List of works - Juan Bernal

Aberrant maturation of astrocytes in thyroid hormone receptor alpha 1 knockout mice reveals an interplay between thyroid hormone receptor isoforms

scientific article

Abnormalities of Triiodothyronine Binding to Lymphocyte and Fibroblast Nuclei from a Patient with Peripheral Tissue Resistance to Thyroid Hormone Action* ⬇️

scientific article published on December 1, 1978

Adult rat brain is sensitive to thyroid hormone. Regulation of RC3/neurogranin mRNA ⬇️

scientific article published on August 1, 1992

Analysis of Rhes activation state and effector function

scientific article published in January 2006

Anxiety, memory impairment, and locomotor dysfunction caused by a mutant thyroid hormone receptor alpha1 can be ameliorated by T3 treatment.

scientific article

Biological activities of thyroid hormone receptors.

scientific article published on November 1997

Brain-specific prostaglandin D2 synthetase mRNA is dependent on thyroid hormone during rat brain development

scientific article

Cell-specific effects of thyroid hormone on RC3/neurogranin expression in rat brain.

scientific article published in March 1996

Cerebral cortex hyperthyroidism of newborn mct8-deficient mice transiently suppressed by lat2 inactivation

scientific article

Characterization of the promoter region and flanking sequences of the neuron-specific gene RC3 (neurogranin).

scientific article published on December 1994

Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism

scientific article published on 04 March 2014

Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism

scientific article

Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism.

scientific article published on March 2014

Concomitant decrease of the effects of thyroxin on TRH-induced TSH release, and of the pituitary content of triiodothyronine in animals on propylthiouracil

scientific article published in September 1974

Congenital goiter with thyroglobulin deficiency

scientific article published in August 1975

Critical role of types 2 and 3 deiodinases in the negative regulation of gene expression by T₃in the mouse cerebral cortex.

scientific article

Deletion of the thyroid hormone receptor alpha 1 prevents the structural alterations of the cerebellum induced by hypothyroidism

scientific article

Developmental expression of the tenascin-C is altered by hypothyroidism in the rat brain

scientific article published in May 1998

Differential effects of triiodothyronine and the thyroid hormone receptor beta-specific agonist GC-1 on thyroid hormone target genes in the b ain.

scientific article published on 21 August 2003

Direct action of triiodothyronine on gene expression in the neonatal brain and cerebellum

scientific article published in October 2008

Dissociation of the triiodothyronine receptor from the nucleus induced by cations: evidence for divalent cation sensitive and insensitive nuclear sites

scientific article published on 01 December 1985

Divergent expression of type 2 deiodinase and the putative thyroxine-binding protein p29, in rat brain, suggests that they are functionally unrelated proteins

scientific article published in March 2003

Editorial: "Thyroid Hormone in Brain and Brain Cells".

scientific article published on 22 June 2015

Effect of Divalent Cations on the Binding of 3,5,3′-Triiodothyronine to Isolated Rat Liver Nuclei* ⬇️

scientific article published on 01 January 1982

Effect of Triiodothyroacetic Acid Treatment in Mct8 Deficiency: A Word of Caution.

scientific article

Effect of the exposure to cold on the extrathyroidal conversion of L-thyroxine to triiodo-L-thyronine, and on intramitochondrial alpha-glycerophosphate dehydrogenase activity in thyroidectomized rats on L-thyroxine

scientific article published on 01 March 1975

Effects of neonatal hypothyroidism on rat brain gene expression

scientific article published in February 1991

Erratum: Thyroid hormone transporters—functions and clinical implications

scientific article published on 20 October 2015

Estimation of nuclear thyroid hormone receptor saturation in human fetal brain and lung during early gestation

scientific article published on 01 October 1988

Expression of neurotrophins and the trk family of neurotrophin receptors in normal and hypothyroid rat brain

scientific article published on 01 December 1994

Expression of type 2 iodothyronine deiodinase in hypothyroid rat brain indicates an important role of thyroid hormone in the development of specific primary sensory systems

scientific article published in May 1999

Generalized deficiency of 3,5,3'-triiodo-L-thyronine (T3) in tissues from rats on a low iodine intake, despite normal circulating T3 levels

scientific article published on 01 April 1989

Generation and characterization of dickkopf3 mutant mice

scientific article

Global Transcriptome Analysis of Primary Cerebrocortical Cells: Identification of Genes Regulated by Triiodothyronine in Specific Cell Types.

scientific article published on 2 November 2015

High sensitivity of a rat liver nucleoplasmic protein to triiodothyronine

scientific article

Hypothyroidism alters the expression of prostaglandin D2 synthase/beta trace in specific areas of the developing rat brain.

