List of works - Spiros C Denaxas

A chronological map of 308 physical and mental health conditions from 4 million individuals in the English National Health Service

scientific article published on 20 May 2019

A novel framework for assessing metadata quality in epidemiological and public health research settings

scientific article published on 20 July 2016

A novel metadata management model to capture consent for record linkage in longitudinal research studies.

scientific article published on 6 November 2017

A population-based study of 92 clinically recognized risk factors for heart failure: co-occurrence, prognosis and preventive potential

scientific article published in March 2022

A semi-supervised approach for rapidly creating clinical biomarker phenotypes in the UK Biobank using different primary care EHR and clinical terminology systems

scientific article published on 05 December 2020

A semi-supervised approach for rapidly creating clinical biomarker phenotypes in the UK Biobank using different primary care EHR and clinical terminology systems.

scientific article published on 19 May 2020

Accuracy of Patient Self-Report of Stroke: A Systematic Review from the UK Biobank Stroke Outcomes Group

scientific article

Allergic disease, corticosteroid use, and risk of Hodgkin lymphoma: A United Kingdom nationwide case-control study

scientific article published on 12 November 2019

An electronic health records cohort study on heart failure following myocardial infarction in England: incidence and predictors ⬇️

scientific article published on 3 March 2018

Antibiotic usage in chronic rhinosinusitis: analysis of national primary care electronic health records

scientific article published on 01 December 2019

Antipsychotic drugs and risks of myocardial infarction: a self-controlled case series study

scientific article published on 8 July 2014

Association between clinically recorded alcohol consumption and initial presentation of 12 cardiovascular diseases: population based cohort study using linked health records.

scientific article published on 22 March 2017

Association of COVID-19 vaccines ChAdOx1 and BNT162b2 with major venous, arterial, or thrombocytopenic events: A population-based cohort study of 46 million adults in England

scientific article published on 22 February 2022

Associations Between Measures of Sarcopenic Obesity and Risk of Cardiovascular Disease and Mortality: A Cohort Study and Mendelian Randomization Analysis Using the UK Biobank

scientific article published on 21 June 2019

Avoidable flaws in observational analyses: an application to statins and cancer

scientific article published on 07 October 2019

Big biomedical data and cardiovascular disease research: opportunities and challenges

scientific article published in July 2015

Big data from electronic health records for early and late translational cardiovascular research: challenges and potential

scientific article published on 29 August 2017

Bleeding in cardiac patients prescribed antithrombotic drugs: electronic health record phenotyping algorithms, incidence, trends and prognosis

scientific article published on 20 November 2019

Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people

scientific article

Causes of death among homeless people: a population-based cross-sectional study of linked hospitalisation and mortality data in England

article

Clarithromycin and endoscopic sinus surgery for adults with chronic rhinosinusitis with and without nasal polyps: study protocol for the MACRO randomised controlled trial.

scientific article published on 29 April 2019

Clinically recorded heart rate and incidence of 12 coronary, cardiac, cerebrovascular and peripheral arterial diseases in 233,970 men and women: A linked electronic health record study ⬇️

scientific article

Comparing and Contrasting A Priori and A Posteriori Generalizability Assessment of Clinical Trials on Type 2 Diabetes Mellitus.

scientific article

Completeness and diagnostic validity of recording acute myocardial infarction events in primary care, hospital care, disease registry, and national mortality records: cohort study

scientific article (publication date: 20 May 2013)

Critical Care Health Informatics Collaborative (CCHIC): Data, tools and methods for reproducible research: A multi-centre UK intensive care database

Data resource profile: cardiovascular disease research using linked bespoke studies and electronic health records (CALIBER)

scientific article

Data-driven identification of ageing-related diseases from electronic health records

scientific article published on 3 February 2021

Defining Disease Phenotypes in Primary Care Electronic Health Records by a Machine Learning Approach: A Case Study in Identifying Rheumatoid Arthritis

scientific article

Defining disease phenotypes using national linked electronic health records: a case study of atrial fibrillation

scientific article

Depression as a Risk Factor for the Initial Presentation of Twelve Cardiac, Cerebrovascular, and Peripheral Arterial Diseases: Data Linkage Study of 1.9 Million Women and Men. ⬇️

scientific article

Desiderata for the development of next-generation electronic health record phenotype libraries

scientific article published on 01 September 2021

Discussion of "Combining Health Data Uses to Ignite Health System Learning".

