List of works - Michaela Fontenay

A G polymorphism in the CRBN gene acts as a biomarker of response to treatment with lenalidomide in low/int-1 risk MDS without del(5q).

scientific article published on 26 February 2013

A common alternative splicing signature is associated with SF3B1 mutations in malignancies from different cell lineages.

scientific article

A role for caspases in the differentiation of erythroid cells and macrophages.

scientific article published on 02 September 2007

A short Gfi-1B isoform controls erythroid differentiation by recruiting the LSD1-CoREST complex through the dimethylation of its SNAG domain.

scientific article

A variant erythroferrone disrupts iron homeostasis in SF3B1-mutated myelodysplastic syndrome

scientific article published on 01 July 2019

AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages

scientific article

APG101 efficiently rescues erythropoiesis in lower risk myelodysplastic syndromes with severe impairment of hematopoiesis

scientific article published on 18 February 2016

Activation of PAK1/2 during the shedding of platelet microvesicles.

scientific article published in January 2009

Activity of the caspase-3/CPP32 enzyme is increased in “early stage” myelodysplastic syndromes with excessive apoptosis, but caspase inhibition does not enhance colony formation in vitro

scientific article published on 01 July 2000

Alpha-defensins secreted by dysplastic granulocytes inhibit the differentiation of monocytes in chronic myelomonocytic leukemia.

scientific article published on 28 October 2009

Analysis of megakaryocyte growth and development factor (thrombopoietin) effects on blast cell and megakaryocyte growth in myelodysplasia.

scientific article

Antileukemic activity of the VPS34-IN1 inhibitor in acute myeloid leukemia

scientific article published on 22 October 2020

Apoptotic pathways to death in myelodysplastic syndromes

scientific article published on 01 September 2008

Architectural and functional heterogeneity of hematopoietic stem/progenitor cells in non-del(5q) myelodysplastic syndromes.

scientific article published on 16 November 2016

Are somatic mutations predictive of response to erythropoiesis stimulating agents in lower risk myelodysplastic syndromes?

scientific article published on 7 April 2016

Assessment of ASC specks as a putative biomarker of pyroptosis in myelodysplastic syndromes: an observational cohort study.

scientific article published on 30 July 2018

BCL-2 and Mutant NRAS Interact Physically and Functionally in a Mouse Model of Progressive Myelodysplasia

scientific article published on 01 December 2007

BCOR and BCORL1 mutations in myelodysplastic syndromes and related disorders.

scientific article

Biology and prognostic impact of clonal plasmacytoid dendritic cells in chronic myelomonocytic leukemia

scientific article published on 20 March 2019

Bone marrow niche-derived extracellular matrix-degrading enzymes influence the progression of B-cell acute lymphoblastic leukemia

scientific article published on 09 January 2020

Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading: implication of the cortical-actin binding protein cortactin

scientific article published in December 2002

Characteristic repartition of monocyte subsets as a diagnostic signature of chronic myelomonocytic leukemia

scientific article published on 7 April 2015

Clonal architecture of chronic myelomonocytic leukemias

scientific article published on 14 January 2013

Comparison of cross-platform flow cytometry minimal residual disease evaluation in multiple myeloma using a common antibody combination and analysis strategy

scientific article published on 28 October 2014

Comparison of cross-platform flow cytometry minimal residual disease evaluation in multiple myeloma using a common antibody combination and analysis strategy.

scientific article published on 17 November 2014

Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation.

scientific article

DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice

scientific article published on 15 February 2016

Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes.

scientific article published on 12 December 2011

Duration of Postoperative Fibrinolysis after Total Hip or Knee Replacement: A Laboratory Follow-up Study

scientific article published on 26 November 2012

Dyserythropoiesis of myelodysplastic syndromes

scientific article published on 7 January 2017

Effect of lenalidomide treatment on clonal architecture of myelodysplastic syndromes without 5q deletion

scientific article published on December 2015

Elevated thrombopoietin serum concentrations in myelodysplasias

scientific article published on 01 January 1998

Erythropoiesis Abnormalities Contribute to Early-Onset Anemia in Patients with Septic Shock

scientific article published on 30 March 2006

Evidence for Rap1 in vascular smooth muscle cells

scientific article published on 01 April 1994

Expression of nucleoside-metabolizing enzymes in myelodysplastic syndromes and modulation of response to azacitidine.

