Search filters

List of works by Michael Spedding

"Calcium antagonists": a class of drugs with a bright future. Part I. Cellular calcium homeostasis and calcium as a coupling messenger.

scientific article published on December 1983

"Calcium antagonists": a class of drugs with a bright future. Part II. Determination of basic pharmacological properties.

scientific article

(Phenylpiperazinyl-butyl)oxindoles as selective 5-HT7 receptor antagonists

scientific article

1,9-Alkano-bridged 2,3,4,5-tetrahydro-1H-3-benzazepines with affinity for the alpha 2-adrenoceptor and the 5-HT1A receptor

scientific article published in February 1990

2,3-benzodiazepine-type AMPA receptor antagonists and their neuroprotective effects.

scientific article published on 10 July 2007

2-2'-Pyridylisatogen, a selective allosteric modulator of P2 receptors, is a spin trapping agent

scientific article published in January 1998

3H-RS-15385-197, a selective and high affinity radioligand for alpha 2-adrenoceptors: implications for receptor classification ⬇️

scientific article published on August 1, 1992

4H-1,2,4-Pyridothiadiazine 1,1-dioxides and 2,3-dihydro-4H-1,2, 4-pyridothiadiazine 1,1-dioxides chemically related to diazoxide and cyclothiazide as powerful positive allosteric modulators of (R/S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propion

scientific article

A One-Step Synthesis of 2-(2-Pyridyl)-3H-indol-3-oneN-Oxide: Is It an Efficient Spin Trap for Hydroxyl Radical?

scientific article published on 01 July 2000

A functional correlate for the dihydropyridine binding site in rat brain

scientific article

A nomenclature for ligand-gated ion channels

scientific article

A novel GABA(A) alpha 5 receptor inhibitor with therapeutic potential

scientific article published on 10 July 2015

A pathophysiological paradigm for the therapy of psychiatric disease

scientific article

A proposal for an updated neuropsychopharmacological nomenclature

scientific article published on 18 September 2013

Activators and inactivators of Ca++ channels: new perspectives.

scientific article published on October 1985

Activators and inactivators of calcium channels: effects in the central nervous system.

scientific article

Acute ketamine challenge increases resting state prefrontal-hippocampal connectivity in both humans and rats

scientific article

Acute stress-induced changes in hippocampal/prefrontal circuits in rats: effects of antidepressants

scientific article

Acute tianeptine treatment selectively modulates neuronal activation in the central nucleus of the amygdala and attenuates fear extinction

scientific article

Acylation Differentiates Two Forms of Agonist Binding to Rat 5-HT1AReceptors

scientific article published on 01 May 1997

Affinity of 2-(tetrahydroisoquinolin-2-ylmethyl)- and 2-(isoindolin-2-ylmethyl)imidazolines for alpha-adrenoceptors. Differential affinity of imidazolines for the [3H]idazoxan-labeled alpha 2-adrenoceptor vs the [3H]yohimbine-labeled site

scientific article published in February 1990

Agomelatine, a melatonin receptor agonist with 5-HT(2C) receptor antagonist properties, protects the developing murine white matter against excitotoxicity

scientific article published on 8 April 2008

Alpha 2-adrenoceptor subtypes and imidazoline-like binding sites in the rat brain

scientific article published on April 1990

Alpha 2-adrenoceptors: more subtypes but fewer functional differences.

scientific article published on April 1994

Altering the course of schizophrenia: progress and perspectives

scientific article published on 4 March 2016

Anatagonism of the inhibitory effects of adenosine 5'-triphosphate on the isolated taenia of the guinea-pig caecum: structure-activity relationships within a series of isatogen derivatives ⬇️

scientific article published on June 1, 1978

Antagonism of Ca2+-induced contractions of K+-depolarized smooth muscle by local anaesthetics

scientific article published in January 1985

Antagonism of adenosine 5'-triphosphate-induced relaxation by 2-2'-pyridylisatogen in the taenia of guinea-pig caecum ⬇️

scientific article published on April 1, 1975

Anti-correlated cortical networks of intrinsic connectivity in the rat brain

scientific article published on 26 September 2013

Antidepressants reverse the attenuation of the neurotrophic MEK/MAPK cascade in frontal cortex by elevated platform stress; reversal of effects on LTP is associated with GluA1 phosphorylation

scientific article published on 9 July 2008

Assessment of "Ca2+ -antagonist" effects of drugs in K+ -depolarized smooth muscle. Differentiation of antagonist subgroups.

