List of works - Martin M Knight

A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion

scientific article published on 29 May 2021

A role for IFT88/the primary cilium in the inflammatory response to interleukin-1

Activation of chondrocytes calcium signalling by dynamic compression is independent of number of cycles

scientific article published on 25 October 2005

Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF-1r Onto the Primary Cilium Associated With Cilia Elongation

scientific article published on June 2015

An improved confocal FRAP technique for the measurement of long-term actin dynamics in individual stress fibers.

scientific article

An in vitro investigation of the inflammatory response to the strain amplitudes which occur during high frequency oscillation ventilation and conventional mechanical ventilation

scientific article published on 22 March 2019

Articular chondrocytes express connexin 43 hemichannels and P2 receptors - a putative mechanoreceptor complex involving the primary cilium?

scientific article published in February 2009

Bardet-Biedl syndrome proteins control cilia length through regulation of actin polymerisation

scientific article published on 16 November 2012

Bardet-Biedl syndrome proteins control the cilia length through regulation of actin polymerization

scientific article

Biomechanical analysis of structural deformation in living cells.

scientific article published on 26 August 2008

Both superficial and deep zone articular chondrocyte subpopulations exhibit the Crabtree effect but have different basal oxygen consumption rates.

scientific article

Cell and nucleus deformation in compressed chondrocyte-alginate constructs: temporal changes and calculation of cell modulus.

scientific article published in February 2002

Cell mechanics, structure, and function are regulated by the stiffness of the three-dimensional microenvironment.

scientific article published on September 2012

Chondrocyte dedifferentiation increases cell stiffness by strengthening membrane-actin adhesion.

scientific article published on 16 December 2015

Chondrocyte deformation induces mitochondrial distortion and heterogeneous intracellular strain fields.

scientific article

Chondrocyte deformation within compressed agarose constructs at the cellular and sub-cellular levels.

scientific article

Chondrocyte deformation within mechanically and enzymatically extracted chondrons compressed in agarose

scientific article published on 01 May 2001

Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling.

scientific article

Ciliary exclusion of Polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney disease model

scientific article published on 06 September 2019

Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated down-regulation of RhoA expression.

scientific article published on 9 April 2018

Compressive Deformation and Damage of Muscle Cell Subpopulations in a Model System

article

Confocal analysis of cytoskeletal organisation within isolated chondrocyte sub-populations cultured in agarose

scientific article published on 01 March 2000

Confocal analysis of local and cellular strains in chondrocyte-agarose constructs subjected to mechanical shear.

scientific article

Correction: Super-Resolution Imaging Strategies for Cell Biologists Using a Spinning Disk Microscope.

scientific article published on 30 December 2013

Cyclic compression of chondrocytes modulates a purinergic calcium signalling pathway in a strain rate- and frequency-dependent manner

scientific article published in November 2006

Cyclic loading opens hemichannels to release ATP as part of a chondrocyte mechanotransduction pathway

scientific article published in April 2010

Cytokine preconditioning of engineered cartilage provides protection against interleukin-1 insult

scientific article

Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers.

scientific article

Deformation properties of articular chondrocytes: a critique of three separate techniques

scientific article published on 01 January 2002

Depletion of chondrocyte primary cilia reduces the compressive modulus of articular cartilage.

scientific article published on 4 December 2013

Differential effects of LifeAct-GFP and actin-GFP on cell mechanics assessed using micropipette aspiration.

scientific article

Dynamic compressive strain influences chondrogenic gene expression in human periosteal cells: a case study

scientific article published on 18 July 2011

Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation.

scientific article published on 8 November 2010

Experimental validation of a flat punch indentation methodology calibrated against unconfined compression tests for determination of soft tissue biomechanics.

scientific article

Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading.

scientific article

Heat shock induces rapid resorption of primary cilia

scientific article published on 20 June 2012

Heat-shock induces rapid resorption of primary cilia

Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β

scientific article

Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment

scientific article published on 10 October 2023

IFT88 influences chondrocyte actin organization and biomechanics.

scientific article

Improved outcome after peripheral nerve injury in mice with increased levels of endogenous ω-3 polyunsaturated fatty acids

scientific article published on 01 January 2012

In vitro encrustation of a semi-permanent polymer-covered nitinol ureter stent: an artificial urine model.

scientific article

Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage

scientific article published on 01 January 2004

Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium

scientific article published on 13 December 2013

Intracellular mechanics and mechanotransduction associated with chondrocyte deformation during pipette aspiration.

scientific article published in January 2006

Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling

scientific journal article

Lithium chloride prevents interleukin-1β induced cartilage degradation and loss of mechanical properties

scientific article published on 14 July 2015

Live cell imaging using confocal microscopy induces intracellular calcium transients and cell death.

scientific article

Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes.

scientific article

Measurement of the deformation of isolated chondrocytes in agarose subjected to cyclic compression.