scientific article

Expression of the transcription factor Evi-1 in human erythroleukemia cell lines and in leukemias

scientific article published in February 1997

Fas expression at diagnosis as a biomarker of azacitidine activity in high-risk MDS and secondary AML

scientific article published on 05 June 2012

Fas/Apo-1(CD95) expression and apoptosis in patients with myelodysplastic syndromes

scientific article published on 01 June 1997

Fetal intracerebral hemorrhage in familial thrombophilia

scientific article published in October 2009

Flow cytometric detection of dyserythropoiesis: a sensitive and powerful diagnostic tool for myelodysplastic syndromes.

scientific article

Flow cytometry detection of platelet procoagulation activity and microparticles in patients with unstable angina treated by percutaneous coronary angioplasty and stent implantation

scientific article published on 01 September 2001

Fluorescence in situ hybridization on methylcellulose cultured hematopoietic stem cells from myelodysplastic syndromes

scientific article published on 01 February 1998

Genetic typing of CBL, ASXL1, RUNX1, TET2 and JAK2 in juvenile myelomonocytic leukaemia reveals a genetic profile distinct from chronic myelomonocytic leukaemia

scientific article published on 19 October 2010

HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia

scientific article

Heat shock proteins in hematopoietic malignancies.

scientific article published on 28 May 2012

High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells

scientific article published on 10 March 2017

Immune responses during COVID-19 infection

scientific article published on 25 August 2020

Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias

scientific article published on 15 April 2011

Impact of a pneumatic tube system transport on hemostasis parameters measurement: the experiment of Cochin universitary hospital (AP-HP, Paris, France).

scientific article published on February 2017

Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes

scientific article published on 03 August 2020

In vitro proliferation and differentiation of erythroid progenitors from patients with myelodysplastic syndromes: evidence for Fas-dependent apoptosis.

scientific article published in March 2002

Incidence and prognostic value of TET2 alterations in de novo acute myeloid leukemia achieving complete remission.

scientific article published on 20 May 2010

Increased apoptosis in mononucleated cells but not in CD34+ cells in blastic forms of myelodysplastic syndromes.

scientific article

Increased proliferation of bone marrow-derived fibroblasts in primitive hypertrophic osteoarthropathy with severe myelofibrosis

scientific article published on 01 June 1995

Ineffective erythropoiesis in myelodysplastic syndromes: correlation with Fas expression but not with lack of erythropoietin receptor signal transduction

scientific article published on 01 August 1999

Inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bone marrow fibroblasts by tyrphostins

scientific article published on 01 April 1992

Lack of evidence of an association between HHV-8 and multiple myeloma

article

Lenalidomide with or without erythropoietin in transfusion-dependent erythropoiesis-stimulating agent-refractory lower-risk MDS without 5q deletion.

scientific article published on 26 October 2015

Lenalidomide-mediated erythroid improvement in non-del(5q) myelodysplastic syndromes is associated with bone marrow immuno-remodeling

scientific article published on 3 October 2017

Leukemic cell xenograft in zebrafish embryo for investigating drug efficacy.

scientific article

Localization of the NRAS:BCL-2 complex determines anti-apoptotic features associated with progressive disease in myelodysplastic syndromes

scientific article published on 12 November 2012

Megakaryocyte growth and development factor-induced proliferation and differentiation are regulated by the mitogen-activated protein kinase pathway in primitive cord blood hematopoietic progenitors.

scientific article published in September 1999

Metabolites of tryptophan catabolism are elevated in sera of patients with myelodysplastic syndromes and inhibit hematopoietic progenitor amplification

scientific article published on 28 February 2013

Mitochondria in hematopoiesis and hematological diseases.

scientific article published on August 2006

Molecular predictors of response to decitabine in advanced chronic myelomonocytic leukemia: a phase 2 trial.

scientific article

Mutation in RAP1 is a rare event in myelodysplastic syndromes.

scientific article

Mutation of the colony-stimulating factor-3 receptor gene is a rare event with poor prognosis in chronic myelomonocytic leukemia.

scientific article published on 18 June 2013

Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes.

