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List of works by Ru-Rong Ji

5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals

scientific article

A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia

scientific article

A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief

retracted scientific article (publication date: 5 June 2014)

A new optogenetic device for spinal cord control of pain

scientific article published on 2 August 2017

A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance.

scientific article

Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice

scientific article published on 17 March 2021

Activation of JNK pathway in persistent pain

scientific article published on 13 March 2008

Activation of extracellular signal-regulated kinase in the anterior cingulate cortex contributes to the induction and expression of affective pain

scientific article

Activation of p38 mitogen-activated protein kinase in spinal microglia contributes to incision-induced mechanical allodynia.

scientific article

Acute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9

scientific article

Acute morphine induces matrix metalloproteinase-9 up-regulation in primary sensory neurons to mask opioid-induced analgesia in mice

scientific article

Anti-PD-1 treatment impairs opioid antinociception in rodents and nonhuman primates

scientific article published on 01 February 2020

Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin

scientific article

Astrocytes in chronic pain and itch

scientific article published on 19 September 2019

Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury

scientific article published on August 2012

Astrocytic neuroligins control astrocyte morphogenesis and synaptogenesis.

scientific article published in November 2017

Bradykinin enhances AMPA and NMDA receptor activity in spinal cord dorsal horn neurons by activating multiple kinases to produce pain hypersensitivity

scientific article published on April 2008

Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission.

scientific article published in August 2005

CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5.

scientific article published on 11 January 2016

Ca2+/calmodulin-dependent protein kinase type IV in dorsal root ganglion: colocalization with peptides, axonal transport and effect of axotomy

scientific article published on 01 May 1996

Cell signaling and the genesis of neuropathic pain

scientific article published on 21 September 2004

Central and peripheral expression of galanin in response to inflammation

article

Central sensitization and LTP: do pain and memory share similar mechanisms?

scientific article

Chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity and COX-2 expression in spinal cord neurons via activation of CXCR2.

scientific article

Chemokine contribution to neuropathic pain: respective induction of CXCL1 and CXCR2 in spinal cord astrocytes and neurons

scientific article published on 04 July 2013

Chemokines, neuronal-glial interactions, and central processing of neuropathic pain

scientific article published on February 2010

Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity.

scientific article published in September 2002

Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice

scientific article

Contribution of Baroreceptor Function to Pain Perception and Perioperative Outcomes

scientific article published on 01 April 2019

Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord

scientific article published on May 2008

DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties

scientific article (publication date: 25 February 2004)

Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers.

scientific article

Delayed activation of spinal microglia contributes to the maintenance of bone cancer pain in female Wistar rats via P2X7 receptor and IL-18.

scientific article

Development of a membrane-anchored chemerin receptor agonist as a novel modulator of allergic airway inflammation and neuropathic pain

scientific article

Dietary control of chronic headache: Involvement of pro-resolution lipid mediators

scholarly article by Thomas Van De Ven & Ru-Rong Ji published November 2013 in Pain

Different effects of opioid and cannabinoid receptor agonists on C-fiber-induced extracellular signal-regulated kinase activation in dorsal horn neurons in normal and spinal nerve-ligated rats

scientific article published on 12 October 2005

Different immune cells mediate mechanical pain hypersensitivity in male and female mice.

scientific article published on 29 June 2015

Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7 : Differential activities of Nav1.7-targeting monoclonal antibodies.

scientific article published on 15 January 2018

Differential wiring of local excitatory and inhibitory synaptic inputs to islet cells in rat spinal lamina II demonstrated by laser scanning photostimulation

scientific article published on 8 February 2007

Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss

scientific article published on 12 October 2003

Distinct Analgesic Actions of DHA and DHA-Derived Specialized Pro-Resolving Mediators on Post-operative Pain After Bone Fracture in Mice.

scientific article

Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain

scientific article

Dorsal root ganglia pulsed radiofrequency treatment alters the spinal immune environment

scientific article published on 21 March 2018

ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity.

scientific article

ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model

article

Effect of administration of high dose intrathecal clonidine or morphine prior to sciatic nerve section on c-Fos expression in rat lumbar spinal cord

article

Effects of bupivacaine and tetrodotoxin on carrageenan-induced hind paw inflammation in rats (Part 2): cytokines and p38 mitogen-activated protein kinases in dorsal root ganglia and spinal cord

scientific article published in July 2006

Emerging role of Toll-like receptors in the control of pain and itch

scientific article

Emerging roles of resolvins in the resolution of inflammation and pain

scientific article

Emerging targets in neuroinflammation-driven chronic pain

scientific article (publication date: July 2014)

Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model

scientific article published in May 2008

Evidence for brain glial activation in chronic pain patients

scientific article

Expression and Role of Voltage-Gated Sodium Channels in Human Dorsal Root Ganglion Neurons with Special Focus on Nav1.7, Species Differences, and Regulation by Paclitaxel

scientific article

Expression of mu-, delta-, and kappa-opioid receptor-like immunoreactivities in rat dorsal root ganglia after carrageenan-induced inflammation

scientific article

Expression of neuropeptide Y and neuropeptide Y (Y1) receptor mRNA in rat spinal cord and dorsal root ganglia following peripheral tissue inflammation

scientific article published on 01 November 1994

Expression of peptides, nitric oxide synthase and NPY receptor in trigeminal and nodose ganglia after nerve lesions

scientific article published in October 1996

Expression of pituitary adenylate cyclase-activating polypeptide in dorsal root ganglia following axotomy: time course and coexistence

scientific article published on 01 December 1995

Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion

scientific article published on 17 February 2014

Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1

scientific article published in April 2014

Fibroblast Growth Factors Regulate Calcitonin Gene-related Peptide mRNA Expression in Rat Motoneurons after Lesion and in Culture

article

Functional selection of protease inhibitory antibodies

scientific article published on 30 July 2019

GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain

Galanin antisense oligonucleotides reduce galanin levels in dorsal root ganglia and induce autotomy in rats after axotomy.

scientific article

Gene Expression Profiling of Cutaneous Injured and Non-Injured Nociceptors in SNI Animal Model of Neuropathic Pain.

scientific article published on 24 August 2017

Glia and pain: is chronic pain a gliopathy?

scientific article published on 20 June 2013

Glial cells and chronic pain

scientific article

Histochemical studies on the medial regions of the brainstem in guinea pigs

scientific article published on January 1, 1992

Increased Expression of Galanin in the Rat Superior Cervical Ganglion after Pre- and Postganglionic Nerve Lesions

scientific article published on 01 May 1994

Induction of CB1 cannabinoid receptor by inflammation in primary afferent neurons facilitates antihyperalgesic effect of peripheral CB1 agonist

article by Fumimasa Amaya et al published September 2006 in Pain

Induction of c-fos expression in the rostral medulla of rats following electroacupuncture stimulation

scientific article published in October 1993

Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade ⬇️

scientific article

Interferon alpha inhibits spinal cord synaptic and nociceptive transmission via neuronal-glial interactions

scientific article published on 27 September 2016

Intracellular signaling in primary sensory neurons and persistent pain

scientific article published on 22 April 2008

Intrathecal administration of antisense oligonucleotide against p38α but not p38β MAP kinase isoform reduces neuropathic and postoperative pain and TLR4-induced pain in male mice

scientific article published on 8 November 2017

Intrathecal bone marrow stromal cells inhibit neuropathic pain via TGF-β secretion

scientific article

Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization.

scientific article published in September 2004

Is Optogenetic Activation of Vglut1-Positive Aβ Low-Threshold Mechanoreceptors Sufficient to Induce Tactile Allodynia in Mice after Nerve Injury?

scientific article published on 31 May 2019

Is endogenous D-serine in the rostral anterior cingulate cortex necessary for pain-related negative affect?

scientific article published on 10 February 2006

Is endogenous d-serine in the rostral anterior cingulate cortex necessary for pain-related negative affect?

Itch control by Toll-like receptors

scientific article published on January 2015

JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats

scientific article

JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain

scientific article published on April 2009

Large A-fiber activity is required for microglial proliferation and p38 MAPK activation in the spinal cord: different effects of resiniferatoxin and bupivacaine on spinal microglial changes after spared nerve injury

scientific article published on 22 September 2009

Light touch induces ERK activation in superficial dorsal horn neurons after inflammation: involvement of spinal astrocytes and JNK signaling in touch‐evoked central sensitization and mechanical allodynia ⬇️

scientific article published on August 31, 2010

Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection

scientific article published on 8 April 2016

Loss of NR1 subunit of NMDARs in primary sensory neurons leads to hyperexcitability and pain hypersensitivity: involvement of Ca(2+)-activated small conductance potassium channels

scientific article published on August 2013

Lysophospholipids contribute to oxaliplatin-induced acute peripheral pain

scientific article published on 04 November 2020

MAP Kinase and Cell Signaling in DRG Neurons and Spinal Microglia in Neuropathic Pain

