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List of works by Frank G. Schaap

A novel sequence variant in APOA5 gene found in patients with severe hypertriglyceridemia

scientific article published in September 2006

Accuracy of prediction scores and novel biomarkers for predicting nonalcoholic fatty liver disease in obese children

scientific article published in March 2013

Alterations of hormonally active fibroblast growth factors after Roux-en-Y gastric bypass surgery

scientific article published on 17 June 2011

ApoAV reduces plasma triglycerides by inhibiting very low density lipoprotein-triglyceride (VLDL-TG) production and stimulating lipoprotein lipase-mediated VLDL-TG hydrolysis

scientific article

Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study

scientific article published on 12 June 2006

Apolipoprotein A5 deficiency aggravates high-fat diet-induced obesity due to impaired central regulation of food intake

scientific article published on 6 May 2013

Apolipoprotein AV does not contribute to hypertriglyceridaemia or triglyceride lowering by dietary fish oil and rosiglitazone in obese Zucker rats

scientific article published on 29 March 2006

Bile acid receptors as targets for drug development.

scientific article published on 27 August 2013

Bile acids drive the newborn's gut microbiota maturation

scientific article published on 23 July 2020

Bile salts predict liver regeneration in rabbit model of portal vein embolization ⬇️

scientific article published on June 27, 2012

Calorie restriction and Roux-en-Y gastric bypass have opposing effects on circulating FGF21 in morbidly obese subjects

scientific article published on 12 June 2014

Can plasma bile salt, triglycerides, and apoA-V levels predict liver regeneration?

scientific article published on December 2012

Cathepsin D regulates lipid metabolism in murine steatohepatitis

scientific article

Changes in Hepatic ApoAV Expression are not Required for the Rapid Triglyceride Lowering Effect of Fish Oil Diet in Rats

scientific article published in January 2008

Cholangiocarcinoma, gone without the Wnt?

scientific article published on September 2016

Cholic acid therapy in Zellweger spectrum disorders.

scientific article published on 28 July 2016

Chronic elevation of plasma fibroblast growth factor 19 in long-term farnesoid X receptor agonist therapy, a happy marriage or cause for oncological concern?

scientific article published on 2 September 2017

Diosgenin-induced biliary cholesterol secretion in mice requires Abcg8.

scientific article published in January 2005

Effect of Plasmapheresis on Cholestatic Pruritus and Autotaxin Activity During Pregnancy

scientific article published on 14 February 2019

Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health

scientific article published on 10 March 2012

Effect of wheat bran derived prebiotic supplementation on gastrointestinal transit, gut microbiota, and metabolic health: a randomized controlled trial in healthy adults with a slow gut transit

scientific article published on 25 January 2020

Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding

scientific article

Efficient lowering of triglyceride levels in mice by human apoAV protein variants associated with hypertriglyceridemia

scientific article

Elevated interleukin-8 in bile of patients with primary sclerosing cholangitis.

scientific article published on 11 February 2016

Estrogen induced hypertriglyceridemia in an apolipoprotein AV deficient patient.

scientific article

Evidence for a complex relationship between apoA-V and apoC-III in patients with severe hypertriglyceridemia

scientific article published on 21 July 2006

Evolution of the family of intracellular lipid binding proteins in vertebrates

scientific article published on October 2002

FXR agonist obeticholic acid induces liver growth but exacerbates biliary injury in rats with obstructive cholestasis

scientific article published in Scientific Reports

FXR, intestinal FiXeR of hepatocellular carcinoma?