scientific article

Engaging with the clinical data transparency initiative: a view from the National Institute for Cardiovascular Outcomes Research (NICOR).

scientific article published in July 2012

Estimated impact of the COVID-19 pandemic on cancer services and excess 1-year mortality in people with cancer and multimorbidity: near real-time data on cancer care, cancer deaths and a population-based cohort study

scientific article published on 17 November 2020

Ethnicity and the first diagnosis of a wide range of cardiovascular diseases: Associations in a linked electronic health record cohort of 1 million patients ⬇️

scientific article

Evaluation of Semantic Web Technologies for Storing Computable Definitions of Electronic Health Records Phenotyping Algorithms.

scientific article

Evaluation of antithrombotic use and COVID-19 outcomes in a nationwide atrial fibrillation cohort

scientific article published on 25 May 2022

Expert panel process to optimise the design of a randomised controlled trial in chronic rhinosinusitis (the MACRO programme)

scientific article published on 23 April 2019

Extracting diagnoses and investigation results from unstructured text in electronic health records by semi-supervised machine learning

scientific article

Feasibility and impact of a computerised clinical decision support system on investigation and initial management of new onset chest pain: a mixed methods study

scientific article published on 26 August 2015

Feasibility study of hospital antimicrobial stewardship analytics using electronic health records

scientific article published on 04 March 2021

Flipping the odds of drug development success through human genomics

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

scientific article published on 09 January 2020

Heterogeneous associations between smoking and a wide range of initial presentations of cardiovascular disease in 1937360 people in England: lifetime risks and implications for risk prediction.

scientific article

Hospital bed capacity and usage across secondary healthcare providers in England during the first wave of the COVID-19 pandemic: a descriptive analysis

scientific article published on 26 January 2021

How Does Cardiovascular Disease First Present in Women and Men? Incidence of 12 Cardiovascular Diseases in a Contemporary Cohort of 1,937,360 People ⬇️

scientific article

Identifying clinically important COPD sub-types using data-driven approaches in primary care population based electronic health records

article

Impact of baseline cases of cough and fever on UK COVID-19 diagnostic testing rates: estimates from the Bug Watch community cohort study

scientific article published in 2021

Impact of baseline cases of cough and fever on UK COVID-19 diagnostic testing rates: estimates from the Bug Watch community cohort study

scientific article published in 2020

Improving the odds of drug development success through human genomics: modelling study

scientific article published on 11 December 2019

Influenza infection and risk of acute myocardial infarction in England and Wales: a CALIBER self-controlled case series study

scientific article

Integrating Bio-ontologies and Controlled Clinical Terminologies: From Base Pairs to Bedside Phenotypes

scientific article published on January 2017

Linked electronic health records for research on a nationwide cohort of more than 54 million people in England: data resource

scientific article published on 07 April 2021

Low eosinophil and low lymphocyte counts and the incidence of 12 cardiovascular diseases: a CALIBER cohort study

scientific article

Machine learning models in electronic health records can outperform conventional survival models for predicting patient mortality in coronary artery disease

scientific article published in PLoS ONE

Metformin use and cardiovascular outcomes after acute myocardial infarction in patients with type 2 diabetes: a cohort study

scientific article published on 09 December 2019

Methods for Enhancing the Reproducibility of Observational Research Using Electronic Health Records: Preliminary Findings from the CALIBER Resource

Methods for enhancing the reproducibility of biomedical research findings using electronic health records

scientific article published on 11 September 2017

Natural language processing for disease phenotyping in UK primary care records for research: a pilot study in myocardial infarction and death

scientific article published on 12 November 2019

Net clinical benefit of warfarin in individuals with atrial fibrillation across stroke risk and across primary and secondary care.