scientific article

Mutations des gènes impliqués dans l’épissage dans les hémopathies malignes humaines

article

Mutations du gèneTET2dans les hémopathies myéloïdes humaines

article

Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms

scientific article published on 8 April 2010

Myeloproliferative/myelodysplastic syndromes

scientific article published on December 2010

New variant of unclassified congenital dyserythropoietic anaemia: the concept of the erythroid regulator?

scientific article published on 11 November 2011

Non-apoptotic functions of caspases in myeloid cell differentiation.

scientific article published on 17 February 2017

Phosphorylation of Rap1GAP during the Cell Cycle

scientific article published on 01 July 1994

Physiopathology of myelodysplastic syndromes

scientific article published in May 2002

Point Mutations in Myelodysplastic Syndromes ⬇️

scientific article published on September 22, 2011

Population pharmacokinetics of fondaparinux administered at prophylactic doses after major orthopaedic surgery in everyday practice

scientific article published on 10 June 2010

Prognostic Role of Gene Mutations in Chronic Myelomonocytic Leukemia Patients Treated With Hypomethylating Agents.

scientific article published on 25 April 2018

Prognostic score including gene mutations in chronic myelomonocytic leukemia.

scientific article

Prolonged SARS-CoV-2 RNA virus shedding and lymphopenia are hallmarks of COVID-19 in cancer patients with poor prognosis

scientific article published on 06 July 2021

Prostaglandin transporter mutations cause pachydermoperiostosis with myelofibrosis

scientific article published on 29 May 2012

RSK2 is a new Pim2 target with pro-survival functions in FLT3-ITD-positive acute myeloid leukemia.

scientific article

Reply to ‘hRap1B-retro: a novel human processed Rap1B gene blurs the picture?’ by Zemojtel et al

article

Rescue of early-stage myelodysplastic syndrome-deriving erythroid precursors by the ectopic expression of a dominant-negative form of FADD.

scientific article

Risk factors for pegylated liposomal doxorubicin-induced palmar-plantar erythrodysesthesia over time: assessment of monocyte count and baseline clinical parameters

scientific article

SETBP1 mutations in 658 patients with myelodysplastic syndromes, chronic myelomonocytic leukemia and secondary acute myeloid leukemias.

scientific article published on 5 February 2013

SF3B1 mutations in myelodysplastic syndromes: clinical associations and prognostic implications

scientific article published on 08 November 2011

SF3B1-mutant myelodysplastic syndrome as a distinct disease subtype - A Proposal of the International Working Group for the Prognosis of Myelodysplastic Syndromes (IWG-PM)

scientific article published on 29 April 2020

STAT3 mutations identified in human hematologic neoplasms induce myeloid malignancies in a mouse bone marrow transplantation model.

scientific article published on 19 July 2013

Spliceosome and other novel mutations in chronic lymphocytic leukemia and myeloid malignancies.

scientific article published on 09 April 2012

Spliceosome mutations in myelodysplastic syndromes and chronic myelomonocytic leukemia.

scientific article published in November 2012

Spontaneous and Fas-induced apoptosis of low-grade MDS erythroid precursors involves the endoplasmic reticulum.

scientific article published on 10 July 2008

Sustained leukemia-free state and molecular response to sorafenib in a patient with chronic myelomonocytic leukemia in transformation driven by homozygous FLT3-ITD malignant hematopoiesis.

scientific article

TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs).

scientific article

TET2 mutations in secondary acute myeloid leukemias: a French retrospective study ⬇️

scientific article published on April 20, 2011

TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups

scientific article published on 11 January 2019

The fraction of CD117/c-KIT-expressing erythroid precursors predicts ESA response in low-risk myelodysplastic syndromes

scientific article published on 09 April 2019

Thrombocytemia and abnormal megakaryopoiesis associated with abnormality of chromosome 1p34 in myelodysplastic syndromes.

