List of works - Kelvin C Luk

Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates.

scientific article

Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders

scientific article published on 29 July 2019

Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau

scientific article published on 01 October 2020

Bent out of shape: α-Synuclein misfolding and the convergence of pathogenic pathways in Parkinson's disease.

scientific article

Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration.

scientific article

Differentially targeted seeding reveals unique pathological alpha-synuclein propagation patterns

scientific article published on 01 June 2022

Erratum to: Transmission of α-synucleinopathy from olfactory structures deep into the temporal lobe

scientific article published on 27 July 2016

Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages

scientific article published on 21 August 2017

Glutamate and regulation of proliferation in the developing mammalian telencephalon

scientific article published in March 2004

Group I mGluR5 metabotropic glutamate receptors regulate proliferation of neuronal progenitors in specific forebrain developmental domains.

scientific article published on 18 October 2007

Interactions between Hsp70 and the hydrophobic core of alpha-synuclein inhibit fibril assembly

scientific journal article

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice ⬇️

scientific article published on April 16, 2012

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

scientific article

LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies

scientific article published on 26 July 2021

Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration.

scientific article

Measurements of auto-antibodies to α-synuclein in the serum and cerebral spinal fluids of patients with Parkinson's disease.

scientific article published on 3 March 2018

Modeling Lewy pathology propagation in Parkinson's disease

scientific article published on January 2014

N-terminal domains elicit formation of functional Pmel17 amyloid fibrils

scientific article published on December 2009

Neurogenesis and stereological morphometry of calretinin-immunoreactive GABAergic interneurons of the neostriatum

scientific article

Oxidative stress and α-synuclein conspire in vulnerable neurons to promote Parkinson's disease progression

scientific article published on 05 August 2019

Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice ⬇️

scientific article (publication date: 16 November 2012)

Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons ⬇️

scientific article published on June 1, 2003

Progressive aggregation of alpha-synuclein and selective degeneration of lewy inclusion-bearing neurons in a mouse model of parkinsonism

scientific article

Sensitive fluorescence polarization technique for rapid screening of alpha-synuclein oligomerization/fibrillization inhibitors.

scientific article published on 10 October 2007

Snca-GFP knock-in mice reflect patterns of endogenous expression and pathological seeding

scientific article published on 11 August 2020

The transcription factor Pitx3 is expressed selectively in midbrain dopaminergic neurons susceptible to neurodegenerative stress

scientific article published on 6 March 2013

Transmission of α-synucleinopathy from olfactory structures deep into the temporal lobe

scientific article

Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson's disease

scientific article published on 08 August 2016

List of works by Kelvin C Luk

Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates.

Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders

Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau

Bent out of shape: α-Synuclein misfolding and the convergence of pathogenic pathways in Parkinson's disease.

Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration.

Differentially targeted seeding reveals unique pathological alpha-synuclein propagation patterns

Erratum to: Transmission of α-synucleinopathy from olfactory structures deep into the temporal lobe

Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages

Glutamate and regulation of proliferation in the developing mammalian telencephalon

Group I mGluR5 metabotropic glutamate receptors regulate proliferation of neuronal progenitors in specific forebrain developmental domains.

Interactions between Hsp70 and the hydrophobic core of alpha-synuclein inhibit fibril assembly

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice ⬇️

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies

Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration.

Measurements of auto-antibodies to α-synuclein in the serum and cerebral spinal fluids of patients with Parkinson's disease.

Modeling Lewy pathology propagation in Parkinson's disease

N-terminal domains elicit formation of functional Pmel17 amyloid fibrils

Neurogenesis and stereological morphometry of calretinin-immunoreactive GABAergic interneurons of the neostriatum

Oxidative stress and α-synuclein conspire in vulnerable neurons to promote Parkinson's disease progression

Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice ⬇️

Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons ⬇️

Progressive aggregation of alpha-synuclein and selective degeneration of lewy inclusion-bearing neurons in a mouse model of parkinsonism

Sensitive fluorescence polarization technique for rapid screening of alpha-synuclein oligomerization/fibrillization inhibitors.

Snca-GFP knock-in mice reflect patterns of endogenous expression and pathological seeding

The transcription factor Pitx3 is expressed selectively in midbrain dopaminergic neurons susceptible to neurodegenerative stress

Transmission of α-synucleinopathy from olfactory structures deep into the temporal lobe

Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson's disease