scholarly article published 2009

MAP kinase and pain

scientific article

Macrophage Toll-like Receptor 9 Contributes to Chemotherapy-Induced Neuropathic Pain in Male Mice

scientific article published on 03 July 2019

Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain

scientific article

Matrix metalloprotease regulation of neuropathic pain

scientific article published on 10 June 2009

Microglia and spinal cord synaptic plasticity in persistent pain

scientific article

Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain

scientific article published on 01 December 2018

Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance

scientific article

Microglial Signaling in Chronic Pain with a Special Focus on Caspase 6, p38 MAP Kinase, and Sex Dependence.

scientific article published on 15 June 2016

Mitogen-activated protein kinases as potential targets for pain killers.

scientific article published on January 2004

Nerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen-activated protein kinase in spinal microglia in the rat spared nerve injury model

scientific article

Neural-glial interaction in the spinal cord for the development and maintenance of nerve injury-induced neuropathic pain

article

Neuroimmune interactions in itch: Do chronic itch, chronic pain, and chronic cough share similar mechanisms?

scientific article

Neuroinflammation and Central Sensitization in Chronic and Widespread Pain.

scientific article published on 19 February 2018

Neuroinflammation, Bone Marrow Stem Cells, and Chronic Pain

scientific article published on 21 August 2017

Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCepsilon: a novel pathway for heat hyperalgesia

scientific journal article

Neuromodulation, Specialized Proresolving Mediators, and Resolution of Pain

scientific article published on 21 July 2020

Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism.

scientific article published in September 2002

Neuropathic pain is constitutively suppressed in early life by anti-inflammatory neuroimmune regulation

scientific article published on January 2015

Neuropeptide Y and Galanin Binding Sites in Rat and Monkev Lumbar Dorsal Root Ganalia and Spinal Cord and Effect of Peripheral Axotomy

scientific article published on 01 March 1995

Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma

scientific article published on 04 September 2013

Neurotrophins: peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity

scientific article published on August 1999

New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms?

scientific article

Nociceptive neurons regulate innate and adaptive immunity and neuropathic pain through MyD88 adapter

scientific article published on 12 August 2014

Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity

scientific article published in December 1999

Nociceptors are interleukin-1beta sensors

scientific article published on December 2008

Organization of intralaminar and translaminar neuronal connectivity in the superficial spinal dorsal horn

scientific article

Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice

scientific article published in April 2012

PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1.

scientific article published on 22 May 2017

Pain regulation by non-neuronal cells and inflammation

scientific article

Perioperative nerve blockade: clues from the bench.

scientific article

Peripheral and central mechanisms of inflammatory pain, with emphasis on MAP kinases

scientific article published in September 2004

Peripheral axonal injury results in reduced mu opioid receptor pre- and post-synaptic action in the spinal cord

scientific article published in September 2005

Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons

scientific article published in July 2004

Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization.

scientific article

Phosphorylation of transcription factor CREB in rat spinal cord after formalin-induced hyperalgesia: relationship to c-fos induction

scientific article published in March 1997

Possible role of spinal astrocytes in maintaining chronic pain sensitization: review of current evidence with focus on bFGF/JNK pathway

scientific article published on November 2006

Prominent Expression of bFGF in Dorsal Root Ganglia after Axotomy

scientific article published on 01 December 1995

Recent Progress in Understanding the Mechanisms of Pain and Itch: the Second Special Issue.

scientific article published on 16 January 2018

Recent progress in understanding the mechanisms of pain and itch ⬇️

scientific article published on April 1, 2012

Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn

scientific article

Repetitive transcranial magnetic stimulation activates specific regions in rat brain.

scientific article

Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1.

scientific article published on December 2011

Resolvin D5 Inhibits Neuropathic and Inflammatory Pain in Male But Not Female Mice: Distinct Actions of D-Series Resolvins in Chemotherapy-Induced Peripheral Neuropathy

scientific article published on 05 July 2019

Resolvin E1 inhibits neuropathic pain and spinal cord microglial activation following peripheral nerve injury

scientific article published on 10 August 2012

Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1.

scientific article

Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions

scientific article

Resolvins are potent analgesics for arthritic pain

scientific article

Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine

scientific article published on 15 December 2006

Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain

scientific article published on 17 November 2018

SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons

scientific article published on 24 November 2016

Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model

scientific article

Sex-Dependent Glial Signaling in Pathological Pain: Distinct Roles of Spinal Microglia and Astrocytes

scientific article published on 05 June 2017

Short small-interfering RNAs produce interferon-α-mediated analgesia

scientific article published on 3 February 2012

Specific agrin isoforms induce cAMP response element binding protein phosphorylation in hippocampal neurons.