scientific article

Thrombopoietin activates human platelets and induces tyrosine phosphorylation of p80/85 cortactin

scientific article published on 01 January 1998

Thrombopoietin is not responsible for the thrombocytosis observed in patients with acute myeloid leukemias and the 3q21q26 syndrome

scientific article published on 01 October 1995

Thrombopoietin stimulates cortactin translocation to the cytoskeleton independently of tyrosine phosphorylation

scientific article published in June 2001

Transforming growth factor beta 1 inhibits mitogen-activated protein kinase induced by basic fibroblast growth factor in smooth muscle cells

scientific article published on May 1996

Transforming growth factor-?1 inhibitory effect of platelet-derived growth factor--induced signal transduction on human bone marrow fibroblasts: Possible involvement of protein phosphatases

scientific article published on 01 September 1992

Tyrosine kinase inhibitors induce down-regulation of c-Kit by targeting the ATP pocket

scientific article

Unusual occurrence of spontaneous haematomas in three asymptomatic HIV-infected haemophilia patients a few days after the onset of ritonavir treatment

scientific article

Use of the 46/1 haplotype to model JAK2(V617F) clonal architecture in PV patients: clonal evolution and impact of IFNα treatment.

scientific article

[Abnormalities of the expression of cytokines and their receptors in myelodysplastic syndromes]

scientific article published on 01 September 1997

[Myelodysplastic syndromes]

scientific article published on 01 December 2010

p-ERK1/2 is a predictive factor of response to erythropoiesis-stimulating agents in low/int-1 myelodysplastic syndromes.

scientific article

List of works by Michaela Fontenay

A G polymorphism in the CRBN gene acts as a biomarker of response to treatment with lenalidomide in low/int-1 risk MDS without del(5q).

A common alternative splicing signature is associated with SF3B1 mutations in malignancies from different cell lineages.

A role for caspases in the differentiation of erythroid cells and macrophages.

A short Gfi-1B isoform controls erythroid differentiation by recruiting the LSD1-CoREST complex through the dimethylation of its SNAG domain.

A variant erythroferrone disrupts iron homeostasis in SF3B1-mutated myelodysplastic syndrome

AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages

APG101 efficiently rescues erythropoiesis in lower risk myelodysplastic syndromes with severe impairment of hematopoiesis

Activation of PAK1/2 during the shedding of platelet microvesicles.

Activity of the caspase-3/CPP32 enzyme is increased in “early stage” myelodysplastic syndromes with excessive apoptosis, but caspase inhibition does not enhance colony formation in vitro

Alpha-defensins secreted by dysplastic granulocytes inhibit the differentiation of monocytes in chronic myelomonocytic leukemia.

Analysis of megakaryocyte growth and development factor (thrombopoietin) effects on blast cell and megakaryocyte growth in myelodysplasia.

Antileukemic activity of the VPS34-IN1 inhibitor in acute myeloid leukemia

Apoptotic pathways to death in myelodysplastic syndromes

Architectural and functional heterogeneity of hematopoietic stem/progenitor cells in non-del(5q) myelodysplastic syndromes.

Are somatic mutations predictive of response to erythropoiesis stimulating agents in lower risk myelodysplastic syndromes?

Assessment of ASC specks as a putative biomarker of pyroptosis in myelodysplastic syndromes: an observational cohort study.

BCL-2 and Mutant NRAS Interact Physically and Functionally in a Mouse Model of Progressive Myelodysplasia

BCOR and BCORL1 mutations in myelodysplastic syndromes and related disorders.

Biology and prognostic impact of clonal plasmacytoid dendritic cells in chronic myelomonocytic leukemia

Bone marrow niche-derived extracellular matrix-degrading enzymes influence the progression of B-cell acute lymphoblastic leukemia

Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading: implication of the cortical-actin binding protein cortactin

Characteristic repartition of monocyte subsets as a diagnostic signature of chronic myelomonocytic leukemia

Clonal architecture of chronic myelomonocytic leukemias

Comparison of cross-platform flow cytometry minimal residual disease evaluation in multiple myeloma using a common antibody combination and analysis strategy

Comparison of cross-platform flow cytometry minimal residual disease evaluation in multiple myeloma using a common antibody combination and analysis strategy.

Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation.

DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice

Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes.

Duration of Postoperative Fibrinolysis after Total Hip or Knee Replacement: A Laboratory Follow-up Study

Dyserythropoiesis of myelodysplastic syndromes

Effect of lenalidomide treatment on clonal architecture of myelodysplastic syndromes without 5q deletion

Elevated thrombopoietin serum concentrations in myelodysplasias

Erythropoiesis Abnormalities Contribute to Early-Onset Anemia in Patients with Septic Shock

Evidence for Rap1 in vascular smooth muscle cells

Expression of nucleoside-metabolizing enzymes in myelodysplastic syndromes and modulation of response to azacitidine.