scientific article published in August 1997

Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a thyroid hormone-regulated gene in specific brain regions.

scientific article

Identification of a thyroid hormone response element in the promoter region of the rat lipocalin-type prostaglandin D synthase (beta-trace) gene.

scientific article published in April 1998

Identification of novel GH-regulated genes in C2C12 cells

scientific article

Identification of the mammalian homolog of the splicing regulator Suppressor-of-white-apricot as a thyroid hormone regulated gene.

scientific article

Identification of the mitochondrial NADH dehydrogenase subunit 3 (ND3) as a thyroid hormone regulated gene by whole genome PCR analysis

scientific journal article

Importance of monocarboxylate transporter 8 for the blood-brain barrier-dependent availability of 3,5,3'-triiodo-L-thyronine

scientific article published on 15 January 2009

In vivo activity of the thyroid hormone receptor beta- and α-selective agonists GC-24 and CO23 on rat liver, heart, and brain

scientific article

Increased oxidative metabolism and neurotransmitter cycling in the brain of mice lacking the thyroid hormone transporter SLC16A2 (MCT8)

scientific article

Independent expression of the alpha and beta c-erbA genes in developing rat brain

scientific article published in September 1991

Induction of platelet-derived growth factor B/c-sis by the v-erbA oncogene in glial cells.

scientific article published on March 1995

Influence of Thyroid Hormone and Thyroid Hormone Receptors in the Generation of Cerebellar γ-Aminobutyric Acid-Ergic Interneurons from Precursor Cells

scientific article published on 30 August 2007

Influence of thyroid hormone on brain gene expression

scientific article published on January 1, 1992

Influence of thyroid hormones on maturation of rat cerebellar astrocytes

scientific article published on 13 February 2007

Inhibition by propylthiouracil of the extrathyroidal formation of triiodothyronine from thyroxine

scientific article published on 01 October 1974

Inhibition of nuclear binding of triiodothyronine by antimycin A in cultured human fibroblasts

scientific article published on 01 September 1987

Involvement of thyrotropin-releasing hormone receptor, somatostatin receptor subtype 2 and corticotropin-releasing hormone receptor type 1 in the control of chicken thyrotropin secretion

scientific article

Iodine and brain development.

scientific article

Iodine supplementation during pregnancy: a public health challenge

scientific article published on 24 October 2007

Is the Intrinsic Genomic Activity of Thyroxine Relevant In Vivo? Effects on Gene Expression in Primary Cerebrocortical and Neuroblastoma Cells

scientific article published on 12 June 2017

Isolation of genomic DNA fragments corresponding to genes modulated in vivo by a transcription factor.

scientific article published on October 1994

Lack of action of exogenously administered T3 on the fetal rat brain despite expression of the monocarboxylate transporter 8.

scientific article

Lack of thyroid hormone receptor alpha1 is associated with selective alterations in behavior and hippocampal circuits.

scientific article

Late maternal hypothyroidism alters the expression of Camk4 in neocortical subplate neurons: a comparison with Nurr1 labeling.

scientific article published on 16 May 2013

MCT8 Deficiency in Male Mice Mitigates the Phenotypic Abnormalities Associated With the Absence of a Functional Type 3 Deiodinase

scientific article published on 2 June 2016

Management of subclinical hypothyroidism in pregnancy: are we too simplistic?

scientific article

Modulation of adult hippocampal neurogenesis by thyroid hormones: implications in depressive-like behavior

scientific article published in April 2006

Mutations of the thyroid hormone transporter MCT8 cause prenatal brain damage and persistent hypomyelination

scientific article

Neonatal hypothyroidism affects the timely expression of myelin-associated glycoprotein in the rat brain.

scientific article published on March 1993

Nuclear binding of triiodothyronine in human mononuclear cells, and lymphocytes in culture

scientific article published on 01 January 1983

Ontogenesis of the nuclear 3,5,3'-triiodothyronine receptor in the human fetal brain

scientific article published on 01 February 1984

Ontogenesis of thyroid hormone receptor in foetal lambs.

scientific article published in October 1987

Partial peripheral resistance to thyroid hormones, a post-receptor defect?

scientific article

Pathophysiology of thyroid hormone deficiency during fetal development.

scientific article

Perspectives in the study of thyroid hormone action on brain development and function

scientific article published on November 2003

Placenta passage of the thyroid hormone analog DITPA to male wild-type and Mct8-deficient mice

scientific article

Post-transcriptional induction of beta 1-adrenergic receptor by retinoic acid, but not triiodothyronine, in C6 glioma cells expressing thyroid hormone receptors

scientific journal article

Preferential saturation of brain 3,5,3'-triiodothyronine receptor during development in fetal lambs

scientific article

RC3/neurogranin is expressed in pyramidal neurons of motor and somatosensory cortex in normal and denervated monkeys.

