 1 is a Therapeutic Target in Chronic Lymphocytic Leukemia.

Chemotherapy-induced augmentation of T cells expressing inhibitory receptors is reversed by treatment with lenalidomide in chronic lymphocytic leukemia

Chronic lymphocytic leukaemia induces an exhausted T cell phenotype in the TCL1 transgenic mouse model.

Clinical aspects of 2009 pandemic influenza A (H1N1) virus infection in Austria

Clonal evolution and heterogeneity in metastatic head and neck cancer-An analysis of the Austrian Study Group of Medical Tumour Therapy study group

Clonal evolution in relapsed and refractory diffuse large B-cell lymphoma is characterized by high dynamics of subclones

Cobas ampliprep/cobas TaqMan HIV-1 v2.0 assay: consequences at the cohort level

Complete remission of Waldenström macroglobulinemia with azacitidine and rituximab

Complications of 5-azacytidine: Three cases of severe ischemic colitis in elderly patients with myelodysplastic syndrome

Constitutive expression of Fas (Apo-1/CD95) ligand on multiple myeloma cells: a potential mechanism of tumor-induced suppression of immune surveillance

DNA Methylation Signatures Predicting Bevacizumab Efficacy in Metastatic Breast Cancer.

Depletion of CLL-associated patrolling monocytes and macrophages controls disease development and repairs immune dysfunction in vivo

Development of CLL in the TCL1 transgenic mouse model is associated with severe skewing of the T-cell compartment homologous to human CLL.

Differential bone marrow homing capacity of VLA-4 and CD38 high expressing chronic lymphocytic leukemia cells

Differential sensitivity of CD4+ and CD8+ T lymphocytes to the killing efficacy of Fas (Apo-1/CD95) ligand+ tumor cells in B chronic lymphocytic leukemia ⬇️

Drug-induced apoptosis is associated with enhanced Fas (Apo-1/CD95) ligand expression but occurs independently of Fas (Apo-1/CD95) signaling in human T-acute lymphatic leukemia cells

Durable remissions with venetoclax monotherapy in secondary AML refractory to hypomethylating agents and high expression of BCL-2 and/or BIM

Establishment and validation of a novel risk model for estimating time to first treatment in 120 patients with chronic myelomonocytic leukaemia

Evaluation of circulating cell-free DNA as a molecular monitoring tool in patients with metastatic cancer

Exome sequencing of the TCL1 mouse model for CLL reveals genetic heterogeneity and dynamics during disease development

Expression levels of CD38 in T cells predict course of disease in male patients with B-chronic lymphocytic leukemia

Expression of Apo-1/Fas (CD95), Bcl-2, Bax and Bcl-x in myeloma cell lines: relationship between responsiveness to anti-Fas mab and p53 functional status

Expression of functional interleukin-15 receptor and autocrine production of interleukin-15 as mechanisms of tumor propagation in multiple myeloma

Fludarabine and rituximab with escalating doses of lenalidomide followed by lenalidomide/rituximab maintenance in previously untreated chronic lymphocytic leukaemia (CLL): the REVLIRIT CLL-5 AGMT phase I/II study

Fludarabine modulates composition and function of the T cell pool in patients with chronic lymphocytic leukaemia

Fluorouracil and Dihydropyrimidine Dehydrogenase Genotyping

How does lenalidomide target the chronic lymphocytic leukemia microenvironment?

IL-10 serum levels in B-cell chronic lymphocytic leukaemia

ILK Induction in Lymphoid Organs by a TNFα-NF-κB-Regulated Pathway Promotes the Development of Chronic Lymphocytic Leukemia.

Increased body mass index is associated with improved overall survival in diffuse large B-cell lymphoma

Independent Prognostic Value of Serum Markers in Diffuse Large B-Cell Lymphoma in the Era of the NCCN-IPI.

Influence of body mass index on survival in indolent and mantle cell lymphomas: analysis of the StiL NHL1 trial

Inhibition of cell proliferation, protein kinase C, and phorbol ester-induced fos expression by the dihydropyridine derivative B859-35.

Initial evaluation of the Roche COBAS TaqMan HIV-1 v2.0 assay for determining viral load in HIV-infected individuals.

Interdependent regulation of p53 and miR-34a in chronic lymphocytic leukemia

Intermittent low-dose bevacizumab in hereditary hemorrhagic telangiectasia : A case report.

Ixazomib-Thalidomide-Dexamethasone for induction therapy followed by Ixazomib maintenance treatment in patients with relapsed/refractory multiple myeloma

Kasabach-Merritt phenomenon in hepatic angiosarcoma

Lenalidomide in combination with vorinostat and dexamethasone for the treatment of relapsed/refractory peripheral T cell lymphoma (PTCL): report of a phase I/II trial

Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy

Liver toxicity during temozolomide chemotherapy caused by Chinese herbs. ⬇️

Lysine residue at position 22 of the AID protein regulates its class switch activity.

Microenvironment-induced CD44v6 promotes early disease progression in chronic lymphocytic leukemia

Milestones in Chronic Lymphocytic Leukemia: An exciting decade of progress-10th anniversary of memo

Mimicking the microenvironment in chronic lymphocytic leukaemia - where does the journey go?

Modulation of Apo-1/Fas (CD95)-induced programmed cell death in myeloma cells by interferon-alpha 2

Molecular and cellular mechanisms of CLL: novel therapeutic approaches.

Molecular responses and chromosomal aberrations in patients with polycythemia vera treated with peg-proline-interferon alpha-2b.

NCCN-IPI score-independent prognostic potential of pretreatment uric acid levels for clinical outcome of diffuse large B-cell lymphoma patients

Novel models for prediction of benefit and toxicity with FOLFIRINOX treatment of pancreatic cancer using clinically available parameters

Old and new news in CLL: "It's the pathway, stupid!".

On the role and significance of Fas (Apo-1/CD95) ligand (FasL) expression in immune privileged tissues and cancer cells using multiple myeloma as a model

PKCbeta is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKCbeta as a therapeutic target in chronic lymphocytic leukemia.

Pleural decortication of a marginal zone lymphoma

Plitidepsin: a potential new treatment for relapsed/refractory multiple myeloma