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List of works by Kenneth M. Scaglione

A Heat Shock Protein 48 (HSP48) Biomolecular Condensate Is Induced during Dictyostelium discoideum Development.

scientific article published on 19 June 2019

A bipartite interaction between Hsp70 and CHIP regulates ubiquitination of chaperoned client proteins

scientific article

Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117.

scientific article

CGG Repeat-Associated Translation Mediates Neurodegeneration in Fragile X Tremor Ataxia Syndrome ⬇️

scientific article published on April 18, 2013

Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages.

scientific article

Changes in protein function underlie the disease spectrum in patients with CHIP mutations

scientific article published on 16 October 2019

Erratum to: The loop-less tmCdc34 E2 mutant defective polyubiquitination in vitro and in vivo supports yeast growth in a manner dependent on Ubp14 and Cka2.

scientific article published on 6 October 2016

Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3.

scientific article

Intrinsic disorder drives N-terminal ubiquitination by Ube2w

scientific article

Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems

scientific article published on 24 November 2015

Most mutations that cause spinocerebellar ataxia autosomal recessive type 16 (SCAR16) destabilize the protein quality-control E3 ligase CHIP.

scientific article published on 9 January 2018

Release of ubiquitin-charged Cdc34-S - Ub from the RING domain is essential for ubiquitination of the SCF(Cdc4)-bound substrate Sic1.

scientific article published in September 2003

SRCP1 Conveys Resistance to Polyglutamine Aggregation

scientific article published on 01 July 2018

The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex

scientific article published on 2 August 2013

The Social Amoeba Dictyostelium discoideum Is Highly Resistant to Polyglutamine Aggregation

scientific article

The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains.

scientific article

The loop-less tmCdc34 E2 mutant defective in polyubiquitination in vitro and in vivo supports yeast growth in a manner dependent on Ubp14 and Cka2.

scientific article published on 31 March 2011

The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin.

scientific article

The ubiquitin-conjugating enzyme (E2) Ube2w ubiquitinates the N terminus of substrates

scientific article

USP5 Is Dispensable for Monoubiquitin Maintenance in Drosophila

scientific article published on 25 February 2016

Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP

scientific journal article

Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23

scientific article

Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3

scientific article

Ubiquitination regulates the neuroprotective function of the deubiquitinase ataxin-3 in vivo.

scientific article published on 08 October 2013

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