List of works - Jie Zheng

1H, 15N and 13C assignments of the targeting (FAT) domain of focal adhesion kinase

scientific article published on 01 May 2002

A study of the binding of NADP coenzymes to dihydrofolate reductase by raman difference spectroscopy.

scientific article

A substrate specific functional polymorphism of human gamma-glutamyl hydrolase alters catalytic activity and methotrexate polyglutamate accumulation in acute lymphoblastic leukaemia cells

scientific article

A vibrational analysis of the catalytically important C4-H bonds of NADH bound to lactate or malate dehydrogenase: ground-state effects

article

Alteration of RNA Splicing by Small-Molecule Inhibitors of the Interaction between NHP2L1 and U4

scientific article published on 06 October 2017

An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth.

scientific article published on January 2007

Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death.

scientific article

Autoinhibition of Dishevelled protein regulated by its extreme C terminus plays a distinct role in Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways.

scientific article published on 21 February 2017

Cellular and cytoskeletal alterations of scleral fibroblasts in response to glucocorticoid steroids

scientific article published on 23 August 2019

Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism

scientific article published on 23 May 2008

Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism.

scientific article

Classical Raman spectroscopic studies of NADH and NAD+ bound to lactate dehydrogenase by difference techniques

scientific article published on 01 February 1989

Computational studies of H5N1 influenza virus resistance to oseltamivir.

scientific article

Conformational change of Dishevelled plays a key regulatory role in the Wnt signaling pathways

scientific article

Crystal Structure of a Full-Length β-Catenin

scientific article

Crystal structures of the Dab homology domains of mouse disabled 1 and 2

scientific article

Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled

scientific article

Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled.

scientific article published on 21 April 2009

Drug Repurposing Identifies Inhibitors of Oseltamivir-Resistant Influenza Viruses

scientific article

Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization.

scientific article

Enhanced affinities and specificities of consolidated ligands for the Src homology (SH) 3 and SH2 domains of Abelson protein-tyrosine kinase.

scientific article

Flexibility of interdomain contacts revealed by topological isomers of bivalent consolidated ligands to the dual Src homology domain SH(32) of abelson.

scientific article

GNAI3: Another Candidate Gene to Screen in Persons with Ocular Albinism.

scientific article published on 08 September 2016

Genome-wide network analysis of Wnt signaling in three pediatric cancers.

scientific article published on 17 October 2013

Identification Of Small Molecule TRABID Deubiquitinase Inhibitors By Computation-Based Virtual Screen.

scientific article

Identification of a specific inhibitor of the dishevelled PDZ domain

scientific article

Identification of the Binding Site for Acidic Phospholipids on the PH Domain of Dynamin: Implications for Stimulation of GTPase Activity

Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein ⬇️

scientific article published on November 2, 2010

KIR2DL2/2DL3-E(35) alleles are functionally stronger than -Q(35) alleles.

scientific article published on 31 March 2016

Key residues responsible for acyl carrier protein and beta-ketoacyl-acyl carrier protein reductase (FabG) interaction

scientific article published on 3 October 2003

Lectin domains in the toxin of Bordetella pertussis: selectin mimicry linked to microbial pathogenesis.

scientific article published on December 1994

Macrophage Wnt7b is critical for kidney repair and regeneration

scientific journal article

Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly.

scientific article published on 9 October 2014

Modulating the wnt signaling pathway with small molecules

scientific article published on 25 January 2017

Optimizing Dvl PDZ domain inhibitor by exploring chemical space.

scientific article published on 09 September 2008

Oxidative stress upregulates Wnt signaling in human retinal microvascular endothelial cells through activation of disheveled

scientific article published on 08 April 2019

PDZ domains and their binding partners: structure, specificity, and modification

scientific article published in 2010

Phosphorylation of paxillin LD4 destabilizes helix formation and inhibits binding to focal adhesion kinase.