Expression of the transcription factor Evi-1 in human erythroleukemia cell lines and in leukemias

Fas expression at diagnosis as a biomarker of azacitidine activity in high-risk MDS and secondary AML

Fas/Apo-1(CD95) expression and apoptosis in patients with myelodysplastic syndromes

Fetal intracerebral hemorrhage in familial thrombophilia

Flow cytometric detection of dyserythropoiesis: a sensitive and powerful diagnostic tool for myelodysplastic syndromes.

Flow cytometry detection of platelet procoagulation activity and microparticles in patients with unstable angina treated by percutaneous coronary angioplasty and stent implantation

Fluorescence in situ hybridization on methylcellulose cultured hematopoietic stem cells from myelodysplastic syndromes

Genetic typing of CBL, ASXL1, RUNX1, TET2 and JAK2 in juvenile myelomonocytic leukaemia reveals a genetic profile distinct from chronic myelomonocytic leukaemia

HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia

Heat shock proteins in hematopoietic malignancies.

High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells

Immune responses during COVID-19 infection

Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias

Impact of a pneumatic tube system transport on hemostasis parameters measurement: the experiment of Cochin universitary hospital (AP-HP, Paris, France).

Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes

In vitro proliferation and differentiation of erythroid progenitors from patients with myelodysplastic syndromes: evidence for Fas-dependent apoptosis.

Incidence and prognostic value of TET2 alterations in de novo acute myeloid leukemia achieving complete remission.

Increased apoptosis in mononucleated cells but not in CD34+ cells in blastic forms of myelodysplastic syndromes.

Increased proliferation of bone marrow-derived fibroblasts in primitive hypertrophic osteoarthropathy with severe myelofibrosis

Ineffective erythropoiesis in myelodysplastic syndromes: correlation with Fas expression but not with lack of erythropoietin receptor signal transduction

Inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bone marrow fibroblasts by tyrphostins

Lack of evidence of an association between HHV-8 and multiple myeloma

Lenalidomide with or without erythropoietin in transfusion-dependent erythropoiesis-stimulating agent-refractory lower-risk MDS without 5q deletion.

Lenalidomide-mediated erythroid improvement in non-del(5q) myelodysplastic syndromes is associated with bone marrow immuno-remodeling

Leukemic cell xenograft in zebrafish embryo for investigating drug efficacy.

Localization of the NRAS:BCL-2 complex determines anti-apoptotic features associated with progressive disease in myelodysplastic syndromes

Megakaryocyte growth and development factor-induced proliferation and differentiation are regulated by the mitogen-activated protein kinase pathway in primitive cord blood hematopoietic progenitors.

Metabolites of tryptophan catabolism are elevated in sera of patients with myelodysplastic syndromes and inhibit hematopoietic progenitor amplification

Mitochondria in hematopoiesis and hematological diseases.

Molecular predictors of response to decitabine in advanced chronic myelomonocytic leukemia: a phase 2 trial.

Mutation in RAP1 is a rare event in myelodysplastic syndromes.

Mutation of the colony-stimulating factor-3 receptor gene is a rare event with poor prognosis in chronic myelomonocytic leukemia.

Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes.

Mutations des gènes impliqués dans l’épissage dans les hémopathies malignes humaines

Mutations du gèneTET2dans les hémopathies myéloïdes humaines

Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms

Myeloproliferative/myelodysplastic syndromes

New variant of unclassified congenital dyserythropoietic anaemia: the concept of the erythroid regulator?

Non-apoptotic functions of caspases in myeloid cell differentiation.

Phosphorylation of Rap1GAP during the Cell Cycle

Physiopathology of myelodysplastic syndromes

Point Mutations in Myelodysplastic Syndromes ⬇️

Population pharmacokinetics of fondaparinux administered at prophylactic doses after major orthopaedic surgery in everyday practice

Prognostic Role of Gene Mutations in Chronic Myelomonocytic Leukemia Patients Treated With Hypomethylating Agents.