scientific article published in December 2005

Regulation of the L1 cell adhesion molecule by thyroid hormone in the developing brain

scientific journal article

Retinoic acid posttranscriptionally up-regulates proteolipid protein gene expression in C6 glioma cells.

scientific article published on December 1993

Rhes is involved in striatal function

scientific journal article

Role of monocarboxylate anion transporter 8 (MCT8) in thyroid hormone transport: Answers from mice

scientific article published in September 2006

Role of thyroid hormone receptor subtypes α and β on gene expression in the cerebral cortex and striatum of postnatal mice

scientific article published on 14 March 2013

T3 receptor occupancy and T3 levels in plasma and cytosol during rat brain development

scientific article published in July 1990

The action of thyroid hormone ⬇️

scientific article published on March 1, 1977

The early ontogenesis of thyroid hormone receptor in the rat fetus

scientific article published in December 1985

The nuclear 3,5,3'-triiodothyronine receptor in human leukaemic cell lines.

scientific article

The significance of thyroid hormone transporters in the brain

scientific article

The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors

scientific article (publication date: 15 January 2004)

The type 2 iodothyronine deiodinase is expressed primarily in glial cells in the neonatal rat brain

scientific article

Thyroglobulin defect in a human congenital goiter

scientific article published in January 1974

Thyroglobulin-like antigens in a goiter with impaired thyroglobulin biosynthesis.

scientific article published in September 1974

Thyroid Hormone Economy in the Perinatal Mouse Brain: Implications for Cerebral Cortex Development.

scientific article published on 12 April 2017

Thyroid Hormone Receptors from Liver Nuclei: Characteristics of Receptor from Normal, Thyroidectomized, and Triiodothyronine-Treated Rats; Measurement of Occupied and Unoccupied Receptors, and Chromatin Binding of Receptors* ⬇️

scientific article published on August 1, 1978

Thyroid Hormone Receptors: Release of Receptor to the Medium Duringin VitroIncubation of Isolated Rat Liver Nuclei ⬇️

scientific article published on March 1, 1977

Thyroid Hormones in Brain Development and Function

scientific article published on 24 April 2015

Thyroid development and effect on the nervous system

scientific article

Thyroid hormone action in the adult brain: gene expression profiling of the effects of single and multiple doses of triiodo-L-thyronine in the rat striatum.

scientific article published on 8 May 2008

Thyroid hormone action: astrocyte-neuron communication

scientific article

Thyroid hormone dependent nuclear proteins from rat liver

scientific article published on 01 April 1982

Thyroid hormone receptor activity in the absence of ligand: physiological and developmental implications.

scientific article

Thyroid hormone receptor/c-erbA: control of commitment and differentiation in the neuronal/chromaffin progenitor line PC12.

scientific article published on April 1993

Thyroid hormone receptors in brain development and function

scientific article published on March 2007

Thyroid hormone regulated genes in cerebral cortex development

scientific article

Thyroid hormone regulates reelin and dab1 expression during brain development

scientific journal article

Thyroid hormone regulation of RC3, a brain-specific gene encoding a protein kinase-C substrate.

scientific article published in August 1993

Thyroid hormone regulation of gene expression in primary cerebrocortical cells: role of thyroid hormone receptor subtypes and interactions with retinoic acid and glucocorticoids

scientific article

Thyroid hormone regulation of gene expression in the developing rat fetal cerebral cortex: prominent role of the Ca2+/calmodulin-dependent protein kinase IV pathway

scientific article published on 7 January 2010

Thyroid hormone regulation of rhes, a novel Ras homolog gene expressed in the striatum

scientific article

Thyroid hormone signaling is highly heterogeneous during pre- and postnatal brain development

scientific article published in October 2004

Thyroid hormone transport in developing brain ⬇️

scientific article published on October 1, 2011

Thyroid hormone transporters--functions and clinical implications

scientific article published on 05 May 2015

Thyroid hormone-dependent regulation of Talpha1 alpha-tubulin during brain development.

scientific article published on March 2002

Thyroid hormone-dependent transcriptional repression of neural cell adhesion molecule during brain maturation.

scientific article

Thyroid hormone-regulated expression of RC3/neurogranin in the immortalized hypothalamic cell line GT1-7.

scientific article published in September 1997

Thyroid hormone-regulated mouse cerebral cortex genes are differentially dependent on the source of the hormone: a study in monocarboxylate transporter-8- and deiodinase-2-deficient mice.