scientific article

Mechanical compression and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose

scientific article published on 27 June 2005

Mechanical compression influences intracellular Ca2+ signaling in chondrocytes seeded in agarose constructs

scientific article published in April 2001

Mechanical loading induces primary cilia disassembly in tendon cells via TGFβ and HDAC6

scientific article published on 23 July 2018

Mechanical loading modulates chondrocyte primary cilia incidence and length.

scientific article

Mechanical loading of chondrocytes embedded in 3D constructs: in vitro methods for assessment of morphological and metabolic response to compressive strain.

scientific article

Mechanical strain disrupts primary cilia structure and modulates hedgehog signalling in adult chondrocytes

Mitochondrial dynamics in chondrocytes and their connection to the mechanical properties of the cytoplasm.

scientific article

Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer

scientific article published on 29 May 2021

Organ-on-a-Chip and Microfluidic Platforms for Oncology in the UK

scientific article published on 19 January 2023

Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes

scientific article published on February 2013

Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes.

scientific article published on 21 January 2014

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response.

scientific article published on 6 April 2012

Primary cilia mediate mechanotransduction through control of ATP-induced Ca2+ signaling in compressed chondrocytes.

scientific article

Purinergic pathway suppresses the release of .NO and stimulates proteoglycan synthesis in chondrocyte/agarose constructs subjected to dynamic compression

scientific article published in December 2006

Quantification of chromatin condensation level by image processing

scientific article published on 5 October 2013

Reduced primary cilia length and altered Arl13b expression are associated with deregulated chondrocyte Hedgehog signaling in alkaptonuria.

scientific article published on 3 February 2017

Response of chondrocyte subpopulations cultured within unloaded and loaded agarose

scientific article published on 01 November 1998

Single photon counting fluorescence lifetime detection of pericellular oxygen concentrations.

scientific article

Smoothened-antagonists reverse homogentisic acid-induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria

scientific article published on 26 December 2016

Solution-Processed Epitaxial Growth of Arbitrary Surface Nanopatterns on Hybrid Perovskite Monocrystalline Thin Films

scientific article published on 27 August 2020

Stem cell differentiation increases membrane-actin adhesion regulating cell blebability, migration and mechanics.

scientific article

Stem cell mechanobiology.

scientific article published on January 2011

Stent encrustation in feline and human artificial urine: does the low molecular weight composition account for the difference?

scientific article

Super-resolution imaging strategies for cell biologists using a spinning disk microscope

scientific article

Surface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cells.

scientific article published on 18 December 2013

Temporal changes in cytoskeletal organisation within isolated chondrocytes quantified using a novel image analysis technique.

scientific article published on May 2001

The effect of mechanical strain or hypoxia on cell death in subpopulations of rat dorsal root ganglion neurons in vitro

scientific article published on 29 July 2010

The influence of elaborated pericellular matrix on the deformation of isolated articular chondrocytes cultured in agarose

scientific article published on 01 October 1998

The potential of pulsed low intensity ultrasound to stimulate chondrocytes matrix synthesis in agarose and monolayer cultures

scientific article

The primary cilium conducts chondrocyte mechanotransduction

The primary cilium influences interleukin-1β-induced NFκB signalling by regulating IKK activity.

scientific article published on 12 April 2014

The rate of hypo-osmotic challenge influences regulatory volume decrease (RVD) and mechanical properties of articular chondrocytes.

scientific article published on 11 November 2014

The shape of the urine stream--from biophysics to diagnostics

scientific article

Tissue stiffening promotes keratinocyte proliferation through activation of epidermal growth factor signaling

scientific article published on 16 May 2018

Topographical regulation of primary cilia orientation and length in mesenchymal stem cells.

scientific article published on 16 November 2012

Topography of calcium phosphate ceramics regulates primary cilia length and TGF receptor recruitment associated with osteogenesis.

scientific article

Transglutaminase-2 Mediates the Biomechanical Properties of the Colorectal Cancer Tissue Microenvironment that Contribute to Disease Progression

scientific article published on 21 May 2019

Viscoelastic cell mechanics and actin remodelling are dependent on the rate of applied pressure.

scientific article published on 11 September 2012

Zonal variation in primary cilia elongation correlates with localized biomechanical degradation in stress deprived tendon

scientific article published on 11 March 2016

List of works by Martin M Knight

A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion

A role for IFT88/the primary cilium in the inflammatory response to interleukin-1

Activation of chondrocytes calcium signalling by dynamic compression is independent of number of cycles

Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF-1r Onto the Primary Cilium Associated With Cilia Elongation

An improved confocal FRAP technique for the measurement of long-term actin dynamics in individual stress fibers.

An in vitro investigation of the inflammatory response to the strain amplitudes which occur during high frequency oscillation ventilation and conventional mechanical ventilation

Articular chondrocytes express connexin 43 hemichannels and P2 receptors - a putative mechanoreceptor complex involving the primary cilium?

Bardet-Biedl syndrome proteins control cilia length through regulation of actin polymerisation

Bardet-Biedl syndrome proteins control the cilia length through regulation of actin polymerization

Biomechanical analysis of structural deformation in living cells.

Both superficial and deep zone articular chondrocyte subpopulations exhibit the Crabtree effect but have different basal oxygen consumption rates.