scientific article

Rational design of T cell receptors with enhanced sensitivity for antigen

scientific article

Small-molecule inhibition of Wnt signaling abrogates dexamethasone-induced phenotype of primary human trabecular meshwork cells

scientific article

Source of Catalysis in the Lactate Dehydrogenase System. Ground-State Interactions in the Enzyme.cntdot.Substrate Complex

article

Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats.

scientific article published on 11 February 2016

Structural Insight into the Mechanisms of Wnt Signaling Antagonism by Dkk

scientific article

Structural and functional insights into the interaction between the Cas family scaffolding protein p130Cas and the focal adhesion-associated protein paxillin

scientific article published on 31 August 2017

Structural and mechanistic insights into the interaction between Pyk2 and paxillin LD motifs

scientific article

Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk

scientific article

Structural features of the focal adhesion kinase-paxillin complex give insight into the dynamics of focal adhesion assembly.

scientific article published on 2 February 2005

Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling

scientific article

Structural modification of acyl carrier protein by butyryl group

scientific article

Structure of the complex between pyridoxal 5'-phosphate and the tyrosine 225 to phenylalanine mutant of Escherichia coli aspartate aminotransferase determined by isotope-edited classical Raman difference spectroscopy

scientific article

Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled

scientific article

Synthesis of potent dishevelled PDZ domain inhibitors guided by virtual screening and NMR studies

scientific article

THE STRUCTURAL BIOLOGY OF TYPE II FATTY ACID BIOSYNTHESIS

scientific article

Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox

scientific article published on 6 July 2017

Tetraspanins regulate the protrusive activities of cell membrane.

scientific article

The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd.

scientific article

The determination of the pKa of histidine residues in proteins by Raman difference spectroscopy

scientific article published in June 1991

The influence of phosphorylation on the activity and structure of the neuronal IQ motif protein, PEP-19.

scientific article published in May 2006

The solution structure and dynamics of the pleckstrin homology domain of G protein-coupled receptor kinase 2 (beta-adrenergic receptor kinase 1). A binding partner of Gbetagamma subunits

scientific article

The solution structure of Abl SH3, and its relationship to SH2 in the SH(32) construct

scientific article

The solution structure of acyl carrier protein from Mycobacterium tuberculosis

scientific article

The structural basis of DKK-mediated inhibition of Wnt/LRP signaling

scientific article published on 15 May 2012

The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin

scientific article (publication date: 30 June 2006)

Transmembrane interactions are needed for KAI1/CD82-mediated suppression of cancer invasion and metastasis.

scientific article published on 30 December 2008

Virtual ligand screening combined with NMR to identify Dvl PDZ domain inhibitors targeting the Wnt signaling.

scientific article published on January 2012

Wnt Signaling Is Required for the Maintenance of Human Limbal Stem/Progenitor Cells In Vitro

scientific article published on 01 January 2019

List of works by Jie Zheng

1H, 15N and 13C assignments of the targeting (FAT) domain of focal adhesion kinase

A study of the binding of NADP coenzymes to dihydrofolate reductase by raman difference spectroscopy.

A substrate specific functional polymorphism of human gamma-glutamyl hydrolase alters catalytic activity and methotrexate polyglutamate accumulation in acute lymphoblastic leukaemia cells

A vibrational analysis of the catalytically important C4-H bonds of NADH bound to lactate or malate dehydrogenase: ground-state effects

Alteration of RNA Splicing by Small-Molecule Inhibitors of the Interaction between NHP2L1 and U4

An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth.

Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death.

Autoinhibition of Dishevelled protein regulated by its extreme C terminus plays a distinct role in Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways.

Cellular and cytoskeletal alterations of scleral fibroblasts in response to glucocorticoid steroids

Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism

Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism.

Classical Raman spectroscopic studies of NADH and NAD+ bound to lactate dehydrogenase by difference techniques

Computational studies of H5N1 influenza virus resistance to oseltamivir.

Conformational change of Dishevelled plays a key regulatory role in the Wnt signaling pathways

Crystal Structure of a Full-Length β-Catenin

Crystal structures of the Dab homology domains of mouse disabled 1 and 2

Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled

Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled.