scientific article

Thyroid hormones and brain development

scientific article published on 01 October 1995

Thyroid hormones and brain development.

scientific article

Thyroid hormones and their receptors: from development to disease

scientific article published in January 2011

Transcriptional induction of RC3/neurogranin by thyroid hormone: differential neuronal sensitivity is not correlated with thyroid hormone receptor distribution in the brain

scientific article published in October 1997

Triiodothyronine stimulates nuclear RNA synthesis

scientific article published on 01 December 1977

Triiodothyronine stimulation of nuclear protein synthesis

scientific article published on 01 February 1978

Type 3 Iodothyronine Deiodinase Is Selectively Expressed in Areas Related to Sexual Differentiation in the Newborn Rat Brain

scientific article published on 01 November 1999

Unliganded c-erbA/thyroid hormone receptor induces trkB expression in neuroblastoma cells.

scientific article published on April 1994

Vitamin D3 inhibits proliferation and increases c-myc expression in fibroblasts from psoriatic patients

scientific article published on September 1998

[Thyroid hormone resistance syndromes]

scientific article published on 03 April 2011

List of works by Juan Bernal

Aberrant maturation of astrocytes in thyroid hormone receptor alpha 1 knockout mice reveals an interplay between thyroid hormone receptor isoforms

Abnormalities of Triiodothyronine Binding to Lymphocyte and Fibroblast Nuclei from a Patient with Peripheral Tissue Resistance to Thyroid Hormone Action* ⬇️

Adult rat brain is sensitive to thyroid hormone. Regulation of RC3/neurogranin mRNA ⬇️

Analysis of Rhes activation state and effector function

Anxiety, memory impairment, and locomotor dysfunction caused by a mutant thyroid hormone receptor alpha1 can be ameliorated by T3 treatment.

Biological activities of thyroid hormone receptors.

Brain-specific prostaglandin D2 synthetase mRNA is dependent on thyroid hormone during rat brain development

Cell-specific effects of thyroid hormone on RC3/neurogranin expression in rat brain.

Cerebral cortex hyperthyroidism of newborn mct8-deficient mice transiently suppressed by lat2 inactivation

Characterization of the promoter region and flanking sequences of the neuron-specific gene RC3 (neurogranin).

Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism

Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism

Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism.

Concomitant decrease of the effects of thyroxin on TRH-induced TSH release, and of the pituitary content of triiodothyronine in animals on propylthiouracil

Congenital goiter with thyroglobulin deficiency

Critical role of types 2 and 3 deiodinases in the negative regulation of gene expression by T₃in the mouse cerebral cortex.

Deletion of the thyroid hormone receptor alpha 1 prevents the structural alterations of the cerebellum induced by hypothyroidism

Developmental expression of the tenascin-C is altered by hypothyroidism in the rat brain

Differential effects of triiodothyronine and the thyroid hormone receptor beta-specific agonist GC-1 on thyroid hormone target genes in the b ain.

Direct action of triiodothyronine on gene expression in the neonatal brain and cerebellum

Dissociation of the triiodothyronine receptor from the nucleus induced by cations: evidence for divalent cation sensitive and insensitive nuclear sites

Divergent expression of type 2 deiodinase and the putative thyroxine-binding protein p29, in rat brain, suggests that they are functionally unrelated proteins

Editorial: "Thyroid Hormone in Brain and Brain Cells".

Effect of Divalent Cations on the Binding of 3,5,3′-Triiodothyronine to Isolated Rat Liver Nuclei* ⬇️

Effect of Triiodothyroacetic Acid Treatment in Mct8 Deficiency: A Word of Caution.

Effect of the exposure to cold on the extrathyroidal conversion of L-thyroxine to triiodo-L-thyronine, and on intramitochondrial alpha-glycerophosphate dehydrogenase activity in thyroidectomized rats on L-thyroxine

Effects of neonatal hypothyroidism on rat brain gene expression

Erratum: Thyroid hormone transporters—functions and clinical implications

Estimation of nuclear thyroid hormone receptor saturation in human fetal brain and lung during early gestation

Expression of neurotrophins and the trk family of neurotrophin receptors in normal and hypothyroid rat brain

Expression of type 2 iodothyronine deiodinase in hypothyroid rat brain indicates an important role of thyroid hormone in the development of specific primary sensory systems

Generalized deficiency of 3,5,3'-triiodo-L-thyronine (T3) in tissues from rats on a low iodine intake, despite normal circulating T3 levels

Generation and characterization of dickkopf3 mutant mice

Global Transcriptome Analysis of Primary Cerebrocortical Cells: Identification of Genes Regulated by Triiodothyronine in Specific Cell Types.