scientific article

Atypical in vitro and in vivo binding of [3H]S-14506 to brain 5-HT1A receptors

article published in 1997

BDNF increases rat brain mitochondrial respiratory coupling at complex I, but not complex II

scientific journal article

Brain plasticity and pathology in psychiatric disease: sites of action for potential therapy

scientific article

Brain-derived neurotrophic factor-mediated effects on mitochondrial respiratory coupling and neuroprotection share the same molecular signalling pathways

scientific article published on February 2012

Calcium antagonist properties of diclofurime isomers. I. Functional aspects

scientific article published in April 1987

Calcium antagonist properties of diclofurime isomers. II. Molecular aspects: allosteric interactions with dihydropyridine recognition sites

scientific article published in April 1987

Calcium channel activation does not increase release of endothelial-derived relaxant factors (EDRF) in rat aorta although tonic release of EDRF may modulate calcium channel activity in smooth muscle

scientific article published on 01 November 1986

Calling all pharmacologists with time to spare! We need you! Build the drug discovery knowledge base, GuidetoPharmacology.org

scientific article published on December 2012

Cerebral ischaemia reduces the density of 5-HT2 binding sites in the frontal cortex of the gerbil

scientific article published on 01 August 1988

Changes in EEG spectral power in the prefrontal cortex of conscious rats elicited by drugs interacting with dopaminergic and noradrenergic transmission

scientific article published on November 1999

Changes in [3H]-PK 11195 and [3H]-8-OH-DPAT binding following forebrain ischaemia in the gerbil

scientific article

Changes in mitochondrial function are pivotal in neurodegenerative and psychiatric disorders: how important is BDNF?

scientific article published on April 2014

Channel nomenclature: IUPHAR recommendations

scientific article published in December 1993

Characterisation of cyclooxygenase 1 and 2 expression in mouse resident peritoneal macrophages in vitro; interactions of non steroidal anti-inflammatory drugs with COX2

scientific article published on 01 May 1995

Chronic restraint stress up-regulates GLT-1 mRNA and protein expression in the rat hippocampus: reversal by tianeptine

scholarly article

Classification of calcium channels and calcium antagonists: progress report

scientific article

Classification of calcium channels and the sites of action of drugs modifying channel function ⬇️

scientific article published on September 1, 1992

Clinical trials in neonates: ethical issues

scientific article published on 9 March 2007

Clozapine inhibits serotoninergic transmission by an action at alpha 1-adrenoceptors not at 5-HT1A receptors

scientific article published in July 1994

Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy

scientific article

Common efficacy of psychotropic drugs in restoring stress-induced impairment of prefrontal plasticity.

scientific article published on December 2006

Comparison between the effects of MDL 72567 and nifedipine on various cardiovascular parameters in conscious sinoaortic-denervated rats and sham-operated controls

scientific article (publication date: October 1987)

Competitive interactions between Bay K 8644 and nifedipine in K+ depolarized smooth muscle: a passive role for Ca2+?

scientific article published in February 1985

Contrasting EEG profiles elicited by antipsychotic agents in the prefrontal cortex of the conscious rat: antagonism of the effects of clozapine by modafinil

scientific article published on November 1999

Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat

scientific article

Current status of drug receptor nomenclature: receptor closure? The role of NC-IUPHAR.