scientific article published on 31 August 2016

Neutrophil Counts and Initial Presentation of 12 Cardiovascular Diseases: A CALIBER Cohort Study

scientific article published on March 2017

On the Accuracy and Scalability of Probabilistic Data Linkage Over the Brazilian 114 Million Cohort

scientific article published in March 2018

Outcomes of specialist discharge coordination and intermediate care schemes for patients who are homeless: analysis protocol for a population-based historical cohort

scientific article published on 14 December 2017

Personalising the decision for prolonged dual antiplatelet therapy: development, validation and potential impact of prognostic models for cardiovascular events and bleeding in myocardial infarction survivors ⬇️

scientific article

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

scientific article published on 29 October 2019

Phenotyping UK Electronic Health Records from 15 Million Individuals for Precision Medicine: The CALIBER Resource

scientific article published on 01 July 2019

Prognosis of undiagnosed chest pain: linked electronic health record cohort study

scientific article

Prognostic burden of heart failure recorded in primary care, acute hospital admissions, or both: a population-based linked electronic health record cohort study in 2.1 million people ⬇️

scientific article published on 23 December 2016

Prognostic models for stable coronary artery disease based on electronic health record cohort of 102 023 patients.

scientific article published on 17 December 2013

Prolonged dual antiplatelet therapy in stable coronary disease: comparative observational study of benefits and harms in unselected versus trial populations ⬇️

scientific article

Reply

Risk factors for incident heart failure in age- and sex-specific strata: a population-based cohort using linked electronic health records

scientific article published on 07 January 2019

Risk of mortality and cardiovascular events following macrolide prescription in chronic rhinosinusitis patients: a cohort study using linked primary care electronic health records

scientific article published on 01 August 2019

Scoring and summarising gene product clusters using the Gene Ontology.

scientific article published on January 2008

Serotonin reuptake inhibitors and mortality in epilepsy: A linked primary-care cohort study

scientific article

Socioeconomic deprivation and regional variation in Hodgkin's lymphoma incidence in the UK: a population-based cohort study of 10 million individuals

scientific article published on 20 September 2019

Socioeconomic deprivation and the incidence of 12 cardiovascular diseases in 1.9 million women and men: implications for risk prediction and prevention.

scientific article

Subtypes of atrial fibrillation with concomitant valvular heart disease derived from electronic health records: phenotypes, population prevalence, trends and prognosis

scientific article published on 13 August 2019

The relationship between sleep duration, cognition and dementia: a Mendelian randomization study

scientific article published on 01 June 2019

The tip of the iceberg: challenges of accessing hospital electronic health record data for biological data mining

scientific article published on 22 September 2016

Time spent at blood pressure target and the risk of death and cardiovascular diseases ⬇️

scientific article published in PLoS ONE

Type 2 diabetes and incidence of a wide range of cardiovascular diseases: a cohort study in 1·9 million people

scientific article

Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1·9 million people

scientific article

Type and timing of heralding in ST-elevation and non-ST-elevation myocardial infarction: an analysis of prospectively collected electronic healthcare records linked to the national registry of acute coronary syndromes

scientific article published on September 2013

UK phenomics platform for developing and validating EHR phenotypes: CALIBER

UK phenomics platform for developing and validating electronic health record phenotypes: CALIBER

scientific article published on 01 December 2019

Use of electronic health records to ascertain, validate and phenotype acute myocardial infarction: A systematic review and recommendations

scientific article published on 05 March 2015

Using big data from health records from four countries to evaluate chronic disease outcomes: a study in 114 364 survivors of myocardial infarction. ⬇️

scientific article published in July 2016

Using nationwide ‘big data’ from linked electronic health records to help improve outcomes in cardiovascular diseases: 33 studies using methods from epidemiology, informatics, economics and social science in the ClinicAl disease research using LInke

White cell count in the normal range and short-term and long-term mortality: international comparisons of electronic health record cohorts in England and New Zealand

scientific article published on 17 February 2017

List of works by Spiros C Denaxas

A chronological map of 308 physical and mental health conditions from 4 million individuals in the English National Health Service

A novel framework for assessing metadata quality in epidemiological and public health research settings

A novel metadata management model to capture consent for record linkage in longitudinal research studies.

