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List of works by Richard T. Wheelhouse

Antitumor imidazotetrazines. 32. Synthesis of novel imidazotetrazinones and related bicyclic heterocycles to probe the mode of action of the antitumor drug temozolomide.

scientific article published on April 1995

Biarylpyrimidines: a new class of ligand for high-order DNA recognition

scientific article published on 01 May 2003

Design, synthesis, and evaluation of novel biarylpyrimidines: a new class of ligand for unusual nucleic acid structures

scientific article published on 01 August 2006

Drug binding to DNA x RNA hybrid structures ⬇️

scientific article

Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells

scientific article published on 01 February 1999

Evaluation of novel imidazotetrazine analogues designed to overcome temozolomide resistance and glioblastoma regrowth.

scientific article

Glioblastoma multiforme therapy and mechanisms of resistance.

scientific article

In-vitro cytotoxic activities of the major bromophenols of the red alga Polysiphonia lanosa and some novel synthetic isomers

scientific article published in September 2004

Inhibition of cobalamin-dependent methionine synthase by substituted benzo-fused heterocycles

scientific article published on 6 December 2006

Metabolism of cryptolepine and 2-fluorocryptolepine by aldehyde oxidase

scientific article published on 18 November 2011

Minor structural modifications to alchemix influence mechanism of action and pharmacological activity.

scientific article published in March 2012

Polar, functionalized guanine-O6 derivatives resistant to repair by O6-alkylguanine-DNA alkyltransferase: implications for the design of DNA-modifying drugs.

scientific article published on 3 February 2006

Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands ⬇️

scientific article published on 14 June 2017

Probing the molecular recognition of a DNA.RNA hybrid duplex

scientific article published on April 2010

Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase

scientific article published in December 2001

Ruthenium-Containing Linear Helicates and Mesocates with Tuneable p53-Selective Cytotoxicity in Colorectal Cancer Cells

scientific article published on 03 July 2018

Stabilization of a Bimolecular Triplex by 3'-S-Phosphorothiolate Modifications: An NMR and UV Thermal Melting Investigation ⬇️

scientific article published on 20 March 2015

Strategy for Imidazotetrazine Prodrugs with Anticancer Activity Independent of MGMT and MMR.

scientific article

Structural studies on bioactive compounds. Part 27. Chemistry of the immunomodulatory agent bropirimine

scientific article published on 01 April 1995

Synthesis and growth-inhibitory activities of imidazo[5,1-]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position

article

Synthesis and quantitative structure-activity relationship of imidazotetrazine prodrugs with activity independent of O6-methylguanine-DNA-methyltransferase, DNA mismatch repair, and p53.

scientific article

Targeting of tumor cells and DNA by a chlorambucil-spermidine conjugate.

scientific article published on August 1992

Telomere-interactive agents affect proliferation rates and induce chromosomal destabilization in sea urchin embryos

scientific article published on 01 August 1999

The medicinal chemistry of imidazotetrazine prodrugs

scientific article

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