scientific article published in May 2004

Depression of sympathetic nervous function by DL-alpha-monofluoromethyldopa, an enzyme-activated, irreversible inhibitor of L-aromatic amino acid decarboxylase

article

Design, synthesis and pharmacological evaluation of new series of naphthalenic analogues as melatoninergic (MT1/MT2) and serotoninergic 5-HT2C dual ligands (I).

scientific article published on 20 January 2012

Differences between the effects of calcium antagonists in the pithed rat preparation

scientific article published on 01 November 1982

Differential effects of calcium channel antagonists on histamine and pentagastrin-stimulated gastric acid secretion in the rat.

scientific article published in September 1985

Differential effects of non-peptidic tachykinin receptor antagonists on Ca2+ channels

scientific article published on 01 March 1994

Drugs in sport: a scientist-athlete's perspective: from ambition to neurochemistry

scientific article (publication date: June 2008)

Editorial

Effects of EGIS-7229 (S 21407), a novel class III antiarrhythmic drug, on myocardial refractoriness to electrical stimulation in vivo and in vitro

scientific article

Effects of EGIS-7625, a selective and competitive 5-HT2B receptor antagonist

scientific article

Effects of metoclopramide and isoprenaline in the rat vas deferens; interactions with alpha-adrenoceptors

scientific article published on January 1980

Effects of phencyclidine (PCP) and MK 801 on the EEGq in the prefrontal cortex of conscious rats; antagonism by clozapine, and antagonists of AMPA-, alpha(1)- and 5-HT(2A)-receptors

scientific article

Egis-11150: a candidate antipsychotic compound with procognitive efficacy in rodents

scientific article published on 21 July 2012

Emotional memory impairments in a genetic rat model of depression: involvement of 5-HT/MEK/Arc signaling in restoration

scientific article published on 18 January 2011

Endocannabinoids potently protect the newborn brain against AMPA-kainate receptor-mediated excitotoxic damage

scientific article published on 8 May 2006

Environmental pharmacology-Dosing the environment: IUPHAR review 36

Factors modifying the tissue selectivity of calcium-antagonists.

scientific article published on January 1990

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

scientific article

Functional correlates of dopamine D3 receptor activation in the rat in vivo and their modulation by the selective antagonist, (+)-S 14297: II. Both D2 and "silent" D3 autoreceptors control synthesis and release in mesolimbic, mesocortical and nigros

scientific article published on November 1995

Functional interactions of calcium-antagonists in K+-depolarized smooth muscle

scientific article published on November 1983

GAP-43 is essential for the neurotrophic effects of BDNF and positive AMPA receptor modulator S18986.

scientific article

GuideToPharmacology.org--an update

scientific article

Guiding principles for the use of knowledge bases and real-world data in clinical decision support systems: report by an international expert workshop at Karolinska Institutet

scientific article published on 29 September 2020

Heterogeneity of alpha 2-adrenoceptors in rat cortex but not human platelets can be defined by 8-OH-DPAT, RU 24969 and methysergide

scientific article published on March 1990

How can drug discovery for psychiatric disorders be improved?

scientific article published in March 2007

IUPHAR guidelines for classification of new receptor-subtypes

scientific article published on 01 August 1995

IUPHAR-DB: new receptors and tools for easy searching and visualization of pharmacological data

scientific article (publication date: 2011)

IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels

scientific article

IUPHAR-DB: updated database content and new features

scientific article

Identification of a novel calcium antagonist binding site in rat brain by SR 33557

scientific article published in January 1993

Identification of separate receptors for adenosine and adenosine 5'-triphosphate in causing relaxations of the isolated taenia of the guinea-pig caecum ⬇️

scientific article published on June 1, 1976

Influence of the novel antidepressant and melatonin agonist/serotonin2C receptor antagonist, agomelatine, on the rat sleep-wake cycle architecture

scientific article

Inhibition of peripheral sympathetic function by alpha-monofluoromethyldopa, an irreversible inhibitor of aromatic amino acid decarboxylase [proceedings] ⬇️

scientific article published on November 1, 1979

Inhibition of the constitutive activity of human 5-HT1A receptors by the inverse agonist, spiperone but not the neutral antagonist, WAY 100,635

scientific article published on March 1997

Inhibition of β-Glucocerebrosidase Activity Preserves Motor Unit Integrity in a Mouse Model of Amyotrophic Lateral Sclerosis

scientific article published on 12 July 2017

Interaction of the anxiogenic agent, RS-30199, with 5-HT1A receptors: modulation of sexual activity in the male rat.