A population-based study of 92 clinically recognized risk factors for heart failure: co-occurrence, prognosis and preventive potential

A semi-supervised approach for rapidly creating clinical biomarker phenotypes in the UK Biobank using different primary care EHR and clinical terminology systems

A semi-supervised approach for rapidly creating clinical biomarker phenotypes in the UK Biobank using different primary care EHR and clinical terminology systems.

Accuracy of Patient Self-Report of Stroke: A Systematic Review from the UK Biobank Stroke Outcomes Group

Allergic disease, corticosteroid use, and risk of Hodgkin lymphoma: A United Kingdom nationwide case-control study

An electronic health records cohort study on heart failure following myocardial infarction in England: incidence and predictors ⬇️

Antibiotic usage in chronic rhinosinusitis: analysis of national primary care electronic health records

Antipsychotic drugs and risks of myocardial infarction: a self-controlled case series study

Association between clinically recorded alcohol consumption and initial presentation of 12 cardiovascular diseases: population based cohort study using linked health records.

Association of COVID-19 vaccines ChAdOx1 and BNT162b2 with major venous, arterial, or thrombocytopenic events: A population-based cohort study of 46 million adults in England

Associations Between Measures of Sarcopenic Obesity and Risk of Cardiovascular Disease and Mortality: A Cohort Study and Mendelian Randomization Analysis Using the UK Biobank

Avoidable flaws in observational analyses: an application to statins and cancer

Big biomedical data and cardiovascular disease research: opportunities and challenges

Big data from electronic health records for early and late translational cardiovascular research: challenges and potential

Bleeding in cardiac patients prescribed antithrombotic drugs: electronic health record phenotyping algorithms, incidence, trends and prognosis

Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people

Causes of death among homeless people: a population-based cross-sectional study of linked hospitalisation and mortality data in England

Clarithromycin and endoscopic sinus surgery for adults with chronic rhinosinusitis with and without nasal polyps: study protocol for the MACRO randomised controlled trial.

Clinically recorded heart rate and incidence of 12 coronary, cardiac, cerebrovascular and peripheral arterial diseases in 233,970 men and women: A linked electronic health record study ⬇️

Comparing and Contrasting A Priori and A Posteriori Generalizability Assessment of Clinical Trials on Type 2 Diabetes Mellitus.

Completeness and diagnostic validity of recording acute myocardial infarction events in primary care, hospital care, disease registry, and national mortality records: cohort study

Critical Care Health Informatics Collaborative (CCHIC): Data, tools and methods for reproducible research: A multi-centre UK intensive care database

Data resource profile: cardiovascular disease research using linked bespoke studies and electronic health records (CALIBER)

Data-driven identification of ageing-related diseases from electronic health records

Defining Disease Phenotypes in Primary Care Electronic Health Records by a Machine Learning Approach: A Case Study in Identifying Rheumatoid Arthritis

Defining disease phenotypes using national linked electronic health records: a case study of atrial fibrillation

Depression as a Risk Factor for the Initial Presentation of Twelve Cardiac, Cerebrovascular, and Peripheral Arterial Diseases: Data Linkage Study of 1.9 Million Women and Men. ⬇️

Desiderata for the development of next-generation electronic health record phenotype libraries

Discussion of "Combining Health Data Uses to Ignite Health System Learning".

Engaging with the clinical data transparency initiative: a view from the National Institute for Cardiovascular Outcomes Research (NICOR).

Estimated impact of the COVID-19 pandemic on cancer services and excess 1-year mortality in people with cancer and multimorbidity: near real-time data on cancer care, cancer deaths and a population-based cohort study

Ethnicity and the first diagnosis of a wide range of cardiovascular diseases: Associations in a linked electronic health record cohort of 1 million patients ⬇️

Evaluation of Semantic Web Technologies for Storing Computable Definitions of Electronic Health Records Phenotyping Algorithms.