Drug Repurposing Identifies Inhibitors of Oseltamivir-Resistant Influenza Viruses

Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization.

Enhanced affinities and specificities of consolidated ligands for the Src homology (SH) 3 and SH2 domains of Abelson protein-tyrosine kinase.

Flexibility of interdomain contacts revealed by topological isomers of bivalent consolidated ligands to the dual Src homology domain SH(32) of abelson.

GNAI3: Another Candidate Gene to Screen in Persons with Ocular Albinism.

Genome-wide network analysis of Wnt signaling in three pediatric cancers.

Identification Of Small Molecule TRABID Deubiquitinase Inhibitors By Computation-Based Virtual Screen.

Identification of a specific inhibitor of the dishevelled PDZ domain

Identification of the Binding Site for Acidic Phospholipids on the PH Domain of Dynamin: Implications for Stimulation of GTPase Activity

Identification of transmembrane protein 88 (TMEM88) as a dishevelled-binding protein ⬇️

KIR2DL2/2DL3-E(35) alleles are functionally stronger than -Q(35) alleles.

Key residues responsible for acyl carrier protein and beta-ketoacyl-acyl carrier protein reductase (FabG) interaction

Lectin domains in the toxin of Bordetella pertussis: selectin mimicry linked to microbial pathogenesis.

Macrophage Wnt7b is critical for kidney repair and regeneration

Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly.

Modulating the wnt signaling pathway with small molecules

Optimizing Dvl PDZ domain inhibitor by exploring chemical space.

Oxidative stress upregulates Wnt signaling in human retinal microvascular endothelial cells through activation of disheveled

PDZ domains and their binding partners: structure, specificity, and modification

Phosphorylation of paxillin LD4 destabilizes helix formation and inhibits binding to focal adhesion kinase.

Rational design of T cell receptors with enhanced sensitivity for antigen

Small-molecule inhibition of Wnt signaling abrogates dexamethasone-induced phenotype of primary human trabecular meshwork cells

Source of Catalysis in the Lactate Dehydrogenase System. Ground-State Interactions in the Enzyme.cntdot.Substrate Complex

Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats.

Structural Insight into the Mechanisms of Wnt Signaling Antagonism by Dkk

Structural and functional insights into the interaction between the Cas family scaffolding protein p130Cas and the focal adhesion-associated protein paxillin

Structural and mechanistic insights into the interaction between Pyk2 and paxillin LD motifs

Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk

Structural features of the focal adhesion kinase-paxillin complex give insight into the dynamics of focal adhesion assembly.

Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling

Structural modification of acyl carrier protein by butyryl group

Structure of the complex between pyridoxal 5'-phosphate and the tyrosine 225 to phenylalanine mutant of Escherichia coli aspartate aminotransferase determined by isotope-edited classical Raman difference spectroscopy

Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled

Synthesis of potent dishevelled PDZ domain inhibitors guided by virtual screening and NMR studies

THE STRUCTURAL BIOLOGY OF TYPE II FATTY ACID BIOSYNTHESIS

Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox

Tetraspanins regulate the protrusive activities of cell membrane.

The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd.

The determination of the pKa of histidine residues in proteins by Raman difference spectroscopy

The influence of phosphorylation on the activity and structure of the neuronal IQ motif protein, PEP-19.

The solution structure and dynamics of the pleckstrin homology domain of G protein-coupled receptor kinase 2 (beta-adrenergic receptor kinase 1). A binding partner of Gbetagamma subunits

The solution structure of Abl SH3, and its relationship to SH2 in the SH(32) construct

The solution structure of acyl carrier protein from Mycobacterium tuberculosis

The structural basis of DKK-mediated inhibition of Wnt/LRP signaling

The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin

Transmembrane interactions are needed for KAI1/CD82-mediated suppression of cancer invasion and metastasis.

Virtual ligand screening combined with NMR to identify Dvl PDZ domain inhibitors targeting the Wnt signaling.

Wnt Signaling Is Required for the Maintenance of Human Limbal Stem/Progenitor Cells In Vitro