scientific article published on June 1998

Interactions between a "calcium channel agonist", Bay K 8644, and calcium antagonists differentiate calcium antagonist subgroups in K+-depolarized smooth muscle

scientific article

International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers.

scientific article published on March 2007

International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands

scientific article

International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands.

scientific article

International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification.

scientific article published in June 1994

International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology

scientific article (publication date: December 2003)

International Union of Pharmacology. LVI. Ghrelin receptor nomenclature, distribution, and function

scientific article

International Union of Pharmacology. XLVI. G protein-coupled receptor list.

scientific article

International Union of Pharmacology. XXXI. Recommendations for the nomenclature of multimeric G protein-coupled receptors.

scientific article

Introduction to the special issue on High Resolution Neuropharmacology

scientific article published on 04 September 2010

Involvement of AMPA receptor phosphorylation in antidepressant actions with special reference to tianeptine

scientific article

Key challenges for the creation and maintenance of specialist protein resources

scientific article

MDL 72567, a dihydropyridine calcium-antagonist, that causes vasodilation and direct sinus bradycardia

scientific article (publication date: July 1987)

Mitochondrial pharmacology: energy, injury and beyond.

scientific article published on April 2014

Modulation of alpha 1-adrenoceptors in rat left ventricle by ischaemia and acyl carnitines: protection by ranolazine

scientific article published on 01 June 1993

Modulation of sexual behaviour in the rat by a potent and selective alpha 2-adrenoceptor antagonist, delequamine (RS-15385-197).

scientific article published in May 1996

Mss4 gene is up-regulated in rat brain after chronic treatment with antidepressant and down-regulated when rats are anhedonic

scientific article published in December 2002

Multiple exposures to familiar conspecific withdrawal is a novel robust stress paradigm in ewes

scientific article published on 16 August 2011

Neural control of dieting

scientific article published in Nature

Neuroprotective effects of modulators of P2 receptors in primary culture of CNS neurones

scientific article published in September 1999

Neuroprotective properties of lifarizine compared with those of other agents in a mouse model of focal cerebral ischaemia

scientific article published on August 1995

Neuroprotective properties of tianeptine: interactions with cytokines

scientific article published in May 2003

New drug binding sites in Ca2+ channels ⬇️

scientific article published on April 1, 1995

Nomenclature of calcium channels and channel modulators: IUPHAR classification

scientific article published in December 1993

Olympics: Run for your life.

scientific article

Optimization of (arylpiperazinylbutyl)oxindoles exhibiting selective 5-HT₇ receptor antagonist activity.

scientific article published on 16 September 2011

Overview of nomenclature of nuclear receptors

scientific article

Paired vasa deferentia: a method of reducing variability in the response to drugs.

scientific article published in January 1974

Pertussis toxin-sensitive G-protein activation does not influence the response to Bay K 8644 in embryonic chick myocytes

scientific article

Pharmacology of sodium and calcium channel modulation in neurons: implications for neuroprotection.

scientific article published on August 1995

Phenotypical Screening on Neuronal Plasticity in Hippocampal-Prefrontal Cortex Connectivity Reveals an Antipsychotic with a Novel Profile

scientific article published in 2022

Plan S: A threat to quality of science?