Cell and nucleus deformation in compressed chondrocyte-alginate constructs: temporal changes and calculation of cell modulus.

Cell mechanics, structure, and function are regulated by the stiffness of the three-dimensional microenvironment.

Chondrocyte dedifferentiation increases cell stiffness by strengthening membrane-actin adhesion.

Chondrocyte deformation induces mitochondrial distortion and heterogeneous intracellular strain fields.

Chondrocyte deformation within compressed agarose constructs at the cellular and sub-cellular levels.

Chondrocyte deformation within mechanically and enzymatically extracted chondrons compressed in agarose

Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling.

Ciliary exclusion of Polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney disease model

Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated down-regulation of RhoA expression.

Compressive Deformation and Damage of Muscle Cell Subpopulations in a Model System

Confocal analysis of cytoskeletal organisation within isolated chondrocyte sub-populations cultured in agarose

Confocal analysis of local and cellular strains in chondrocyte-agarose constructs subjected to mechanical shear.

Correction: Super-Resolution Imaging Strategies for Cell Biologists Using a Spinning Disk Microscope.

Cyclic compression of chondrocytes modulates a purinergic calcium signalling pathway in a strain rate- and frequency-dependent manner

Cyclic loading opens hemichannels to release ATP as part of a chondrocyte mechanotransduction pathway

Cytokine preconditioning of engineered cartilage provides protection against interleukin-1 insult

Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers.

Deformation properties of articular chondrocytes: a critique of three separate techniques

Depletion of chondrocyte primary cilia reduces the compressive modulus of articular cartilage.

Differential effects of LifeAct-GFP and actin-GFP on cell mechanics assessed using micropipette aspiration.

Dynamic compressive strain influences chondrogenic gene expression in human periosteal cells: a case study

Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation.

Experimental validation of a flat punch indentation methodology calibrated against unconfined compression tests for determination of soft tissue biomechanics.

Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading.

Heat shock induces rapid resorption of primary cilia

Heat-shock induces rapid resorption of primary cilia

Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β

Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment

IFT88 influences chondrocyte actin organization and biomechanics.

Improved outcome after peripheral nerve injury in mice with increased levels of endogenous ω-3 polyunsaturated fatty acids

In vitro encrustation of a semi-permanent polymer-covered nitinol ureter stent: an artificial urine model.

Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage

Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium

Intracellular mechanics and mechanotransduction associated with chondrocyte deformation during pipette aspiration.

Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling

Lithium chloride prevents interleukin-1β induced cartilage degradation and loss of mechanical properties

Live cell imaging using confocal microscopy induces intracellular calcium transients and cell death.

Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes.

Measurement of the deformation of isolated chondrocytes in agarose subjected to cyclic compression.

Mechanical compression and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose

Mechanical compression influences intracellular Ca2+ signaling in chondrocytes seeded in agarose constructs

Mechanical loading induces primary cilia disassembly in tendon cells via TGFβ and HDAC6

Mechanical loading modulates chondrocyte primary cilia incidence and length.

Mechanical loading of chondrocytes embedded in 3D constructs: in vitro methods for assessment of morphological and metabolic response to compressive strain.

Mechanical strain disrupts primary cilia structure and modulates hedgehog signalling in adult chondrocytes

Mitochondrial dynamics in chondrocytes and their connection to the mechanical properties of the cytoplasm.

Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer

Organ-on-a-Chip and Microfluidic Platforms for Oncology in the UK

Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes

Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes.

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response.

Primary cilia mediate mechanotransduction through control of ATP-induced Ca2+ signaling in compressed chondrocytes.

Purinergic pathway suppresses the release of .NO and stimulates proteoglycan synthesis in chondrocyte/agarose constructs subjected to dynamic compression

Quantification of chromatin condensation level by image processing

Reduced primary cilia length and altered Arl13b expression are associated with deregulated chondrocyte Hedgehog signaling in alkaptonuria.

Response of chondrocyte subpopulations cultured within unloaded and loaded agarose

Single photon counting fluorescence lifetime detection of pericellular oxygen concentrations.

Smoothened-antagonists reverse homogentisic acid-induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria

Solution-Processed Epitaxial Growth of Arbitrary Surface Nanopatterns on Hybrid Perovskite Monocrystalline Thin Films

Stem cell differentiation increases membrane-actin adhesion regulating cell blebability, migration and mechanics.

Stem cell mechanobiology.

Stent encrustation in feline and human artificial urine: does the low molecular weight composition account for the difference?

Super-resolution imaging strategies for cell biologists using a spinning disk microscope

Surface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cells.

Temporal changes in cytoskeletal organisation within isolated chondrocytes quantified using a novel image analysis technique.

The effect of mechanical strain or hypoxia on cell death in subpopulations of rat dorsal root ganglion neurons in vitro

The influence of elaborated pericellular matrix on the deformation of isolated articular chondrocytes cultured in agarose

The potential of pulsed low intensity ultrasound to stimulate chondrocytes matrix synthesis in agarose and monolayer cultures