Evaluation of antithrombotic use and COVID-19 outcomes in a nationwide atrial fibrillation cohort

Expert panel process to optimise the design of a randomised controlled trial in chronic rhinosinusitis (the MACRO programme)

Extracting diagnoses and investigation results from unstructured text in electronic health records by semi-supervised machine learning

Feasibility and impact of a computerised clinical decision support system on investigation and initial management of new onset chest pain: a mixed methods study

Feasibility study of hospital antimicrobial stewardship analytics using electronic health records

Flipping the odds of drug development success through human genomics

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Heterogeneous associations between smoking and a wide range of initial presentations of cardiovascular disease in 1937360 people in England: lifetime risks and implications for risk prediction.

Hospital bed capacity and usage across secondary healthcare providers in England during the first wave of the COVID-19 pandemic: a descriptive analysis

How Does Cardiovascular Disease First Present in Women and Men? Incidence of 12 Cardiovascular Diseases in a Contemporary Cohort of 1,937,360 People ⬇️

Identifying clinically important COPD sub-types using data-driven approaches in primary care population based electronic health records

Impact of baseline cases of cough and fever on UK COVID-19 diagnostic testing rates: estimates from the Bug Watch community cohort study

Impact of baseline cases of cough and fever on UK COVID-19 diagnostic testing rates: estimates from the Bug Watch community cohort study

Improving the odds of drug development success through human genomics: modelling study

Influenza infection and risk of acute myocardial infarction in England and Wales: a CALIBER self-controlled case series study

Integrating Bio-ontologies and Controlled Clinical Terminologies: From Base Pairs to Bedside Phenotypes

Linked electronic health records for research on a nationwide cohort of more than 54 million people in England: data resource

Low eosinophil and low lymphocyte counts and the incidence of 12 cardiovascular diseases: a CALIBER cohort study

Machine learning models in electronic health records can outperform conventional survival models for predicting patient mortality in coronary artery disease

Metformin use and cardiovascular outcomes after acute myocardial infarction in patients with type 2 diabetes: a cohort study

Methods for Enhancing the Reproducibility of Observational Research Using Electronic Health Records: Preliminary Findings from the CALIBER Resource

Methods for enhancing the reproducibility of biomedical research findings using electronic health records

Natural language processing for disease phenotyping in UK primary care records for research: a pilot study in myocardial infarction and death

Net clinical benefit of warfarin in individuals with atrial fibrillation across stroke risk and across primary and secondary care.

Neutrophil Counts and Initial Presentation of 12 Cardiovascular Diseases: A CALIBER Cohort Study

On the Accuracy and Scalability of Probabilistic Data Linkage Over the Brazilian 114 Million Cohort

Outcomes of specialist discharge coordination and intermediate care schemes for patients who are homeless: analysis protocol for a population-based historical cohort

Personalising the decision for prolonged dual antiplatelet therapy: development, validation and potential impact of prognostic models for cardiovascular events and bleeding in myocardial infarction survivors ⬇️

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

Phenotyping UK Electronic Health Records from 15 Million Individuals for Precision Medicine: The CALIBER Resource

Prognosis of undiagnosed chest pain: linked electronic health record cohort study

Prognostic burden of heart failure recorded in primary care, acute hospital admissions, or both: a population-based linked electronic health record cohort study in 2.1 million people ⬇️

Prognostic models for stable coronary artery disease based on electronic health record cohort of 102 023 patients.

Prolonged dual antiplatelet therapy in stable coronary disease: comparative observational study of benefits and harms in unselected versus trial populations ⬇️

Reply

Risk factors for incident heart failure in age- and sex-specific strata: a population-based cohort using linked electronic health records

Risk of mortality and cardiovascular events following macrolide prescription in chronic rhinosinusitis patients: a cohort study using linked primary care electronic health records

Scoring and summarising gene product clusters using the Gene Ontology.

Serotonin reuptake inhibitors and mortality in epilepsy: A linked primary-care cohort study

Socioeconomic deprivation and regional variation in Hodgkin's lymphoma incidence in the UK: a population-based cohort study of 10 million individuals

Socioeconomic deprivation and the incidence of 12 cardiovascular diseases in 1.9 million women and men: implications for risk prediction and prevention.

Subtypes of atrial fibrillation with concomitant valvular heart disease derived from electronic health records: phenotypes, population prevalence, trends and prognosis