scientific article published in Science

Plasticity at hippocampal to prefrontal cortex synapses is impaired by loss of dopamine and stress: importance for psychiatric diseases

scientific article published in January 2004

Positive allosteric modulators of AMPA receptors are neuroprotective against lesions induced by an NMDA agonist in neonatal mouse brain

scientific article

Potentiation by 2,2'-pyridylisatogen tosylate of ATP-responses at a recombinant P2Y1 purinoceptor

scientific article published in March 1996

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

scientific article published on 17 August 2018

Protection of stress-induced impairment of hippocampal/prefrontal LTP through blockade of glucocorticoid receptors: implication of MEK signaling

scientific article published on 16 March 2008

Protective effects of ranolazine in guinea-pig hearts during low-flow ischaemia and their association with increases in active pyruvate dehydrogenase

scientific article

Quantitative analysis of the dihydropyridines, 3-(2-furoyl)-5-methoxycarbonyl-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine and nifedipine, by hig

scientific article published on 01 February 1986

RS-45041-190: a selective, high-affinity ligand for I2 imidazoline receptors.

scientific article published in September 1995

Rapid effects of melatonin on hormonal and behavioral stressful responses in ewes

article

Reasons why stroke trials underestimate the neuroprotective effects of drugs

scientific article published on 01 January 2002

Receptor classification and nomenclature: the revolution and the resolution

scientific article published in July 1994

Regulation of AMPA receptor surface trafficking and synaptic plasticity by a cognitive enhancer and antidepressant molecule.

scientific article published on 26 June 2012

Resolution of controversies in drug/receptor interactions by protein structure. Limitations and pharmacological solutions

scientific article

Role of spin trapping and P2Y receptor antagonism in the neuroprotective effects of 2,2'-pyridylisatogen tosylate and related compounds

scientific article published in May 2002

S 14297, a novel selective ligand at cloned human dopamine D3 receptors, blocks 7-OH-DPAT-induced hypothermia in rats

scientific article published on August 1994

S 14506: novel receptor coupling at 5-HT(1A) receptors.

scientific article

S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: II. Modulation of hippocampal serotonin release in relation to potential anxiolytic properties.

scientific article published in July 1997

S 16924 ((R)-2-[1-[2-(2,3-dihydro-benzo[1,4] dioxin-5-yloxy)-ethyl]-pyrrolidin-3yl]-1-(4-fluoro-phenyl)-ethanone), a novel, potential antipsychotic with marked serotonin (5-HT)1A agonist properties: II. Functional profile in comparison to clozapine a

scientific article published on 01 September 1998

Selective antagonism of calcium channel activators by fluspirilene

scientific article published in June 1990

Stereospecific blockade of α2-adrenoceptors by (+)-butaclamol: implications for the characterization of dopamine receptors

scientific article published on 01 January 1982

Structure-affinity relationships of 12-sulfonyl derivatives of 5,8,8a,9,10,11,12,12a,13,13a-decahydro-6H-isoquino[2,1-g][1 ,6] naphthyridines at alpha-adrenoceptors

scientific article published in February 1991

Sub-anesthetic ketamine modulates intrinsic BOLD connectivity within the hippocampal-prefrontal circuit in the rat.

scientific article published on 18 October 2013

Synaptic plasticity and neuropathology: new approaches in drug discovery

scientific article published in January 2005

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Introduction and Other Protein Targets

scientific article published on 01 December 2019

The AMPA receptor positive allosteric modulator, S18986, is neuroprotective against neonatal excitotoxic and inflammatory brain damage through BDNF synthesis

scientific article

The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors

scientific article

The Concise Guide to PHARMACOLOGY 2013/14: catalytic receptors

scientific article

The Concise Guide to PHARMACOLOGY 2013/14: enzymes.

scientific article

The Concise Guide to PHARMACOLOGY 2013/14: ion channels

scientific article

The Concise Guide to PHARMACOLOGY 2013/14: ligand-gated ion channels.