scientific article

Spinal CCL2 Promotes Central Sensitization, Long-Term Potentiation, and Inflammatory Pain via CCR2: Further Insights into Molecular, Synaptic, and Cellular Mechanisms.

scientific article published on 6 March 2017

Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord

scientific article

Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1

scientific article published on November 2010

Spinal sensory projection neuron responses to spinal cord stimulation are mediated by circuits beyond gate control

scientific article published on 13 May 2015

Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca²⁺ channel complex

scientific article published on 5 June 2011

TLR signaling adaptor protein MyD88 in primary sensory neurons contributes to persistent inflammatory and neuropathic pain and neuroinflammation

scientific article published on 17 June 2016

TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice

scientific article

TNF-α contributes to spinal cord synaptic plasticity and inflammatory pain: distinct role of TNF receptor subtypes 1 and 2.

scientific article

TNF-α/TNFR1 Signaling is Required for the Full Expression of Acute and Chronic Itch in Mice via Peripheral and Central Mechanisms ⬇️

scientific article published on April 2017

TRAF6 upregulation in spinal astrocytes maintains neuropathic pain by integrating TNF-α and IL-1β signaling

scientific article

Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain.

scientific article published on 17 October 2016

Targeting astrocyte signaling for chronic pain

scientific article published on October 2010

Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain

scientific article published on 8 May 2017

Targeting microglial purinergic signaling to improve morphine analgesia

scientific article published on 26 June 2010

The Qualitative Hyperalgesia Profile: A New Metric to Assess Chronic Post-Thoracotomy Pain

scientific article

The c-Jun N-terminal kinase 1 (JNK1) in spinal astrocytes is required for the maintenance of bilateral mechanical allodynia under a persistent inflammatory pain condition

scientific article

The effect of intrathecal neuropeptide Y on the flexor reflex in rats after carrageenan-induced inflammation

article

The pattern of expression of the voltage-gated sodium channels Na(v)1.8 and Na(v)1.9 does not change in uninjured primary sensory neurons in experimental neuropathic pain models

scientific article published in April 2002

Tissue plasminogen activator contributes to morphine tolerance and induces mechanical allodynia via astrocytic IL-1β and ERK signaling in the spinal cord of mice

scientific article published on 21 May 2013

Toll-like receptor 4 contributes to chronic itch, alloknesis, and spinal astrocyte activation in male mice

scientific article

Toll-like receptor 7 mediates pruritus

scientific article

Topical capsaicin treatment suppresses formalin-induced fos expression in rat spinal cord

scientific article published on 01 January 1994

Transcriptional Profiling of Somatostatin Interneurons in the Spinal Dorsal Horn

scientific article published in Scientific Reports

Transcriptional and functional profiles of voltage-gated Na+ channels in injured and non-injured DRG neurons in the SNI model of neuropathic pain

article

Transition to chronic pain: opportunities for novel therapeutics

scientific article published on 01 July 2018

Treating triple-negative breast cancer by a combination of rapamycin and cyclophosphamide: an in vivo bioluminescence imaging study

scientific article

Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats

scientific article published in September 2003

Upregulation of the Voltage-Gated Sodium Channel 2 Subunit in Neuropathic Pain Models: Characterization of Expression in Injured and Non-Injured Primary Sensory Neurons

article

Use of bulleyaconitine A as an adjuvant for prolonged cutaneous analgesia in the rat.

scientific article published on October 2008

VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch ⬇️

scientific article published on November 2010

[Electroacupuncture enhances enkephalin mRNA expression in the spinal cord and medulla, an in situ hybridization study]

scientific article published on 01 August 1993

aFGF, bFGF and NGF differentially regulate neuropeptide expression in dorsal root ganglia after axotomy and induce autotomy

scientific article published on 01 October 1996

beta-Endorphin-containing memory-cells and mu-opioid receptors undergo transport to peripheral inflamed tissue

scientific article

miRNA-711 Binds and Activates TRPA1 Extracellularly to Evoke Acute and Chronic Pruritus

scientific article published on 19 July 2018

p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia

scientific article

p38 MAPK, microglial signaling, and neuropathic pain

scientific article

p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain.

scientific article published in May 2003

β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain

scientific article

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