scientific article published on 25 November 2014

Fatty acid-binding proteins in the heart

scientific article published on March 1, 1998

Fibroblast growth factor 19, an anticholestatic drug produced by human liver

scientific article published on 24 January 2012

Fibroblast growth factor 21 is induced by endoplasmic reticulum stress

scientific journal article

Gallbladder Dyskinesia Is Associated With an Impaired Postprandial Fibroblast Growth Factor 19 Response in Critically Ill Patients

scientific article published on 05 June 2019

Gut microbes take it to the next level? First insights into FXR agonists of microbial origin

scientific article published on 10 July 2020

Hepatocyte nuclear factor-4alpha regulates the human apolipoprotein AV gene: identification of a novel response element and involvement in the control by peroxisome proliferator-activated receptor-gamma coactivator-1alpha, AMP-activated protein kina

scientific article published on 28 July 2005

High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis

scientific article

How sweet it is to activate FXR

scientific article published on 24 March 2014

Hypertriglyceridaemia and low plasma HDL in a patient with apolipoprotein A-V deficiency due to a novel mutation in the APOA5 gene

scientific article published in April 2008

Impact of global Fxr deficiency on experimental acute pancreatitis and genetic variation in the FXR locus in human acute pancreatitis

scientific article

Interactions between bile salts, gut microbiota, and hepatic innate immunity.

scientific article

Intestinal failure to produce FGF19: A culprit in intestinal failure-associated liver disease?

scientific article published on 18 March 2015

Low circulating concentrations of citrulline and FGF19 predict chronic cholestasis and poor survival in adult patients with chronic intestinal failure: development of a Model for End-Stage Intestinal Failure (MESIF risk score)

scientific article published on 01 June 2019

Molecular cloning of fatty acid-transport protein cDNA from rat

scientific journal article

Mutations in the Isocitrate Dehydrogenase Genes IDH1 and IDH2 in Tumors ⬇️

scientific article published on January 1, 2013

One-step purification of rat heart-type fatty acid-binding protein expressed in Escherichia coli.

scientific article

Pandora's box opens for cholestatic liver disease

scientific article published on 12 January 2016

Pharmacological activation of the bile acid nuclear farnesoid X receptor is feasible in patients with quiescent Crohn's colitis.

scientific article

Pituitary TSH controls bile salt synthesis

scientific article published on 09 February 2015

Plasma apoAV levels are markedly elevated in severe hypertriglyceridemia and positively correlated with the APOA5 S19W polymorphism

scientific article published on 13 June 2006

Plasma apolipoprotein AV levels in mice are positively associated with plasma triglyceride levels.

scientific article published on 13 January 2009

Prevention and reversal of hepatic steatosis with a high-protein diet in mice.

scientific article

Prolonged fibroblast growth factor 19 response in patients with primary sclerosing cholangitis after an oral chenodeoxycholic acid challenge

scientific article published on 30 September 2016

Prometheus' little helper, a novel role for fibroblast growth factor 15 in compensatory liver growth

scientific article published on 16 July 2013

Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice

scientific article published in June 2003

Role of fibroblast growth factor 19 in the control of glucose homeostasis.

scientific article published on July 2012

Serum Autotaxin Activity Correlates With Pruritus in Pediatric Cholestatic Disorders

scientific article published in April 2016

Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions

scientific article published in October 2012

Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: conjugated hypercholanemia without a clear clinical phenotype

scientific article published on 25 August 2014

The hepatic response to FGF19 is impaired in patients with nonalcoholic fatty liver disease and insulin resistance.

scientific article

The human gallbladder secretes fibroblast growth factor 19 into bile: towards defining the role of fibroblast growth factor 19 in the enterobiliary tract.

scientific article

The influence of chemotherapy-associated sinusoidal dilatation on short-term outcome after partial hepatectomy for colorectal liver metastases: A systematic review with meta-analysis.

scientific article

The role of bile salts in liver regeneration

scientific article

Thyroid hormone regulates the hypotriglyceridemic gene APOA5

scientific journal article

Validation of the peak bilirubin criterion for outcome after partial hepatectomy.

scientific article published on 02 July 2016

Yin Yang 1 and farnesoid X receptor: a balancing act in non-alcoholic fatty liver disease?

scientific article published on 08 March 2013

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