scientific article

The Concise Guide to PHARMACOLOGY 2013/14: nuclear hormone receptors

scientific article

The Concise Guide to PHARMACOLOGY 2013/14: overview

scientific article

The Concise Guide to PHARMACOLOGY 2013/14: transporters

scientific article

The Concise Guide to PHARMACOLOGY 2015/16: Overview

scientific article

The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology

scientific article published on 05 February 2020

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

scientific article

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY.

scientific article published on 15 November 2017

The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY

scientific article published on 01 January 2020

The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands

scientific article (publication date: 2014)

The IUPHAR/BPS guide to PHARMACOLOGY in 2022: curating pharmacology for COVID-19, malaria and antibacterials

scientific article published on 01 January 2022

The effect of chronic tianeptine administration on the brain mitochondria: direct links with an animal model of depression

scientific article published on 02 March 2016

The effect of lifarizine (RS-87476), a novel sodium and calcium channel modulator, on ischaemic dopamine depletion in the corpus striatum of the gerbil

scientific article published on May 1993

The effects of 2-2'-pyridylisatogen tosylate on the electrical activity of smooth muscle of the isolated taenia caeci of the guinea-pig [proceedings] ⬇️

scientific article published on June 1, 1978

The effects of AMPA receptor antagonists in models of stroke and neurodegeneration

scientific article published in September 2005

The effects of calcium antagonists on calcium overload contractures in embryonic chick myocytes induced by ouabain and veratrine.

scientific article published on May 1989

The expanding role of immunopharmacology: IUPHAR Review 16

scientific article (publication date: September 2015)

The glycine transporter-1 inhibitors NFPS and Org 24461: a pharmacological study

scientific article published in March 2003

The guinea-pig ileum preparation as a model for 5-HT1A receptors: anomalous effects with RS-30199-193.

scientific article published in October 1991

The hippocampal to prefrontal cortex circuit in mice: a promising electrophysiological signature in models for psychiatric disorders

scientific article published on 12 March 2015

The hippocampal-prefrontal pathway: the weak link in psychiatric disorders?

scientific article

The influence of the initial stretch and the agonist-induced tone on the effect of basal and stimulated release of EDRF.

scientific article published on August 1990

The low-frequency blood oxygenation level-dependent functional connectivity signature of the hippocampal-prefrontal network in the rat brain

scientific article published on 23 October 2012

The mechanism of the relaxant effect of 2-2'-pyridylisatogen on the isolated taenia of the guinea-pig caecum ⬇️

scientific article published on August 1, 1978

The neuroprotective activity of 8-alkylamino-1,4-benzoxazine antioxidants

scientific article published in July 2001

The problems associated with the use of 2,2′-pyridylisatogen tosylate in evaluating the allegedly purinergic innervation of peripheral organs ⬇️

scientific article published on May 1, 1978

The protective effect of tianeptine on Gp120-induced apoptosis in astroglial cells: role of GS and NOS, and NF-κB suppression

scientific article published on November 2011

The α2-adrenoceptor antagonist SK & F 104078 has high affinity for 5-HT1A and 5-HT2 receptors

scientific article published on 01 July 1989

Tianeptine and its enantiomers: effects on spatial memory in rats with medial septum lesions

scientific article published in August 2001

Tianeptine potentiates AMPA receptors by activating CaMKII and PKA via the p38, p42/44 MAPK and JNK pathways

scientific article published on 25 October 2011

Transduction is a major factor influencing receptor characterization.

scientific article published on May 1997

Vasodilation by medroxalol mediated by beta 2-adrenergic receptor stimulation

scientific article published on 01 January 1983

Voltage-dependent calcium channels: structures and drug-binding sites

scientific article published on February 1, 1992

X. International Union of Pharmacology recommendations for nomenclature of new receptor subtypes.

scientific article published in March 1996

[3H]p-Aminoclonidine and [3H]idazoxan label different populations of imidazoline sites on rat kidney

scientific article published on 01 February 1993

[Medicines interacting with mitochondria: anti-ischemic effects of trimetazidine]

article

Paulina is supported by:

About Paulina

Help