High sensitivity of a rat liver nucleoplasmic protein to triiodothyronine

Hypothyroidism alters the expression of prostaglandin D2 synthase/beta trace in specific areas of the developing rat brain.

Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a thyroid hormone-regulated gene in specific brain regions.

Identification of a thyroid hormone response element in the promoter region of the rat lipocalin-type prostaglandin D synthase (beta-trace) gene.

Identification of novel GH-regulated genes in C2C12 cells

Identification of the mammalian homolog of the splicing regulator Suppressor-of-white-apricot as a thyroid hormone regulated gene.

Identification of the mitochondrial NADH dehydrogenase subunit 3 (ND3) as a thyroid hormone regulated gene by whole genome PCR analysis

Importance of monocarboxylate transporter 8 for the blood-brain barrier-dependent availability of 3,5,3'-triiodo-L-thyronine

In vivo activity of the thyroid hormone receptor beta- and α-selective agonists GC-24 and CO23 on rat liver, heart, and brain

Increased oxidative metabolism and neurotransmitter cycling in the brain of mice lacking the thyroid hormone transporter SLC16A2 (MCT8)

Independent expression of the alpha and beta c-erbA genes in developing rat brain

Induction of platelet-derived growth factor B/c-sis by the v-erbA oncogene in glial cells.

Influence of Thyroid Hormone and Thyroid Hormone Receptors in the Generation of Cerebellar γ-Aminobutyric Acid-Ergic Interneurons from Precursor Cells

Influence of thyroid hormone on brain gene expression

Influence of thyroid hormones on maturation of rat cerebellar astrocytes

Inhibition by propylthiouracil of the extrathyroidal formation of triiodothyronine from thyroxine

Inhibition of nuclear binding of triiodothyronine by antimycin A in cultured human fibroblasts

Involvement of thyrotropin-releasing hormone receptor, somatostatin receptor subtype 2 and corticotropin-releasing hormone receptor type 1 in the control of chicken thyrotropin secretion

Iodine and brain development.

Iodine supplementation during pregnancy: a public health challenge

Is the Intrinsic Genomic Activity of Thyroxine Relevant In Vivo? Effects on Gene Expression in Primary Cerebrocortical and Neuroblastoma Cells

Isolation of genomic DNA fragments corresponding to genes modulated in vivo by a transcription factor.

Lack of action of exogenously administered T3 on the fetal rat brain despite expression of the monocarboxylate transporter 8.

Lack of thyroid hormone receptor alpha1 is associated with selective alterations in behavior and hippocampal circuits.

Late maternal hypothyroidism alters the expression of Camk4 in neocortical subplate neurons: a comparison with Nurr1 labeling.

MCT8 Deficiency in Male Mice Mitigates the Phenotypic Abnormalities Associated With the Absence of a Functional Type 3 Deiodinase

Management of subclinical hypothyroidism in pregnancy: are we too simplistic?

Modulation of adult hippocampal neurogenesis by thyroid hormones: implications in depressive-like behavior

Mutations of the thyroid hormone transporter MCT8 cause prenatal brain damage and persistent hypomyelination

Neonatal hypothyroidism affects the timely expression of myelin-associated glycoprotein in the rat brain.

Nuclear binding of triiodothyronine in human mononuclear cells, and lymphocytes in culture

Ontogenesis of the nuclear 3,5,3'-triiodothyronine receptor in the human fetal brain

Ontogenesis of thyroid hormone receptor in foetal lambs.

Partial peripheral resistance to thyroid hormones, a post-receptor defect?

Pathophysiology of thyroid hormone deficiency during fetal development.

Perspectives in the study of thyroid hormone action on brain development and function

Placenta passage of the thyroid hormone analog DITPA to male wild-type and Mct8-deficient mice

Post-transcriptional induction of beta 1-adrenergic receptor by retinoic acid, but not triiodothyronine, in C6 glioma cells expressing thyroid hormone receptors

Preferential saturation of brain 3,5,3'-triiodothyronine receptor during development in fetal lambs

RC3/neurogranin is expressed in pyramidal neurons of motor and somatosensory cortex in normal and denervated monkeys.

Regulation of the L1 cell adhesion molecule by thyroid hormone in the developing brain

Retinoic acid posttranscriptionally up-regulates proteolipid protein gene expression in C6 glioma cells.

Rhes is involved in striatal function

Role of monocarboxylate anion transporter 8 (MCT8) in thyroid hormone transport: Answers from mice

Role of thyroid hormone receptor subtypes α and β on gene expression in the cerebral cortex and striatum of postnatal mice